|
CU22545A1
(es)
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
|
EP0092918B1
(en)
|
1982-04-22 |
1988-10-19 |
Imperial Chemical Industries Plc |
Continuous release formulations
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
FR2556739A1
(fr)
|
1983-12-19 |
1985-06-21 |
Pasteur Institut |
Lignees cellulaires secretant des anticorps monoclonaux contre la pg e2, leur preparation, les anticorps obtenus et leur application
|
|
US4753894A
(en)
|
1984-02-08 |
1988-06-28 |
Cetus Corporation |
Monoclonal anti-human breast cancer antibodies
|
|
US4943533A
(en)
|
1984-03-01 |
1990-07-24 |
The Regents Of The University Of California |
Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
|
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
|
US6492107B1
(en)
|
1986-11-20 |
2002-12-10 |
Stuart Kauffman |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
|
|
DE3546806C2
(es)
|
1985-03-30 |
1991-03-28 |
Marc Genf/Geneve Ch Ballivet |
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
JP3040121B2
(ja)
|
1988-01-12 |
2000-05-08 |
ジェネンテク,インコーポレイテッド |
増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
|
|
US5006309A
(en)
|
1988-04-22 |
1991-04-09 |
Abbott Laboratories |
Immunoassay device with liquid transfer between wells by washing
|
|
US5089424A
(en)
|
1988-06-14 |
1992-02-18 |
Abbott Laboratories |
Method and apparatus for heterogeneous chemiluminescence assay
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP0436597B1
(en)
|
1988-09-02 |
1997-04-02 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
|
AU643427B2
(en)
|
1988-10-31 |
1993-11-18 |
Immunex Corporation |
Interleukin-4 receptors
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5063081A
(en)
|
1988-11-14 |
1991-11-05 |
I-Stat Corporation |
Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
|
CA2057923A1
(en)
|
1989-05-16 |
1990-11-17 |
William D. Huse |
Co-expression of heteromeric receptors
|
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
|
AU6430190A
(en)
|
1989-10-10 |
1991-05-16 |
Pitman-Moore, Inc. |
Sustained release composition for macromolecular proteins
|
|
EP0550436A1
(en)
|
1989-11-06 |
1993-07-14 |
Alkermes Controlled Therapeutics, Inc. |
Protein microspheres and methods of using them
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
AU7247191A
(en)
|
1990-01-11 |
1991-08-05 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
AT396939B
(de)
|
1990-05-29 |
1993-12-27 |
Alois Dipl Ing Dr Jungbauer |
Komplexes virales antigen von hiv-1 bindendes rekombinantes protein
|
|
ES2139598T3
(es)
|
1990-07-10 |
2000-02-16 |
Medical Res Council |
Procedimientos para la produccion de miembros de parejas de union especifica.
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
WO1992002551A1
(en)
|
1990-08-02 |
1992-02-20 |
B.R. Centre Limited |
Methods for the production of proteins with a desired function
|
|
AU8505191A
(en)
|
1990-08-24 |
1992-03-17 |
Ixsys, Inc. |
Methods of synthesizing oligonucleotides with random codons
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
US5780279A
(en)
|
1990-12-03 |
1998-07-14 |
Genentech, Inc. |
Method of selection of proteolytic cleavage sites by directed evolution and phagemid display
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
WO1992011272A1
(en)
|
1990-12-20 |
1992-07-09 |
Ixsys, Inc. |
Optimization of binding proteins
|
|
ATE439435T1
(de)
|
1991-03-01 |
2009-08-15 |
Dyax Corp |
Chimäres protein mit mikroprotein mit zwei oder mehr disulfidbindungen und ausgestaltungen davon
|
|
CZ282603B6
(cs)
|
1991-03-06 |
1997-08-13 |
Merck Patent Gesellschaft Mit Beschränkter Haftun G |
Humanizované a chimerické monoklonální protilátky
|
|
DE69233701T2
(de)
|
1991-03-18 |
2008-04-10 |
New York University |
Monoklonale und chimäre Antikörper spezifisch für menschlichen Tumornekrosefaktor
|
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
US5656272A
(en)
|
1991-03-18 |
1997-08-12 |
New York University Medical Center |
Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
|
|
EP1471142B1
(en)
|
1991-04-10 |
2008-11-19 |
The Scripps Research Institute |
Heterodimeric receptor libraries using phagemids
|
|
US5795965A
(en)
|
1991-04-25 |
1998-08-18 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human to human interleukin-6 receptor
|
|
ATE221379T1
(de)
|
1991-05-01 |
2002-08-15 |
Jackson H M Found Military Med |
Verfahren zur behandlung infektiöser respiratorischer erkrankungen
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
CA2069530A1
(en)
|
1991-06-03 |
1992-12-04 |
Cass J. Grandone |
Reagent pack for immunoassays
|
|
DE4118120A1
(de)
|
1991-06-03 |
1992-12-10 |
Behringwerke Ag |
Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
CA2110799A1
(en)
|
1991-06-14 |
1992-12-23 |
Arnold H. Horwitz |
Microbially-produced antibody fragments and their conjugates
|
|
CA2103059C
(en)
|
1991-06-14 |
2005-03-22 |
Paul J. Carter |
Method for making humanized antibodies
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
EP1136556B1
(en)
|
1991-11-25 |
2005-06-08 |
Enzon, Inc. |
Method of producing multivalent antigen-binding proteins
|
|
WO1993011236A1
(en)
|
1991-12-02 |
1993-06-10 |
Medical Research Council |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
|
|
WO1993011794A1
(en)
|
1991-12-13 |
1993-06-24 |
Xoma Corporation |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US5912015A
(en)
|
1992-03-12 |
1999-06-15 |
Alkermes Controlled Therapeutics, Inc. |
Modulated release from biocompatible polymers
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
