GEAP202416430A - N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels - Google Patents

N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

Info

Publication number
GEAP202416430A
GEAP202416430A GEAP202416430A GEAP2024016430A GEAP202416430A GE AP202416430 A GEAP202416430 A GE AP202416430A GE AP202416430 A GEAP202416430 A GE AP202416430A GE AP2024016430 A GEAP2024016430 A GE AP2024016430A GE AP202416430 A GEAP202416430 A GE AP202416430A
Authority
GE
Georgia
Prior art keywords
theta
pulses
intensity
carboxamides
modulators
Prior art date
Application number
GEAP202416430A
Other languages
English (en)
Georgian (ka)
Inventor
Elizabeth Mary Beck
Robert Pullin
Jardi Gorka Etxebarria
Dean Stamos
Yvonne Schmidt
Joseph Pontillo
Stephen Andrew Thomson
David Matthew Shaw
Nadia M Ahmad
Meireles Lidio Marx Carvalho
Sarah Skerratt
Ruah Sara S Hadida
Timothy Donald Neubert
Dennis James Hurley
Jinglan Zhou
Steven John Durrant
Christopher Wray
Anisa Nizarali Virani
Kiri North
James Dodd
Michael Edward O'donnell
Bhairavi Galan
Ronald Marcellus Knegtel
Ewa Iwona Chudyk
Joanne Louise Pinder
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of GEAP202416430A publication Critical patent/GEAP202416430A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
GEAP202416430A 2021-06-04 2022-06-03 N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels GEAP202416430A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202163196946P 2021-06-04 2021-06-04

Publications (1)

Publication Number Publication Date
GEAP202416430A true GEAP202416430A (en) 2024-03-25

Family

ID=82483401

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP202416430A GEAP202416430A (en) 2021-06-04 2022-06-03 N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

Country Status (33)

Country Link
US (3) US11827627B2 (enExample)
EP (2) EP4347031B1 (enExample)
JP (1) JP2024522292A (enExample)
KR (1) KR20240031300A (enExample)
CN (1) CN117794920A (enExample)
AR (1) AR126073A1 (enExample)
AU (1) AU2022284886A1 (enExample)
CA (1) CA3221259A1 (enExample)
CL (1) CL2023003625A1 (enExample)
CO (1) CO2023017899A2 (enExample)
CR (1) CR20230586A (enExample)
DK (1) DK4347031T3 (enExample)
DO (1) DOP2023000267A (enExample)
EC (1) ECSP23095485A (enExample)
ES (1) ES3058787T3 (enExample)
FI (1) FI4347031T3 (enExample)
GE (1) GEAP202416430A (enExample)
HR (1) HRP20251504T1 (enExample)
IL (1) IL308953A (enExample)
JO (1) JOP20230316B1 (enExample)
LT (1) LT4347031T (enExample)
MA (1) MA64853B1 (enExample)
MD (1) MD4347031T2 (enExample)
MX (1) MX2023014378A (enExample)
PE (1) PE20241335A1 (enExample)
PL (1) PL4347031T3 (enExample)
PT (1) PT4347031T (enExample)
RS (1) RS67577B1 (enExample)
SI (1) SI4347031T1 (enExample)
SM (1) SMT202500481T1 (enExample)
TW (1) TW202313593A (enExample)
UY (1) UY39800A (enExample)
WO (1) WO2022256622A1 (enExample)

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BR112022010924A2 (pt) 2019-12-06 2022-09-06 Vertex Pharma Tetra-hidrofuranos substituídos como moduladores de canais de sódio
SMT202500481T1 (it) 2021-06-04 2026-01-12 Vertex Pharma N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio
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CN119731169A (zh) * 2022-08-28 2025-03-28 上海汇伦医药股份有限公司 一种钠通道调节剂及其应用
WO2024123815A1 (en) * 2022-12-06 2024-06-13 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
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WO2024188367A1 (zh) * 2023-03-10 2024-09-19 西藏海思科制药有限公司 一种四氢呋喃衍生物及其在医药上的应用
WO2024217528A1 (zh) * 2023-04-20 2024-10-24 西藏海思科制药有限公司 一种杂环化合物及其在医药上的应用
CN119371405A (zh) 2023-07-26 2025-01-28 上海闻耐医药科技有限公司 多取代吡咯烷类衍生物、其制备方法及用途
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WO2025108234A1 (zh) * 2023-11-20 2025-05-30 四川科伦药物研究院有限公司 化合物、其制备方法及用途
CN120192306A (zh) * 2023-12-21 2025-06-24 武汉熙瑞医药科技有限公司 一种含苯环的多环化合物、其药物组合物及其应用
WO2025162194A1 (zh) * 2024-01-31 2025-08-07 上海汇伦医药股份有限公司 钠通道调节剂新化合物及其应用
WO2025168043A1 (zh) * 2024-02-08 2025-08-14 上海枢境生物科技有限公司 并环类衍生物、制备方法及其用途
CN120040430A (zh) * 2024-02-23 2025-05-27 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的可药用盐、其结晶形式及用途
CN120040429B (zh) * 2024-02-23 2026-03-31 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的结晶形式及其用途
CN117902972B (zh) * 2024-03-19 2024-06-11 深圳创元生物医药科技有限公司 一种2,4-二羟基苯乙酸的制备方法
CN120774914A (zh) * 2024-04-03 2025-10-14 武汉人福创新药物研发中心有限公司 作为Nav1.8抑制剂的四氢呋喃吡啶酮类化合物
CN118388466A (zh) * 2024-04-23 2024-07-26 安润医药科技（苏州）有限公司 作钠通道调节剂的酰胺衍生物及其用途
WO2025252109A1 (zh) * 2024-06-04 2025-12-11 成都苑东生物制药股份有限公司 一种取代四氢呋喃类衍生物、其制备方法及用途
WO2026012382A1 (zh) * 2024-07-10 2026-01-15 海思科医药集团股份有限公司 一种硫杂环戊基衍生物的药物制剂及其在医药上的应用
WO2026030525A1 (en) 2024-07-31 2026-02-05 Vertex Pharmaceuticals Incorporated Zilvetrigine dosage forms and dosing regimens for treating pain
CN119285621B (zh) * 2024-12-13 2025-07-18 嘉兴安帝康生物科技有限公司 作为钠通道调节剂的四氢呋喃甲酰胺类化合物及其在医药上的应用

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