GB2353282C - Control of gene expression - Google Patents
Control of gene expressionInfo
- Publication number
- GB2353282C GB2353282C GB0024727A GB0024727A GB2353282C GB 2353282 C GB2353282 C GB 2353282C GB 0024727 A GB0024727 A GB 0024727A GB 0024727 A GB0024727 A GB 0024727A GB 2353282 C GB2353282 C GB 2353282C
- Authority
- GB
- United Kingdom
- Prior art keywords
- expression
- gene expression
- organism
- organ
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000014509 gene expression Effects 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 108700005078 Synthetic Genes Proteins 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 230000000754 repressing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8283—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for virus resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
- C12N2330/51—Specially adapted vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/38—Vector systems having a special element relevant for transcription being a stuffer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/55—Vector systems having a special element relevant for transcription from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP2492A AUPP249298A0 (en) | 1998-03-20 | 1998-03-20 | Synthetic genes and genetic constructs comprising same I |
| AUPP2499A AUPP249998A0 (en) | 1998-03-20 | 1998-03-20 | Gene expression I |
| PCT/AU1999/000195 WO1999049029A1 (en) | 1998-03-20 | 1999-03-19 | Control of gene expression |
Publications (5)
| Publication Number | Publication Date |
|---|---|
| GB0024727D0 GB0024727D0 (en) | 2000-11-22 |
| GB2353282A GB2353282A (en) | 2001-02-21 |
| GB2353282B GB2353282B (en) | 2003-06-04 |
| GB2353282A8 GB2353282A8 (en) | 2008-06-23 |
| GB2353282C true GB2353282C (en) | 2013-02-27 |
Family
ID=25645735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0024727A Expired - Lifetime GB2353282C (en) | 1998-03-20 | 1999-03-19 | Control of gene expression |
Country Status (20)
| Country | Link |
|---|---|
| US (6) | US20030074684A1 (enExample) |
| EP (5) | EP1555317B1 (enExample) |
| JP (4) | JP4187413B2 (enExample) |
| KR (3) | KR20010042069A (enExample) |
| CN (3) | CN101818145A (enExample) |
| AT (2) | ATE526405T1 (enExample) |
| AU (6) | AU743316C (enExample) |
| BR (1) | BRPI9908967B1 (enExample) |
| CA (3) | CA2323726C (enExample) |
| CZ (1) | CZ295108B6 (enExample) |
| DK (1) | DK1624060T3 (enExample) |
| ES (2) | ES2374534T3 (enExample) |
| GB (1) | GB2353282C (enExample) |
| HU (1) | HU230353B1 (enExample) |
| NZ (2) | NZ506648A (enExample) |
| PL (1) | PL343064A1 (enExample) |
| SG (2) | SG141233A1 (enExample) |
| SK (1) | SK287538B6 (enExample) |
| WO (1) | WO1999049029A1 (enExample) |
| ZA (1) | ZA200004507B (enExample) |
Families Citing this family (300)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586661B1 (en) | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
| US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| ATE526405T1 (de) | 1998-03-20 | 2011-10-15 | Commw Scient Ind Res Org | Synthetische gene und genetische zusammensetzungen diesen enthaltend |
| AUPP249298A0 (en) * | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| US8598332B1 (en) * | 1998-04-08 | 2013-12-03 | Bayer Cropscience N.V. | Methods and means for obtaining modified phenotypes |
| US20040214330A1 (en) | 1999-04-07 | 2004-10-28 | Waterhouse Peter Michael | Methods and means for obtaining modified phenotypes |
| EP2267139B1 (en) * | 1998-04-08 | 2017-03-22 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
| AR020078A1 (es) | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| US6939712B1 (en) * | 1998-12-29 | 2005-09-06 | Impedagen, Llc | Muting gene activity using a transgenic nucleic acid |
| EP2314700A1 (en) * | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
| AU2008202208C1 (en) * | 1999-01-30 | 2014-04-24 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a defined gene |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| KR20010112944A (ko) * | 1999-04-21 | 2001-12-22 | 이곤 이 버그 | 폴리뉴클레오티드 서열의 기능을 억제하기 위한 방법 및조성물 |
| US20040138168A1 (en) * | 1999-04-21 | 2004-07-15 | Wyeth | Methods and compositions for inhibiting the function of polynucleotide sequences |
| EP1801215B1 (en) * | 1999-05-10 | 2013-02-27 | Syngenta Participations AG | Regulation of viral gene expression |
| US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| DE60037735T2 (de) | 1999-08-26 | 2009-01-02 | Calgene Llc, Davis | Pflanzen mit veränderten mehrfachungesättigten fettsäuren |
| US7531718B2 (en) | 1999-08-26 | 2009-05-12 | Monsanto Technology, L.L.C. | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| US7067722B2 (en) | 1999-08-26 | 2006-06-27 | Monsanto Technology Llc | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| GB9927444D0 (en) * | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| US8202979B2 (en) | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| US7491805B2 (en) | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| WO2003070918A2 (en) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
| US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
| WO2002081628A2 (en) | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| US8273866B2 (en) | 2002-02-20 | 2012-09-25 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
| JP2003526367A (ja) | 2000-03-16 | 2003-09-09 | ジェネティカ インコーポレイテッド | Rna干渉の方法とrna干渉組成物 |
| US8202846B2 (en) | 2000-03-16 | 2012-06-19 | Cold Spring Harbor Laboratory | Methods and compositions for RNA interference |
| AU2001240375A1 (en) * | 2000-03-17 | 2001-10-03 | Benitec Australia Limited | Genetic silencing |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Rna 간섭의 rna 서열 특이적인 매개체 |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| US20080032942A1 (en) | 2000-08-30 | 2008-02-07 | Mcswiggen James | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
| JP2004507250A (ja) | 2000-08-30 | 2004-03-11 | ノース・キャロライナ・ステイト・ユニヴァーシティ | タンパク質含量を変化させる分子デコイを含有するトランスジェニック植物 |
| CA2427347C (en) | 2000-10-31 | 2011-01-18 | Commonwealth Scientific And Industrial Research Organisation | Method and means for producing barley yellow dwarf virus resistant cereal plants |
| CA2427825A1 (en) | 2000-11-07 | 2002-05-16 | North Carolina State University | Putrescine-n-methyltransferase promoter |
| KR100909681B1 (ko) | 2000-12-01 | 2009-07-29 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Rna 간섭을 매개하는 작은 rna 분자 |
| US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| US7767802B2 (en) | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| EP1354035B1 (en) | 2001-01-26 | 2016-08-24 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for producing efficient silencing construct using recombinational cloning |
| CA2369944A1 (en) | 2001-01-31 | 2002-07-31 | Nucleonics Inc. | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
| US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| US7109165B2 (en) | 2001-05-18 | 2006-09-19 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US20050014172A1 (en) | 2002-02-20 | 2005-01-20 | Ivan Richards | RNA interference mediated inhibition of muscarinic cholinergic receptor gene expression using short interfering nucleic acid (siNA) |
| US20050148530A1 (en) | 2002-02-20 | 2005-07-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20030175950A1 (en) * | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| US7517864B2 (en) | 2001-05-18 | 2009-04-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050256068A1 (en) | 2001-05-18 | 2005-11-17 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA) |
| US20050159378A1 (en) | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| US8008472B2 (en) | 2001-05-29 | 2011-08-30 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) |
| KR20040019301A (ko) | 2001-06-08 | 2004-03-05 | 벡터 토바코 리미티드 | 담배에서 니코틴 및 니트로사민 수준의 조절 |
| AUPR621501A0 (en) | 2001-07-06 | 2001-08-02 | Commonwealth Scientific And Industrial Research Organisation | Delivery of ds rna |
| ES2606290T3 (es) | 2001-07-12 | 2017-03-23 | University Of Massachusetts | Producción in vivo de ARN de interferencia pequeños que median el silenciamiento génico |
| CA2936534C (en) | 2001-07-23 | 2021-01-26 | The Board Of Trustees Of Leland Stanford Junior University | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
| US10590418B2 (en) | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
| US7612194B2 (en) | 2001-07-24 | 2009-11-03 | Monsanto Technology Llc | Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof |
| US20050037989A1 (en) * | 2001-08-27 | 2005-02-17 | Lewis David L. | Inhibition of gene function by delivery of polynucleotide-based gene expression inhibitors to mammalian cells in vivo |
| US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| CA2474910A1 (en) | 2002-02-01 | 2003-08-07 | Sequitur, Inc. | Oligonucleotide compositions with enhanced efficiency |
| US7910724B2 (en) | 2002-02-20 | 2011-03-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA) |
| US7678897B2 (en) | 2002-02-20 | 2010-03-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA) |
| US7928220B2 (en) | 2002-02-20 | 2011-04-19 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA) |
| US7667030B2 (en) | 2002-02-20 | 2010-02-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA) |
| US7691999B2 (en) | 2002-02-20 | 2010-04-06 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA) |
| EP1474433A4 (en) * | 2002-02-20 | 2005-02-23 | Sirna Therapeutics Inc | VALIDATION AND IDENTIFICATION OF RNA INTERFERENCE FACILITATED TARGETS USING SHORT INTERFERENT NUCLEIC ACID (siNA) |