SG48760A1
(en)
|
1992-07-24 |
2003-03-18 |
Abgenix Inc |
Generation of xenogenetic antibodies
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US5736137A
(en)
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
|
PT752248E
(pt)
|
1992-11-13 |
2001-01-31 |
Idec Pharma Corp |
Aplicacao terapeutica de anticorpos quimericos e marcados radioactivamente contra antigenios de diferenciacao restrita de linfocitos b humanos para o tratamento do linfoma de celulas b
|
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
|
AU6132994A
(en)
|
1993-02-02 |
1994-08-29 |
Scripps Research Institute, The |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
US6491916B1
(en)
|
1994-06-01 |
2002-12-10 |
Tolerance Therapeutics, Inc. |
Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies
|
|
WO1995001997A1
(en)
|
1993-07-09 |
1995-01-19 |
Smithkline Beecham Corporation |
RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
|
|
WO1995009917A1
(en)
|
1993-10-07 |
1995-04-13 |
The Regents Of The University Of California |
Genetically engineered bispecific tetravalent antibodies
|
|
EP0659766A1
(en)
|
1993-11-23 |
1995-06-28 |
Schering-Plough |
Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
|
|
US5565352A
(en)
|
1993-11-24 |
1996-10-15 |
Arch Development Corporation |
Deubiquitinating enzyme: compositions and methods
|
|
AU696293B2
(en)
|
1993-12-08 |
1998-09-03 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
CA2178590A1
(en)
|
1993-12-10 |
1995-06-15 |
Joan D. Tyner |
Reagents and methods for the detection of methotrexate
|
|
GB9401182D0
(en)
|
1994-01-21 |
1994-03-16 |
Inst Of Cancer The Research |
Antibodies to EGF receptor and their antitumour effect
|
|
DK0744958T3
(da)
|
1994-01-31 |
2003-10-20 |
Univ Boston |
Polyklonale antistofbiblioteker
|
|
ZA95960B
(en)
|
1994-03-14 |
1995-10-10 |
Genetics Inst |
Use of interleukin-12 antagonists in the treatment of autoimmune diseases
|
|
PL181342B1
(pl)
|
1994-03-17 |
2001-07-31 |
Merck Patent Gmbh |
Jednolancuchowe anty-EGFR Fv i przeciwciala anty-EGFR, czasteczka DNA, sposoby wytwarzania jednolancuchowego przeciwciala anty-EGFR i przeciwciala anty-EGFR oraz kompozycja farmaceutyczna PL PL PL PL PL PL PL
|
|
IL109632A
(en)
|
1994-05-11 |
2007-03-08 |
Yeda Res & Dev |
Modulators of the function of tnf receptors
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
DE69534530T2
(de)
|
1994-08-12 |
2006-07-06 |
Immunomedics, Inc. |
Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
|
|
DE69630514D1
(de)
|
1995-01-05 |
2003-12-04 |
Univ Michigan |
Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
|
|
GB9504344D0
(en)
|
1995-03-03 |
1995-04-19 |
Unilever Plc |
Antibody fragment production
|
|
US6091001A
(en)
|
1995-03-29 |
2000-07-18 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
AU705616B2
(en)
|
1995-04-21 |
1999-05-27 |
Cell Genesys, Inc. |
Generation of large genomic DNA deletions
|
|
DE69637481T2
(de)
|
1995-04-27 |
2009-04-09 |
Amgen Fremont Inc. |
Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
WO1996040210A1
(en)
|
1995-06-07 |
1996-12-19 |
Imclone Systems Incorporated |
Antibody and antibody fragments for inhibiting the growth of tumors
|
|
US7060808B1
(en)
|
1995-06-07 |
2006-06-13 |
Imclone Systems Incorporated |
Humanized anti-EGF receptor monoclonal antibody
|
|
WO1997007788A2
(en)
|
1995-08-31 |
1997-03-06 |
Alkermes Controlled Therapeutics, Inc. |
Composition for sustained release of an agent
|
|
WO1997014719A1
(en)
|
1995-10-16 |
1997-04-24 |
Unilever N.V. |
A bifunctional or bivalent antibody fragment analogue
|
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
|
US6331431B1
(en)
|
1995-11-28 |
2001-12-18 |
Ixsys, Inc. |
Vacuum device and method for isolating periplasmic fraction from cells
|
|
BRPI9707379C8
(pt)
|
1996-02-09 |
2017-12-12 |
Abbott Biotech Ltd |
composições farmacêuticas compreendendo anticorpo humano recombinante geneticamente engenheirado, e anticorpo humano recombinante geneticamente engenheirado.
|
|
DK0885002T3
(da)
|
1996-03-04 |
2011-08-22 |
Penn State Res Found |
Materialer og fremgangsmåder til forøgelse af cellulær internalisering
|
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
|
NZ331688A
(en)
|
1996-03-28 |
2000-02-28 |
Univ Johns Hopkins |
Soluble divalent and multivalent heterodimeric analogs of proteins
|
|
JP2000508892A
(ja)
|
1996-04-04 |
2000-07-18 |
ユニリーバー・ナームローゼ・ベンノートシャープ |
多価および多特異的抗原結合タンパク
|
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
|
US6699658B1
(en)
|
1996-05-31 |
2004-03-02 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
US6986890B1
(en)
|
1996-11-21 |
2006-01-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Anti-human VEGF receptor Flt-1 monoclonal antibody
|
|
US7258857B2
(en)
|
1996-11-22 |
2007-08-21 |
The Trustees Of Columbia University In The City Of New York |
Rage-related methods for treating inflammation
|
|
ES2301183T3
(es)
|
1996-12-03 |
2008-06-16 |
Amgen Fremont Inc. |
Anticuerpo completamente humano que se une al receptor del egfr.
|
|
ATE287257T1
(de)
|
1997-01-16 |
2005-02-15 |
Massachusetts Inst Technology |
Zubereitung von partikelhaltigen arzneimitteln zur inhalation
|
|
DE69835143T2
(de)
|
1997-01-21 |
2007-06-06 |
The General Hospital Corp., Boston |
Selektion von proteinen mittels rns-protein fusionen
|
|
US6057098A
(en)
|
1997-04-04 |
2000-05-02 |
Biosite Diagnostics, Inc. |
Polyvalent display libraries
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
ES2273415T3
(es)
|
1997-04-07 |
2007-05-01 |
Genentech, Inc. |
Anticuerpos anti-vegf.
