MX2018015722A - Oligonucleotidos antisentido para modular expresion del requisito de alta temperatura a 1 (htra1). - Google Patents
Oligonucleotidos antisentido para modular expresion del requisito de alta temperatura a 1 (htra1).Info
- Publication number
- MX2018015722A MX2018015722A MX2018015722A MX2018015722A MX2018015722A MX 2018015722 A MX2018015722 A MX 2018015722A MX 2018015722 A MX2018015722 A MX 2018015722A MX 2018015722 A MX2018015722 A MX 2018015722A MX 2018015722 A MX2018015722 A MX 2018015722A
- Authority
- MX
- Mexico
- Prior art keywords
- antisense oligonucleotides
- expression
- htra1 expression
- modulating
- modulating htra1
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
Abstract
La presente invención se refiere a oligonucleótidos (oligómeros) antisentido que son complementarios a HTRA1, que conducen a la modulación de la expresión de HTRA1. La modulación de la expresión de HTRA1 resulta beneficiosa para un abanico de trastornos médicos, tales como la degeneración macular, por ejemplo la degeneración macular asociada a la edad.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16177508 | 2016-07-01 | ||
EP17170129 | 2017-05-09 | ||
PCT/EP2017/065937 WO2018002105A1 (en) | 2016-07-01 | 2017-06-28 | Antisense oligonucleotides for modulating htra1 expression |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018015722A true MX2018015722A (es) | 2019-05-27 |
Family
ID=59295175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018015722A MX2018015722A (es) | 2016-07-01 | 2017-06-28 | Oligonucleotidos antisentido para modular expresion del requisito de alta temperatura a 1 (htra1). |
Country Status (21)
Country | Link |
---|---|
US (2) | US10519450B2 (es) |
EP (1) | EP3478839A1 (es) |
JP (3) | JP7060525B2 (es) |
KR (1) | KR20190025970A (es) |
CN (1) | CN109415732B (es) |
AU (1) | AU2017289204A1 (es) |
BR (1) | BR112018077321A2 (es) |
CA (1) | CA3026855A1 (es) |
CL (1) | CL2018003698A1 (es) |
CO (1) | CO2018013240A2 (es) |
CR (1) | CR20180606A (es) |
IL (1) | IL263489A (es) |
MA (1) | MA45620A (es) |
MX (1) | MX2018015722A (es) |
PE (1) | PE20190381A1 (es) |
PH (1) | PH12018502707A1 (es) |
RU (1) | RU2019101298A (es) |
SG (2) | SG11201811554SA (es) |
TW (1) | TW201803990A (es) |
WO (1) | WO2018002105A1 (es) |
ZA (1) | ZA201808291B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
HUE064412T2 (hu) | 2016-06-21 | 2024-03-28 | Orion Ophthalmology LLC | Heterociklusos prolinamid-származékok |
BR112018077321A2 (pt) | 2016-07-01 | 2019-04-24 | F. Hoffmann-La Roche Ag | oligonucleotídeos anti-sentido para modular a expressão de htra1 |
EP3728590A1 (en) | 2017-12-22 | 2020-10-28 | Roche Innovation Center Copenhagen A/S | Novel thiophosphoramidites |
BR112020010090A2 (pt) | 2017-12-22 | 2020-11-03 | Roche Innovation Center Copenhagen A/S | oligonucleotídeo gapmer, sal farmaceuticamente aceitável do mesmo, conjugado, composição farmacêutica e uso dos mesmos |
AU2018386524A1 (en) | 2017-12-22 | 2020-07-02 | Roche Innovation Center Copenhagen A/S | Oligonucleotides comprising a phosphorodithioate internucleoside linkage |
EP3752612A4 (en) | 2018-02-12 | 2021-11-10 | Ionis Pharmaceuticals, Inc. | MODIFIED COMPOUNDS AND USES THEREOF |
WO2020007772A1 (en) * | 2018-07-02 | 2020-01-09 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting gbp-1 |
WO2020109343A1 (en) * | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Combination therapy for treatment of macular degeneration |