| US8258288B2 (en) | 2002-02-20 | 2012-09-04 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA) |
| US7700760B2 (en) | 2002-02-20 | 2010-04-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA) |
| US7935812B2 (en) | 2002-02-20 | 2011-05-03 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
| US20090253774A1 (en) | 2002-02-20 | 2009-10-08 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF PLATELET DERIVED GROWTH FACTOR (PDGF) AND PLATELET DERIVED GROWTH FACTOR RECEPTOR (PDGFR) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US7667029B2 (en) | 2002-02-20 | 2010-02-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA) |
| US20090253773A1 (en) | 2002-02-20 | 2009-10-08 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US7683165B2 (en) | 2002-02-20 | 2010-03-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA) |
| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US7928218B2 (en) | 2002-02-20 | 2011-04-19 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) |
| US7897753B2 (en) | 2002-02-20 | 2011-03-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA) |
| JP2005517427A (ja) | 2002-02-20 | 2005-06-16 | サーナ・セラピューティクス・インコーポレイテッド | 短干渉核酸(siNA)を用いるC型肝炎ウイルス(HCV)遺伝子発現のRNA干渉媒介性阻害 |
| US8067575B2 (en) | 2002-02-20 | 2011-11-29 | Merck, Sharp & Dohme Corp. | RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA) |
| US7928219B2 (en) | 2002-02-20 | 2011-04-19 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA) |
| US8013143B2 (en) | 2002-02-20 | 2011-09-06 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA) |
| US20090192105A1 (en) | 2002-02-20 | 2009-07-30 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF INTERCELLULAR ADHESION MOLECULE (ICAM) GENE EXPRESSION USING SHORT INTERFERING NUCELIC ACID (siNA) |
| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| AU2003219833A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF CHROMOSOME TRANSLOCATION GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP1432724A4 (en) * | 2002-02-20 | 2006-02-01 | Sirna Therapeutics Inc | INTERFERENCE MEDIATION INHIBITION OF GENE RNA FROM MAP KINASE |
| US7795422B2 (en) | 2002-02-20 | 2010-09-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
| US7683166B2 (en) | 2002-02-20 | 2010-03-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA) |
| US7662952B2 (en) | 2002-02-20 | 2010-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA) |
| US7897757B2 (en) | 2002-02-20 | 2011-03-01 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) |
| US20090099117A1 (en) | 2002-02-20 | 2009-04-16 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF MYOSTATIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US7893248B2 (en) | 2002-02-20 | 2011-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| US7897752B2 (en) | 2002-02-20 | 2011-03-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA) |
| CA2478910C (en) * | 2002-03-14 | 2012-08-21 | Commonwealth Scientific And Industrial Research Organisation | Methods and means for monitoring and modulating gene silencing |
| AR039113A1 (es) | 2002-03-21 | 2005-02-09 | Monsanto Technology Llc | Construcciones de acidos nucleicos y metodos para producir composiciones de aceites de semillas alteradas |
| US7566813B2 (en) | 2002-03-21 | 2009-07-28 | Monsanto Technology, L.L.C. | Nucleic acid constructs and methods for producing altered seed oil compositions |
| US7166771B2 (en) | 2002-06-21 | 2007-01-23 | Monsanto Technology Llc | Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs |
| US20040180438A1 (en) | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
| DK1504126T3 (da) | 2002-05-03 | 2014-06-10 | Univ Duke | Fremgangsmåde til regulering af genekspression |
| US20050042646A1 (en) | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
| US7452987B2 (en) | 2002-08-05 | 2008-11-18 | Silence Therapeutics Aktiengesellschaft (Ag) | Interfering RNA molecules |
| US20080274989A1 (en) | 2002-08-05 | 2008-11-06 | University Of Iowa Research Foundation | Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof |
| US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
| JP4339852B2 (ja) | 2002-08-12 | 2009-10-07 | ニュー・イングランド・バイオラブズ・インコーポレイティッド | 遺伝子サイレンシングに関する方法および組成物 |
| EP3170890A1 (en) | 2002-08-21 | 2017-05-24 | Revivicor, Inc. | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
| US7923547B2 (en) | 2002-09-05 | 2011-04-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US20040242518A1 (en) * | 2002-09-28 | 2004-12-02 | Massachusetts Institute Of Technology | Influenza therapeutic |
| WO2004041838A1 (en) * | 2002-11-01 | 2004-05-21 | University Of Massachusetts | Regulation of transcription elongation factors |
| US7078234B2 (en) | 2002-12-18 | 2006-07-18 | Monsanto Technology Llc | Maize embryo-specific promoter compositions and methods for use thereof |
| CA2519912A1 (en) | 2003-03-28 | 2004-10-14 | Monsanto Technology Llc | Regulatory regions that promote early plant seed enhanced transcription |
| JP2006526394A (ja) * | 2003-06-03 | 2006-11-24 | ベニテック オーストラリア リミテッド | 二本鎖核酸 |
| WO2004108903A2 (en) | 2003-06-06 | 2004-12-16 | Arborgen, Llc | Plant transformation and selection |
| EP1636385A4 (en) * | 2003-06-24 | 2010-06-02 | Mirus Bio Corp | INHIBITION OF GENE FUNCTION BY IN VIVO DISTRIBUTION OF GENE EXPRESSION INHIBITORS BASED ON POLYNUCLEOTIDES IN MAMMALIAN CELLS |
| JP5183064B2 (ja) * | 2003-07-02 | 2013-04-17 | エムユーエスシー ファウンデイション フォー リサーチ デべロップメント | 甲殻類動物、及び他の無脊椎動物における、dsRNAで誘導された特異的、及び非特異的免疫、及びそこで使用する生物送達媒体 |
| AU2004259019B2 (en) * | 2003-07-21 | 2010-09-23 | Lifecell Corporation | Acellular tissue matrices made from galactose alpha-1,3-galactose-deficient tissue |
| CN1871341A (zh) | 2003-08-20 | 2006-11-29 | 悉尼北方和中部海岸区医疗服务系统 | 提高胚胎生存力的方法 |
| IL157538A0 (en) | 2003-08-21 | 2004-03-28 | Bar Ilan Res & Dev Company Ltd | Plant resistant to cytoplasm-feeding parasites |
| EP1664298A4 (en) * | 2003-09-12 | 2010-03-17 | Commw Scient Ind Res Org | MODIFIED GEN-SILENCING NUCLEIC ACID MOLECULES AND USES THEREOF |
| EP1685148A2 (en) | 2003-11-05 | 2006-08-02 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | PORCINE ISOGLOBOSIDE 3 SYNTHASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION |
| CN103397019A (zh) | 2003-11-21 | 2013-11-20 | 雷维维科公司 | 干扰rna在生产转基因动物中的用途 |
| US8304189B2 (en) | 2003-12-01 | 2012-11-06 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
| EP1701611B1 (en) | 2003-12-24 | 2011-05-18 | G2 Inflammation Pty Ltd | Transgenic non-human mammal comprising a polynucleotide encoding human or humanized c5ar |
| US20060075515A1 (en) | 2004-08-11 | 2006-04-06 | Luethy Michael H | Enhanced zein reduction in transgenic corn seed |
| US7855323B2 (en) | 2004-02-10 | 2010-12-21 | Monsanto Technology Llc | Recombinant DNA for gene suppression |
| US7683237B2 (en) | 2004-02-10 | 2010-03-23 | Monsanto Technology Llc | Maize seed with synergistically enhanced lysine content |
| ATE452188T1 (de) | 2004-02-10 | 2010-01-15 | Sirna Therapeutics Inc | Rna-interferenz-vermittelte hemmung der genexpression unter verwendung multifunktioneller sina (short interfering nucleic acid) |
| AR047598A1 (es) | 2004-02-10 | 2006-01-25 | Monsanto Technology Llc | Semilla de maiz transgenica con mayor contenido de aminoacidos |
| KR101246862B1 (ko) | 2004-03-05 | 2013-03-27 | 베니텍 리미티드 | RNAi 제제의 동시 전달을 위한 다중 프로모터 발현카세트 |
| KR20070002057A (ko) | 2004-03-17 | 2007-01-04 | 레비비코르 인코포레이션 | 기능성 알파 1,3 갈락토실트랜스펙션스페라제의 어떠한발현도 결여된 동물로부터 유래된 조직 산물 |
| US20060041961A1 (en) | 2004-03-25 | 2006-02-23 | Abad Mark S | Genes and uses for pant improvement |
| WO2005095614A1 (en) | 2004-03-31 | 2005-10-13 | Commonwealth Scientific And Industrial Research Organistion | Genes involved in plant fibre development |
| CA2762011C (en) | 2004-04-09 | 2019-05-07 | Monsanto Technology Llc | Compositions and methods for control of insect infestations in plants |
| CA2563875C (en) | 2004-04-22 | 2015-06-30 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| EP1747022A4 (en) | 2004-04-23 | 2010-03-31 | Univ Columbia | INHIBITION OF HAIRLESS PROTEIN MRNA |
| US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| US20060075522A1 (en) | 2004-07-31 | 2006-04-06 | Jaclyn Cleveland | Genes and uses for plant improvement |
| CN101056534B (zh) | 2004-10-13 | 2012-10-10 | 乔治亚大学研究基金会公司 | 抗线虫的转基因植物 |
| US20100170000A9 (en) | 2004-10-25 | 2010-07-01 | Devgen Nv | Rna constructs |
| ATE556126T1 (de) * | 2004-10-29 | 2012-05-15 | Life Technologies Corp | Funktionalisierte fluoreszierende nanokristalle und verfahren zu deren herstellung und verwendung |
| US8404927B2 (en) * | 2004-12-21 | 2013-03-26 | Monsanto Technology Llc | Double-stranded RNA stabilized in planta |
| MX2007007948A (es) | 2004-12-28 | 2007-09-11 | Pioneer Hi Bred Int | Calidad de grano mejorada a traves de la expresion alterada de las proteinas de semilla. |
| WO2006076423A2 (en) | 2005-01-12 | 2006-07-20 | Monsanto Technology, Llc | Genes and uses for plant improvement |
| ATE530656T1 (de) | 2005-02-23 | 2011-11-15 | Univ North Carolina State | Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. |
| US8519225B2 (en) | 2006-02-10 | 2013-08-27 | Monsanto Technology Llc | Identification and use of target genes for control of plant parasitic nematodes |
| DE202005004135U1 (de) * | 2005-03-11 | 2005-05-19 | Klocke Verpackungs-Service Gmbh | Mehrkomponentenverpackung mit Applikator |
| JP2008536874A (ja) * | 2005-04-15 | 2008-09-11 | ボード オブ リージェンツ ザ ユニバーシティー オブ テキサス システム | 中性脂質組成物によるsiRNAの送達 |