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
WO1999006834A2
(en)
|
1997-08-04 |
1999-02-11 |
Ixsys, Incorporated |
Methods for identifying ligand specific binding molecules
|
|
US5989463A
(en)
|
1997-09-24 |
1999-11-23 |
Alkermes Controlled Therapeutics, Inc. |
Methods for fabricating polymer-based controlled release devices
|
|
SE512663C2
(sv)
|
1997-10-23 |
2000-04-17 |
Biogram Ab |
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
|
|
EP1027439B1
(en)
|
1997-10-27 |
2010-03-17 |
Bac Ip B.V. |
Multivalent antigen-binding proteins
|
|
US7179892B2
(en)
|
2000-12-06 |
2007-02-20 |
Neuralab Limited |
Humanized antibodies that recognize beta amyloid peptide
|
|
WO1999045031A2
(en)
|
1998-03-03 |
1999-09-10 |
Abgenix, Inc. |
Cd147 binding molecules as therapeutics
|
|
US20020029391A1
(en)
|
1998-04-15 |
2002-03-07 |
Claude Geoffrey Davis |
Epitope-driven human antibody production and gene expression profiling
|
|
PT1071700E
(pt)
|
1998-04-20 |
2010-04-23 |
Glycart Biotechnology Ag |
Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos
|
|
KR100960211B1
(ko)
|
1998-05-06 |
2010-05-27 |
제넨테크, 인크. |
이온 교환 크로마토그래피에 의한 단백질 정제 방법
|
|
AU747231B2
(en)
|
1998-06-24 |
2002-05-09 |
Alkermes, Inc. |
Large porous particles emitted from an inhaler
|
|
AU770555B2
(en)
|
1998-08-17 |
2004-02-26 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
SG143018A1
(en)
|
1998-12-23 |
2008-06-27 |
Pfizer |
Human monoclonal antibodies to ctla-4
|
|
ES2694002T3
(es)
|
1999-01-15 |
2018-12-17 |
Genentech, Inc. |
Polipéptido que comprende una región Fc de IgG1 humana variante
|
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
EP2319870A3
(en)
|
1999-03-25 |
2011-10-26 |
Abbott GmbH & Co. KG |
Human antibodies that bind human IL-12 and methods for producing
|
|
WO2000061739A1
(fr)
|
1999-04-09 |
2000-10-19 |
Kyowa Hakko Kogyo Co., Ltd. |
Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle
|
|
CN1119415C
(zh)
|
1999-06-04 |
2003-08-27 |
长春迈灵生物工程有限公司 |
抗ca125双功能基因工程抗体的克隆与表达
|
|
US6531580B1
(en)
|
1999-06-24 |
2003-03-11 |
Ixsys, Inc. |
Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same
|
|
KR20020012292A
(ko)
|
1999-06-25 |
2002-02-15 |
제넨테크, 인크. |
항-ErbB 항체-메이탄시노이드 결합체를 사용한 치료방법
|
|
EP1230269A2
(en)
|
1999-11-03 |
2002-08-14 |
Maxygen, Inc. |
Antibody diversity generation
|
|
BR0108188A
(pt)
|
2000-02-10 |
2003-02-25 |
Abbott Lab |
Anticorpos que se ligam a interleucina-18 humana e métodos de produção e uso
|
|
PL358187A1
(en)
|
2000-02-24 |
2004-08-09 |
Genentech, Inc. |
Caspase activated prodrugs therapy
|
|
EP1266009B1
(en)
|
2000-02-25 |
2008-12-31 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
ANTI-EGFRvIII SCFVS WITH IMPROVED CYTOTOXICITY AND YIELD, IMMUNOTOXINS BASED THEREON, AND METHODS OF USE THEREOF
|
|
US7094566B2
(en)
|
2000-03-16 |
2006-08-22 |
Amgen Inc., |
IL-17 receptor like molecules and uses thereof
|
|
US20040038339A1
(en)
|
2000-03-24 |
2004-02-26 |
Peter Kufer |
Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex
|
|
PT2857516T
(pt)
|
2000-04-11 |
2017-08-28 |
Genentech Inc |
Anticorpos multivalentes e utilizações dos mesmos
|
|
MXPA02010787A
(es)
|
2000-05-03 |
2003-07-14 |
Amgen Inc |
Peptidos modificados como agentes terapeuticos.
|
|
ES2259030T3
(es)
|
2000-05-19 |
2006-09-16 |
Scancell Limited |
Anticuerpos humanizados frente al receptor del factor de crecimiento epidermico.
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
ATE309385T1
(de)
|
2000-06-28 |
2005-11-15 |
Glycofi Inc |
Verfahren für die herstellung modifizierter glykoproteine
|
|
MXPA02012867A
(es)
|
2000-06-29 |
2003-09-05 |
Abbott Lab |
Anticuerpos de especificidad doble y metodos para la elaboracion y el uso de los mismos.
