|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US5240848A
(en)
|
1988-11-21 |
1993-08-31 |
Monsanto Company |
Dna sequences encoding human vascular permeability factor having 189 amino acids
|
|
US5328470A
(en)
|
1989-03-31 |
1994-07-12 |
The Regents Of The University Of Michigan |
Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
|
|
US5332671A
(en)
|
1989-05-12 |
1994-07-26 |
Genetech, Inc. |
Production of vascular endothelial cell growth factor and DNA encoding same
|
|
US5194596A
(en)
|
1989-07-27 |
1993-03-16 |
California Biotechnology Inc. |
Production of vascular endothelial cell growth factor
|
|
US5219739A
(en)
|
1989-07-27 |
1993-06-15 |
Scios Nova Inc. |
DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
|
|
ATE162219T1
(de)
|
1989-11-16 |
1998-01-15 |
Univ Duke |
Transformation von tierischen hautzellen mit hilfe von partikeln
|
|
US5672697A
(en)
|
1991-02-08 |
1997-09-30 |
Gilead Sciences, Inc. |
Nucleoside 5'-methylene phosphonates
|
|
US6291438B1
(en)
|
1993-02-24 |
2001-09-18 |
Jui H. Wang |
Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
|
|
US5858988A
(en)
|
1993-02-24 |
1999-01-12 |
Wang; Jui H. |
Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use
|
|
TW404844B
(en)
|
1993-04-08 |
2000-09-11 |
Oxford Biosciences Ltd |
Needleless syringe
|
|
KR970703357A
(ko)
|
1994-06-01 |
1997-07-03 |
다알렌 반스톤 |
병원체-저해제로서의, 측쇄를 가지는 올리고누클레오티드(branched oligonu-cleotides as pathogen-inhibitory agents)
|
|
US6383814B1
(en)
|
1994-12-09 |
2002-05-07 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
|
AU5545596A
(en)
|
1995-04-28 |
1996-11-18 |
Medtronic, Inc. |
Intraparenchymal infusion catheter system
|
|
US5684143A
(en)
|
1996-02-21 |
1997-11-04 |
Lynx Therapeutics, Inc. |
Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
|
|
US5735814A
(en)
|
1996-04-30 |
1998-04-07 |
Medtronic, Inc. |
Techniques of treating neurodegenerative disorders by brain infusion
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
US6177403B1
(en)
|
1996-10-21 |
2001-01-23 |
The Trustees Of The University Of Pennsylvania |
Compositions, methods, and apparatus for delivery of a macromolecular assembly to an extravascular tissue of an animal
|
|
US6042820A
(en)
|
1996-12-20 |
2000-03-28 |
Connaught Laboratories Limited |
Biodegradable copolymer containing α-hydroxy acid and α-amino acid units
|
|
US6472375B1
(en)
|
1998-04-16 |
2002-10-29 |
John Wayne Cancer Institute |
DNA vaccine and methods for its use
|
|
EP1016726A1
(en)
|
1998-12-30 |
2000-07-05 |
Introgene B.V. |
Gene therapy to promote angiogenesis
|
|
EP2180054A1
(en)
|
1999-12-24 |
2010-04-28 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
WO2002081628A2
(en)
|
2001-04-05 |
2002-10-17 |
Ribozyme Pharmaceuticals, Incorporated |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
|
|
EP2390331B1
(en)
|
2001-09-28 |
2018-04-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
MicroRNA molecules
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US20050096284A1
(en)
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
|
AU2003223775A1
(en)
|
2002-04-30 |
2003-11-17 |
Duke University |
Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use
|
|
ES2534926T3
(es)
|
2002-07-19 |
2015-04-30 |
Beth Israel Deaconess Medical Center |
Métodos para tratar la preeclampsia
|
|
US20040241854A1
(en)
|
2002-08-05 |
2004-12-02 |
Davidson Beverly L. |
siRNA-mediated gene silencing
|
|
