CU22545A1
(es)
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
EP0092918B1
(en)
|
1982-04-22 |
1988-10-19 |
Imperial Chemical Industries Plc |
Continuous release formulations
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
FR2556739A1
(fr)
|
1983-12-19 |
1985-06-21 |
Pasteur Institut |
Lignees cellulaires secretant des anticorps monoclonaux contre la pg e2, leur preparation, les anticorps obtenus et leur application
|
US4753894A
(en)
|
1984-02-08 |
1988-06-28 |
Cetus Corporation |
Monoclonal anti-human breast cancer antibodies
|
US4943533A
(en)
|
1984-03-01 |
1990-07-24 |
The Regents Of The University Of California |
Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
DE3590766C2
(es)
|
1985-03-30 |
1991-01-10 |
Marc Genf/Geneve Ch Ballivet |
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
US5763192A
(en)
|
1986-11-20 |
1998-06-09 |
Ixsys, Incorporated |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2 Inc |
Geänderte antikörper.
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
WO1989006692A1
(en)
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
US5006309A
(en)
|
1988-04-22 |
1991-04-09 |
Abbott Laboratories |
Immunoassay device with liquid transfer between wells by washing
|
US5089424A
(en)
|
1988-06-14 |
1992-02-18 |
Abbott Laboratories |
Method and apparatus for heterogeneous chemiluminescence assay
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
JP3771253B2
(ja)
|
1988-09-02 |
2006-04-26 |
ダイアックス コープ. |
新規な結合タンパク質の生成と選択
|
WO1990005183A1
(en)
|
1988-10-31 |
1990-05-17 |
Immunex Corporation |
Interleukin-4 receptors
|
AU634186B2
(en)
|
1988-11-11 |
1993-02-18 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
US5063081A
(en)
|
1988-11-14 |
1991-11-05 |
I-Stat Corporation |
Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
EP0478627A4
(en)
|
1989-05-16 |
1992-08-19 |
William D. Huse |
Co-expression of heteromeric receptors
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
AU6430190A
(en)
|
1989-10-10 |
1991-05-16 |
Pitman-Moore, Inc. |
Sustained release composition for macromolecular proteins
|
JP2571874B2
(ja)
|
1989-11-06 |
1997-01-16 |
アルカーメス コントロールド セラピューティクス,インコーポレイテッド |
タンパク質マイクロスフェア組成物
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
CA2050918A1
(en)
|
1990-01-12 |
1991-07-13 |
Raju Kucherlapati |
Generation of xenogeneic antibodies
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
AT396939B
(de)
|
1990-05-29 |
1993-12-27 |
Alois Dipl Ing Dr Jungbauer |
Komplexes virales antigen von hiv-1 bindendes rekombinantes protein
|
ES2139598T3
(es)
|
1990-07-10 |
2000-02-16 |
Medical Res Council |
Procedimientos para la produccion de miembros de parejas de union especifica.
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
EP0542810A1
(en)
|
1990-08-02 |
1993-05-26 |
B.R. Centre Limited |
Methods for the production of proteins with a desired function
|
EP0544809B1
(en)
|
1990-08-24 |
1998-12-16 |
Ixsys, Inc. |
Methods of synthesizing oligonucleotides with random codons
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech Inc |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
US5780279A
(en)
|
1990-12-03 |
1998-07-14 |
Genentech, Inc. |
Method of selection of proteolytic cleavage sites by directed evolution and phagemid display
|
EP0563296B1
(en)
|
1990-12-20 |
1999-03-17 |
Ixsys, Inc. |
Optimization of binding proteins
|
EP1820858B1
(en)
|
1991-03-01 |
2009-08-12 |
Dyax Corporation |
Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
|
EP0531472B1
(en)
|
1991-03-06 |
2003-08-13 |
MERCK PATENT GmbH |
Humanized monoclonal antibodies
|
US5656272A
(en)
|
1991-03-18 |
1997-08-12 |
New York University Medical Center |
Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
|
ES2156859T5
(es)
|
1991-03-18 |
2008-03-16 |
New York University |
Anticuerpos monoclonales y quimericos especificos para el factor de necrosis tumoral humano.