| WO2006113743A2 (en) * | 2005-04-18 | 2006-10-26 | Massachusetts Institute Of Technology | Compositions and methods for rna interference with sialidase expression and uses thereof |
| ATE552343T1 (de) | 2005-04-19 | 2012-04-15 | Basf Plant Science Gmbh | Endosperm-spezifische expression und/oder expression in keimenden embryos monokotyledoner pflanzen |
| EP1896595A2 (en) | 2005-05-25 | 2008-03-12 | Pioneer-Hi-Bred International, Inc. | Methods for improving crop plant architecture and yield |
| BRPI0616181B1 (pt) | 2005-09-16 | 2024-03-05 | Monsanto Technology Llc | Construção de polinucleotídeo isolada, sequência de ribonucleotídeo de fita dupla, microrganismo transgênico, seu método de produção, e métodos para controle de infestação por coleóptero praga, para melhorar o rendimento e a tolerância a estiagem de um cultivo, e para produção de um produto comercial, alimento ou ração |
| BRPI0615791B1 (pt) | 2005-09-16 | 2018-04-03 | Devgen Nv | Rna de fita dupla isolado compreendendo fitas complementares aneladas, método de controle de infestação de peste e uso de uma ração artificial compreendendo a sequência de ribonucleotídeo de fita dupla para tratar infestação de plantas por insetos |
| CN101268194A (zh) | 2005-09-20 | 2008-09-17 | 巴斯福植物科学有限公司 | 使用ta-siRNA调控基因表达的方法 |
| EP1934348B1 (en) | 2005-10-11 | 2018-05-02 | Ben-Gurion University Of The Negev Research And Development Authority | Compositions for silencing the expression of vdac1 and uses thereof |
| WO2007045040A1 (en) | 2005-10-20 | 2007-04-26 | Commonwealth Scientific And Industrial Research Organisation | Cereals with altered dormancy |
| DK1974040T3 (da) | 2006-01-17 | 2012-12-17 | Synthon Biopharmaceuticals Bv | Sammensætninger og fremgangsmåder til humanisering og optimering af N-glycanet i planter. |
| CN101421295B (zh) | 2006-02-09 | 2012-05-02 | 先锋高级育种国际公司 | 用于提高作物植物中的氮利用效率的基因 |
| WO2007095496A2 (en) | 2006-02-13 | 2007-08-23 | Monsanto Technology Llc | Selecting and stabilizing dsrna constructs |
| CN101421406B (zh) | 2006-02-13 | 2016-08-31 | 孟山都技术有限公司 | 用于产生改变的种子油组成的核酸构建体和方法 |
| FR2898908A1 (fr) | 2006-03-24 | 2007-09-28 | Agronomique Inst Nat Rech | Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence |
| WO2007124312A2 (en) | 2006-04-19 | 2007-11-01 | Pioneer Hi-Bred International, Inc. | Isolated polynucleotide molecules corresponding to mutant and wild-type alleles of the maize d9 gene and methods of use |
| AU2007272314B2 (en) | 2006-07-12 | 2014-05-01 | Commonwealth Scientific And Industrial Research Organisation | Polynucleotides and methods for enhancing salinity tolerance in plants |
| WO2008027592A2 (en) | 2006-08-31 | 2008-03-06 | Monsanto Technology, Llc | Phased small rnas |
| CN101195821A (zh) | 2006-12-04 | 2008-06-11 | 中国科学院上海生命科学研究院 | 利用RNAi技术改良植物抗虫性的方法 |
| RU2009130380A (ru) | 2007-01-10 | 2011-02-20 | Санофи-Авентис (Fr) | Способ определения стабильности органических метиленаминов в присутствии семикарбазид-чувствительной аминоксидазы |
| ATE533353T1 (de) | 2007-02-05 | 2011-12-15 | Univ Singapore | Mutmasslicher cytokininrezeptor und verfahren für seine verwendung |
| US8067390B2 (en) * | 2007-03-02 | 2011-11-29 | The Board Of Regents Of The University Of Texas System | Therapeutic targeting of interleukins using siRNA in neutral liposomes |
| HUE027018T2 (en) | 2007-03-21 | 2016-08-29 | Brookhaven Science Ass Llc | Combination hairpin antisense compositions and methods for modulating expression |
| US9662383B2 (en) * | 2007-03-26 | 2017-05-30 | University Of Massachusetts | Compositions and methods for increasing immunogenicity of glycoprotein vaccines |
| WO2008157263A2 (en) | 2007-06-15 | 2008-12-24 | Arkansas State University | Methods of delivery of molecules to cells using a ricin subunit and compositions relating to same |
| US8642846B2 (en) | 2007-08-13 | 2014-02-04 | Commonwealth Scientific And Industrial Research Organisation | Barley with low levels of hordeins |
| CN101932708A (zh) | 2007-08-14 | 2010-12-29 | 联邦科学工业研究组织 | 改进的基因沉默方法 |
| WO2009026660A1 (en) | 2007-08-30 | 2009-03-05 | Walter And Eliza Hall Institute Of Medical Research | Dendritic cell marker and uses thereof |
| CA2706439C (en) | 2007-11-20 | 2015-04-21 | Pioneer Hi-Bred International, Inc. | Maize ethylene signaling genes and modulation of same for improved stress tolerance in plants |
| CN101970668B (zh) | 2007-11-27 | 2014-05-07 | 澳大利亚联邦科学与工业研究组织 | 淀粉代谢途径经过修饰的作物 |
| US8809626B2 (en) | 2007-12-21 | 2014-08-19 | Keygene N.V. | Trichome specific promoters |
| CA2720396A1 (en) * | 2008-04-04 | 2009-10-08 | Robert Shorr | Pharmaceutical composition |
| JP5722765B2 (ja) | 2008-04-24 | 2015-05-27 | ニューサウス イノベイションズ ピーティーワイ リミテッド | 藍藻類サキシトキシン遺伝子クラスタおよびシアノトキシンを有する生物の検出 |
| WO2009132351A2 (en) * | 2008-04-25 | 2009-10-29 | University Of Medicine And Dentistry Of New Jersey | Anti-sense microrna expression vectors |
| US8093043B2 (en) | 2008-06-04 | 2012-01-10 | New York University | β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis |
| WO2010005527A1 (en) | 2008-06-30 | 2010-01-14 | Angioblast Systems, Inc. | Treatment of eye diseases and excessive neovascularization using a combined therapy |
| CN102202498B (zh) | 2008-07-21 | 2016-09-07 | 澳大利亚联邦科学与工业研究组织 | 改良的棉籽油及应用 |
| CN102164476A (zh) | 2008-09-29 | 2011-08-24 | 孟山都技术公司 | 大豆转基因事件mon87705及其检测方法 |
| BRPI0920107A2 (pt) | 2008-10-30 | 2015-08-18 | Pioneer Hi Bred Int | Polinucleotídeo isolado, cassete de expressão recombinante, célula hospedeira, planta tansgênica, semente transgênica, método para modular gs em uma planta, método para reduzir atividade de polipeptídeo da enzima gs em uma célula de planta. |
| CA2743057C (en) | 2008-11-07 | 2019-11-26 | Research Development Foundation | Compositions and methods for the inhibition of cripto/grp78 complex formation and signaling |
| CA2780482A1 (en) | 2008-11-17 | 2010-05-10 | Anil K. Sood | Hdl particles for delivery of nucleic acids |
| WO2010065437A1 (en) | 2008-12-03 | 2010-06-10 | Research Development Foundation | Modulation of olfml-3 mediated angiogenesis |
| WO2010065867A1 (en) | 2008-12-04 | 2010-06-10 | Pioneer Hi-Bred International, Inc. | Methods and compositions for enhanced yield by targeted expression of knotted1 |
| US8497075B2 (en) | 2008-12-09 | 2013-07-30 | Novartis Ag | Methods of identifying a modulator that inhibits the binding between Epstein-Barr virus induced receptor 2 and cholesterol derived ligands |
| WO2010101818A1 (en) | 2009-03-02 | 2010-09-10 | Pioneer Hi-Bred International, Inc. | Nac transcriptional activators involved in abiotic stress tolerance |
| CA2755870C (en) | 2009-03-20 | 2019-04-09 | Angioblast Systems, Inc. | Production of reprogrammed pluripotent cells |
| US20110045080A1 (en) * | 2009-03-24 | 2011-02-24 | William Marsh Rice University | Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto |
| US8987553B2 (en) | 2009-04-14 | 2015-03-24 | Pioneer Hi Bred International Inc | Modulation of ACC synthase improves plant yield under low nitrogen conditions |
| MX2011010763A (es) | 2009-04-17 | 2011-12-16 | Basf Plant Science Co Gmbh | Promotor de planta operable en endosperma y usos del mismo. |
| WO2010123904A1 (en) | 2009-04-20 | 2010-10-28 | Monsanto Technology Llc | Multiple virus resistance in plants |
| WO2010139026A1 (en) | 2009-06-05 | 2010-12-09 | Centenary Institute Of Cancer Medicine And Cell Biology | Therapeutic and diagnostic molecules |
| ES2879599T3 (es) | 2009-06-08 | 2021-11-22 | Nunhems Bv | Plantas tolerantes a la sequía |
| EA201200177A1 (ru) | 2009-07-24 | 2012-06-29 | Пайонир Хай-Бред Интернэшнл, Инк. | Применение связок компонентов домена димеризации для регулирования архитектуры растения |
| CN101760555B (zh) * | 2009-09-30 | 2012-06-27 | 西南大学 | 一种基于pcr技术鉴定单拷贝转基因烟草的方法 |
| BR112012007516A2 (pt) | 2009-10-02 | 2015-09-15 | Pioneer Hi Bred Int | ácido nucléico isolado, plantas , células vegetais, métodos de redução de produção de etileno em uma planta, de aumento de produtividade em uma planta e de aumento de tolerância à aridez, cassete de expressão e semente |
| EP3406720A1 (en) | 2009-12-18 | 2018-11-28 | Arrowhead Pharmaceuticals, Inc. | Organic compositions to treat hsf1-related diseases |
| EP2521788A1 (en) | 2010-01-06 | 2012-11-14 | Pioneer Hi-Bred International Inc. | Identification of diurnal rhythms in photosynthetic and non-photosynthetic tissues from zea mays and use in improving crop plants |
| JP2013519869A (ja) | 2010-02-10 | 2013-05-30 | ノバルティス アーゲー | 筋肉成長のための方法および化合物 |
| US8710207B2 (en) * | 2010-05-10 | 2014-04-29 | The Texas A&M University Systems | Compositions, organisms, systems, and methods for expressing a gene product in plants using SCBV expression control sequences operable in monocots and dicots |
| MX344585B (es) | 2010-05-28 | 2016-12-20 | Nunhems Bv | Platas con un tamaño de fruto incrementado. |
| WO2012007945A2 (en) | 2010-07-12 | 2012-01-19 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center | Isolated polynucleotides and methods and plants using same for regulating plant acidity |
| EP3192880B1 (en) | 2010-08-18 | 2019-10-09 | Fred Hutchinson Cancer Research Center | Nucleic acid agents for use in treating facioscapulohumeral dystrophy (fshd) |
| WO2012027467A1 (en) * | 2010-08-26 | 2012-03-01 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20120107355A1 (en) | 2010-10-27 | 2012-05-03 | Harrisvaccines, Inc. | Method of rapidly producing improved vaccines for animals |
| KR101903778B1 (ko) | 2010-10-28 | 2018-10-04 | 베니텍 바이오파마 리미티드 | Hbv 치료 |
| EP2632472B1 (en) | 2010-10-29 | 2017-12-13 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina) |