|
|
CA2410551A1
(en)
|
2000-06-30 |
2002-01-10 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) |
Heterodimeric fusion proteins
|
|
US20090081234A1
(en)
|
2000-08-07 |
2009-03-26 |
George Heavner |
Anti-tnf antibodies, compositions, methods and uses for treatment of depression and related conditions
|
|
GB0020685D0
(en)
|
2000-08-22 |
2000-10-11 |
Novartis Ag |
Organic compounds
|
|
AU2002211658A1
(en)
|
2000-10-13 |
2002-04-22 |
Uab Research Foundation |
Human anti-epidermal growth factor receptor single-chain antibodies
|
|
JP5312721B2
(ja)
|
2000-11-07 |
2013-10-09 |
シティ・オブ・ホープ |
Cd19特異的再指向免疫細胞
|
|
TWI255272B
(en)
|
2000-12-06 |
2006-05-21 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
|
US6818392B2
(en)
|
2000-12-06 |
2004-11-16 |
Abbott Laboratories |
Monoclonal antibodies to human immunodeficiency virus and uses thereof
|
|
EP2325205A3
(en)
|
2000-12-28 |
2011-10-12 |
Altus Pharmaceuticals Inc. |
Crystals of whole antibodies and fragments thereof and methods for making and using them
|
|
MA26040A1
(fr)
|
2001-01-05 |
2004-04-01 |
Pfizer |
Des anticorps pour recepteur i de facteur de croissance insulinique
|
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
WO2002097048A2
(en)
|
2001-05-30 |
2002-12-05 |
Centocor, Inc. |
ANTI-p40 IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES
|
|
WO2002096458A1
(en)
|
2001-05-30 |
2002-12-05 |
Genentech, Inc. |
Anti-ngf antibodies for the treatment of various disorders
|
|
RU2335507C2
(ru)
|
2001-06-13 |
2008-10-10 |
Генмаб А/С |
Человеческие моноклональные антитела к рецептору эпидермального фактора роста (egfr), способ их получения и их использование, гибридома, трансфектома, трансгенное животное, экспрессионный вектор
|
|
JP4249013B2
(ja)
|
2001-07-31 |
2009-04-02 |
佑 本庶 |
Pd−1に対し特異性を有する物質
|
|
EP1432444A4
(en)
|
2001-08-17 |
2005-11-02 |
Lilly Co Eli |
ANTI-BETA ANTIBODIES
|
|
US7247304B2
(en)
|
2001-08-23 |
2007-07-24 |
Genmab A/S |
Methods of treating using anti-IL-15 antibodies
|
|
AU2002332290B2
(en)
|
2001-09-25 |
2007-11-08 |
Astellas Pharma Inc. |
Recombinant anti-osteopontin antibody and use thereof
|
|
CA2462113C
(en)
|
2001-10-01 |
2013-01-29 |
Dyax Corp. |
Multi-chain eukaryotic display vectors and uses thereof
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
NZ532526A
(en)
|
2001-10-25 |
2007-01-26 |
Genentech Inc |
Compositions comprising a glycoprotein having a Fc region
|
|
WO2003039486A2
(en)
|
2001-11-09 |
2003-05-15 |
Idec Pharmaceuticals Corporation |
Anti-cd80 antibody having adcc activity for adcc mediated killing of b cell lymphoma cells alone or in combination with other therapies
|
|
CN100374457C
(zh)
|
2001-11-14 |
2008-03-12 |
森托科尔公司 |
抗il-6抗体、组合物、方法和用途
|
|
WO2003062375A2
(en)
|
2001-12-19 |
2003-07-31 |
Genentech, Inc. |
Stabilizing polypeptides which have been exposed to urea
|
|
AU2003210802B2
(en)
|
2002-02-05 |
2009-09-10 |
Genentech Inc. |
Protein purification
|
|
BR0307548A
(pt)
|
2002-02-11 |
2006-01-17 |
Genentech Inc |
Método de produção de uma variante de anticorpo, variante de anticorpo, composição, ácido nucléico isolado, vetor, célula hospedeira, processo para a produção de uma variante de anticorpo e método de determinação do coeficiente de associação de antìgeno de um anticorpo
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US7657380B2
(en)
|
2003-12-04 |
2010-02-02 |
Xencor, Inc. |
Methods of generating variant antibodies with increased host string content
|
|
US7419821B2
(en)
|
2002-03-05 |
2008-09-02 |
I-Stat Corporation |
Apparatus and methods for analyte measurement and immunoassay
|
|
JP2005535572A
(ja)
|
2002-04-12 |
2005-11-24 |
メディミューン,インコーポレーテッド |
組換え抗インターロイキン−9抗体
|
|
EP1495055B1
(en)
|
2002-04-18 |
2013-08-14 |
Genencor International, Inc. |
Production of functional antibodies in filamentous fungi
|
|
JP4319979B2
(ja)
|
2002-04-26 |
2009-08-26 |
ジェネンテック・インコーポレーテッド |
タンパク質の非アフィニティ精製
|
|
US20030206898A1
(en)
|
2002-04-26 |
2003-11-06 |
Steven Fischkoff |
Use of anti-TNFalpha antibodies and another drug
|
|
WO2003093317A1
(en)
|
2002-04-30 |
2003-11-13 |
Kyowa Hakko Kogyo Co., Ltd. |
Antibody to human insulin-like growth factor
|
|
EP2316921B1
(en)
|
2002-05-24 |
2014-05-14 |
Merck Sharp & Dohme Corp. |
Neutralizing human anti-IGFR antibody
|
|
US9321832B2
(en)
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
CN105884893A
(zh)
|
2002-07-18 |
2016-08-24 |
莫鲁斯有限公司 |
抗体混合物的重组生产
|
|
US20040018577A1
(en)