US20050106731A1
(en)
*
|
2002-08-05 |
2005-05-19 |
Davidson Beverly L. |
siRNA-mediated gene silencing with viral vectors
|
|
US7956176B2
(en)
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US8604183B2
(en)
|
2002-11-05 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
EP2305812A3
(en)
|
2002-11-14 |
2012-06-06 |
Dharmacon, Inc. |
Fuctional and hyperfunctional sirna
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
US7790867B2
(en)
|
2002-12-05 |
2010-09-07 |
Rosetta Genomics Inc. |
Vaccinia virus-related nucleic acids and microRNA
|
|
US6913890B2
(en)
|
2002-12-18 |
2005-07-05 |
Palo Alto Research Center Incorporated |
Process for preparing albumin protein conjugated oligonucleotide probes
|
|
AU2003299864A1
(en)
|
2002-12-27 |
2004-07-29 |
P. Radhakrishnan |
Sirna compounds and methods for the downregulation of gene expression
|
|
US20040198640A1
(en)
|
2003-04-02 |
2004-10-07 |
Dharmacon, Inc. |
Stabilized polynucleotides for use in RNA interference
|
|
DK1620544T3
(en)
|
2003-04-17 |
2019-01-14 |
Alnylam Pharmaceuticals Inc |
MODIFIED iRNA AGENTS
|
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
|
DK1633767T3
(en)
|
2003-06-02 |
2019-03-25 |
Univ Massachusetts |
METHODS AND COMPOSITIONS FOR MANAGING THE EFFECT OF RNA SILENCING
|
|
ES2357116T5
(es)
|
2003-06-02 |
2021-09-03 |
Univ Massachusetts |
Métodos y composiciones para mejorar la eficacia y especificad de FNAi
|
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
CA2549720C
(en)
|
2003-12-19 |
2013-10-15 |
Chiron Corporation |
Cell transfecting formulations of small interfering rna, related compositions and methods of making and use
|
|
US20050176045A1
(en)
*
|
2004-02-06 |
2005-08-11 |
Dharmacon, Inc. |
SNP discriminatory siRNA
|
|
WO2005077333A2
(en)
|
2004-02-10 |
2005-08-25 |
University Of Florida Research Foundation, Inc. |
Gel-based delivery of recombinant adeno-associated virus vectors
|
|
AU2005222902B2
(en)
|
2004-03-12 |
2010-06-10 |
Alnylam Pharmaceuticals, Inc. |
iRNA agents targeting VEGF
|
|
US20060014289A1
(en)
|
2004-04-20 |
2006-01-19 |
Nastech Pharmaceutical Company Inc. |
Methods and compositions for enhancing delivery of double-stranded RNA or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
|
|
EP1752536A4
(en)
|
2004-05-11 |
2008-04-16 |
Alphagen Co Ltd |
POLYNUCLEOTIDE CAUSING RNA INTERFERENCE AND METHOD OF REGULATING GENE EXPRESSION WITH THE USE OF THE SAME
|
|
AU2005252663B2
(en)
|
2004-06-03 |
2011-07-07 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
EP1828390B1
(en)
|
2004-12-15 |
2012-06-13 |
The University Of North Carolina At Chapel Hill |
Chimeric vectors
|
|
EP2239328A3
(en)
|
2005-08-18 |
2011-01-05 |
Alnylam Pharmaceuticals Inc. |
Methods and compositions for treating neurological disease
|
|
WO2007051045A2
(en)
|
2005-10-28 |
2007-05-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of huntingtin gene
|
|
US8101741B2
(en)
|
2005-11-02 |
2012-01-24 |
Protiva Biotherapeutics, Inc. |
Modified siRNA molecules and uses thereof
|
|
CA2628113A1
(en)
|
2005-11-04 |
2007-05-18 |
Nastech Pharmaceutical Company Inc. |
Peptide-dicer substrate rna conjugates as delivery vehicles for sirna
|
|
WO2007087451A2
(en)
|
2006-01-25 |
2007-08-02 |
University Of Massachusetts |
Compositions and methods for enhancing discriminatory rna interference
|
|
US9198981B2
(en)
|
2006-02-01 |
2015-12-01 |
The University Of Kentucky |
Modulation of angiogenesis
|