| JP6063869B2 (ja) | 2010-11-04 | 2017-01-18 | アリスタ シリアル テクノロジーズ プロプライエタリー リミテッドArista Cereal Technologies Pty Ltd | 高アミロースコムギ |
| AU2011325871B2 (en) | 2010-11-05 | 2016-02-04 | Medvet Science Pty Ltd | Markers of endothelial progenitor cells and uses thereof |
| NZ759163A (en) | 2011-02-14 | 2023-03-31 | Revivicor Inc | Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof |
| US10030245B2 (en) | 2011-03-23 | 2018-07-24 | E I Du Pont De Nemours And Company | Methods for producing a complex transgenic trait locus |
| CN103502269A (zh) | 2011-04-29 | 2014-01-08 | 先锋国际良种公司 | 下调同源域-亮氨酸拉链i类同源盒基因以改进植物性能 |
| ES2828482T3 (es) | 2011-06-13 | 2021-05-26 | Csl Ltd | Anticuerpos contra el g-csfr y su uso |
| EP2721160A2 (en) | 2011-06-14 | 2014-04-23 | Synthon Biopharmaceuticals B.V. | Compositions and methods for making and biocontaining auxotrophic transgenic plants |
| CN104080914A (zh) | 2011-06-21 | 2014-10-01 | 先锋国际良种公司 | 产生雄性不育植物的组合物和方法 |
| MX2014005212A (es) | 2011-10-31 | 2014-11-25 | Pioneer Hi Bred Int | Mejoramiento de la tolerancia a la sequia, eficiencia de uso de nitrogeno y rendimiento de una planta. |
| EP2773183B1 (en) | 2011-11-04 | 2024-10-09 | Arista Cereal Technologies Pty Ltd | High amylose wheat - ii |
| UA116097C2 (uk) | 2011-12-11 | 2018-02-12 | Зе Стейт Оф Ізраел, Міністрі Оф Агрікалче Енд Руерал Девелопмент, Агрікалчерал Рісьоч Організейшн, (А.Р.О.), Волкані Сентре | Спосіб модуляції провідності устячка рослини |
| DK2798065T3 (da) | 2011-12-27 | 2019-09-16 | Commw Scient Ind Res Org | Samtidig geninaktivering og undertrykkelse af geninaktivering i samme celle |
| WO2013096991A1 (en) | 2011-12-27 | 2013-07-04 | Commonwealth Scientific And Industrial Research Organisation | Production of dihydrosterculic acid and derivatives thereof |
| PH12021552871A1 (en) | 2011-12-27 | 2022-09-28 | Commw Scient Ind Res Org | Processes for producing lipids |
| BR112014016870A2 (pt) | 2012-01-09 | 2017-06-27 | Huesken Dieter | composições orgânicas para tratar doenças relacionadas com beta-catenina |
| BR112014017196A2 (pt) | 2012-01-11 | 2017-06-13 | The Australian National University | métodos para a modulação ou inibição da modulação da arquitetura da raiz de uma planta, planta, planta transgênica, peptídeo regulador de arquitetura de raiz isolado (rar), polinucleotídeo isolado, vetor recombinante, célula hospedeira transgênica e promotor de planta isolado |
| WO2013138309A1 (en) | 2012-03-13 | 2013-09-19 | Pioneer Hi-Bred International, Inc. | Genetic reduction of male fertility in plants |
| US9783814B2 (en) | 2012-03-13 | 2017-10-10 | Pioneer Hi-Bred International, Inc. | Genetic reduction of male fertility in plants |
| SG11201406843WA (en) | 2012-04-25 | 2014-11-27 | Commw Scient Ind Res Org | High oleic acid oils |
| CN102719454B (zh) * | 2012-06-15 | 2014-07-30 | 华南农业大学 | 一种优化的硫化物醌氧化还原酶基因及其表达载体 |
| WO2014027021A1 (en) | 2012-08-16 | 2014-02-20 | Vib Vzw | Means and methods for altering the lignin pathway in plants |
| WO2014045126A2 (en) | 2012-09-18 | 2014-03-27 | Uti Limited Partnership | Treatment of pain by inhibition of usp5 de-ubiquitinase |
| AU2014211570A1 (en) | 2013-01-29 | 2015-07-23 | The University Court Of The University Of Glasgow | Methods and means for increasing stress tolerance and biomass in plants |
| EP2961853B1 (en) | 2013-02-28 | 2018-09-19 | The Board of Regents of The University of Texas System | Methods for classifying a cancer as susceptible to tmepai-directed therapies and treating such cancers |
| US20160002648A1 (en) | 2013-03-11 | 2016-01-07 | Mei Guo | Genes for improving nutrient uptake and abiotic stress tolerance in plants |
| WO2014164074A1 (en) | 2013-03-13 | 2014-10-09 | Pioneer Hi-Bred International, Inc. | Enhanced nitrate uptake and nitrate translocation by over-expressing maize functional low-affinity nitrate transporters in transgenic maize |
| WO2014164116A1 (en) | 2013-03-13 | 2014-10-09 | Pioneer Hi-Bred International, Inc. | Functional expression of bacterial major facilitator superfamily (sfm) gene in maize to improve agronomic traits and grain yield |
| US20140304857A1 (en) | 2013-03-14 | 2014-10-09 | Pioneer Hi Bred International Inc | Maize stress related transcription factor 18 and uses thereof |
| BR112015023700A2 (pt) | 2013-03-15 | 2017-07-18 | Pioneer Hi Bred Int | método de aprimoramento da tolerância ao estresse abiótico em uma planta de cultura agrícola , planta de milho transgênica, célula vegetal, semente, método de regulação negativa de um gene de acc oxidase endógeno em uma planta de milho. |
| EP2976429B1 (en) | 2013-03-21 | 2017-04-19 | VIB vzw | Means and methods for the reduction of photorespiration in crops |
| EP2810952A1 (en) | 2013-06-03 | 2014-12-10 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Novel pest control methods |
| EP3007547B1 (en) | 2013-06-11 | 2018-07-18 | Syngenta Participations AG | Methods for generating transgenic plants |
| WO2014197943A1 (en) | 2013-06-13 | 2014-12-18 | Commonwealth Scientific And Industrial Research Organisation | Barley with very low levels of hordeins |
| KR20200108903A (ko) | 2013-06-25 | 2020-09-21 | 더 월터 앤드 엘리자 홀 인스티튜트 오브 메디컬 리서치 | 세포내 감염의 치료 방법 |
| US10428336B2 (en) | 2013-10-16 | 2019-10-01 | The Australian National University | Method for modulating plant growth |
| BR112016009178B1 (pt) | 2013-11-04 | 2020-12-15 | Lifecell Corporation | Método de preparação de um produto de tecido e uso de um produto de tecido |
| EP3069137A1 (en) | 2013-11-05 | 2016-09-21 | Novartis Ag | Organic compounds |
| KR102339724B1 (ko) | 2013-11-28 | 2021-12-17 | 씨에스엘 리미티드 | 신장병증의 치료 방법 |
| CA2933590C (en) | 2013-12-11 | 2023-10-03 | Sloan-Kettering Institute For Cancer Research | Glucocorticoid inhibitors for treatment of prostate cancer |
| DK3082860T3 (da) | 2013-12-18 | 2021-01-25 | Csl Ltd | Fremgangsmåde til behandling af sår |
| WO2015116680A1 (en) | 2014-01-30 | 2015-08-06 | Two Blades Foundation | Plants with enhanced resistance to phytophthora |
| US10258639B2 (en) | 2014-05-06 | 2019-04-16 | Research Development Foundation | Methods for treating insulin resistance and for sensitizing patients to GLP1 agonist therapy |
| WO2015171603A1 (en) | 2014-05-06 | 2015-11-12 | Two Blades Foundation | Methods for producing plants with enhanced resistance to oomycete pathogens |
| CA2954203C (en) | 2014-07-07 | 2023-12-05 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing industrial products from plant lipids |
| WO2016005449A1 (en) | 2014-07-08 | 2016-01-14 | Vib Vzw | Means and methods to increase plant yield |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| AU2015360794B2 (en) | 2014-12-08 | 2021-07-08 | The Board Of Regents Of The University Of Texas System | Lipocationic polymers and uses thereof |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| WO2016196489A1 (en) | 2015-05-29 | 2016-12-08 | Arcadia Biosciences | Reduced gluten grains and compositions thereof |
| MX394129B (es) | 2015-06-19 | 2025-03-24 | Arcadia Biosciences Inc | Trigo con actividad reducida de lipooxigenasa. |
| US10000766B2 (en) * | 2015-07-17 | 2018-06-19 | National Chung Hsing University | Recombinant construct, recombinant microorganism, recombinant plant cell and method of providing plant with resistance against DNA virus and RNA virus |
| EP3344774A1 (en) | 2015-09-04 | 2018-07-11 | Keygene N.V. | Diplospory gene |
| JP7041616B2 (ja) | 2015-09-14 | 2022-03-24 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | リポカチオン性デンドリマーおよびその使用 |
| WO2017062790A1 (en) | 2015-10-09 | 2017-04-13 | Two Blades Foundation | Cold shock protein receptors and methods of use |
| WO2017083920A1 (en) | 2015-11-18 | 2017-05-26 | Commonwealth Scientific And Industrial Research Organisation | Rice grain with thickened aleurone |
| US10849906B2 (en) | 2015-11-30 | 2020-12-01 | Yanhui Xie | Use of Akt2 in diagnosis and treatment of tumor |
| WO2017161264A1 (en) | 2016-03-18 | 2017-09-21 | Pioneer Hi-Bred International, Inc. | Methods and compositions for producing clonal, non-reduced, non-recombined gametes |
| WO2017162265A1 (en) * | 2016-03-21 | 2017-09-28 | Biontech Rna Pharmaceuticals Gmbh | Trans-replicating rna |
| US12133287B1 (en) | 2016-04-20 | 2024-10-29 | Tm Ip Holdings, Llc | Transpositional modulation fortified communications traffic management |
| US12185424B2 (en) | 2016-04-20 | 2024-12-31 | Tm Ip Holdings, Llc | Secure routing of data packets including with use with transpositional modulation fortified communications |
| CN109414408B (zh) | 2016-05-16 | 2022-03-29 | 得克萨斯州大学系统董事会 | 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 |
| EP3500279A4 (en) * | 2016-08-19 | 2020-04-22 | Calimmune, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANINE CONDITIONS USING A RECOMBINANT SELF-COMPLEMENTARY ADENO-ASSOCIATED VIRUS. |
| KR102759317B1 (ko) | 2016-08-19 | 2025-01-31 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 재조합 자기-상보적인 아데노-부속 바이러스를 이용한 병태의 치료 방법 및 조성물 |
| CN107841510B (zh) * | 2016-09-20 | 2021-02-09 | 中国科学院青岛生物能源与过程研究所 | 一种原核细胞转录后水平控制不同基因表达比例的方法 |
| JP7282378B2 (ja) | 2016-12-07 | 2023-05-29 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インコーポレイティド | IL-1Ra cDNA |
| EP3673066A4 (en) | 2017-09-15 | 2021-05-26 | Commonwealth Scientific and Industrial Research Organisation | RNA MOLECULES |
| US20210179721A1 (en) | 2017-11-29 | 2021-06-17 | Csl Limited | Method of treating or preventing ischemia-reperfusion injury |
| WO2019178645A1 (en) | 2018-03-23 | 2019-09-26 | Csl Limited | Method of treating asthma |