|
2002-07-29 |
2004-01-29 |
Emerson Campbell John Lewis |
Multiple hybrid immunoassay
|
|
US20040033228A1
(en)
|
2002-08-16 |
2004-02-19 |
Hans-Juergen Krause |
Formulation of human antibodies for treating TNF-alpha associated disorders
|
|
UA87979C2
(ru)
|
2002-08-19 |
2009-09-10 |
Астразенека Аб |
Человеческое моноклональное антитело, которое нейтрализует моноцитарный хемоатрактантный белок (мср-1)
|
|
JP5303092B2
(ja)
|
2002-09-11 |
2013-10-02 |
ジェネンテック, インコーポレイテッド |
タンパク質精製
|
|
US7820166B2
(en)
|
2002-10-11 |
2010-10-26 |
Micromet Ag |
Potent T cell modulating molecules
|
|
CA2508375C
(en)
|
2002-12-02 |
2014-05-27 |
Abgenix, Inc. |
Antibodies directed to tumor necrosis factor and uses thereof
|
|
AR042485A1
(es)
|
2002-12-16 |
2005-06-22 |
Genentech Inc |
Anticuerpo humanizado que se une al cd20 humano
|
|
CA2511598C
(en)
*
|
2002-12-24 |
2016-09-13 |
Rinat Neuroscience Corp. |
Anti-ngf antibodies and methods using same
|
|
US7569364B2
(en)
|
2002-12-24 |
2009-08-04 |
Pfizer Inc. |
Anti-NGF antibodies and methods using same
|
|
US7575893B2
(en)
|
2003-01-23 |
2009-08-18 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
|
JP3803790B2
(ja)
|
2003-02-17 |
2006-08-02 |
株式会社東北テクノアーチ |
新規なダイアボディ型二重特異性抗体
|
|
ES2564103T3
(es)
|
2003-03-05 |
2016-03-17 |
Halozyme, Inc. |
Glicoproteína hialuronidasa soluble (sHASEGP), proceso para prepararla, usos y composiciones farmacéuticas que la comprenden
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
JP2007535895A
(ja)
|
2003-05-01 |
2007-12-13 |
イムクローン システムズ インコーポレイティド |
ヒトインシュリン様成長因子−1受容体に対する完全ヒト抗体
|
|
RU2005141512A
(ru)
|
2003-05-31 |
2007-07-20 |
Микромет Аг (De) |
Фармацевтические композиции, включающие биспецифические анти-cd3, анти-cd19 конструкции антител для лечения расстройств, связанных с b-клетками
|
|
AR042955A1
(es)
|
2003-07-18 |
2005-07-13 |
Amgen Inc |
Agentes de union especifica al factor de crecimiento de hepatocitos
|
|
EP3095793B1
(en)
|
2003-07-28 |
2020-03-25 |
Genentech, Inc. |
Reducing protein a leaching during protein a affinity chromatography
|
|
US20050026881A1
(en)
|
2003-07-31 |
2005-02-03 |
Robinson Cynthia B. |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
|
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
|
WO2005044853A2
(en)
|
2003-11-01 |
2005-05-19 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
US7662928B2
(en)
|
2003-08-08 |
2010-02-16 |
The Research Foundation Of State University Of New York |
Anti-FcRn antibodies for treatment of auto/allo immune conditions
|
|
EP2502935B1
(en)
|
2003-08-22 |
2017-03-29 |
Biogen MA Inc. |
Improved antibodies having altered effector function and methods for making the same
|
|
US20050042664A1
(en)
|
2003-08-22 |
2005-02-24 |
Medimmune, Inc. |
Humanization of antibodies
|
|
US7682833B2
(en)
|
2003-09-10 |
2010-03-23 |
Abbott Point Of Care Inc. |
Immunoassay device with improved sample closure
|
|
US7723099B2
(en)
|
2003-09-10 |
2010-05-25 |
Abbott Point Of Care Inc. |
Immunoassay device with immuno-reference electrode
|
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
|
CN1997897A
(zh)
|
2003-10-24 |
2007-07-11 |
梅德特龙尼克有限公司 |
通过削弱促炎介质的产生治疗神经病症的技术
|
|
US7968684B2
(en)
|
2003-11-12 |
2011-06-28 |
Abbott Laboratories |
IL-18 binding proteins
|
|
EP2264191A1
(en)
|
2003-11-21 |
2010-12-22 |
ANP Technologies, Inc. |
Asymmetrically branched polymer conjugates and microarray assays
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
ITRM20030601A1
(it)
|
2003-12-24 |
2005-06-25 |
Lay Line Genomics Spa |
Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
|
|
US7794713B2
(en)
|
2004-04-07 |
2010-09-14 |
Lpath, Inc. |
Compositions and methods for the treatment and prevention of hyperproliferative diseases
|
|
CA2562771C
(en)
|
2004-04-12 |
2013-04-09 |
Medimmune, Inc. |
Anti-il-9 antibody formulations and uses thereof
|
|
JP2007535317A
(ja)
|
2004-04-15 |
2007-12-06 |
グライコフィ, インコーポレイテッド |
下等真核生物におけるガラクトシル化された糖タンパク質の産生
|
|
CA2566647A1
(en)
|
2004-05-13 |
2005-12-22 |
Imclone Systems Incorporated |
Inhibition of macrophage-stimulating protein receptor (ron)
|
|
WO2005118635A2
(en)
|
2004-06-03 |
2005-12-15 |
Novimmune S.A. |
Anti-cd3 antibodies and methods of use thereof
|
|
WO2006020258A2
(en)
|
2004-07-17 |
2006-02-23 |
Imclone Systems Incorporated |
Novel tetravalent bispecific antibody
|
|
MX2007001221A
(es)
|
2004-08-04 |
2007-03-23 |
Amgen Inc |
Anticuerpos para proteina dickkopf-1 (dkk-1).
