SG10201406016SA - Pharmaceutical composition comprising anti-mirna antisense oligonucleotides - Google Patents
Pharmaceutical composition comprising anti-mirna antisense oligonucleotidesInfo
- Publication number
- SG10201406016SA SG10201406016SA SG10201406016SA SG10201406016SA SG10201406016SA SG 10201406016S A SG10201406016S A SG 10201406016SA SG 10201406016S A SG10201406016S A SG 10201406016SA SG 10201406016S A SG10201406016S A SG 10201406016SA SG 10201406016S A SG10201406016S A SG 10201406016SA
- Authority
- SG
- Singapore
- Prior art keywords
- pharmaceutical composition
- antisense oligonucleotides
- mirna antisense
- mirna
- oligonucleotides
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78899506P | 2006-04-03 | 2006-04-03 | |
DKPA200600478 | 2006-04-03 | ||
US79681306P | 2006-05-01 | 2006-05-01 | |
DKPA200600615 | 2006-05-01 | ||
US83871006P | 2006-08-18 | 2006-08-18 | |
DKPA200601401 | 2006-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201406016SA true SG10201406016SA (en) | 2014-11-27 |
Family
ID=43062722
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201406016SA SG10201406016SA (en) | 2006-04-03 | 2007-03-30 | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
SG201102154-0A SG170773A1 (en) | 2006-04-03 | 2007-03-30 | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG201102154-0A SG170773A1 (en) | 2006-04-03 | 2007-03-30 | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
Country Status (9)
Country | Link |
---|---|
US (1) | US8163708B2 (en) |
EP (4) | EP2666859B1 (en) |
CN (1) | CN102851291B (en) |
EA (4) | EA201100810A1 (en) |
ES (1) | ES2569558T3 (en) |
MY (1) | MY162210A (en) |
NZ (1) | NZ571569A (en) |
PL (1) | PL2666859T3 (en) |
SG (2) | SG10201406016SA (en) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2623598B1 (en) * | 2007-10-04 | 2018-08-01 | Roche Innovation Center Copenhagen A/S | Micromirs |
US20110257244A1 (en) * | 2008-01-18 | 2011-10-20 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides and small molecules for use in reducing micro rna activity levels and uses thereof |
US8404659B2 (en) * | 2008-03-07 | 2013-03-26 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of MicroRNA related diseases |
WO2010012667A1 (en) | 2008-08-01 | 2010-02-04 | Santaris Pharma A/S | Micro-rna mediated modulation of colony stimulating factors |
US10138485B2 (en) | 2008-09-22 | 2018-11-27 | Rxi Pharmaceuticals Corporation | Neutral nanotransporters |
WO2010122538A1 (en) * | 2009-04-24 | 2010-10-28 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of hcv patients that are non-responders to interferon |
CA2781618A1 (en) * | 2009-11-25 | 2011-06-03 | Elitech Holding B.V. | Minor groove binder (mgb)-oligonucleotide mirna antagonists |
AU2011219029B2 (en) | 2010-02-26 | 2017-02-02 | Columbia University | Methods and compositions for the detection and treatment of cancer involving miRNAs and miRNA inhibitors and targets |
JP6060071B2 (en) | 2010-03-24 | 2017-01-11 | アールエックスアイ ファーマシューティカルズ コーポレーション | RNA interference in skin and fibrosis applications |
US9095504B2 (en) | 2010-03-24 | 2015-08-04 | Rxi Pharmaceuticals Corporation | RNA interference in ocular indications |
AU2011232669B2 (en) * | 2010-03-26 | 2016-08-25 | The Ohio State University | Materials and methods related to modulation of mismatch repair and genomic stability by miR-155 |
US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
EP3260540A1 (en) | 2010-11-12 | 2017-12-27 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
CN103620035B (en) * | 2011-04-25 | 2021-04-23 | 赛诺菲 | microRNA compounds and methods for modulating MIR-21 activity |
WO2013013165A2 (en) * | 2011-07-21 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Use of lna compounds for therapeutic inhibition of mir-21 in systemic lupus erythematosus |
EP2766482B1 (en) * | 2011-10-11 | 2016-12-07 | The Brigham and Women's Hospital, Inc. | Micrornas in neurodegenerative disorders |