| CN112513297B (zh) | 2018-03-28 | 2024-10-22 | 得克萨斯州大学系统董事会 | 鉴定从外排体分离的dna中的表观遗传改变 |
| CA3133899A1 (en) | 2018-03-30 | 2019-10-03 | University Of Geneva | Micro rna expression constructs and uses thereof |
| JP2022512706A (ja) | 2018-10-16 | 2022-02-07 | エフ.ホフマン-ラ ロシュ アーゲー | 眼科におけるAkt阻害剤の使用 |
| CN113316722A (zh) | 2019-01-17 | 2021-08-27 | 豪夫迈·罗氏有限公司 | E3泛素连接酶(ube3a)蛋白质靶标 |
| CA3129248A1 (en) | 2019-02-08 | 2020-08-13 | Board Of Regents, The University Of Texas System | Telomerase-containing exosomes for treatment of diseases associated with aging and age-related organ dysfunction |
| US20220298522A1 (en) | 2019-07-30 | 2022-09-22 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization | Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby |
| EP3825408A1 (en) | 2019-11-19 | 2021-05-26 | FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. | Methods of multi-species insect pest control |
| IL297450A (en) | 2020-04-20 | 2022-12-01 | Univ Texas | Compositions of biologically active dry powder, methods for production and use |
| US20230242643A1 (en) | 2020-05-27 | 2023-08-03 | Antion Biosciences Sa | Adapter molecules to re-direct car t cells to an antigen of interest |
| WO2022006286A1 (en) | 2020-06-30 | 2022-01-06 | Lunglife Ai | Methods for detecting lung cancer |
| US20240083990A1 (en) | 2021-01-26 | 2024-03-14 | Universite Brest Bretagne Occidentale | Novel stim1 splicing variants and uses thereof |
| WO2023012342A1 (en) | 2021-08-06 | 2023-02-09 | Kws Vegetables B.V. | Durable downy mildew resistance in spinach |
| WO2023020980A1 (en) | 2021-08-16 | 2023-02-23 | F. Hoffmann-La Roche Ag | E3 ubiquitin ligase (ube3a) protein targets |
| CN116145266B (zh) * | 2021-11-19 | 2025-08-29 | 广东少和生物科技有限公司 | 蛹虫草Ptrpc重叠启动子文库及其应用 |
| GB202206507D0 (en) | 2022-05-04 | 2022-06-15 | Antion Biosciences Sa | Expression construct |
| WO2023230531A1 (en) | 2022-05-24 | 2023-11-30 | Lunglife Ai, Inc. | Methods for detecting circulating genetically abnormal cells |
| WO2024028794A1 (en) | 2022-08-02 | 2024-02-08 | Temple Therapeutics BV | Methods for treating endometrial and ovarian hyperproliferative disorders |
| GB202306619D0 (en) | 2023-05-04 | 2023-06-21 | Antion Biosciences Sa | Cell |
| EP4477069A1 (en) | 2023-06-16 | 2024-12-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Unreduced clonal gamete formation and polyploid genome design in the solanaceae |
| WO2025007195A1 (en) | 2023-07-05 | 2025-01-09 | CSL Innovation Pty Ltd | Methods of treating or preventing a complication of sickle cell disease |
| GB202402745D0 (en) | 2024-02-27 | 2024-04-10 | Antion Biosciences Sa | Cell |
| WO2025248505A1 (en) | 2024-05-31 | 2025-12-04 | Wayne State University | Methods for treating endometrial and ovarian hyperproliferative disorders |
Family Cites Families (229)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US74684A (en) * | 1868-02-18 | of wallingford | ||
| US165894A (en) * | 1875-07-20 | Improvement in vessels for removing foul water from docks | ||
| US36197A (en) * | 1862-08-12 | Improvement in compound bullets for small-arms | ||
| US114784A (en) * | 1871-05-16 | Improvement in compounds for cure of chills and fever | ||
| US86356A (en) * | 1869-02-02 | Improvement in the construction of fire-proof safes | ||
| US266005A (en) * | 1882-10-17 | William allen | ||
| US27783A (en) * | 1860-04-10 | Improvement in apparatus for evaporating sugar-juices | ||
| US56235A (en) * | 1866-07-10 | Improvement in paring-knives | ||
| US3931397A (en) | 1971-11-05 | 1976-01-06 | Beecham Group Limited | Biologically active material |
| US4024222A (en) | 1973-10-30 | 1977-05-17 | The Johns Hopkins University | Nucleic acid complexes |
| US4034323A (en) * | 1975-03-24 | 1977-07-05 | Oki Electric Industry Company, Ltd. | Magnetic relay |
| US4283393A (en) | 1979-03-13 | 1981-08-11 | Merck & Co., Inc. | Topical application of interferon inducers |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4605394A (en) | 1982-12-03 | 1986-08-12 | Simon V. Skurkovich | Methods for the treatment of pathological conditions by removing interferon from the organism |
| DE3208247A1 (de) | 1982-03-08 | 1983-09-22 | Philips Patentverwaltung Gmbh, 2000 Hamburg | Cuvette fuer die atom-absorptions-spektrometrie |
| JPS5936698A (ja) | 1982-08-20 | 1984-02-28 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えdnaおよび形質転換動物細胞 |
| NZ209840A (en) * | 1983-10-17 | 1988-11-29 | Kaji Akira | A method of inhibiting viral propagation by hybridising dna with the viral rna thus blocking its action |
| US5272065A (en) * | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US5208149A (en) * | 1983-10-20 | 1993-05-04 | The Research Foundation Of State University Of New York | Nucleic acid constructs containing stable stem and loop structures |
| EP0140308B2 (en) | 1983-10-20 | 2001-10-17 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition utilizing mRNA interfering complementary RNA |
| US5190931A (en) * | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US5173410A (en) | 1984-02-15 | 1992-12-22 | Lubrizol Genetics Inc. | Transfer vector |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4766072A (en) | 1985-07-17 | 1988-08-23 | Promega Corporation | Vectors for in vitro production of RNA copies of either strand of a cloned DNA sequence |
| GB8521646D0 (en) | 1985-08-30 | 1985-10-02 | English Clays Lovering Pochin | Inorganic fillers |
| CA1326450C (en) | 1985-08-26 | 1994-01-25 | William A. Carter | Modulation of aids virus-related events by double stranded rnas (dsrnas) |
| US6617496B1 (en) | 1985-10-16 | 2003-09-09 | Monsanto Company | Effecting virus resistance in plants through the use of negative strand RNAs |
| GB8601680D0 (en) | 1986-01-23 | 1986-02-26 | Agricultural Genetics Co | Modification of plant viruses |
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| IL81737A (en) | 1986-03-28 | 1992-11-15 | Calgene Inc | Regulation of gene expression in plant cells |
| US5017488A (en) * | 1986-04-01 | 1991-05-21 | University Of Medicine And Dentistry Of New Jersey | Highly efficient dual T7/T3 promoter vector PJKF16 and dual SP6/T3 promoter vector PJFK15 |
| EP0278667B1 (en) * | 1987-02-09 | 1994-07-20 | Mycogen Plant Science, Inc. | Hybrid RNA virus |
| PH24467A (en) | 1987-03-03 | 1990-07-18 | Hem Res Inc | Synergistics interplay of lymphokines and dsrnas |
| US4950652A (en) | 1987-03-23 | 1990-08-21 | Hem Research, Inc. | dsRNAs for combination therapy in the treatment of viral diseases |
| AU1820588A (en) | 1987-07-17 | 1989-01-19 | Hem Research, Inc. | Double-stranded rna correction of abnormalities in circulating immune complexes and monocyte function |
| IE72103B1 (en) | 1987-08-12 | 1997-03-12 | Hem Res Inc | Promotion of host defense by systemic dsRNA treatment |
| IE66830B1 (en) | 1987-08-12 | 1996-02-07 | Hem Res Inc | Topically active compositions of double-stranded RNAs |
| DE3853755T2 (de) | 1987-09-04 | 1995-12-14 | Hem Pharma Corp | Diagnose von Mangelzuständen doppelsträngiger RNS. |
| US5874555A (en) | 1987-10-30 | 1999-02-23 | California Institute Of Technology | Triple helices and processes for making same |
| US4963532A (en) | 1987-11-25 | 1990-10-16 | Hem Research, Inc. | dsRNA-based prevention of viral escape |
| EP0640688A1 (en) | 1987-12-15 | 1995-03-01 | Gene Shears Pty. Limited | Ribozymes |
| US5254678A (en) * | 1987-12-15 | 1993-10-19 | Gene Shears Pty. Limited | Ribozymes |
| PH25365A (en) | 1987-12-23 | 1991-05-13 | Hem Research | Rhase l inhibitor as a marker for virus infections |
| US5922602A (en) | 1988-02-26 | 1999-07-13 | Biosource Technologies, Inc. | Cytoplasmic inhibition of gene expression |
| GB8810120D0 (en) | 1988-04-28 | 1988-06-02 | Plant Genetic Systems Nv | Transgenic nuclear male sterile plants |
| CA1320446C (en) | 1988-06-20 | 1993-07-20 | William A. Carter | Modulation of lymphokine-resistant cellular states by dsrnas |
| EP0350151B1 (en) | 1988-07-07 | 1994-03-30 | Hem Pharmaceuticals Corp. | Diagnosing and treating chronic fatigue syndrome |
| US5597718A (en) * | 1988-10-04 | 1997-01-28 | Agracetus | Genetically engineering cotton plants for altered fiber |
| US5198346A (en) * | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5434070A (en) * | 1989-02-24 | 1995-07-18 | The University Of Medicine And Dentistry Of New Jersey | Reverse transcriptases from Escherichia coli and Myxococcus xanthus |
| US5780269A (en) | 1989-02-24 | 1998-07-14 | The University Of Medicine And Denistry Of New Jersey | Hybrid molecules |
| US5436141A (en) | 1989-02-24 | 1995-07-25 | University Of Medicine And Dentistry Of New Jersey | Method for synthesizing stable single-stranded CDNA in eukaryotes by means of a bacterial retron and products |
| US5405775A (en) * | 1989-02-24 | 1995-04-11 | The University Of Medicine And Dentistry Of New Jersey | Retrons coding for hybrid DNA/RNA molecules |
| ATE140961T1 (de) | 1989-03-16 | 1996-08-15 | Boehringer Ingelheim Int | Genetische einheiten zur inhibierung der funktion von rna |
| US5034323A (en) | 1989-03-30 | 1991-07-23 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| US5231020A (en) | 1989-03-30 | 1993-07-27 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| WO1990012488A2 (en) | 1989-04-05 | 1990-11-01 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | A clone of double-stranded rna virus applied to antibody production, study of retrovirus-like frameshifting and production of proteins in yeast |
| WO1990012094A1 (en) | 1989-04-05 | 1990-10-18 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | A clone of double-stranded rna virus and applications thereof |