WO2020109344A1 (en) * | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Occular administration device for antisense oligonucleotides |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
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JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
EP2341057A3 (en) | 1997-09-12 | 2011-11-23 | Exiqon A/S | Oligonucleotide Analogues |
WO2000008134A2 (en) | 1998-08-03 | 2000-02-17 | Novartis Ag | HUMAN HtrA SERINE PROTEASE |
AU758956B2 (en) | 1999-02-12 | 2003-04-03 | Daiichi Sankyo Company, Limited | Novel nucleosides and oligonucleotide analogues |
EP1178999B1 (en) | 1999-05-04 | 2007-03-14 | Santaris Pharma A/S | L-ribo-lna analogues |
US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
AU2003281969B2 (en) | 2002-11-18 | 2011-01-27 | Roche Innovation Center Copenhagen A/S | Amino-LNA, thio-LNA and alpha-L-oxy-LN |
EP1888083B1 (en) | 2005-05-24 | 2011-12-28 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to lmw-ptpase |
WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
CA2640171C (en) | 2006-01-27 | 2014-10-28 | Isis Pharmaceuticals, Inc. | 6-modified bicyclic nucleic acid analogs |
US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
ES2389737T3 (es) | 2006-05-11 | 2012-10-31 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos modificados en 5' |
DK2044223T3 (da) * | 2006-07-26 | 2012-10-08 | Univ Yale Inc | Diagnosticering og behandling af aldersrelateret makuladegeneration |
WO2008067040A2 (en) * | 2006-10-06 | 2008-06-05 | University Of Utah Research Foundation | Method of detecting ocular diseases and pathologic conditions and treatment of same |
EP2097448A4 (en) | 2006-12-22 | 2010-07-21 | Univ Utah Res Found | METHOD FOR DETECTING DISEASES AND OCULAR DISEASE CONDITIONS AND TREATMENT THEREOF |
WO2008150729A2 (en) | 2007-05-30 | 2008-12-11 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
EP2173760B2 (en) | 2007-06-08 | 2015-11-04 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
TW200911290A (en) * | 2007-07-02 | 2009-03-16 | Alcon Res Ltd | RNAI-mediated inhibition of HTRA1 for treatment of macular degeneration |
US8278283B2 (en) | 2007-07-05 | 2012-10-02 | Isis Pharmaceuticals, Inc. | 6-disubstituted or unsaturated bicyclic nucleic acid analogs |
CA2704809A1 (en) | 2007-11-01 | 2009-05-07 | University Of Iowa Research Foundation | Rca locus analysis to assess susceptibility to amd and mpgnii |
WO2009067647A1 (en) | 2007-11-21 | 2009-05-28 | Isis Pharmaceuticals, Inc. | Carbocyclic alpha-l-bicyclic nucleic acid analogs |
EP2356129B1 (en) | 2008-09-24 | 2013-04-03 | Isis Pharmaceuticals, Inc. | Substituted alpha-l-bicyclic nucleosides |
EP2462153B1 (en) | 2009-08-06 | 2015-07-29 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
WO2011156202A1 (en) | 2010-06-08 | 2011-12-15 | Isis Pharmaceuticals, Inc. | Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom |
FR2965278B1 (fr) | 2010-09-23 | 2014-10-10 | Univ Caen Basse Normandie | Procede d'obtention in vitro ou ex vivo de chondrocytes et leurs utilisations |
CN104136451A (zh) | 2011-09-07 | 2014-11-05 | 玛瑞纳生物技术有限公司 | 具有构象限制的单体的核酸化合物的合成和用途 |
US9221864B2 (en) | 2012-04-09 | 2015-12-29 | Isis Pharmaceuticals, Inc. | Tricyclic nucleic acid analogs |
EP2850184A4 (en) | 2012-05-16 | 2016-01-27 | Rana Therapeutics Inc | COMPOSITIONS AND METHOD FOR MODULATING GENE EXPRESSION |
