FI954403A - 3-(4-(2-aminoetoksi)bentsoyyli)-2-aryyli-6-hydroksibentso(b)tiofeenien synteesi - Google Patents

3-(4-(2-aminoetoksi)bentsoyyli)-2-aryyli-6-hydroksibentso(b)tiofeenien synteesi Download PDF

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Publication number
FI954403A
FI954403A FI954403A FI954403A FI954403A FI 954403 A FI954403 A FI 954403A FI 954403 A FI954403 A FI 954403A FI 954403 A FI954403 A FI 954403A FI 954403 A FI954403 A FI 954403A
Authority
FI
Finland
Prior art keywords
hydroxybenzo
thiophenes
aminoethoxy
benzoyl
aryl
Prior art date
Application number
FI954403A
Other languages
English (en)
Swedish (sv)
Other versions
FI954403A0 (fi
FI121424B (fi
Inventor
Elizabeth Smith Labell
Wayne Douglas Luke
Iii John Mcneill Mcgill
Randal Scot Miller
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26976194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI954403(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/308,325 external-priority patent/US5629425A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI954403A0 publication Critical patent/FI954403A0/fi
Publication of FI954403A publication Critical patent/FI954403A/fi
Application granted granted Critical
Publication of FI121424B publication Critical patent/FI121424B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
FI954403A 1994-09-19 1995-09-18 Menetelmä 6-hydroksi-2-(4-hydroksifenyyli)-3-[4-(2-piperidinoetoksi)-bentsoyyli]bentso[b]tiofeenihydrokloridin kiteisen solvaatin valmistamiseksi ja kiteiset 1,2-dikloorietaani- ja 1,2,3-triklooripropaanisolvaatit FI121424B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/308,325 US5629425A (en) 1994-09-19 1994-09-19 Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US30832594 1994-09-19
US42791495A 1995-04-26 1995-04-26
US42791495 1995-04-26

Publications (3)

Publication Number Publication Date
FI954403A0 FI954403A0 (fi) 1995-09-18
FI954403A true FI954403A (fi) 1996-03-20
FI121424B FI121424B (fi) 2010-11-15

Family

ID=26976194

Family Applications (2)

Application Number Title Priority Date Filing Date
FI954403A FI121424B (fi) 1994-09-19 1995-09-18 Menetelmä 6-hydroksi-2-(4-hydroksifenyyli)-3-[4-(2-piperidinoetoksi)-bentsoyyli]bentso[b]tiofeenihydrokloridin kiteisen solvaatin valmistamiseksi ja kiteiset 1,2-dikloorietaani- ja 1,2,3-triklooripropaanisolvaatit
FI954402A FI112226B (fi) 1994-09-19 1995-09-18 Ei solvatoitu, kiteinen 6-hydroksi-2-(4-hydroksifenyyli)-3-[4-(2-piperidinoetoksi)bentsoyyli]bentso[b]tiofeenihydrokloridi

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI954402A FI112226B (fi) 1994-09-19 1995-09-18 Ei solvatoitu, kiteinen 6-hydroksi-2-(4-hydroksifenyyli)-3-[4-(2-piperidinoetoksi)bentsoyyli]bentso[b]tiofeenihydrokloridi

Country Status (51)