GB2509682B (en) | 2011-10-19 | 2016-07-27 | Council Scient Ind Res | Biomarkers useful for detection of types, grades and stages of human breast cancer |
KR20220028183A (en) | 2012-04-25 | 2022-03-08 | 사노피 | Microrna compounds and methods for modulating mir-21 activity |
WO2013173608A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics, Inc. | Compositions and methods for modulating mecp2 expression |
WO2013173599A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics, Inc. | Compositions and methods for modulating hemoglobin gene family expression |
CA2873766A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating atp2a2 expression |
US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
UA116639C2 (en) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Methods for treatment of alport syndrome |
US20150291958A1 (en) | 2012-11-15 | 2015-10-15 | Roche Innovation Center Copenhagen A/S | Anti apob antisense conjugate compounds |
TWI680767B (en) | 2013-05-01 | 2020-01-01 | 美商雷格勒斯治療公司 | Compounds and methods for enhanced cellular uptake |
US9309513B2 (en) | 2013-05-01 | 2016-04-12 | Regulus Therapeutics Inc. | MicroRNA compounds and methods for modulating miR-122 |
CN104031987B (en) * | 2014-05-12 | 2016-08-31 | 贵州省人民医院 | MiRNA application in myocardial fibrosis disease treatment |
WO2016070060A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
CN107206089A (en) * | 2014-11-10 | 2017-09-26 | 葛兰素史克知识产权第二有限公司 | Joint durable action composition and method for hepatitis C |
US10900036B2 (en) | 2015-03-17 | 2021-01-26 | The General Hospital Corporation | RNA interactome of polycomb repressive complex 1 (PRC1) |
CN105087477A (en) * | 2015-05-21 | 2015-11-25 | 王松灵 | Application of mesenchymal stem cell modified by miR-21 antisense nucleotide |
MX368314B (en) | 2015-06-05 | 2019-09-27 | Miragen Therapeutics Inc | Mir-155 inhibitors for treating cutaneous t cell lymphoma (ctcl). |
US10179913B2 (en) * | 2015-08-26 | 2019-01-15 | Kaohsiung Medical University | MicroRNA-328 anti-sense composition and therapeutic use |
JP6666002B2 (en) | 2015-10-07 | 2020-03-13 | 国立大学法人京都大学 | Composition for preventing or treating TDP-43 proteinenopathy |
CN107034216A (en) * | 2016-02-04 | 2017-08-11 | 中国科学技术大学 | The design and application of miRancer molecules |
AU2017353907B2 (en) | 2016-11-01 | 2023-11-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
WO2018170759A1 (en) * | 2017-03-22 | 2018-09-27 | 深圳市博奥康生物科技有限公司 | Recombinant ad-140-148a-185-tud adenovirus, and construction and application thereof |
WO2019000151A1 (en) * | 2017-06-26 | 2019-01-03 | 深圳市博奥康生物科技有限公司 | Recombinant adeno-associated virus for simultaneously inhibiting expressions of three micrornas |
WO2019000147A1 (en) * | 2017-06-26 | 2019-01-03 | 深圳市博奥康生物科技有限公司 | Tud rna effectively inhibiting expression of human mir-148a, mir-152 and mir-185 and use thereof |
WO2019000143A1 (en) * | 2017-06-26 | 2019-01-03 | 深圳市博奥康生物科技有限公司 | Recombinant adeno-associated virus knocking down mirna expression |
WO2019215333A1 (en) * | 2018-05-11 | 2019-11-14 | Alpha Anomeric Sas | Oligonucleotides conjugates comprising 7'-5'-alpha-anomeric-bicyclic sugar nucleosides |
CA3140285A1 (en) | 2019-05-16 | 2020-11-19 | Aptatargets, S.L. | Treatment of tlr-4 mediated diseases and conditions with aptamers targeting tlr-4 |
EP3990028A4 (en) | 2019-06-26 | 2023-08-09 | Biorchestra Co., Ltd. | Micellar nanoparticles and uses thereof |
WO2024026490A1 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Polynucleotides encoding linked antigens and uses thereof |
Family Cites Families (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4962029A (en) | 1987-10-02 | 1990-10-09 | Cetus Corporation | Covalent oligonucleotide-horseradish peroxidase conjugate |
US4914210A (en) | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
US4920115A (en) | 1988-12-28 | 1990-04-24 | Virginia Commonwealth University | Method of lowering LDL cholesterol in blood |