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
AU662148B2
(en)
|
1991-04-10 |
1995-08-24 |
Scripps Research Institute, The |
Heterodimeric receptor libraries using phagemids
|
JP3370324B2
(ja)
|
1991-04-25 |
2003-01-27 |
中外製薬株式会社 |
ヒトインターロイキン−6受容体に対する再構成ヒト抗体
|
ATE221379T1
(de)
|
1991-05-01 |
2002-08-15 |
Jackson H M Found Military Med |
Verfahren zur behandlung infektiöser respiratorischer erkrankungen
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
CA2069530A1
(en)
|
1991-06-03 |
1992-12-04 |
Cass J. Grandone |
Reagent pack for immunoassays
|
DE4118120A1
(de)
|
1991-06-03 |
1992-12-10 |
Behringwerke Ag |
Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
|
EP0590058B1
(en)
|
1991-06-14 |
2003-11-26 |
Genentech, Inc. |
HUMANIZED Heregulin ANTIBODy
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
WO1992022324A1
(en)
|
1991-06-14 |
1992-12-23 |
Xoma Corporation |
Microbially-produced antibody fragments and their conjugates
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
DE69229477T2
(de)
|
1991-09-23 |
1999-12-09 |
Cambridge Antibody Tech |
Methoden zur Herstellung humanisierter Antikörper
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
AU3178993A
(en)
|
1991-11-25 |
1993-06-28 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
WO1993011236A1
(en)
|
1991-12-02 |
1993-06-10 |
Medical Research Council |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
|
CA2103887C
(en)
|
1991-12-13 |
2005-08-30 |
Gary M. Studnicka |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
US5912015A
(en)
|
1992-03-12 |
1999-06-15 |
Alkermes Controlled Therapeutics, Inc. |
Modulated release from biocompatible polymers
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
ATE381614T1
(de)
|
1992-07-24 |
2008-01-15 |
Amgen Fremont Inc |
Bildung von xenogenen antikörpern
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
US5736137A
(en)
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
DK0669836T3
(da)
|
1992-11-13 |
1996-10-14 |
Idec Pharma Corp |
Terapeutisk anvendelse af kimære og radioaktivt mærkede antistoffer og humant B-lymfocytbegrænset differentieringsantigen til behandling af B-cellelymfom
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
AU6132994A
(en)
|
1993-02-02 |
1994-08-29 |
Scripps Research Institute, The |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
US6491916B1
(en)
|
1994-06-01 |
2002-12-10 |
Tolerance Therapeutics, Inc. |
Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies
|
WO1995001997A1
(en)
|
1993-07-09 |
1995-01-19 |
Smithkline Beecham Corporation |
RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
|
WO1995009917A1
(en)
|
1993-10-07 |
1995-04-13 |
The Regents Of The University Of California |
Genetically engineered bispecific tetravalent antibodies
|
EP0659766A1
(en)
|
1993-11-23 |
1995-06-28 |
Schering-Plough |
Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
|
US5565352A
(en)
|
1993-11-24 |
1996-10-15 |
Arch Development Corporation |
Deubiquitinating enzyme: compositions and methods
|
JPH09506262A
(ja)
|
1993-12-08 |
1997-06-24 |
ジェンザイム・コーポレイション |
特異的抗体の製造方法
|
CA2178590A1
(en)
|
1993-12-10 |
1995-06-15 |
Joan D. Tyner |
Reagents and methods for the detection of methotrexate
|
GB9401182D0
(en)
|
1994-01-21 |
1994-03-16 |
Inst Of Cancer The Research |
Antibodies to EGF receptor and their antitumour effect
|
DE69531148T2
(de)
|
1994-01-31 |
2004-04-29 |
Trustees Of Boston University, Boston |
Bibliotheken aus polyklonalen antikörpern
|
ZA95960B
(en)
|
1994-03-14 |
1995-10-10 |
Genetics Inst |
Use of interleukin-12 antagonists in the treatment of autoimmune diseases
|
ES2191702T3
(es)
|
1994-03-17 |
2003-09-16 |
Merck Patent Gmbh |
Fv monocatenarios anti-egfr y anticuerpos anti-egfr.