| JPH04507083A (ja) | 1989-05-19 | 1992-12-10 | ヘム・リサーチ・インコーポレーテッド | 規定された構造の短い治療用dsRNA |
| US5122466A (en) | 1989-06-13 | 1992-06-16 | North Carolina State University | Ballistic transformation of conifers |
| GB8916213D0 (en) | 1989-07-14 | 1989-08-31 | Ici Plc | Dna constructs,cells and plants derived therefrom |
| ES2161681T3 (es) | 1989-08-10 | 2001-12-16 | Aventis Cropscience Nv | Plantas con flores modificadas. |
| US5747308A (en) | 1989-10-25 | 1998-05-05 | Celltech Therapeutics Limited | Recombinant DNA method |
| HUT57265A (en) * | 1989-11-03 | 1991-11-28 | Zaadunie Bv | Process for producing plants of diminished infection-sensitivity |
| US5939600A (en) * | 1989-11-03 | 1999-08-17 | Goldbach; Robert Willem | Nucleic acids encoding tospovirus genome and expression thereof |
| US5457189A (en) | 1989-12-04 | 1995-10-10 | Isis Pharmaceuticals | Antisense oligonucleotide inhibition of papillomavirus |
| US5578718A (en) * | 1990-01-11 | 1996-11-26 | Isis Pharmaceuticals, Inc. | Thiol-derivatized nucleosides |
| US6245560B1 (en) * | 1990-01-18 | 2001-06-12 | The United States Of America As Represented By The Department Of Health And Human Services | Vector with multiple target response elements affecting gene expression |
| WO1991010453A1 (en) * | 1990-01-18 | 1991-07-25 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Vector with multiple target response elements affecting gene expression |
| US5168064A (en) | 1990-04-20 | 1992-12-01 | The Regents Of The University Of California | Endo-1,4-β-glucanase gene and its use in plants |
| GB9009307D0 (en) | 1990-04-25 | 1990-06-20 | Ici Plc | Dna,constructs,cells and plant derived therefrom |
| AU7906691A (en) * | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
| US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| AU8059891A (en) | 1990-06-13 | 1992-01-07 | Trustees Of Princeton University, The | A (lac) repressor-hsv vp16 chimeric transcriptional activator protein system functioning in transfected mammalian cells |
| KR970005274B1 (ko) | 1990-08-14 | 1997-04-15 | 아이시스 파마슈티칼스, 인코포레이티드 | 안티센스 올리고뉴클레오티드에 의한 a형 인플루엔자 바이러스, 안 아아보스트레인(ann arbor strain) h2n2의 억제 |
| DE4027616A1 (de) * | 1990-08-31 | 1992-03-05 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von polymerase-aktivitaet |
| MX9100993A (es) | 1990-09-10 | 1992-05-04 | Us Agriculture | Secuencia de adn aislado y enzima acido 1-aminociclopropan-1-carboxilico sintasa,recombinante |
| US5306862A (en) * | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| SE9004095L (sv) | 1990-12-21 | 1992-06-01 | Amylogene Hb | Genetisk foeraendring av potatis foer bildning av staerkelse av amylostyp |
| SE467358B (sv) | 1990-12-21 | 1992-07-06 | Amylogene Hb | Genteknisk foeraendring av potatis foer bildning av staerkelse av amylopektintyp |
| EP0568641A4 (en) | 1991-01-25 | 1994-09-14 | Us Biochemical Corp | Regulation of nucleic acid translation |
| GB9105383D0 (en) | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
| GB9106713D0 (en) | 1991-03-28 | 1991-05-15 | Ici Plc | Dna,dna constructs,cells and plants derived therefrom |
| CZ214593A3 (en) | 1991-04-16 | 1994-07-13 | Mogen Int | Plants exhibiting male sterility, process of obtaining thereof and recombinant dna for application of such process |
| US5683985A (en) | 1991-04-18 | 1997-11-04 | The Salk Institute For Biological Studies | Oligonucleotide decoys and methods relating thereto |
| FR2675803B1 (fr) | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
| GB9109063D0 (en) | 1991-04-26 | 1991-06-12 | Ici Plc | Modification of lignin synthesis in plants |
| WO1992021757A1 (en) | 1991-05-30 | 1992-12-10 | Plant Genetic Systems, N.V. | Nematode-responsive plant promoters |
| CA2112373C (en) | 1991-07-11 | 2010-04-20 | Timothy A. Holton | Genetic sequences encoding flavonoid pathway enzymes and uses therefor |
| US6010908A (en) | 1992-08-21 | 2000-01-04 | The Regents Of The University Of California | Gene therapy by small fragment homologous replacement |
| US5714323A (en) | 1991-08-30 | 1998-02-03 | The University Of Medecine And Dentistry Of New Jersey | Over expression of single-stranded molecules |
| CA2073630C (en) | 1991-08-30 | 2007-12-11 | Atsushi Ohshima | Method for synthesizing single-stranded stem-loop dnas, the products and uses therefor |
| JPH07500970A (ja) | 1991-11-20 | 1995-02-02 | シンヘンタ モーヘン ベースローテン フェンノートシャップ | 植物寄生線虫に対する低下された感受性を有する植物の生産方法 |
| FR2685346B1 (fr) * | 1991-12-18 | 1994-02-11 | Cis Bio International | Procede de preparation d'arn double-brin, et ses applications. |
| DE69331050T2 (de) | 1992-02-19 | 2002-06-20 | The State Of Oregon Acting By And Through The Oregon Stateboard Of Higher Education On Behalf Of The Universtiy Of Oregon, Corvallis | Produktion virus-resistenter pflanzen durch einführung von nicht-translatierbarer viraler plus-strang-rna |
| DE4208107A1 (de) | 1992-03-13 | 1993-09-16 | Bayer Ag | Pseudorabies-virus (prv)-polynukleotide und ihre verwendung zur herstellung von virusresistenten eukaryotischen zellen |
| US5593874A (en) * | 1992-03-19 | 1997-01-14 | Monsanto Company | Enhanced expression in plants |
| US5496698A (en) * | 1992-08-26 | 1996-03-05 | Ribozyme Pharmaceuticals, Inc. | Method of isolating ribozyme targets |
| GB9210273D0 (en) | 1992-05-13 | 1992-07-01 | Ici Plc | Dna |
| US5693535A (en) | 1992-05-14 | 1997-12-02 | Ribozyme Pharmaceuticals, Inc. | HIV targeted ribozymes |
| US6451603B1 (en) | 1992-06-29 | 2002-09-17 | Gene Shears Pty. Limited | Ribozyme nucleic acids and methods of use thereof for controlling viral pathogens |
| DE69321122D1 (de) * | 1992-07-02 | 1998-10-22 | Hybridon Inc | Selbststabilisierte oligonukleotide als therapeutika |
| CA2120258A1 (en) | 1992-07-30 | 1994-02-17 | Marc Zabeau | Dna constructs, cells and plants derived therefrom |
| CA2106260A1 (en) * | 1992-09-17 | 1994-03-18 | Robert M. Kotin | Human adeno-associated virus integration site dna and uses thereof |
| WO1994007367A1 (en) | 1992-09-29 | 1994-04-14 | Apollon, Inc. | Anti-viral oligomers that bind polypurine tracts of single-stranded rna or rna-dna hybrids |
| CA2146113A1 (en) | 1992-10-15 | 1994-10-15 | Adrianus Johannes Van Tunen | Genetic moderation of restoration or plant phenotypes |
| US6872872B1 (en) | 1992-11-17 | 2005-03-29 | E. I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants |
| US6372965B1 (en) | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
| ZA939767B (en) | 1993-01-21 | 1994-09-14 | Univ North Carolina State | Nematode-resistant transgenic plants |
| EP0684998A1 (en) | 1993-02-05 | 1995-12-06 | Monsanto Company | Altered linolenic and linoleic acid content in plants |
| US6069298A (en) | 1993-02-05 | 2000-05-30 | Regents Of The University Of Minnesota | Methods and an acetyl CoA carboxylase gene for conferring herbicide tolerance and an alteration in oil content of plants |
| EP0620281A3 (en) * | 1993-03-31 | 1995-05-03 | Mitsubishi Corp | Oilseed-producing oilseeds with modified amino and fatty acid compositions. |
| WO1994029465A1 (en) | 1993-06-08 | 1994-12-22 | Nunhems Zaden B.V. | Process for generating male sterile plants |
| WO1995003406A2 (en) | 1993-07-19 | 1995-02-02 | Gen-Probe Incorporated | Enhancement of oligonucleotide inhibition of protein production, cell proliferation, and/or multiplication of infectious disease pathogens |
| US5739309A (en) | 1993-07-19 | 1998-04-14 | Gen-Probe Incorporated | Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens |
| US5808036A (en) | 1993-09-01 | 1998-09-15 | Research Corporation Technologies Inc. | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| CA2105364A1 (en) | 1993-09-01 | 1995-03-02 | Eric T. Kool | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| DE69435112D1 (de) | 1993-09-10 | 2008-08-21 | Univ Columbia | Verwendung von grünem fluoreszenzprotein |
| GB9318927D0 (en) | 1993-09-13 | 1993-10-27 | Zeneca Ltd | Regulation of senescence |
| CA2172153C (en) | 1993-09-20 | 2010-03-09 | John C. Reed | Regulation of bcl-2 gene expression |
| US5858981A (en) | 1993-09-30 | 1999-01-12 | University Of Pennsylvania | Method of inhibiting phagocytosis |
| GB9320548D0 (en) | 1993-10-06 | 1993-11-24 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5624803A (en) | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
| US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US5578716A (en) | 1993-12-01 | 1996-11-26 | Mcgill University | DNA methyltransferase antisense oligonucleotides |
| US5908779A (en) | 1993-12-01 | 1999-06-01 | University Of Connecticut | Targeted RNA degradation using nuclear antisense RNA |
| FR2714383B1 (fr) | 1993-12-29 | 1996-02-09 | Centre Nat Rech Scient | Contrôle de l'expression de gènes. |
| WO1995018854A1 (en) | 1994-01-05 | 1995-07-13 | Gene Shears Pty., Ltd. | Ribozymes targeting the retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs |
| US5849991A (en) * | 1994-01-27 | 1998-12-15 | Bresatch Limited | Mice homozygous for an inactivated α 1,3-galactosyl transferase gene |
| CA2183992A1 (en) | 1994-02-23 | 1995-08-31 | Dan T. Stinchcomb | Method and reagent for inhibiting the expression of disease related genes |
| US5686649A (en) | 1994-03-22 | 1997-11-11 | The Rockefeller University | Suppression of plant gene expression using processing-defective RNA constructs |
| US5631148A (en) | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
| US6054299A (en) * | 1994-04-29 | 2000-04-25 | Conrad; Charles A. | Stem-loop cloning vector and method |