JPH06311885A (en) | 1992-08-25 | 1994-11-08 | Mitsubishi Kasei Corp | Anti-sense compound complementary with gene of hepatitis c virus |
US6423489B1 (en) | 1992-09-10 | 2002-07-23 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of Hepatitis C virus-associated diseases |
US6433159B1 (en) | 1992-09-10 | 2002-08-13 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of Hepatitis C virus associated diseases |
DE69330372T2 (en) | 1992-09-10 | 2002-03-14 | Isis Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH HEPATITIS C VIRUSES |
WO1995030746A1 (en) | 1994-05-10 | 1995-11-16 | The General Hospital Corporation | Antisense inhibition of hepatitis c virus |
MX9709914A (en) | 1995-06-07 | 1998-03-31 | Pfizer | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION. |
WO1998023593A1 (en) | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Apo b-secretion/mtp inhibitory amides |
CA2283379A1 (en) | 1997-03-05 | 1998-09-11 | Michael G. Katze | Novel screening methods to identify agents that selectively inhibit hepatitis c virus replication |
EP2341057A3 (en) | 1997-09-12 | 2011-11-23 | Exiqon A/S | Oligonucleotide Analogues |
AU777049B2 (en) | 1999-03-18 | 2004-09-30 | Qiagen Gmbh | Xylo-LNA analogues |
ATE332909T1 (en) | 1999-03-24 | 2006-08-15 | Exiqon As | IMPROVED SYNTHESIS FOR 2.2.1.ÖBICYCLO-NUCLEOSIDES |
ATE356824T1 (en) | 1999-05-04 | 2007-04-15 | Santaris Pharma As | L-RIBO-LNA ANALOGUE |
US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
AU7406700A (en) | 1999-10-04 | 2001-05-10 | Exiqon A/S | Design of high affinity rnase h recruiting oligonucleotide |
WO2001025478A1 (en) * | 1999-10-04 | 2001-04-12 | Exiqon A/S | A method of increasing the specificity of oxy-lna oligonucleotides |
IL139450A0 (en) | 1999-11-10 | 2001-11-25 | Pfizer Prod Inc | Methods of administering apo b-secretion/mtp inhibitors |
US6998484B2 (en) | 2000-10-04 | 2006-02-14 | Santaris Pharma A/S | Synthesis of purine locked nucleic acid analogues |
AU2002250236A1 (en) | 2001-03-02 | 2002-09-19 | Medimmune, Inc. | Cd2 antagonists for treatment of autoimmune or inflammatory disease |
JP2004532022A (en) | 2001-03-26 | 2004-10-21 | サーナ・セラピューティクス・インコーポレイテッド | Oligonucleotide-mediated inhibition of hepatitis B virus and hepatitis C virus replication |
WO2002094250A2 (en) | 2001-05-18 | 2002-11-28 | Cureon A/S | Therapeutic uses of lna-modified oligonucleotides in infectious diseases |
DE60202681T2 (en) | 2001-07-12 | 2006-01-12 | Santaris Pharma A/S | PROCESS FOR THE PREPARATION OF LNA PHOSPHORAMIDITE |
US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
EP2224003B1 (en) | 2001-09-28 | 2018-04-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
ATE519774T1 (en) | 2002-02-20 | 2011-08-15 | Sirna Therapeutics Inc | RNA DISRUPTION-MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) GENE EXPRESSION WITH SHORT INTERFERING NUCLEIC ACID (SINA) |
CA2484526C (en) | 2002-05-08 | 2009-10-13 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
WO2004014313A2 (en) | 2002-08-12 | 2004-02-19 | Bristol-Myers Squibb Company | Combination pharmaceutical agents as inhibitors of hcv replication |
UA79300C2 (en) | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
CA2505801A1 (en) | 2002-11-13 | 2004-05-27 | Rosanne Crooke | Antisense modulation of apolipoprotein b expression |
CA2506576C (en) | 2002-11-18 | 2018-03-06 | Santaris Pharma A/S | Antisense gapmer oligonucleotides |
US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
FR2848572B1 (en) | 2002-12-12 | 2005-12-09 | Univ Joseph Fourier | INHIBITOR MOLECULES OF PROTEIN SYNTHESIS OF HEPATITIS C VIRUS AND METHOD FOR SCREENING THESE INHIBITORY MOLECULES |
AU2004215097A1 (en) | 2003-02-10 | 2004-09-10 | National Institute Of Advanced Industrial Science And Technology | Regulation of gene expression by DNA interference |
DE602004022020D1 (en) | 2003-02-10 | 2009-08-27 | Santaris Pharma As | OLIGOMER COMPOUNDS FOR MODULATING THE EXPRESSION OF SURVIVIN |
CA2533701A1 (en) | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