|
IL109632A
(en)
|
1994-05-11 |
2007-03-08 |
Yeda Res & Dev |
Modulators of the function of tnf receptors
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
IL114909A
(en)
|
1994-08-12 |
1999-10-28 |
Immunomedics Inc |
Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
|
EP0805678B1
(en)
|
1995-01-05 |
2003-10-29 |
THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN |
Surface-modified nanoparticles and method of making and using same
|
GB9504344D0
(en)
|
1995-03-03 |
1995-04-19 |
Unilever Plc |
Antibody fragment production
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
US6091001A
(en)
|
1995-03-29 |
2000-07-18 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
KR100479146B1
(ko)
|
1995-04-21 |
2005-05-16 |
셀 제네시스, 인코포레이티드 |
큰게놈dna결실유발법
|
KR100654645B1
(ko)
|
1995-04-27 |
2007-04-04 |
아브게닉스, 인크. |
면역화된 제노마우스 유래의 인간 항체
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
US7060808B1
(en)
|
1995-06-07 |
2006-06-13 |
Imclone Systems Incorporated |
Humanized anti-EGF receptor monoclonal antibody
|
EP0831880A4
(en)
|
1995-06-07 |
2004-12-01 |
Imclone Systems Inc |
ANTIBODIES AND FRAGMENTS OF ANTIBODIES INHIBITING TUMOR GROWTH
|
US5916597A
(en)
|
1995-08-31 |
1999-06-29 |
Alkermes Controlled Therapeutics, Inc. |
Composition and method using solid-phase particles for sustained in vivo release of a biologically active agent
|
BR9606706A
(pt)
|
1995-10-16 |
1999-04-06 |
Unilever Nv |
Análogo de fragmento de anticorpo biespecífico ou bivalente uso processo para produzir o mesmo
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
US6331431B1
(en)
|
1995-11-28 |
2001-12-18 |
Ixsys, Inc. |
Vacuum device and method for isolating periplasmic fraction from cells
|
CZ292465B6
(cs)
|
1996-02-09 |
2003-09-17 |
Abbott Laboratories (Bermuda) Ltd. |
Lidské protilátky k lidskému TNFalfa
|
ATE508733T1
(de)
|
1996-03-04 |
2011-05-15 |
Penn State Res Found |
Materialien und verfahren zur steigerung der zellulären internalisierung
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
WO1997035991A1
(en)
|
1996-03-28 |
1997-10-02 |
The Johns Hopkins University |
Soluble divalent and multivalent heterodimeric analogs of proteins
|
JP2000508892A
(ja)
|
1996-04-04 |
2000-07-18 |
ユニリーバー・ナームローゼ・ベンノートシャープ |
多価および多特異的抗原結合タンパク
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
US6699658B1
(en)
|
1996-05-31 |
2004-03-02 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
US6986890B1
(en)
|
1996-11-21 |
2006-01-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Anti-human VEGF receptor Flt-1 monoclonal antibody
|
US7258857B2
(en)
|
1996-11-22 |
2007-08-21 |
The Trustees Of Columbia University In The City Of New York |
Rage-related methods for treating inflammation
|
ATE549918T1
(de)
|
1996-12-03 |
2012-04-15 |
Amgen Fremont Inc |
Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden
|
DE69732306T2
(de)
|
1997-01-16 |
2006-01-12 |
Massachusetts Institute Of Technology, Cambridge |
Zubereitung von partikelhaltigen arzneimitteln zur inhalation
|
DE69835143T2
(de)
|
1997-01-21 |
2007-06-06 |
The General Hospital Corp., Boston |