|
EP1989307B1
(en)
|
2006-02-08 |
2012-08-08 |
Quark Pharmaceuticals, Inc. |
NOVEL TANDEM siRNAS
|
|
JPWO2007094218A1
(ja)
|
2006-02-16 |
2009-07-02 |
国立大学法人岐阜大学 |
修飾オリゴヌクレオチド
|
|
EP1986697B1
(en)
|
2006-02-17 |
2016-06-29 |
GE Healthcare Dharmacon, Inc. |
Compositions and methods for inhibiting gene silencing by rna interference
|
|
US20090306178A1
(en)
|
2006-03-27 |
2009-12-10 |
Balkrishen Bhat |
Conjugated double strand compositions for use in gene modulation
|
|
EP2046993A4
(en)
|
2006-07-07 |
2010-11-17 |
Univ Massachusetts |
RNA SILENCING COMPOSITIONS, AND METHODS OF TREATING HUNTINGTON CHOREA
|
|
US20080039415A1
(en)
|
2006-08-11 |
2008-02-14 |
Gregory Robert Stewart |
Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
|
|
WO2008036841A2
(en)
|
2006-09-22 |
2008-03-27 |
Dharmacon, Inc. |
Tripartite oligonucleotide complexes and methods for gene silencing by rna interference
|
|
CA2666657A1
(en)
|
2006-10-18 |
2008-04-24 |
Nastech Pharmaceutical Company Inc. |
Nicked or gapped nucleic acid molecules and uses thereof
|
|
US8906874B2
(en)
|
2006-11-09 |
2014-12-09 |
Gradalis, Inc. |
Bi-functional shRNA targeting Stathmin 1 and uses thereof
|
|
TW200836762A
(en)
|
2006-11-27 |
2008-09-16 |
Enzon Pharmaceuticals Inc |
Polymeric short interfering RNA conjugates
|
|
CA2679342A1
(en)
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting hif1a gene expression and uses thereof
|
|
WO2008154482A2
(en)
|
2007-06-08 |
2008-12-18 |
Sirnaomics, Inc. |
Sirna compositions and methods of use in treatment of ocular diseases
|
|
US20110046206A1
(en)
|
2007-06-22 |
2011-02-24 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
JP2010537640A
(ja)
|
2007-08-27 |
2010-12-09 |
ボストン バイオメディカル， インコーポレイテッド |
マイクロｒｎａ模倣剤または阻害剤としての非対称性ｒｎａ二重鎖の組成物
|
|
CN101199858A
(zh)
|
2007-10-18 |
2008-06-18 |
广州拓谱基因技术有限公司 |
治疗眼科疾病的多靶点小干扰rna鸡尾酒制剂及制备方法
|
|
TW200927177A
(en)
|
2007-10-24 |
2009-07-01 |
Nat Inst Of Advanced Ind Scien |
Lipid-modified double-stranded RNA having potent RNA interference effect
|
|
WO2009082607A2
(en)
|
2007-12-04 |
2009-07-02 |
Alnylam Pharmaceuticals, Inc. |
Targeting lipids
|
|
US9029524B2
(en)
|
2007-12-10 |
2015-05-12 |
California Institute Of Technology |
Signal activated RNA interference
|
|
US20110081362A1
(en)
|
2008-01-31 |
2011-04-07 |
The Brigham And Women's Hospital, Inc. |
Treatment of cancer
|
|
US10131904B2
(en)
|
2008-02-11 |
2018-11-20 |
Rxi Pharmaceuticals Corporation |
Modified RNAi polynucleotides and uses thereof
|
|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
|
EP2318528A1
(en)
|
2008-07-24 |
2011-05-11 |
Rxi Pharmaceuticals Corporation |
Rnai constructs and uses therof
|
|
CA2746527A1
(en)
|
2008-09-22 |
2010-03-25 |
Rxi Pharmaceuticals Corporation |
Rna interference in skin indications
|
|
EP2358398A2
(en)
|
2008-10-24 |
2011-08-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
|
CA2750561C
(en)
|
2009-01-26 |
2017-10-10 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein c-iii expression
|
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
KR101141544B1
(ko)
|
2009-03-13 |
2012-05-03 |
한국과학기술원 |
에스아이알엔에이 다중 접합체 및 이의 제조방법
|
|
WO2010118263A1
(en)
|
2009-04-08 |
2010-10-14 |
University Of Massachusetts |
Single-nucleotide polymorphism (snp) targeting therapies for the treatment of huntington's disease
|
|
WO2010138263A2
(en)
|
2009-05-28 |
2010-12-02 |
University Of Massachusetts |
Novel aav 's and uses thereof