Country Link
US (4) US5731327A (fi)
JP (2) JPH08193081A (fi)
KR (2) KR100367376B1 (fi)
CN (2) CN1068324C (fi)
AP (1) AP754A (fi)
AT (2) AT407988B (fi)
AU (3) AU691955B2 (fi)
BE (2) BE1009625A3 (fi)
BG (1) BG62793B1 (fi)
BR (2) BR9504059A (fi)
CA (2) CA2158399C (fi)
CH (3) CH691478A5 (fi)
CO (2) CO4410191A1 (fi)
CZ (2) CZ290343B6 (fi)
DE (3) DE19549755B4 (fi)
DK (4) DK175897B1 (fi)
EE (1) EE03386B1 (fi)
EG (1) EG23763A (fi)
ES (2) ES2129293B1 (fi)
FI (2) FI121424B (fi)
FR (2) FR2724655B1 (fi)
GB (2) GB2293602B (fi)
GE (1) GEP19991821B (fi)
GR (2) GR1002709B (fi)
HK (1) HK1019009A1 (fi)
HR (2) HRP950482B1 (fi)
HU (2) HU225417B1 (fi)
IE (2) IE80883B1 (fi)
IL (3) IL115314A (fi)
IS (1) IS1788B (fi)
IT (2) IT1277602B1 (fi)
LU (2) LU88660A1 (fi)
LV (2) LV11178B (fi)
MY (1) MY116371A (fi)
NL (2) NL1001194C2 (fi)
NO (2) NO308107B1 (fi)
NZ (2) NZ280028A (fi)
OA (1) OA10406A (fi)
PE (2) PE32796A1 (fi)
PL (2) PL182450B1 (fi)
PT (2) PT101770B (fi)
RO (2) RO115259B1 (fi)
RS (2) RS49513B (fi)
SE (2) SE520721C2 (fi)
SI (2) SI9500293A (fi)
SK (1) SK283502B6 (fi)
TR (1) TR199501136A2 (fi)
TW (1) TW412534B (fi)
UA (2) UA42716C2 (fi)
UY (1) UY24040A1 (fi)
WO (1) WO1996009045A1 (fi)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
USRE38968E1 (en) 1992-07-28 2006-02-07 Eli Lilly And Company Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride
USRE39049E1 (en) 1992-07-28 2006-03-28 Eli Lilly And Company Methods for inhibiting bone loss
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
CO4410191A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US6458811B1 (en) * 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
EP2266560A1 (en) * 1996-03-26 2010-12-29 Eli Lilly & Company Benzothiophenes, formulations containing same, and methods
ZA979723B (en) 1996-10-30 1999-07-29 Lilly Co Eli Methods of preventing breast cancer.
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
DK1175433T3 (da) 1999-05-04 2005-09-19 Strakan Int Ltd Androgenglycosider og androgen aktivitet deraf
US6921827B2 (en) * 2000-11-27 2005-07-26 Eli Lilly And Company Process for preparing 3-aryl-benzo{b} thiophenes
KR20040088519A (ko) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. 활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
EP1826205A1 (en) 2002-09-30 2007-08-29 A/S GEA Farmaceutisk Fabrik Novel raloxifene succinic acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these
US6861422B2 (en) 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
US20060106010A1 (en) * 2003-05-27 2006-05-18 Black Larry J Methods for inhibiting bone loss
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004029784A1 (de) 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004030502A1 (de) 2004-06-24 2006-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
DE102004033670A1 (de) 2004-07-09 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US7728134B2 (en) 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060074088A1 (en) 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
US7759485B2 (en) 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US20060035903A1 (en) 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
EP1630163A1 (de) 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
NZ553804A (en) 2004-09-29 2010-07-30 Bayer Schering Pharma Ag Thermodynamically stable form of bay 43-9006 tosylate
US20060068010A1 (en) * 2004-09-30 2006-03-30 Stephen Turner Method for improving the bioavailability of orally delivered therapeutics
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102004058337A1 (de) 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US7439358B2 (en) 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
EP2540725A1 (de) 2006-05-04 2013-01-02 Boehringer Ingelheim International GmbH Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
KR20090082399A (ko) * 2006-10-17 2009-07-30 씨아이피엘에이 엘티디. 벤조티오펜 화합물의 결정형 및 그의 제조방법
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
DE102007032451B4 (de) 2007-07-12 2010-09-30 Icfs Gmbh Verfahren zur Herstellung von aromatischen Ketonen
US20090023799A1 (en) * 2007-07-20 2009-01-22 George Laurence CRYSTALS OF (2-AMINO-4,5,6,7-TETRAHYDROBENZO[b]THIEN-3-YL)(4-CHLOROPHENYL)METHANONE
WO2009019205A1 (en) 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Crystalline form of a dihydropteridione derivative
WO2009080364A1 (en) * 2007-12-21 2009-07-02 Synthon B.V. Raloxifene composition
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
US20110088613A1 (en) * 2008-06-09 2011-04-21 Massimo Ferrari Process for controlling the growth of a raloxifene hydrochloride crystal
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
RU2011113823A (ru) 2008-09-10 2012-10-20 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Комбинированная терапия, предназначенная для лечения диабета и связанных с ним состояний
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
JP2012512848A (ja) 2008-12-23 2012-06-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 有機化合物の塩の形態
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
ES2437916T3 (es) 2009-07-02 2014-01-15 Synthon B.V. Composición de raloxifeno
EP2314581B1 (en) 2009-10-23 2012-07-25 Hexal AG A process for preparing benzo[b]thiophene derivatives
NZ599298A (en) 2009-11-27 2014-11-28 Boehringer Ingelheim Int Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
JP6034781B2 (ja) 2010-05-05 2016-11-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 併用療法
EP3725325B1 (en) 2010-06-24 2023-05-31 Boehringer Ingelheim International GmbH Diabetes therapy
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
IT1403083B1 (it) * 2010-10-25 2013-10-04 Fidia Farmaceutici Nuova forma polimorfa di raloxifene cloridrato
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
DK2731947T3 (en) 2011-07-15 2019-04-23 Boehringer Ingelheim Int SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
IN2013MU00665A (fi) 2013-03-05 2015-07-03 Cipla Ltd
JP2016525532A (ja) 2013-07-26 2016-08-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 骨髄異形成症候群の処置
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
CN104496963A (zh) * 2014-12-02 2015-04-08 千辉药业（安徽）有限责任公司 一种盐酸雷洛昔芬的制备方法
CA3022202A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869485A (en) * 1969-09-25 1975-03-04 Allied Chem Preparation of acid chlorides with phosgene in the presence of a catalyst
GB1456323A (en) * 1974-06-06 1976-11-24 Labaz Benzothiophenes process for preparing them and pharmaceutical compositions containing the same
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
IL65379A0 (en) 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
ZA822247B (en) 1981-04-03 1983-11-30 Lilly Co Eli Benzothiophene compounds and process for preparing them
GB2097788B (en) 1981-04-03 1985-04-24 Lilly Co Eli Benzothiophene compounds and process for preparing them
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
IL65378A (en) * 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
DE4117512A1 (de) 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5169860A (en) 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
TW383306B (en) 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
ATE157869T1 (de) 1993-06-24 1997-09-15 Lilly Co Eli Antiöstrogene 2-phenyl-3-aroylbenzothiophene als hypoglykämische mittel
US6756388B1 (en) 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5523416A (en) 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
CO4410191A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS

Also Published As

Publication number Publication date
PL182450B1 (pl) 2002-01-31
SI9500293A (en) 1996-06-30
ITMI951936A0 (it) 1995-09-15
PT101770B (pt) 1997-04-30
UY24040A1 (es) 1996-03-07
ITMI951935A1 (it) 1997-03-15
FI954402A (fi) 1996-03-20
FR2724655A1 (fr) 1996-03-22
HUT75033A (en) 1997-03-28
GEP19991821B (en) 1999-11-05
HRP950482A2 (en) 1998-02-28
FI954403A0 (fi) 1995-09-18
US6399778B1 (en) 2002-06-04
NL1001196C2 (nl) 1997-04-04
CH691125A5 (de) 2001-04-30
NZ280028A (en) 1997-05-26
SE520721C2 (sv) 2003-08-12
CO4410190A1 (es) 1997-01-09
ES2109882A1 (es) 1998-01-16
NL1001194A1 (nl) 1996-03-19
CZ290343B6 (cs) 2002-07-17
DK102795A (da) 1996-03-20
CO4410191A1 (es) 1997-01-09
FI954402A0 (fi) 1995-09-18
HK1019009A1 (en) 2000-01-14
DK175897B1 (da) 2005-05-30
AT502957A1 (de) 2007-06-15
UA44240C2 (uk) 2002-02-15
BR9504059A (pt) 1996-09-24
BG101242A (en) 1998-03-31
HU9502723D0 (en) 1995-11-28
DK2897A (da) 1997-01-09
EE9700055A (et) 1997-08-15
IE950721A1 (en) 1996-03-20
GR1002697B (el) 1997-05-22
IT1277602B1 (it) 1997-11-11
KR960010637A (ko) 1996-04-20
HU9502721D0 (en) 1995-11-28
NO313996B1 (no) 2003-01-13
CN1075069C (zh) 2001-11-21
PT101771A (pt) 1996-04-30
SE9503214L (sv) 1996-03-20
NZ280027A (en) 1997-05-26
TW412534B (en) 2000-11-21
SK23397A3 (en) 1997-08-06
DE19534745A1 (de) 1996-04-04
MY116371A (en) 2004-01-31
IL115315A (en) 1999-09-22
RS49513B (sr) 2006-10-27
GB9519032D0 (en) 1995-11-15
BE1009626A3 (fr) 1997-06-03
PT101770A (pt) 1996-04-30
SE9503214D0 (sv) 1995-09-15
LV11178B (en) 1996-08-20
AP9700938A0 (en) 1997-04-30
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ES2129293B1 (es) 2000-01-16
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CA2158400C (en) 2006-10-24
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HRP950483B1 (en) 2003-02-28
DK2797A (da) 1997-01-09
FI121424B (fi) 2010-11-15
HU227683B1 (en) 2011-11-28
DE19534744A1 (de) 1996-03-21
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GB2293382B (en) 1998-08-19
AT407988B (de) 2001-07-25
IL115314A0 (en) 1996-05-14
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