HU226769B1 - N-substituted 2-cyanopyrrolidines and pharmaceutical compositions containing them - Google Patents

N-substituted 2-cyanopyrrolidines and pharmaceutical compositions containing them Download PDF

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Publication number
HU226769B1
HU226769B1 HU0104495A HUP0104495A HU226769B1 HU 226769 B1 HU226769 B1 HU 226769B1 HU 0104495 A HU0104495 A HU 0104495A HU P0104495 A HUP0104495 A HU P0104495A HU 226769 B1 HU226769 B1 HU 226769B1
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HU
Hungary
Prior art keywords
amino
acetyl
adamantyl
pharmaceutically acceptable
acid addition
Prior art date
Application number
HU0104495A
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English (en)
Hungarian (hu)
Inventor
Edwin Bernard Villhauer
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HUP0104495A2 publication Critical patent/HUP0104495A2/hu
Publication of HUP0104495A3 publication Critical patent/HUP0104495A3/hu
Publication of HU226769B1 publication Critical patent/HU226769B1/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HU0104495A 1998-12-10 1999-12-09 N-substituted 2-cyanopyrrolidines and pharmaceutical compositions containing them HU226769B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20906898A 1998-12-10 1998-12-10
PCT/EP1999/009708 WO2000034241A1 (en) 1998-12-10 1999-12-09 N-substituted 2-cyanopyrrolidines

Publications (3)

Publication Number Publication Date
HUP0104495A2 HUP0104495A2 (hu) 2002-04-29
HUP0104495A3 HUP0104495A3 (en) 2002-11-28
HU226769B1 true HU226769B1 (en) 2009-09-28

Family

ID=22777194

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104495A HU226769B1 (en) 1998-12-10 1999-12-09 N-substituted 2-cyanopyrrolidines and pharmaceutical compositions containing them

Country Status (34)

Country Link
US (1) US6166063A (cg-RX-API-DMAC10.html)
EP (1) EP1137635B1 (cg-RX-API-DMAC10.html)
JP (2) JP3681110B2 (cg-RX-API-DMAC10.html)
KR (2) KR100509311B1 (cg-RX-API-DMAC10.html)
CN (1) CN1160330C (cg-RX-API-DMAC10.html)
AR (1) AR023719A1 (cg-RX-API-DMAC10.html)
AT (1) ATE307112T1 (cg-RX-API-DMAC10.html)
BR (1) BRPI9915985B8 (cg-RX-API-DMAC10.html)
CA (1) CA2350609C (cg-RX-API-DMAC10.html)
CO (1) CO5150173A1 (cg-RX-API-DMAC10.html)
CY (3) CY1105355T1 (cg-RX-API-DMAC10.html)
CZ (1) CZ299151B6 (cg-RX-API-DMAC10.html)
DE (3) DE122008000007I1 (cg-RX-API-DMAC10.html)
DK (1) DK1137635T3 (cg-RX-API-DMAC10.html)
ES (1) ES2251847T3 (cg-RX-API-DMAC10.html)
FR (1) FR08C0005I2 (cg-RX-API-DMAC10.html)
HK (1) HK1040394B (cg-RX-API-DMAC10.html)
HU (1) HU226769B1 (cg-RX-API-DMAC10.html)
ID (1) ID28796A (cg-RX-API-DMAC10.html)
IL (2) IL143091A0 (cg-RX-API-DMAC10.html)
LU (2) LU91409I2 (cg-RX-API-DMAC10.html)
MY (1) MY123244A (cg-RX-API-DMAC10.html)
NL (2) NL300333I2 (cg-RX-API-DMAC10.html)
NO (3) NO318741B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ511935A (cg-RX-API-DMAC10.html)
PE (1) PE20001317A1 (cg-RX-API-DMAC10.html)
PL (1) PL199443B1 (cg-RX-API-DMAC10.html)
RU (1) RU2251544C2 (cg-RX-API-DMAC10.html)
SK (1) SK286635B6 (cg-RX-API-DMAC10.html)
TR (1) TR200101478T2 (cg-RX-API-DMAC10.html)
TW (1) TW509674B (cg-RX-API-DMAC10.html)
UY (1) UY25843A1 (cg-RX-API-DMAC10.html)
WO (1) WO2000034241A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200104581B (cg-RX-API-DMAC10.html)

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