| US6146886A (en) | 1994-08-19 | 2000-11-14 | Ribozyme Pharmaceuticals, Inc. | RNA polymerase III-based expression of therapeutic RNAs |
| CA2199820A1 (en) | 1994-09-12 | 1996-03-21 | Kevin J. Scanlon | Modulation of drug radiation resistant genes |
| US5576716A (en) * | 1994-12-07 | 1996-11-19 | Sadler; Kermit M. | Owner oriented system for locating lost or stolen property |
| AU5741396A (en) | 1995-05-11 | 1996-11-29 | Hybridon, Inc. | Pyrimidine targeting hairpin triplex-forming oligonucleotide s |
| US5691140A (en) | 1995-05-18 | 1997-11-25 | New England Biolabs, Inc. | Bidirectional in vitro transcription vectors utilizing a single RNA polymerase for both directions |
| US5693773A (en) | 1995-06-07 | 1997-12-02 | Hybridon Incorporated | Triplex-forming antisense oligonucleotides having abasic linkers targeting nucleic acids comprising mixed sequences of purines and pyrimidines |
| CA2226088A1 (en) | 1995-06-30 | 1997-01-23 | Dna Plant Technology Corporation | Delayed ripening tomato plants |
| FR2737501B1 (fr) * | 1995-07-31 | 1997-10-24 | Transgene Sa | Nouveaux virus auxiliaires pour la preparation de vecteurs viraux recombinants |
| AU6904596A (en) | 1995-09-13 | 1997-04-01 | Chiron Corporation | Method and construct for screening for inhibitors of transcriptional activation |
| EP0851919A1 (en) * | 1995-09-20 | 1998-07-08 | University of Massachusetts Worcester | Antisense oligonucleotide chemotherapy for benign hyperplasia or cancer of the prostate |
| WO1997013865A1 (en) | 1995-10-06 | 1997-04-17 | Plant Genetic Systems, N.V. | Seed shattering |
| JPH09110894A (ja) | 1995-10-17 | 1997-04-28 | Soyaku Gijutsu Kenkyusho:Kk | ハイブリッドdna/rnaオリゴヌクレオチド及び抗ウイルス剤 |
| EP0771878A1 (en) | 1995-10-31 | 1997-05-07 | Plant Genetic Systems N.V. | Plants with reduced glucosinolate content |
| US5773692A (en) | 1995-12-12 | 1998-06-30 | Her Majesty The Queen In Right Of Canada, As Represented By Agriculture And Agri-Food Canada | Anti-sense RNA for CAB transcript to reduce chlorophyll content in plants |
| CA2279669A1 (en) | 1995-12-15 | 1997-06-16 | Enzo Therapeutics, Inc. | Property effecting and/or property exhibiting constructs for the expression of non-native nucleic acid processing components for therapeutic and diagnostic uses |
| IT1283876B1 (it) | 1996-01-12 | 1998-05-07 | Univ Roma | Molecole chimeriche ribozima-snrna ad attivita' catalitica per rna a localizzazione nucleare |
| EP0880598A4 (en) * | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US5891855A (en) * | 1996-02-12 | 1999-04-06 | The Scripps Research Institute | Inhibitors of leaderless protein export |
| JP3847366B2 (ja) | 1996-02-22 | 2006-11-22 | アンジェスMg株式会社 | アンチセンスオリゴヌクレオチドを用いた固定性分裂終了細胞増殖剤 |
| US5989864A (en) * | 1996-10-29 | 1999-11-23 | Smithkline Beecham Corporation | DNA encoding spo-rel polypeptides |
| US6153815A (en) | 1996-03-13 | 2000-11-28 | National Research Council Of Canada | DNA sequences from brassicaceae encoding squalene epoxidase and process of raising squalene levels in plants therewith |
| CA2248549A1 (en) * | 1996-03-15 | 1997-09-18 | Munin Corporation | Extracellular matrix signalling molecules |
| US6022863A (en) | 1996-05-21 | 2000-02-08 | Yale University | Regulation of gene expression |
| EA004402B1 (ru) | 1996-05-24 | 2004-04-29 | Байоджен, Инк. | Модуляторы регенерации тканей |
| US5994526A (en) | 1996-06-21 | 1999-11-30 | Plant Genetic Systems | Gene expression in plants |
| CA2255057A1 (en) | 1996-06-21 | 1997-12-31 | Plant Genetic Systems, N.V. | Gene expression in plants |
| US5952546A (en) * | 1996-06-27 | 1999-09-14 | Dna Plant Technology Corporation | Delayed ripening tomato plants with T-DNA bearing a truncated ACC2 synthase gene |
| US5850026A (en) | 1996-07-03 | 1998-12-15 | Cargill, Incorporated | Canola oil having increased oleic acid and decreased linolenic acid content |
| JP2001503735A (ja) | 1996-07-03 | 2001-03-21 | ユニバーシティ オブ ピッツバーグ | 親水性活性試薬のためのエマルジョン処方物 |
| JP4301576B2 (ja) * | 1996-08-02 | 2009-07-22 | ローラス セラピューティクス インコーポレイテッド | リボヌクレオチドレダクターゼのr1およびr2成分に対して指向される抗腫瘍アンチセンス配列 |
| DE19631919C2 (de) | 1996-08-07 | 1998-07-16 | Deutsches Krebsforsch | Anti-Sinn-RNA mit Sekundärstruktur |
| US5747338A (en) | 1996-08-15 | 1998-05-05 | Chiron Corporation | Method and construct for screening for inhibitors of transcriptional activation |
| US6225290B1 (en) | 1996-09-19 | 2001-05-01 | The Regents Of The University Of California | Systemic gene therapy by intestinal cell transformation |
| US5814500A (en) * | 1996-10-31 | 1998-09-29 | The Johns Hopkins University School Of Medicine | Delivery construct for antisense nucleic acids and methods of use |
| GB9703146D0 (en) | 1997-02-14 | 1997-04-02 | Innes John Centre Innov Ltd | Methods and means for gene silencing in transgenic plants |
| CN1248292A (zh) | 1997-02-21 | 2000-03-22 | 丹尼斯科有限公司 | 淀粉分支酶表达的反义内含子的抑制作用 |
| CN1226930A (zh) * | 1997-03-10 | 1999-08-25 | 日本烟草产业株式会社 | 反义核苷酸序列 |
| GB9706381D0 (en) | 1997-03-27 | 1997-05-14 | Cambridge Advanced Tech | Improvements relating to the specificity of gene expression |
| US7589253B2 (en) | 1997-04-15 | 2009-09-15 | Commonwealth Scientific And Industrial Research Organisation | Fatty acid epoxygenase genes from plants and uses therefor in modifying fatty acid metabolism |
| US5942395A (en) | 1997-05-09 | 1999-08-24 | Universite De Montreal | Hybrid ribozymes and methods of use |
| GB9710475D0 (en) * | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
| WO1999009045A1 (en) * | 1997-08-20 | 1999-02-25 | Somagenics, Inc. | Antisense and antigene therapeutics with improved binding properties and methods for their use |
| GB9720148D0 (en) | 1997-09-22 | 1997-11-26 | Innes John Centre Innov Ltd | Gene silencing materials and methods |
| WO1999025853A1 (en) | 1997-11-18 | 1999-05-27 | Pioneer Hi-Bred International, Inc. | Targeted manipulation of herbicide-resistance genes in plants |
| DE19754622A1 (de) | 1997-12-09 | 1999-06-10 | Antje Von Dr Schaewen | Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| ATE526405T1 (de) | 1998-03-20 | 2011-10-15 | Commw Scient Ind Res Org | Synthetische gene und genetische zusammensetzungen diesen enthaltend |
| EP2267139B1 (en) | 1998-04-08 | 2017-03-22 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
| US8598332B1 (en) | 1998-04-08 | 2013-12-03 | Bayer Cropscience N.V. | Methods and means for obtaining modified phenotypes |
| US20040214330A1 (en) | 1999-04-07 | 2004-10-28 | Waterhouse Peter Michael | Methods and means for obtaining modified phenotypes |
| EP0959133A1 (en) | 1998-05-22 | 1999-11-24 | Centrum Voor Plantenveredelings- En Reproduktieonderzoek (Cpro-Dlo) | A process for inhibiting expression of genes |
| AR020078A1 (es) | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| US6040908A (en) * | 1998-07-28 | 2000-03-21 | Litton Systems, Inc. | Method for stress tuning fiber optic sensor coils |
| EP2314700A1 (en) | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| EP1173594B1 (en) | 1999-04-20 | 2008-10-29 | Bayer BioScience N.V. | Methods for delivering inhibitory rna to plants and applications thereof |
| KR20010112944A (ko) | 1999-04-21 | 2001-12-22 | 이곤 이 버그 | 폴리뉴클레오티드 서열의 기능을 억제하기 위한 방법 및조성물 |
| US20040138168A1 (en) | 1999-04-21 | 2004-07-15 | Wyeth | Methods and compositions for inhibiting the function of polynucleotide sequences |
| WO2000076308A1 (en) | 1999-06-14 | 2000-12-21 | Exelixis, Inc. | Animal models and methods for analysis of lipid metabolism and screening of pharmaceutical and pesticidal agents that modulate lipid metabolism |
| BR0012325A (pt) | 1999-07-09 | 2002-05-21 | American Home Prod | Métodos e composições para prevenção da formação de rna anormal durante a transcrição de uma sequência de plasmìdeo |
| US6423885B1 (en) * | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| WO2001019857A2 (en) | 1999-09-16 | 2001-03-22 | Genoptera, Llc | Facilitative transporter (ft1 and ft2) from drosophila melanogaster and uses thereof |
| WO2001029058A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6291504B1 (en) | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
| GB9925459D0 (en) | 1999-10-27 | 1999-12-29 | Plant Bioscience Ltd | Gene silencing |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| WO2001037654A2 (en) | 1999-11-24 | 2001-05-31 | Dna Plant Technology Corporation | METHOD OF EXPRESSING dsRNA IN PLANTS TO INHIBIT INSECT PESTS |
| AU2058401A (en) | 1999-11-29 | 2001-06-04 | Genoptera, Llc | Nucleic acids and polypeptides of invertebrate receptors and methods of use |
| GB9930691D0 (en) | 1999-12-24 | 2000-02-16 | Devgen Nv | Improvements relating to double-stranded RNA inhibition |
| AU2001240375A1 (en) | 2000-03-17 | 2001-10-03 | Benitec Australia Limited | Genetic silencing |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Rna 간섭의 rna 서열 특이적인 매개체 |
| GB2362383B (en) | 2000-05-19 | 2003-12-31 | Devgen Nv | Gene expression system |
| US6995258B1 (en) * | 2000-05-25 | 2006-02-07 | City Of Hope | Nucleolar targeting of therapeutics against HIV |
| HUP0302320A3 (en) | 2000-06-23 | 2005-11-28 | Pioneer Hi Bred Int | Recombinant constructs and their use in reducing gene expression |
| US7109393B2 (en) | 2000-08-15 | 2006-09-19 | Mendel Biotechnology, Inc. | Methods of gene silencing using inverted repeat sequences |
| KR100909681B1 (ko) | 2000-12-01 | 2009-07-29 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Rna 간섭을 매개하는 작은 rna 분자 |
| US20020150968A1 (en) * | 2001-01-10 | 2002-10-17 | Wang Peng G. | Glycoconjugate and sugar nucleotide synthesis using solid supports |
