IT1283876B1 - Molecole chimeriche ribozima-snrna ad attivita' catalitica per rna a localizzazione nucleare - Google Patents
Molecole chimeriche ribozima-snrna ad attivita' catalitica per rna a localizzazione nucleareInfo
- Publication number
- IT1283876B1 IT1283876B1 IT96RM000017A ITRM960017A IT1283876B1 IT 1283876 B1 IT1283876 B1 IT 1283876B1 IT 96RM000017 A IT96RM000017 A IT 96RM000017A IT RM960017 A ITRM960017 A IT RM960017A IT 1283876 B1 IT1283876 B1 IT 1283876B1
- Authority
- IT
- Italy
- Prior art keywords
- catalytic activity
- nuclear
- molecules
- chimeric ribozyme
- snrna molecules
- Prior art date
Links
- 230000003197 catalytic effect Effects 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96RM000017A IT1283876B1 (it) | 1996-01-12 | 1996-01-12 | Molecole chimeriche ribozima-snrna ad attivita' catalitica per rna a localizzazione nucleare |
DE69613336T DE69613336T2 (de) | 1996-01-12 | 1996-12-20 | Chimere ribozym-snRNA Moleküle mit katalytischen Aktivität nuklearer RNAs |
EP96830641A EP0784094B1 (en) | 1996-01-12 | 1996-12-20 | Ribozyme -snRNA chimeric molecules having a catalytic activity for nuclear RNAs |
ES96830641T ES2160796T3 (es) | 1996-01-12 | 1996-12-20 | Moleculas quimericas ribozima-arnsn que tienen actividad catalitica para arns nucleares. |
AT96830641T ATE202143T1 (de) | 1996-01-12 | 1996-12-20 | Chimere ribozym-snrna moleküle mit katalytischen aktivität nuklearer rnas |
US08/781,620 US5994124A (en) | 1996-01-12 | 1997-01-09 | Ribozyme-snRNA chimeric molecules having a catalytic activity for nuclear RNAs |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96RM000017A IT1283876B1 (it) | 1996-01-12 | 1996-01-12 | Molecole chimeriche ribozima-snrna ad attivita' catalitica per rna a localizzazione nucleare |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM960017A0 ITRM960017A0 (it) | 1996-01-12 |
ITRM960017A1 ITRM960017A1 (it) | 1997-07-12 |
IT1283876B1 true IT1283876B1 (it) | 1998-05-07 |
Family
ID=11403768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT96RM000017A IT1283876B1 (it) | 1996-01-12 | 1996-01-12 | Molecole chimeriche ribozima-snrna ad attivita' catalitica per rna a localizzazione nucleare |
Country Status (6)
Country | Link |
---|---|
US (1) | US5994124A (it) |
EP (1) | EP0784094B1 (it) |
AT (1) | ATE202143T1 (it) |
DE (1) | DE69613336T2 (it) |
ES (1) | ES2160796T3 (it) |
IT (1) | IT1283876B1 (it) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274369B1 (en) * | 1996-02-02 | 2001-08-14 | Invitrogen Corporation | Method capable of increasing competency of bacterial cell transformation |
US6692910B2 (en) * | 1997-07-28 | 2004-02-17 | The University Of Connecticut | Inhibition of a target messenger RNA with a modified U1 small nuclear RNA |
AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
KR101085210B1 (ko) | 1998-03-20 | 2011-11-21 | 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 | 유전자 발현 조절방법 |
US20030036519A1 (en) * | 1998-04-21 | 2003-02-20 | Ryszard Kole | Stable alteration of pre-mrna splicing patterns by modified rnas |
US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
AUPR621501A0 (en) | 2001-07-06 | 2001-08-02 | Commonwealth Scientific And Industrial Research Organisation | Delivery of ds rna |
WO2004050674A2 (en) * | 2002-12-04 | 2004-06-17 | Algos Therapeutics, Inc. | Methods and materials for modulating trpm2 |
JP4634372B2 (ja) * | 2003-03-27 | 2011-02-16 | ピーティーシー セラピューティクス,インコーポレーテッド | tRNAスプライシングエンドヌクレアーゼに標的化する化合物の同定方法、および該化合物の抗真菌剤としての使用 |
EP2363025A1 (en) * | 2003-03-27 | 2011-09-07 | PTC Therapeutics, Inc. | Targeting enzymes of the TRNA splicing pathway for identification of anti-fungal and/or anti-proliferative molecules |
US20070020630A1 (en) * | 2003-03-27 | 2007-01-25 | Trotta Christopher R | Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents |
US20050053985A1 (en) * | 2003-07-02 | 2005-03-10 | Ptc Therapeutics, Inc. | RNA processing protein complexes and uses thereof |
CA2568603A1 (en) * | 2003-09-12 | 2005-03-24 | Commonwealth Scientific And Industrial Research Organisation | Modified gene-silencing nucleic acid molecules and uses thereof |
US9040491B2 (en) * | 2006-08-30 | 2015-05-26 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits based on small nuclear RNAs |
EP2152873A2 (en) * | 2007-03-16 | 2010-02-17 | Biorigen S.r.l | Gene expression regulation technology and noncoding rnas for diagnosis and therapy |
US9470350B2 (en) | 2013-07-23 | 2016-10-18 | Spencer Composites Corporation | Metal-to-composite interfaces |
AU2022337146A1 (en) * | 2021-09-03 | 2024-03-14 | Tacit Therapeutics, Inc. | Rna editing via recruitment of spliceosome components |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993024133A1 (en) * | 1992-05-27 | 1993-12-09 | City Of Hope | CHIMERIC tRNALYS-RIBOZYME MOLECULES |
AU6805694A (en) * | 1993-06-18 | 1995-01-17 | Ciba-Geigy Ag | Chimeric plant genes possessing independent regulatory sequences |
US5695938A (en) * | 1994-12-09 | 1997-12-09 | City Of Hope | Anti-HIV ribozymes |
-
1996
- 1996-01-12 IT IT96RM000017A patent/IT1283876B1/it active IP Right Grant
- 1996-12-20 ES ES96830641T patent/ES2160796T3/es not_active Expired - Lifetime
- 1996-12-20 EP EP96830641A patent/EP0784094B1/en not_active Expired - Lifetime
- 1996-12-20 AT AT96830641T patent/ATE202143T1/de active
- 1996-12-20 DE DE69613336T patent/DE69613336T2/de not_active Expired - Lifetime
-
1997
- 1997-01-09 US US08/781,620 patent/US5994124A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE202143T1 (de) | 2001-06-15 |
EP0784094A1 (en) | 1997-07-16 |
US5994124A (en) | 1999-11-30 |
DE69613336D1 (de) | 2001-07-19 |
ES2160796T3 (es) | 2001-11-16 |
ITRM960017A1 (it) | 1997-07-12 |
DE69613336T2 (de) | 2002-04-18 |
EP0784094B1 (en) | 2001-06-13 |
ITRM960017A0 (it) | 1996-01-12 |
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