EP2920304B1 (en) | 2012-11-15 | 2019-03-06 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
KR102162324B1 (ko) | 2015-10-30 | 2020-10-07 | 제넨테크, 인크. | 항-HtrA1 항체 및 이의 사용 방법 |
BR112018077321A2 (pt) | 2016-07-01 | 2019-04-24 | F. Hoffmann-La Roche Ag | oligonucleotídeos anti-sentido para modular a expressão de htra1 |
JP7033591B2 (ja) | 2016-11-11 | 2022-03-10 | ロシュ イノベーション センター コペンハーゲン エーエス | 治療用オリゴヌクレオチドの捕捉および検出 |
US20190055564A1 (en) | 2017-06-01 | 2019-02-21 | F. Hoffmann-La Roche Ag | Antisense oligonucleotides for modulating htra1 expression |
-
2017
- 2017-06-28 BR BR112018077321-2A patent/BR112018077321A2/pt not_active IP Right Cessation
- 2017-06-28 CN CN201780039864.6A patent/CN109415732B/zh active Active
- 2017-06-28 SG SG11201811554SA patent/SG11201811554SA/en unknown
- 2017-06-28 TW TW106121548A patent/TW201803990A/zh unknown
- 2017-06-28 MA MA045620A patent/MA45620A/fr unknown
- 2017-06-28 RU RU2019101298A patent/RU2019101298A/ru not_active Application Discontinuation
- 2017-06-28 KR KR1020197003217A patent/KR20190025970A/ko not_active Application Discontinuation
- 2017-06-28 JP JP2018568277A patent/JP7060525B2/ja active Active
- 2017-06-28 CR CR20180606A patent/CR20180606A/es unknown
- 2017-06-28 SG SG10202005885VA patent/SG10202005885VA/en unknown
- 2017-06-28 WO PCT/EP2017/065937 patent/WO2018002105A1/en unknown
- 2017-06-28 MX MX2018015722A patent/MX2018015722A/es unknown
- 2017-06-28 AU AU2017289204A patent/AU2017289204A1/en not_active Abandoned
- 2017-06-28 EP EP17736594.7A patent/EP3478839A1/en active Pending
- 2017-06-28 PE PE2018003308A patent/PE20190381A1/es unknown
- 2017-06-28 US US15/635,629 patent/US10519450B2/en active Active
- 2017-06-28 CA CA3026855A patent/CA3026855A1/en not_active Abandoned
-
2018
- 2018-12-04 IL IL263489A patent/IL263489A/en unknown
- 2018-12-06 CO CONC2018/0013240A patent/CO2018013240A2/es unknown
- 2018-12-07 ZA ZA201808291A patent/ZA201808291B/en unknown
- 2018-12-19 CL CL2018003698A patent/CL2018003698A1/es unknown
- 2018-12-20 PH PH12018502707A patent/PH12018502707A1/en unknown
-
2019
- 2019-12-30 US US16/730,779 patent/US20200399641A1/en not_active Abandoned
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2022
- 2022-04-14 JP JP2022067085A patent/JP7416852B2/ja active Active
-
2024
- 2024-01-04 JP JP2024000178A patent/JP2024029178A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
BR112018077321A2 (pt) | 2019-04-24 |
JP7060525B2 (ja) | 2022-04-26 |
RU2019101298A (ru) | 2020-08-03 |
US10519450B2 (en) | 2019-12-31 |
TW201803990A (zh) | 2018-02-01 |
CO2018013240A2 (es) | 2018-12-14 |
PH12018502707A1 (en) | 2019-11-11 |
US20180002701A1 (en) | 2018-01-04 |
JP7416852B2 (ja) | 2024-01-17 |
CA3026855A1 (en) | 2018-01-04 |
JP2019522987A (ja) | 2019-08-22 |
CN109415732B (zh) | 2024-01-02 |
CR20180606A (es) | 2019-02-14 |
ZA201808291B (en) | 2019-10-30 |
JP2022106785A (ja) | 2022-07-20 |
US20200399641A1 (en) | 2020-12-24 |
WO2018002105A1 (en) | 2018-01-04 |
MA45620A (fr) | 2019-05-08 |
SG10202005885VA (en) | 2020-07-29 |
AU2017289204A1 (en) | 2019-01-17 |
RU2019101298A3 (es) | 2021-01-26 |
CL2018003698A1 (es) | 2019-04-05 |
IL263489A (en) | 2019-01-31 |
PE20190381A1 (es) | 2019-03-08 |
KR20190025970A (ko) | 2019-03-12 |
SG11201811554SA (en) | 2019-01-30 |
JP2024029178A (ja) | 2024-03-05 |
CN109415732A (zh) | 2019-03-01 |
EP3478839A1 (en) | 2019-05-08 |
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