MA45620A - Oligonucléotides antisens pour la modulation de l'expression de htra1 - Google Patents
Oligonucléotides antisens pour la modulation de l'expression de htra1Info
- Publication number
- MA45620A MA45620A MA045620A MA45620A MA45620A MA 45620 A MA45620 A MA 45620A MA 045620 A MA045620 A MA 045620A MA 45620 A MA45620 A MA 45620A MA 45620 A MA45620 A MA 45620A
- Authority
- MA
- Morocco
- Prior art keywords
- modulation
- oligonucleotides
- antisens
- htra1
- expression
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne des oligonucléotides antisens (oligomères) complémentaires de htra1, conduisant à une modulation de l'expression de htra1. La modulation de l'expression de htra est bénéfique pour une gamme de troubles médicaux, tels que la dégénérescence maculaire, par exemple. Dégénérescence maculaire liée à l'âge.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16177508 | 2016-07-01 | ||
EP17170129 | 2017-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA45620A true MA45620A (fr) | 2019-05-08 |
Family
ID=59295175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA045620A MA45620A (fr) | 2016-07-01 | 2017-06-28 | Oligonucléotides antisens pour la modulation de l'expression de htra1 |
Country Status (21)
Country | Link |
---|---|
US (2) | US10519450B2 (fr) |
EP (1) | EP3478839A1 (fr) |
JP (3) | JP7060525B2 (fr) |
KR (1) | KR20190025970A (fr) |
CN (2) | CN118325897A (fr) |
AU (1) | AU2017289204A1 (fr) |
BR (1) | BR112018077321A2 (fr) |
CA (1) | CA3026855A1 (fr) |
CL (1) | CL2018003698A1 (fr) |
CO (1) | CO2018013240A2 (fr) |
CR (1) | CR20180606A (fr) |
IL (1) | IL263489A (fr) |
MA (1) | MA45620A (fr) |
MX (1) | MX2018015722A (fr) |
PE (1) | PE20190381A1 (fr) |
PH (1) | PH12018502707A1 (fr) |
RU (1) | RU2019101298A (fr) |
SG (2) | SG10202005885VA (fr) |
TW (1) | TW201803990A (fr) |
WO (1) | WO2018002105A1 (fr) |
ZA (1) | ZA201808291B (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3472151A4 (fr) | 2016-06-21 | 2020-03-04 | Orion Ophthalmology LLC | Dérivés de prolinamide carbocycliques |
EP4257191A3 (fr) | 2016-06-21 | 2023-11-22 | Orion Ophthalmology LLC | Dérivés hétérocycliques de prolinamide |
CA3026855A1 (fr) | 2016-07-01 | 2018-01-04 | F. Hoffmann-La Roche Ag | Oligonucleotides antisens pour la modulation de l'expression de htra1 |
WO2019122277A1 (fr) | 2017-12-22 | 2019-06-27 | Roche Innovation Center Copenhagen A/S | Nouvelles thiophosphoramidites |
EP3728591A1 (fr) | 2017-12-22 | 2020-10-28 | Roche Innovation Center Copenhagen A/S | Oligonucléotides gapmères comprenant une liaison internucléosidique phosphorodithioate |
CN111757936A (zh) | 2017-12-22 | 2020-10-09 | 罗氏创新中心哥本哈根有限公司 | 包含二硫代磷酸酯核苷间连接的寡核苷酸 |
US11332733B2 (en) | 2018-02-12 | 2022-05-17 | lonis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
WO2020007772A1 (fr) * | 2018-07-02 | 2020-01-09 | Roche Innovation Center Copenhagen A/S | Oligonucléotides antisens ciblant gbp-1 |
WO2020109344A1 (fr) * | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Dispositif d'administration oculaire pour oligonucléotides antisens |
WO2020109343A1 (fr) * | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Polythérapie pour le traitement de la dégénérescence maculaire |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
AU9063398A (en) | 1997-09-12 | 1999-04-05 | Exiqon A/S | Oligonucleotide analogues |