CA2532795A1 (en) | 2003-08-07 | 2005-02-17 | Avi Biopharma, Inc. | Sense antiviral compound and method for treating ssrna viral infection |
US20050142581A1 (en) | 2003-09-04 | 2005-06-30 | Griffey Richard H. | Microrna as ligands and target molecules |
WO2005054494A2 (en) | 2003-11-26 | 2005-06-16 | University Of Massachusetts | Sequence-specific inhibition of small rna function |
UA83510C2 (en) | 2003-12-09 | 2008-07-25 | Янссен Фармацевтика Н.В. | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b |
ATE467679T1 (en) * | 2003-12-23 | 2010-05-15 | Santaris Pharma As | OLIGOMERIC COMPOUNDS FOR MODULATING BCL-2 |
EP2295604B1 (en) | 2004-02-09 | 2015-04-08 | Thomas Jefferson University | Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features |
US20050182005A1 (en) | 2004-02-13 | 2005-08-18 | Tuschl Thomas H. | Anti-microRNA oligonucleotide molecules |
CA2556435C (en) * | 2004-02-13 | 2014-08-12 | The Rockefeller University | Anti-microrna oligonucleotide molecules |
CN1961081B (en) | 2004-04-07 | 2012-09-05 | 埃克斯魁恩公司 | Methods for quantification of microRNA and small interfering RNA |
US7365058B2 (en) | 2004-04-13 | 2008-04-29 | The Rockefeller University | MicroRNA and methods for inhibiting same |
EP1745150A4 (en) | 2004-04-20 | 2008-02-27 | Genaco Biomedial Products Inc | Method for detecting ncrna |
PL1747023T5 (en) | 2004-05-04 | 2017-05-31 | Univ Leland Stanford Junior | Methods and compositions for reducing hcv viral genome amounts in a target cell |
US20080213891A1 (en) | 2004-07-21 | 2008-09-04 | Alnylam Pharmaceuticals, Inc. | RNAi Agents Comprising Universal Nucleobases |
CA2574088C (en) | 2004-07-21 | 2013-09-17 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a modified or non-natural nucleobase |
FR2873694B1 (en) | 2004-07-27 | 2006-12-08 | Merck Sante Soc Par Actions Si | NEW AZA-INDOLES INHIBITORS OF MTP AND APOB |
AU2005330637B2 (en) | 2004-08-04 | 2012-09-20 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase |
JP5192234B2 (en) | 2004-08-10 | 2013-05-08 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | Chemically modified oligonucleotide |
PL2409713T3 (en) | 2004-08-10 | 2016-02-29 | Kastle Therapeutics Llc | Oligonucleotides for use in modulating lipoprotein and cholesterol levels in humans |
EP1791954A1 (en) | 2004-09-07 | 2007-06-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial |
US7528118B2 (en) | 2004-09-24 | 2009-05-05 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of ApoB and uses thereof |
WO2006137941A2 (en) | 2004-11-12 | 2006-12-28 | Ambion, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
WO2006053430A1 (en) | 2004-11-17 | 2006-05-26 | Protiva Biotherapeutics, Inc. | Sirna silencing of apolipoprotein b |
US20060185027A1 (en) | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
EP1838870A2 (en) | 2004-12-29 | 2007-10-03 | Exiqon A/S | NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF MICRORNAS AND THEIR TARGET MRNAs |
ES2430319T3 (en) | 2005-04-19 | 2013-11-20 | Surface Logix, Inc. | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion |
US20060265771A1 (en) | 2005-05-17 | 2006-11-23 | Lewis David L | Monitoring microrna expression and function |
US20090209621A1 (en) | 2005-06-03 | 2009-08-20 | The Johns Hopkins University | Compositions and methods for decreasing microrna expression for the treatment of neoplasia |
US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
WO2007021896A2 (en) | 2005-08-10 | 2007-02-22 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro rna and uses thereof |
WO2007027775A2 (en) * | 2005-08-29 | 2007-03-08 | Isis Pharmaceuticals, Inc. | Methods for use in modulating mir-122a |
DK1931780T3 (en) | 2005-08-29 | 2016-01-25 | Regulus Therapeutics Inc | Antisense-forbindelser med forøget anti-microrna-aktivitet |
WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
EA200800823A1 (en) | 2005-09-15 | 2008-10-30 | Сантарис Фарма А/С | COMPOUNDS-ANTAGONISTS OF RNA TO INHIBIT EXPRESSION OF ARO-B100 |
