HRP20190826T1 - Konjugati oligonukleotida - Google Patents

Konjugati oligonukleotida Download PDF

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Publication number
HRP20190826T1
HRP20190826T1 HRP20190826TT HRP20190826T HRP20190826T1 HR P20190826 T1 HRP20190826 T1 HR P20190826T1 HR P20190826T T HRP20190826T T HR P20190826TT HR P20190826 T HRP20190826 T HR P20190826T HR P20190826 T1 HRP20190826 T1 HR P20190826T1
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Croatia
Prior art keywords
region
oligomeric compound
compound according
group
phosphodiester
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HRP20190826TT
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English (en)
Croatian (hr)
Inventor
Nanna ALBÆK
Henrik Frydenlund Hansen
Susanne KAMMLER
Jacob Ravn
Henrik ØRUM
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Roche Innovation Center Copenhagen A/S
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Publication of HRP20190826T1 publication Critical patent/HRP20190826T1/hr

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/351—Conjugate
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/30—Chemical structure
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    • C12N2310/3517—Marker; Tag
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HRP20190826TT 2012-11-15 2013-11-14 Konjugati oligonukleotida HRP20190826T1 (hr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP12192773 2012-11-15
EP13153296 2013-01-30
EP13157237 2013-02-28
EP13174092 2013-06-27
PCT/EP2013/073858 WO2014076195A1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates
EP13791808.2A EP2920304B1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Publications (1)

Publication Number Publication Date
HRP20190826T1 true HRP20190826T1 (hr) 2019-06-28

Family

ID=49584733

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20190826TT HRP20190826T1 (hr) 2012-11-15 2013-11-14 Konjugati oligonukleotida

Country Status (22)

Country Link
US (4) US10077443B2 (https=)
EP (3) EP2920307B1 (https=)
JP (3) JP6452614B2 (https=)
KR (2) KR20150083920A (https=)
CN (3) CN117126846A (https=)
AU (2) AU2013346767B2 (https=)
BR (2) BR112015011112A2 (https=)
CA (2) CA2889044A1 (https=)
DK (2) DK2920307T3 (https=)
ES (1) ES2724853T3 (https=)
HK (2) HK1210213A1 (https=)
HR (1) HRP20190826T1 (https=)
IL (2) IL238448B (https=)
MX (2) MX363068B (https=)
MY (1) MY173826A (https=)
NZ (1) NZ708171A (https=)
PL (1) PL2920304T3 (https=)
RU (3) RU2018112970A (https=)
SG (2) SG11201503821YA (https=)
SI (1) SI2920304T1 (https=)
WO (2) WO2014076195A1 (https=)
ZA (1) ZA201503375B (https=)

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