|
|
US7476724B2
(en)
|
2004-08-05 |
2009-01-13 |
Genentech, Inc. |
Humanized anti-cmet antibodies
|
|
GB0417487D0
(en)
|
2004-08-05 |
2004-09-08 |
Novartis Ag |
Organic compound
|
|
KR20070057839A
(ko)
|
2004-08-19 |
2007-06-07 |
제넨테크, 인크. |
변경된 이펙터 기능을 갖는 폴리펩티드 변이체
|
|
GB0419424D0
(en)
|
2004-09-02 |
2004-10-06 |
Viragen Scotland Ltd |
Transgene optimisation
|
|
HRP20120171T1
(hr)
|
2004-09-03 |
2012-03-31 |
Genentech |
Humanizirani anti-beta 7 antagonisti i njihove uporabe
|
|
WO2006037604A1
(en)
|
2004-10-01 |
2006-04-13 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Novel antibodies directed to the mammalian eag1 ion channel protein
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
US20060253100A1
(en)
|
2004-10-22 |
2006-11-09 |
Medtronic, Inc. |
Systems and Methods to Treat Pain Locally
|
|
AU2005299716B2
(en)
|
2004-10-22 |
2012-09-06 |
Amgen Inc. |
Methods for refolding of recombinant antibodies
|
|
US7423128B2
(en)
|
2004-11-03 |
2008-09-09 |
Amgen Fremont Inc. |
Anti-properdin antibodies, and methods for making and using same
|
|
PE20061401A1
(es)
|
2004-12-15 |
2006-12-23 |
Neuralab Ltd |
ANTICUERPOS Aß PARA MEJORAR LA COGNICION
|
|
US20080267971A1
(en)
|
2004-12-21 |
2008-10-30 |
Green Larry L |
Antibodies Directed to Angiopoietin-2 and Uses Thereof
|
|
WO2006081139A2
(en)
|
2005-01-26 |
2006-08-03 |
Abgenix, Inc. |
Antibodies against interleukin-1 beta
|
|
KR101289537B1
(ko)
|
2005-02-15 |
2013-07-31 |
듀크 유니버시티 |
항-cd19 항체 및 종양학에서 이의 용도
|
|
AU2006216291B2
(en)
|
2005-02-27 |
2011-01-27 |
Institute For Antibodies Co., Ltd. |
Anti-IgSF4 antibody and utilization of the same
|
|
ATE549358T1
(de)
|
2005-03-24 |
2012-03-15 |
Thrombogenics Nv |
Neuer anti-plgf-antikörper
|
|
CN101484182B
(zh)
|
2005-04-06 |
2014-06-11 |
Ibc药品公司 |
由同二聚体、同四聚体或二聚体的二聚体组成的稳定连接复合体的生产方法及用途
|
|
AP2007004243A0
(en)
|
2005-04-25 |
2007-12-31 |
Pfizer |
Antibodies to myostatin
|
|
US7592429B2
(en)
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
|
EP1885755A4
(en)
|
2005-05-05 |
2009-07-29 |
Univ Duke |
CD19 ANTIBODY THERAPY FOR AUTOIMMUNE DISEASES
|
|
JP5339901B2
(ja)
|
2005-05-10 |
2013-11-13 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
炎症傷害の処置および評価
|
|
UA96416C2
(uk)
|
2005-05-27 |
2011-11-10 |
Байоджэн Айдэк Ма Инк. |
Антитіло, яке зв'язується з tweak людини
|
|
WO2006130429A2
(en)
|
2005-05-27 |
2006-12-07 |
Biogen Idec Ma Inc. |
Treatment of cancer
|
|
ITRM20050290A1
(it)
|
2005-06-07 |
2006-12-08 |
Lay Line Genomics Spa |
Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
|
|
KR20080017025A
(ko)
|
2005-06-24 |
2008-02-25 |
노보자임스 에이/에스 |
약학적 용도의 리파제
|
|
PT1896073E
(pt)
|
2005-06-30 |
2013-05-28 |
Janssen Biotech Inc |
Composições, métodos e aplicações de anticorpos anti-il-23
|
|
US20090215992A1
(en)
|
2005-08-19 |
2009-08-27 |
Chengbin Wu |
Dual variable domain immunoglobulin and uses thereof
|
|
AU2006283532B2
(en)
|
2005-08-19 |
2012-04-26 |
Abbvie Inc. |
Dual variable domain immunoglobin and uses thereof
|
|
US20070041905A1
(en)
|
2005-08-19 |
2007-02-22 |
Hoffman Rebecca S |
Method of treating depression using a TNF-alpha antibody
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
NO345919B1
(no)
|
2005-08-26 |
2021-10-18 |
Roche Glycart Ag |
Modifiserte antigen-bindende molekyler med endret celle-signaliseringsaktivitet
|
|
US7906116B2
(en)
|
2005-09-01 |
2011-03-15 |
Parkash Gill |
Methods for using and identifying modulators of Delta-like 4
|
|
CA2862540C
(en)
|
2005-09-21 |
2018-07-31 |
The Regents Of The University Of California |
Systems, compositions, and methods for local imaging and treatment of pain
|
|
US9119828B2
(en)
|
2005-09-23 |
2015-09-01 |
The United States Of America As Represented By The Secretary Of The Army |
Antibodies with simultaneous subsite specificities to protein and lipid epitopes
|
|
EP3770174A1
(en)
|
2005-10-11 |
2021-01-27 |
Amgen Research (Munich) GmbH |
Compositions comprising cross-species-specific antibodies and uses thereof
|
|
US20080299137A1
(en)
|
2005-10-28 |
2008-12-04 |
Novo Nordisk A/S |
Fusion Proteins That Bind Effector Lymphocytes And Target Cells
|
|
UA96139C2
(uk)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Антитіло до нейропіліну-1 (nrp1)
|
|
TW200736277A
(en)
|
2005-11-14 |
2007-10-01 |
Amgen Inc |
RANKL antibody-PTH/PTHrP chimeric molecules
|
|
US7820165B2
(en)
|
2005-11-21 |
2010-10-26 |
Merck Serono, S.A. |
Compositions and methods of producing hybrid antigen binding molecules and uses thereof
|
|
CA2628703C
(en)
|
2005-11-30 |
2019-10-29 |
Abbott Laboratories |
Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
|
|
DK1979001T3
(da)
|
2005-12-13 |
2012-07-16 |
Medimmune Ltd |
Bindingsproteiner, der er specifikke for insulinlignende vækstfaktorer og anvendelser deraf
|
|
AR056857A1
(es)
|
2005-12-30 |
2007-10-24 |
U3 Pharma Ag |
Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
|
|
KR101535678B1
(ko)
|
2006-01-23 |
2015-07-09 |
조셉 피. 에리코 |
표적 약물 개발의 방법 및 조성물
|
|
WO2007117749A2
(en)
|
2006-01-31 |
2007-10-18 |
Novartis Ag |
Il-17 antagonistic antibodies fpr treating cancer
|
|
SG170750A1
(en)
|
2006-03-17 |
2011-05-30 |
Biogen Idec Inc |
Stabilized polypeptide compositions
|
|
MX2008012023A
(es)
|
2006-03-21 |
2008-10-01 |
Wyeth Corp |
Metodos para prevenir y tratar enfermedades amiloidogenicas.