WO2000008134A2 (fr) | 1998-08-03 | 2000-02-17 | Novartis Ag | SERINE PROTEASE DE HtrA HUMAINE |
RU2233844C2 (ru) | 1999-02-12 | 2004-08-10 | Санкио Компани Лимитед | Новые нуклеозидные и олигонуклеотидные аналоги |
US7053207B2 (en) | 1999-05-04 | 2006-05-30 | Exiqon A/S | L-ribo-LNA analogues |
US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
EP2141233B1 (fr) | 2002-11-18 | 2016-10-19 | Roche Innovation Center Copenhagen A/S | Conception antisens |
CA2609180A1 (fr) | 2005-05-24 | 2006-11-30 | Isis Pharmaceuticals, Inc. | Compositions et utilisations dans la lmw-ptpase |
WO2007031091A2 (fr) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Composes antagonistes d'arn de modulation de l'expression de p21 ras |
AU2007211080B9 (en) | 2006-01-27 | 2012-05-03 | Isis Pharmaceuticals, Inc. | 6-modified bicyclic nucleic acid analogs |
ES2389737T3 (es) | 2006-05-11 | 2012-10-31 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos modificados en 5' |
US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
JP2009544317A (ja) | 2006-07-26 | 2009-12-17 | イェール ユニバーシティー | 加齢性黄斑変性の診断および治療 |
EP2081596A4 (fr) | 2006-10-06 | 2010-07-21 | Univ Utah Res Found | Procede de detection de maladies et d'affections pathologiques de l' il et traitement de celles-ci |
US20100129358A1 (en) | 2006-12-22 | 2010-05-27 | University Of Utah Research Foundation | Method of detecting ocular diseases and pathologic conditions and treatment of same |
AU2008260277C1 (en) | 2007-05-30 | 2014-04-17 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
US8278426B2 (en) | 2007-06-08 | 2012-10-02 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
TW200911290A (en) | 2007-07-02 | 2009-03-16 | Alcon Res Ltd | RNAI-mediated inhibition of HTRA1 for treatment of macular degeneration |
DK2176280T4 (en) | 2007-07-05 | 2015-07-20 | Isis Pharmaceuticals Inc | 6-Disubstituerede bicykliske nukleinsyreanaloge |
WO2009059321A2 (fr) | 2007-11-01 | 2009-05-07 | University Of Iowa Research Foundation | Analyse de lieu de rca pour estimer la sensibilité à l'amd et au mpgnii |
WO2009067647A1 (fr) | 2007-11-21 | 2009-05-28 | Isis Pharmaceuticals, Inc. | Analogues d'acide nucléique alpha-l-bicyclique carbocyclique |
US8501805B2 (en) | 2008-09-24 | 2013-08-06 | Isis Pharmaceuticals, Inc. | Substituted alpha-L-bicyclic nucleosides |
US9012421B2 (en) | 2009-08-06 | 2015-04-21 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
EP2580228B1 (fr) | 2010-06-08 | 2016-03-23 | Ionis Pharmaceuticals, Inc. | 2' amino- et 2' thio-nucléosides bicycliques substitués et composés oligomères préparés à partir de ces derniers |
FR2965278B1 (fr) | 2010-09-23 | 2014-10-10 | Univ Caen Basse Normandie | Procede d'obtention in vitro ou ex vivo de chondrocytes et leurs utilisations |
US9751909B2 (en) | 2011-09-07 | 2017-09-05 | Marina Biotech, Inc. | Synthesis and uses of nucleic acid compounds with conformationally restricted monomers |
WO2013154798A1 (fr) | 2012-04-09 | 2013-10-17 | Isis Pharmaceuticals, Inc. | Analogues tricycliques d'acide nucléique |
EP2850184A4 (fr) | 2012-05-16 | 2016-01-27 | Rana Therapeutics Inc | Compositions et méthodes pour moduler l'expression génique |
JP6452614B2 (ja) | 2012-11-15 | 2019-01-16 | ロシュ イノベーション センター コペンハーゲン エーエス | オリゴヌクレオチドコンジュゲート |
IL295097A (en) | 2015-10-30 | 2022-09-01 | Genentech Inc | Anti-htra1 antibodies and methods of using them |