|
|
GB0910723D0
(en)
|
2009-06-22 |
2009-08-05 |
Sylentis Sau |
Novel drugs for inhibition of gene expression
|
|
DK2470656T3
(da)
|
2009-08-27 |
2015-06-22 |
Idera Pharmaceuticals Inc |
Sammensætning til hæmning af genekspression og anvendelser heraf
|
|
US20150025122A1
(en)
|
2009-10-12 |
2015-01-22 |
Larry J. Smith |
Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
|
|
WO2011097643A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
WO2011109698A1
(en)
|
2010-03-04 |
2011-09-09 |
Rxi Pharmaceuticals Corporation |
Formulations and methods for targeted delivery to phagocyte cells
|
|
CN106074591B
(zh)
|
2010-03-24 |
2020-01-14 |
菲奥医药公司 |
眼部症候中的rna干扰
|
|
US9080171B2
(en)
|
2010-03-24 |
2015-07-14 |
RXi Parmaceuticals Corporation |
Reduced size self-delivering RNAi compounds
|
|
BR112012024049A2
(pt)
|
2010-03-24 |
2017-03-01 |
Rxi Pharmaceuticals Corp |
interferência de rna em indicações dérmicas e fibróticas
|
|
KR101869570B1
(ko)
|
2010-04-28 |
2018-06-20 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물
|
|
WO2012005898A2
(en)
|
2010-06-15 |
2012-01-12 |
Alnylam Pharmaceuticals, Inc. |
Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof
|
|
CN102946908B
(zh)
|
2010-06-18 |
2015-04-22 |
Lsip基金运营联合公司 |
显性等位基因表达抑制剂
|
|
US8586301B2
(en)
|
2010-06-30 |
2013-11-19 |
Stratos Genomics, Inc. |
Multiplexed identification of nucleic acid sequences
|
|
CA2812046A1
(en)
|
2010-09-15 |
2012-03-22 |
Alnylam Pharmaceuticals, Inc. |
Modified irna agents
|
|
WO2012078637A2
(en)
|
2010-12-06 |
2012-06-14 |
Immune Disease Institute, Inc. |
Composition and method for oligonucleotide delivery
|
|
EP2652134B1
(en)
|
2010-12-17 |
2017-03-01 |
Arrowhead Pharmaceuticals, Inc. |
Galactose cluster-pharmacokinetic modulator targeting moiety for sirna
|
|
CN103562387A
(zh)
|
2011-03-03 |
2014-02-05 |
夸克医药公司 |
Toll样受体途径的寡核苷酸调剂
|
|
GB201105137D0
(en)
*
|
2011-03-28 |
2011-05-11 |
Isis Innovation |
Therapeutic molecules for use in the suppression of Parkinson's disease
|
|
US20140275211A1
(en)
|
2011-06-21 |
2014-09-18 |
Alnylam Pharmaceuticals, Inc. |
Assays and methods for determining activity of a therapeutic agent in a subject
|
|
WO2013165816A2
(en)
|
2012-05-02 |
2013-11-07 |
Merck Sharp & Dohme Corp. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
|
CN108148838A
(zh)
|
2012-05-22 |
2018-06-12 |
奥利克斯医药有限公司 |
具有细胞内穿透能力的诱导rna干扰的核酸分子及用途
|
|
CA2877985C
(en)
|
2012-07-10 |
2020-10-27 |
Baseclick Gmbh |
Anandamide-modified nucleic acid molecules
|
|
EP2895200B1
(en)
|
2012-09-14 |
2019-11-06 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
WO2014047649A1
(en)
|
2012-09-24 |
2014-03-27 |
The Regents Of The University Of California |
Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
|
|
US10077443B2
(en)
|
2012-11-15 |
2018-09-18 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugates
|
|
US20140200124A1
(en)
|
2013-01-15 |
2014-07-17 |
Karen Michelle JAMES |
Physical Therapy Device and Methods for Use Thereof
|
|
DK2991656T3
(da)
|
2013-05-01 |
2020-03-23 |
Ionis Pharmaceuticals Inc |
Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression
|
|
CA2951816A1
(en)
|
2013-06-12 |
2014-12-18 |
Oncoimmunin, Inc. |
Systemic in vivo delivery of oligonucleotides
|
|
CN105324119A
(zh)
|
2013-06-16 |
2016-02-10 |
国立大学法人东京医科齿科大学 |
具有外显子跳跃效应的双链反义核酸
|
|
US9862350B2
(en)
|
2013-08-12 |
2018-01-09 |
Tk Holdings Inc. |
Dual chambered passenger airbag
|
|