|
|
US20070232556A1
(en)
|
2006-03-31 |
2007-10-04 |
Montine Thomas J |
Methods and compositions for the treatment of neurological diseases and disorders
|
|
WO2007120651A2
(en)
|
2006-04-10 |
2007-10-25 |
Abbott Biotechnology Ltd. |
Uses and compositions for treatment of juvenile rheumatoid arthritis
|
|
BRPI0709977A2
(pt)
|
2006-04-14 |
2011-08-02 |
Novartis Ag |
uso de anticorpos de il-1 para o tratamento de distúrbios oftálmicos
|
|
BRPI0710826A2
(pt)
|
2006-04-21 |
2011-08-23 |
Novartis Ag |
composições farmacêuticas de anticorpo anti-cd40 antagonista
|
|
US20080118978A1
(en)
|
2006-04-28 |
2008-05-22 |
Takashi Sato |
Anti-tumor agent
|
|
CN101058609B
(zh)
|
2006-05-26 |
2011-04-13 |
神州细胞工程有限公司 |
人源抗体及其表达
|
|
NZ573819A
(en)
|
2006-06-02 |
2011-09-30 |
Aveo Pharmaceuticals Inc |
Hepatocyte growth factor (hgf) binding proteins
|
|
CA2654304A1
(en)
|
2006-06-06 |
2007-12-13 |
Genentech, Inc. |
Compositions and methods for modulating vascular development
|
|
CL2007001623A1
(es)
|
2006-06-06 |
2008-01-18 |
Genentech Inc |
Anticuerpo anti-dll4; polinucleotido que lo codifica; vector y celula huesped que comprenden dicho polinucleotido; metodo para elaborar el anticuerpo e inmunojugado; metodo de deteccion de dll4 y metodo diagnostico de un trastorno asociado a dll4; composicion que comprende al anticuerpo.
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
ES2427924T3
(es)
|
2006-06-30 |
2013-11-04 |
Merck Sharp & Dohme Corp. |
Biomarcador IGFBP2
|
|
PL2468770T3
(pl)
|
2006-07-14 |
2018-07-31 |
Ac Immune S.A. |
Humanizowane przeciwciało przeciw amyloidowi beta
|
|
HRP20140331T1
(hr)
|
2006-08-14 |
2014-05-09 |
Xencor, Inc. |
Optimizirana antitijela usmjerena na cd19
|
|
KR101625961B1
(ko)
|
2006-09-08 |
2016-05-31 |
애브비 바하마스 리미티드 |
인터루킨-13 결합 단백질
|
|
SI2066694T1
(sl)
|
2006-09-29 |
2016-02-29 |
Oncomed Pharmaceuticals, Inc. |
Sestavki in postopki za diagnosticiranje in zdravljenje raka
|
|
EP2684895A1
(en)
|
2006-10-27 |
2014-01-15 |
AbbVie Biotechnology Ltd |
Crystalline anti-hTNFalpha antibodies
|
|
AU2007313685C1
(en)
|
2006-11-02 |
2015-09-17 |
Genentech, Inc. |
Humanized anti-Factor D antibodies
|
|
AU2007338734A1
(en)
|
2006-12-20 |
2008-07-03 |
Vasgene Therapeutics, Inc. |
Methods for using and identifying modulators of delta-like 4
|
|
DE602008004296D1
(de)
|
2007-02-14 |
2011-02-17 |
Vaccinex Inc |
Humanisierte anti-cd100-antikörper
|
|
SI2716301T1
(sl)
|
2007-02-16 |
2017-07-31 |
Merrimack Pharmaceuticals, Inc. |
Protitelesa proti ErbB3 in uporaba le-teh
|
|
MY166021A
(en)
|
2007-03-22 |
2018-05-21 |
Biogen Ma Inc |
Binding proteins,including antibodies,antibody derivatives and antibody fragments,that specifically bind cd154 and uses thereof
|
|
RU2009140134A
(ru)
|
2007-04-23 |
2011-05-27 |
Вайет (Us) |
Способы и композиции для лечения и мониторинга лечения связанных с ил-13 нарушений
|
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
|
EP1997832A1
(en)
|
2007-05-29 |
2008-12-03 |
Ganymed Pharmaceuticals AG |
Monoclonal antibodies against Claudin-18 for treatment of cancer
|
|
DK2164992T3
(en)
|
2007-05-30 |
2016-08-15 |
Lpath Inc |
COMPOSITIONS AND METHODS FOR BONDING OF LYTHOPHOSPHATIC ACID
|
|
WO2009003142A1
(en)
|
2007-06-27 |
2008-12-31 |
The Board Of Trustees Of The Leland, Stanford Junior University |
Beta2-microglobulin and c reactive protein (crp) as biomarkers for peripheral artery disease
|
|
EP2626371A1
(en)
|
2007-07-31 |
2013-08-14 |
MedImmune, LLC |
Multispecific epitope binding proteins and uses thereof
|
|
WO2009020654A1
(en)
*
|
2007-08-08 |
2009-02-12 |
Abbott Laboratories |
Compositions and methods for crystallizing antibodies
|
|
CA2696263C
(en)
|
2007-08-15 |
2017-06-13 |
Bing Liu |
Monospecific and multispecific antibodies and method of use
|
|
JP5746861B2
(ja)
|
2007-10-19 |
2015-07-08 |
アボット・ラボラトリーズAbbott Laboratories |
哺乳動物のngalに結合する抗体及びその使用
|
|
JP5737944B2
(ja)
|
2007-12-17 |
2015-06-17 |
ファイザー・リミテッドPfizer Limited |
間質性膀胱炎の治療
|
|
AU2009204501B2
(en)
|
2008-01-07 |
2015-02-12 |
Amgen Inc. |
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
|
|
WO2009091912A2
(en)
|
2008-01-15 |
2009-07-23 |
Abbott Laboratories |