| CA2369944A1 (en) | 2001-01-31 | 2002-07-31 | Nucleonics Inc. | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
| AUPR621501A0 (en) | 2001-07-06 | 2001-08-02 | Commonwealth Scientific And Industrial Research Organisation | Delivery of ds rna |
| ES2606290T3 (es) | 2001-07-12 | 2017-03-23 | University Of Massachusetts | Producción in vivo de ARN de interferencia pequeños que median el silenciamiento génico |
| ATE439041T1 (de) | 2001-09-13 | 2009-08-15 | California Inst Of Techn | Verfahren zur expression von kleinen antiviralen rna-molekülen innerhalb einer zelle |
| EP1436401A4 (en) | 2001-09-27 | 2006-06-14 | Timothy Albert Holton | STEM-LOOP VECTOR SYSTEM |
| US20030148519A1 (en) * | 2001-11-14 | 2003-08-07 | Engelke David R. | Intracellular expression and delivery of siRNAs in mammalian cells |
| GB0130955D0 (en) | 2001-12-24 | 2002-02-13 | Cancer Res Ventures | Expression system |
| US20040022748A1 (en) | 2002-03-12 | 2004-02-05 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Method of enhancing skin lightening |
| US7576262B2 (en) | 2002-03-14 | 2009-08-18 | Commonwealth Scientific And Industrial Research Organization | Modified gene-silencing RNA and uses thereof |
| ITRM20020253A1 (it) | 2002-05-08 | 2003-11-10 | Univ Roma | Molecole chimeriche di snrna con sequenze antisenso per le giunzioni di splicing del gene della distrofina e applicazioni terapeutiche. |
| US20040106566A1 (en) * | 2002-05-17 | 2004-06-03 | Shi-Lung Lin | RNA-splicing and processing-directed gene silencing and the relative applications thereof |
| US20040234504A1 (en) * | 2002-12-18 | 2004-11-25 | Verma Inder M. | Methods of inhibiting gene expression by RNA interference |
| CA2516310C (en) | 2003-02-19 | 2014-12-09 | Commonwealth Scientific And Industrial Research Organisation | Efficient gene silencing in plants using short dsrna sequences |
| EP1664298A4 (en) | 2003-09-12 | 2010-03-17 | Commw Scient Ind Res Org | MODIFIED GEN-SILENCING NUCLEIC ACID MOLECULES AND USES THEREOF |
| US20100058490A1 (en) | 2006-05-03 | 2010-03-04 | Commonwealth Schientific And Industrial Research Organization | Gene Silencing Methods |
| US9642116B2 (en) * | 2008-03-05 | 2017-05-02 | Nxp B.V. | Dynamic MBSFN area configuration method in consideration of radio resource efficiency and system thereof |
-
1999
- 1999-03-19 AT AT04015041T patent/ATE526405T1/de not_active IP Right Cessation
- 1999-03-19 GB GB0024727A patent/GB2353282C/en not_active Expired - Lifetime
- 1999-03-19 CN CN200910206175A patent/CN101818145A/zh active Pending
- 1999-03-19 CA CA002323726A patent/CA2323726C/en not_active Expired - Lifetime
- 1999-03-19 AT AT05013010T patent/ATE526406T1/de not_active IP Right Cessation
- 1999-03-19 JP JP2000537990A patent/JP4187413B2/ja not_active Expired - Lifetime
- 1999-03-19 SK SK1372-2000A patent/SK287538B6/sk not_active IP Right Cessation
- 1999-03-19 HU HU0101225A patent/HU230353B1/hu unknown
- 1999-03-19 AU AU29163/99A patent/AU743316C/en not_active Revoked
- 1999-03-19 CA CA002487328A patent/CA2487328A1/en not_active Abandoned
- 1999-03-19 KR KR1020007010419A patent/KR20010042069A/ko not_active Ceased
- 1999-03-19 CN CNA2005100833251A patent/CN1796556A/zh active Pending
- 1999-03-19 CA CA002513336A patent/CA2513336A1/en not_active Abandoned
- 1999-03-19 EP EP04015041A patent/EP1555317B1/en not_active Revoked
- 1999-03-19 CZ CZ20003346A patent/CZ295108B6/cs not_active IP Right Cessation
- 1999-03-19 PL PL99343064A patent/PL343064A1/xx not_active IP Right Cessation
- 1999-03-19 SG SG200503921-9A patent/SG141233A1/en unknown
- 1999-03-19 EP EP07008204.5A patent/EP1857549B1/en not_active Expired - Lifetime
- 1999-03-19 NZ NZ506648A patent/NZ506648A/en not_active IP Right Cessation
- 1999-03-19 KR KR1020107006892A patent/KR101054060B1/ko not_active Expired - Lifetime
- 1999-03-19 DK DK05013010.3T patent/DK1624060T3/da active
- 1999-03-19 EP EP10183258.2A patent/EP2302057B1/en not_active Expired - Lifetime
- 1999-03-19 CN CN99804255A patent/CN1294631A/zh active Pending
- 1999-03-19 WO PCT/AU1999/000195 patent/WO1999049029A1/en not_active Ceased
- 1999-03-19 BR BRPI9908967A patent/BRPI9908967B1/pt active IP Right Grant
- 1999-03-19 KR KR1020067005341A patent/KR101085210B1/ko not_active Expired - Lifetime
- 1999-03-19 ES ES05013010T patent/ES2374534T3/es not_active Expired - Lifetime
- 1999-03-19 EP EP05013010A patent/EP1624060B1/en not_active Revoked
- 1999-03-19 EP EP99910039A patent/EP1071762A4/en not_active Ceased
- 1999-03-19 NZ NZ547283A patent/NZ547283A/en not_active IP Right Cessation
- 1999-03-19 SG SG200205122A patent/SG115493A1/en unknown
- 1999-03-19 ES ES04015041T patent/ES2374290T3/es not_active Expired - Lifetime
-
2000
- 2000-08-30 ZA ZA200004507A patent/ZA200004507B/xx unknown
-
2001
- 2001-11-30 US US09/997,905 patent/US20030074684A1/en not_active Abandoned
-
2002
- 2002-04-24 AU AU35647/02A patent/AU3564702A/en not_active Abandoned
-
2003
- 2003-08-22 US US10/646,070 patent/US7754697B2/en not_active Expired - Fee Related
-
2004
- 2004-04-08 US US10/821,710 patent/US20040237145A1/en not_active Abandoned
-
2005
- 2005-06-17 AU AU2005202658A patent/AU2005202658B2/en not_active Expired
- 2005-08-02 JP JP2005223953A patent/JP4187737B2/ja not_active Expired - Lifetime
- 2005-09-02 US US11/218,999 patent/US8168774B2/en not_active Expired - Fee Related
- 2005-09-09 AU AU2005209648A patent/AU2005209648B2/en not_active Expired
- 2005-09-15 AU AU2005211538A patent/AU2005211538C1/en not_active Expired
-
2007
- 2007-11-21 JP JP2007302237A patent/JP4460600B2/ja not_active Expired - Lifetime
-
2008
- 2008-11-21 AU AU2008249157A patent/AU2008249157B2/en not_active Ceased
-
2009
- 2009-07-08 JP JP2009161847A patent/JP4981103B2/ja not_active Expired - Lifetime
-
2012
- 2012-04-27 US US13/458,704 patent/US20120277285A1/en not_active Abandoned
-
2013
- 2013-12-20 US US14/137,737 patent/US9963698B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2353282B (en) | Control of gene expression | |
| EP1681349A3 (en) | Genetic control of plant growth and development | |
| WO1998042851A8 (en) | Plants with modified growth | |
| WO1998045456A8 (de) | 2-desoxyglucose-6-phosphat (2-dog-6-p) phosphatase dna-sequenzen als selektionsmarker in pflanzen | |
| EP0568537A4 (en) | GENETIC MODIFICATION OF ENDOTHEL CELLS. | |
| ES2134170A1 (es) | Elementos reguladores de la transcripcion, secuencia reguladora y metodos que utilizan tales elementos para esta transcripcion. | |
| ES2180641T3 (es) | Inhibicion citoplasmica de la expresion genetica. | |
| MX9705039A (es) | Genes y proteinas de muerte celular programada. | |
| IL193758A0 (en) | Genetically engineered duckweed | |
| AR089780A2 (es) | Secuencias reguladoras para el control selectivo de la expresion de genes en plantas | |
| CY1108240T1 (el) | ΑΠΟΜΟΝΩΜΕΝΑ ΠΟΛΥΝΟΥΚΛΕΟΤΙΔΙΑ ΤΑ ΟΠΟΙΑ ΕΧΟΥΝ ΕΝΑ ΜΕΙΩΜΕΝΟ ΠΕΡΙΕΧΟΜΕΝΟ ΜΟΤΙΒΩΝ 5΄CpG3΄ ΕΠΙΓΕΝΕΤΙΚΟΥ ΕΛΕΓΧΟΥ ΚΑΙ ΟΙ ΧΡΗΣΕΙΣ ΤΟΥΣ | |
| ATE405658T1 (de) | Neue selektionsverfahren | |
| MXPA02012557A (es) | Composiciones y metodos para la modificacion de la expresion del gen. | |
| WO1999054436A3 (en) | Nucleic acids and proteins of c. elegans insulin-like genes and uses thereof | |
| EP1728859A4 (en) | SEQUENCE CAPABLE OF ACCELERATING GENE EXPRESSION AT A MODERATELY LOW TEMPERATURE | |
| DE69940610D1 (de) | Regulierende sequenzen des villin-gens aus der maus und verwendung zur herstellung von transgenen tieren | |
| WO2001075128A3 (de) | Verfahren zur herstellung von leguminosen mit erhöhtem proteingehalt bei verlängerter samenfüllungsdauer | |
| DE58909205D1 (de) | Expressionsvektor und Verfahren zur regulierbaren Herstellung von Proteinen in Eukaryonten. | |
| EP0976832A3 (en) | Promoter functional in a plant cell | |
| AU2001254765A1 (en) | Atrsp gene promoters |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 711B | Application made for correction of error (sect. 117/77) | ||
| 711G | Correction allowed (sect. 117/1977) | ||
| 732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1035742 Country of ref document: HK |
|
| 732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
| S13A | Application for inventor to be mentioned (section 13(1)/patents act 1977) | ||
| S13A | Application for inventor to be mentioned (section 13(1)/patents act 1977) | ||
| S72 | Application for revocation before the comptroller (sect. 72/patents act 1977) |
Free format text: APPLICATION FILED; APPLICATION MADE TO THE COMPTROLLER FOR REVOCATION |
|
| S75 | Amendment of patent in infringement or revocation proceedings before the comptroller (sect. 75/patents act 1977) |
Free format text: APPLICATION OPEN FOR OPPOSITION; PATENTS FORM 15 GIVING THE COMPTROLLER NOTICE OF OPPOSITION TO THE AMENDMENTS. YOU ALSO NEED TO FILE TWO COPIES OF A STATEMENT SETTING OUT FULLY THE FACTS OF YOUR CASE AND THE RELIEF THAT YOU ARE SEEKING. SECTION: 75 BEFORE THE COMPTROLLER PATENT NUMBER: GB2353282 TITLE OF PATENT: CONTROL OF GENE EXPRESSION INTERNATIONAL CLASSIFICATION: C12N NAME OF PROPRIETOR: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION THE AMENDMENTS SUBMITTED ARE UNCONDITIONAL AMENDMENTS. FOR A COPY OF THESE AMENDMENTS, PHONE LITIGATION SECTION (01633 814376) |
|
| S75 | Amendment of patent in infringement or revocation proceedings before the comptroller (sect. 75/patents act 1977) |
Free format text: SPECIFICATION AMENDED; APPLICATION TO AMEND SPECIFICATION UNDER SECTION 75 BEFORE THE COMPTROLLER FILED ON 1 JULY 2011 ALLOWED 1 AUGUST 2012 |
|
| PE20 | Patent expired after termination of 20 years |
Expiry date: 20190318 |