WO2015057847A1
(en)
|
2013-10-16 |
2015-04-23 |
Cerulean Pharma Inc. |
Conjugates, particles, compositions, and related methods
|
|
WO2015070173A1
(en)
|
2013-11-08 |
2015-05-14 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for detecting oligonucleotides
|
|
US20160348103A1
(en)
|
2014-01-27 |
2016-12-01 |
The Board Of Trustees Of The Leland Stanford Junior University |
Oligonucleotides and Methods for Treatment of Cardiomyopathy Using RNA Interference
|
|
EP3733856A1
(en)
|
2014-04-18 |
2020-11-04 |
University of Massachusetts |
Exosomal loading using hydrophobically modified oligonucleotides
|
|
WO2015168661A1
(en)
|
2014-05-01 |
2015-11-05 |
Smith Larry J |
METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
|
|
CA3215908A1
(en)
|
2014-05-22 |
2015-11-26 |
Alnylam Pharmaceuticals, Inc. |
Angiotensinogen (agt) irna compositions and methods of use thereof
|
|
US10588980B2
(en)
|
2014-06-23 |
2020-03-17 |
Novartis Ag |
Fatty acids and their use in conjugation to biomolecules
|
|
WO2016055601A1
(en)
|
2014-10-10 |
2016-04-14 |
F. Hoffmann-La Roche Ag |
Galnac phosphoramidites, nucleic acid conjugates thereof and their use
|
|
SMT202000454T1
(it)
|
2015-04-03 |
2020-11-10 |
Univ Massachusetts |
Cmposti oligonucleotidici per bersagliare l'mrn della huntingtina
|
|
PT3277815T
(pt)
|
2015-04-03 |
2021-11-11 |
Beth Israel Deaconess Medical Ct Inc |
Compostos de oligonucleótidos para o tratamento de pré-eclâmpsia e outros distúrbios angiogénicos
|
|
EP3277811B1
(en)
|
2015-04-03 |
2020-12-23 |
University of Massachusetts |
Fully stabilized asymmetric sirna
|
|
AU2016246820B2
(en)
|
2015-04-10 |
2021-08-12 |
Hudsonalpha Institute For Biotechnology |
Method for blocking miRNA
|
|
IL316159A
(en)
|
2015-06-15 |
2024-12-01 |
Mpeg La Llc |
Defined Oligonucleotide Multimers and Methods for Manufacture Thereof
|
|
CN108135921B
(zh)
|
2015-07-22 |
2023-10-17 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
US10633653B2
(en)
|
2015-08-14 |
2020-04-28 |
University Of Massachusetts |
Bioactive conjugates for oligonucleotide delivery
|
|
CN105194689A
(zh)
|
2015-10-10 |
2015-12-30 |
湖南中楚博生物科技有限公司 |
一种基于siRNA的双偶联复合物
|
|
WO2017132669A1
(en)
|
2016-01-31 |
2017-08-03 |
University Of Massachusetts |
Branched oligonucleotides
|
|
JP2019513371A
(ja)
|
2016-04-01 |
2019-05-30 |
アビディティー バイオサイエンシーズ エルエルシー |
核酸ポリペプチド組成物とその使用
|
|
WO2017174572A1
(en)
|
2016-04-04 |
2017-10-12 |
F. Hoffmann-La Roche Ag |
Nucleic acid sample preparation methods
|
|
US10036024B2
(en)
*
|
2016-06-03 |
2018-07-31 |
Purdue Research Foundation |
siRNA compositions that specifically downregulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD)
|
|
CA3033368A1
(en)
|
2016-08-12 |
2018-02-15 |
University Of Massachusetts |
Conjugated oligonucleotides
|
|
US10941402B2
(en)
|
2016-09-01 |
2021-03-09 |
Proqr Therapeutics Ii B.V. |
Chemically modified single-stranded RNA-editing oligonucleotides
|
|
US11603532B2
(en)
|
2017-06-02 |
2023-03-14 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
JP7406793B2
(ja)
|
2017-06-23 |
2023-12-28 |
ユニバーシティー オブ マサチューセッツ |
２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
|
|
CA3071086A1
(en)
|
2017-08-18 |
2019-02-21 |
The Procter & Gamble Company |
Cleaning agent
|
|
WO2020033899A1
(en)
|
2018-08-10 |
2020-02-13 |
University Of Massachusetts |
Modified oligonucleotides targeting snps
|
|
CN113614232A
(zh)
|
2019-01-18 |
2021-11-05 |
马萨诸塞大学 |
动态药代动力学修饰锚
|