Improved mammalian expression vectors and uses thereof
|
|
US8962803B2
(en)
|
2008-02-29 |
2015-02-24 |
AbbVie Deutschland GmbH & Co. KG |
Antibodies against the RGM A protein and uses thereof
|
|
US20100260668A1
(en)
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
|
EP2899209A1
(en)
|
2008-04-29 |
2015-07-29 |
Abbvie Inc. |
Dual Variable Domain Immunoglobulins and uses thereof
|
|
CA2723219A1
(en)
|
2008-05-09 |
2009-11-12 |
Abbott Gmbh & Co. Kg |
Antibodies to receptor of advanced glycation end products (rage) and uses thereof
|
|
EP2297208A4
(en)
|
2008-06-03 |
2012-07-11 |
Abbott Lab |
DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES
|
|
BRPI0913406A2
(pt)
*
|
2008-06-03 |
2018-01-09 |
Abbott Lab |
imunoglobulinas de domínio variável duplo e usos das mesmas
|
|
US8741287B2
(en)
|
2008-06-18 |
2014-06-03 |
Abbott Laboratories |
PlGF-1 assay and kits and components thereof
|
|
BRPI0915825A2
(pt)
|
2008-07-08 |
2015-11-03 |
Abbott Lab |
proteínas de ligação à prostaglandina e2 usos das mesmas
|
|
US8822645B2
(en)
|
2008-07-08 |
2014-09-02 |
Abbvie Inc. |
Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
|
|
WO2010017103A2
(en)
|
2008-08-04 |
2010-02-11 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic |
Fully human anti-human nkg2d monoclonal antibodies
|
|
CA2737035A1
(en)
*
|
2008-09-30 |
2010-04-08 |
Abbott Laboratories |
Improved method of rna display
|
|
WO2010065882A1
(en)
|
2008-12-04 |
2010-06-10 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
|
TW201613969A
(en)
|
2009-03-05 |
2016-04-16 |
Abbvie Inc |
IL-17 binding proteins
|
|
MX2011011670A
(es)
|
2009-05-01 |
2011-11-18 |
Abbott Lab |
Inmunoglobulinas de dominio variable dual y usos de las mismas.
|
|
JP2012525155A
(ja)
|
2009-05-01 |
2012-10-22 |
アボット・ラボラトリーズ |
二重可変ドメイン免疫グロブリンおよびこの使用
|
|
TW201109438A
(en)
|
2009-07-29 |
2011-03-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
CA2771575A1
(en)
|
2009-08-29 |
2011-03-03 |
Abbott Laboratories |
Therapeutic dll4 binding proteins
|
|
RU2012112550A
(ru)
|
2009-09-01 |
2013-10-10 |
Эбботт Лэборетриз |
Иммуноглобулины с двумя вариабельными доменами и их применение
|
|
UY32920A
(es)
|
2009-10-02 |
2011-04-29 |
Boehringer Ingelheim Int |
Moleculas de unión biespecíficas para la terapia anti-angiogénesis
|
|
UY32949A
(es)
|
2009-10-15 |
2011-02-28 |
Abbott Lab |
Proteínas de unión a il-1
|
|
US8716450B2
(en)
|
2009-10-15 |
2014-05-06 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
UY32979A
(es)
*
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
WO2011084714A2
(en)
|
2009-12-17 |
2011-07-14 |
Biogen Idec Ma Inc. |
STABILIZED ANTI-TNF-ALPHA scFv MOLECULES OR ANTI-TWEAK scFv MOLECULES AND USES THEREOF
|
|
CA2791631A1
(en)
|
2010-03-02 |
2011-09-09 |
Abbvie Inc. |
Therapeutic dll4 binding proteins
|
|
KR20130010123A
(ko)
*
|
2010-04-07 |
2013-01-25 |
아비에 인코포레이티드 |
TNF-α 결합 단백질
|
|
US8841417B2
(en)
|
2010-05-14 |
2014-09-23 |
Abbvie Inc. |
IL-1 binding proteins
|
|
SG188944A1
(en)
|
2010-06-24 |
2013-05-31 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
TW201206473A
(en)
|
2010-08-03 |
2012-02-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
JP2014500712A
(ja)
|
2010-11-02 |
2014-01-16 |
アッヴィ・インコーポレイテッド |
二重可変ドメイン免疫グロブリンおよびその使用
|
|
AR083705A1
(es)
|
2010-11-04 |
2013-03-13 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
CN104203978A
(zh)
|
2011-10-24 |
2014-12-10 |
艾伯维股份有限公司 |
针对硬化蛋白的免疫结合剂
|
|
BR112014016299A8
(pt)
|
2011-12-30 |
2017-07-04 |
Abbvie Inc |
imunoglobulinas de domínio variável e usos das mesmas
|
|
TW201333035A
(zh)
|
2011-12-30 |
2013-08-16 |
Abbvie Inc |
針對il-13及/或il-17之雙特異性結合蛋白
|
|
TW201333033A
(zh)
|
2011-12-30 |
2013-08-16 |
Abbvie Inc |
雙可變域免疫球蛋白及其用途
|
|
UY35110A
(es)
|
2012-11-01 |
2014-05-30 |
Abbvie Inc |
Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas
|
|
US20140213772A1
(en)
|
2012-12-28 |
2014-07-31 |
Abbvie, Inc. |
Cross-over dual variable domain immunoglobulin constructs
|
|
TW201446800A
(zh)
|
2013-03-15 |
2014-12-16 |
Abbvie Inc |
針對TNFα之雙特異性結合蛋白
|
|
CA2904448A1
(en)
|
2013-03-15 |
2014-09-18 |
Tariq Ghayur |
Dual specific binding proteins directed against il-1.beta. and/or il-17
|