CA3026855A1 (fr) | 2016-07-01 | 2018-01-04 | F. Hoffmann-La Roche Ag | Oligonucleotides antisens pour la modulation de l'expression de htra1 |
WO2018087200A1 (fr) | 2016-11-11 | 2018-05-17 | Roche Innovation Center Copenhagen A/S | Capture et détection d'oligonucléotides thérapeutiques |
US20190055564A1 (en) | 2017-06-01 | 2019-02-21 | F. Hoffmann-La Roche Ag | Antisense oligonucleotides for modulating htra1 expression |
-
2017
- 2017-06-28 CA CA3026855A patent/CA3026855A1/fr not_active Abandoned
- 2017-06-28 PE PE2018003308A patent/PE20190381A1/es unknown
- 2017-06-28 CN CN202311861292.3A patent/CN118325897A/zh active Pending
- 2017-06-28 AU AU2017289204A patent/AU2017289204A1/en not_active Abandoned
- 2017-06-28 SG SG10202005885VA patent/SG10202005885VA/en unknown
- 2017-06-28 BR BR112018077321-2A patent/BR112018077321A2/pt not_active IP Right Cessation
- 2017-06-28 MX MX2018015722A patent/MX2018015722A/es unknown
- 2017-06-28 WO PCT/EP2017/065937 patent/WO2018002105A1/fr unknown
- 2017-06-28 KR KR1020197003217A patent/KR20190025970A/ko not_active Application Discontinuation
- 2017-06-28 MA MA045620A patent/MA45620A/fr unknown
- 2017-06-28 RU RU2019101298A patent/RU2019101298A/ru not_active Application Discontinuation
- 2017-06-28 TW TW106121548A patent/TW201803990A/zh unknown
- 2017-06-28 CR CR20180606A patent/CR20180606A/es unknown
- 2017-06-28 JP JP2018568277A patent/JP7060525B2/ja active Active
- 2017-06-28 US US15/635,629 patent/US10519450B2/en active Active
- 2017-06-28 CN CN201780039864.6A patent/CN109415732B/zh active Active
- 2017-06-28 SG SG11201811554SA patent/SG11201811554SA/en unknown
- 2017-06-28 EP EP17736594.7A patent/EP3478839A1/fr active Pending
-
2018
- 2018-12-04 IL IL263489A patent/IL263489A/en unknown
- 2018-12-06 CO CONC2018/0013240A patent/CO2018013240A2/es unknown
- 2018-12-07 ZA ZA201808291A patent/ZA201808291B/en unknown
- 2018-12-19 CL CL2018003698A patent/CL2018003698A1/es unknown
- 2018-12-20 PH PH12018502707A patent/PH12018502707A1/en unknown
-
2019
- 2019-12-30 US US16/730,779 patent/US20200399641A1/en not_active Abandoned
-
2022
- 2022-04-14 JP JP2022067085A patent/JP7416852B2/ja active Active
-
2024
- 2024-01-04 JP JP2024000178A patent/JP2024029178A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
PH12018502707A1 (en) | 2019-11-11 |
CR20180606A (es) | 2019-02-14 |
EP3478839A1 (fr) | 2019-05-08 |
CL2018003698A1 (es) | 2019-04-05 |
CA3026855A1 (fr) | 2018-01-04 |
US20200399641A1 (en) | 2020-12-24 |
CO2018013240A2 (es) | 2018-12-14 |
SG11201811554SA (en) | 2019-01-30 |
JP2024029178A (ja) | 2024-03-05 |
IL263489A (en) | 2019-01-31 |
JP7060525B2 (ja) | 2022-04-26 |
RU2019101298A3 (fr) | 2021-01-26 |
KR20190025970A (ko) | 2019-03-12 |
JP7416852B2 (ja) | 2024-01-17 |
MX2018015722A (es) | 2019-05-27 |
WO2018002105A1 (fr) | 2018-01-04 |
PE20190381A1 (es) | 2019-03-08 |
BR112018077321A2 (pt) | 2019-04-24 |
AU2017289204A1 (en) | 2019-01-17 |
SG10202005885VA (en) | 2020-07-29 |
JP2019522987A (ja) | 2019-08-22 |
ZA201808291B (en) | 2019-10-30 |
US20180002701A1 (en) | 2018-01-04 |
RU2019101298A (ru) | 2020-08-03 |
JP2022106785A (ja) | 2022-07-20 |
US10519450B2 (en) | 2019-12-31 |
CN109415732A (zh) | 2019-03-01 |
CN118325897A (zh) | 2024-07-12 |
TW201803990A (zh) | 2018-02-01 |
CN109415732B (zh) | 2024-01-02 |
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