JP5213723B2 (en) | 2006-01-27 | 2013-06-19 | アイシス ファーマシューティカルズ, インコーポレーテッド | Oligomer compounds and compositions for use in modulating microRNA |
AU2007234191B2 (en) | 2006-04-03 | 2012-07-12 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-miRNA antisense oligonucleotides |
WO2007134014A2 (en) | 2006-05-05 | 2007-11-22 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of gcgr |
ES2389737T3 (en) | 2006-05-11 | 2012-10-31 | Isis Pharmaceuticals, Inc. | 5 'modified bicyclic nucleic acid analogs |
US20080199961A1 (en) | 2006-08-25 | 2008-08-21 | Avi Biopharma, Inc. | ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF miRNA BIOGENESIS |
AU2007296054B2 (en) | 2006-09-15 | 2013-03-28 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
MX2009002856A (en) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Polymeric conjugates containing positively-charged moieties. |
WO2008046911A2 (en) | 2006-10-20 | 2008-04-24 | Exiqon A/S | Novel human micrornas associated with cancer |
WO2008057234A2 (en) | 2006-10-24 | 2008-05-15 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of t cell signaling threshold and t cell sensitivity to antigens |
US20100021914A1 (en) | 2006-11-23 | 2010-01-28 | Querdenker Aps | Oligonucleotides for modulating target rna activity |
WO2008074328A2 (en) | 2006-12-21 | 2008-06-26 | Exiqon A/S | Microrna target site blocking oligos and uses thereof |
WO2008113832A2 (en) | 2007-03-22 | 2008-09-25 | Santaris Pharma A/S | SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF TARGET mRNA |
WO2008124384A2 (en) | 2007-04-03 | 2008-10-16 | Aegerion Pharmaceuticals, Inc. | Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c |
CA2688321A1 (en) | 2007-05-30 | 2008-12-11 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
WO2008154401A2 (en) | 2007-06-08 | 2008-12-18 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
US20090082297A1 (en) | 2007-06-25 | 2009-03-26 | Lioy Daniel T | Compositions and Methods for Regulating Gene Expression |
US20110009466A1 (en) | 2007-08-29 | 2011-01-13 | President And Fellows Of Harvard College | Methods of increasing gene expression through rna protection |
EP2623598B1 (en) | 2007-10-04 | 2018-08-01 | Roche Innovation Center Copenhagen A/S | Micromirs |
US8404659B2 (en) | 2008-03-07 | 2013-03-26 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of MicroRNA related diseases |
WO2010122538A1 (en) | 2009-04-24 | 2010-10-28 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of hcv patients that are non-responders to interferon |
-
2007
- 2007-03-30 SG SG10201406016SA patent/SG10201406016SA/en unknown
- 2007-03-30 EP EP13172958.4A patent/EP2666859B1/en active Active
- 2007-03-30 EA EA201100810A patent/EA201100810A1/en unknown
- 2007-03-30 US US12/295,960 patent/US8163708B2/en active Active
- 2007-03-30 MY MYPI20083769A patent/MY162210A/en unknown
- 2007-03-30 PL PL13172958T patent/PL2666859T3/en unknown
- 2007-03-30 EA EA201100811A patent/EA201100811A1/en unknown
- 2007-03-30 CN CN201210247597.0A patent/CN102851291B/en active Active
- 2007-03-30 NZ NZ571569A patent/NZ571569A/en not_active IP Right Cessation
- 2007-03-30 EP EP18177355.7A patent/EP3431602A1/en active Pending
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SG170773A1 (en) | 2011-05-30 |
ES2569558T3 (en) | 2016-05-11 |
EP2666859A3 (en) | 2014-05-07 |
EP2666859B1 (en) | 2019-01-02 |
EP2261333B1 (en) | 2016-03-30 |
EA201100811A1 (en) | 2012-06-29 |
EP3431602A1 (en) | 2019-01-23 |
US8163708B2 (en) | 2012-04-24 |
MY162210A (en) | 2017-05-31 |
PL2666859T3 (en) | 2019-09-30 |
CN102851291B (en) | 2016-03-09 |
EA201100810A1 (en) | 2012-06-29 |
CN102851291A (en) | 2013-01-02 |
EP2261333A3 (en) | 2014-03-19 |
EP2666859A2 (en) | 2013-11-27 |
EA201100812A1 (en) | 2012-06-29 |
EP2261333A2 (en) | 2010-12-15 |
NZ571569A (en) | 2011-09-30 |
EA201100813A1 (en) | 2012-06-29 |
EP3502255A1 (en) | 2019-06-26 |
US20100286234A1 (en) | 2010-11-11 |
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