Selektion von proteinen mittels rns-protein fusionen
|
US6057098A
(en)
|
1997-04-04 |
2000-05-02 |
Biosite Diagnostics, Inc. |
Polyvalent display libraries
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
CA2286330C
(en)
|
1997-04-07 |
2008-06-10 |
Genentech, Inc. |
Anti-vegf antibodies
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
AU8691398A
(en)
|
1997-08-04 |
1999-02-22 |
Ixsys, Incorporated |
Methods for identifying ligand specific binding molecules
|
US5989463A
(en)
|
1997-09-24 |
1999-11-23 |
Alkermes Controlled Therapeutics, Inc. |
Methods for fabricating polymer-based controlled release devices
|
SE512663C2
(sv)
|
1997-10-23 |
2000-04-17 |
Biogram Ab |
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
|
ATE461282T1
(de)
|
1997-10-27 |
2010-04-15 |
Bac Ip Bv |
Multivalente antigenbindende proteine
|
US7179892B2
(en)
|
2000-12-06 |
2007-02-20 |
Neuralab Limited |
Humanized antibodies that recognize beta amyloid peptide
|
WO1999045031A2
(en)
|
1998-03-03 |
1999-09-10 |
Abgenix, Inc. |
Cd147 binding molecules as therapeutics
|
US20020029391A1
(en)
|
1998-04-15 |
2002-03-07 |
Claude Geoffrey Davis |
Epitope-driven human antibody production and gene expression profiling
|
DE69942021D1
(de)
|
1998-04-20 |
2010-04-01 |
Glycart Biotechnology Ag |
Glykosylierungs-engineering von antikörpern zur verbesserung der antikörperabhängigen zellvermittelten zytotoxizität
|
NZ507557A
(en)
|
1998-05-06 |
2003-10-31 |
Genentech Inc |
Protein purification by ion exchange chromatography
|
DE69907456T2
(de)
|
1998-06-24 |
2004-03-25 |
Advanced Inhalation Research, Inc., Cambridge |
Grosse poröse partikel ausgestossen von einem inhalator
|
AU770555B2
(en)
|
1998-08-17 |
2004-02-26 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
CN1328571B
(zh)
|
1998-12-23 |
2016-08-31 |
辉瑞大药厂 |
抗ctla-4的人单克隆抗体
|
EP2386574A3
(en)
|
1999-01-15 |
2012-06-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
DK2168984T3
(da)
|
1999-03-25 |
2012-12-10 |
Abbott Gmbh & Co Kg |
Humane antistoffer, som binder humant IL-12, og fremgangsmåder til pro-duktion heraf
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
DK2270147T4
(da)
|
1999-04-09 |
2020-08-31 |
Kyowa Kirin Co Ltd |
Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle
|
CA2370466C
(en)
|
1999-06-25 |
2011-02-08 |
Sharon Erickson |
Methods of treatment using anti-erbb antibody-maytansinoid conjugates
|
CN1119415C
(zh)
|
1999-06-04 |
2003-08-27 |
长春迈灵生物工程有限公司 |
抗ca125双功能基因工程抗体的克隆与表达
|
US6531580B1
(en)
|
1999-06-24 |
2003-03-11 |
Ixsys, Inc. |
Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same
|
EP1230269A2
(en)
|
1999-11-03 |
2002-08-14 |
Maxygen, Inc. |
Antibody diversity generation
|
CN102504024A
(zh)
|
2000-02-10 |
2012-06-20 |
雅培制药有限公司 |
结合人白介素-18的抗体及制备和使用方法
|
AU783679B2
(en)
|
2000-02-24 |
2005-11-24 |
Genentech Inc. |
Caspase activated prodrugs therapy
|
YU63302A
(sh)
|
2000-02-25 |
2005-09-19 |
The Government Of The Un.Stat. |
Anti-egfrv iii scfvs sa pojačanom citotoksičnošću i povećanim prinosom, imunotoksini na bazi istog i metodi za upotrebu na bazi istog
|
US7094566B2
(en)
|
2000-03-16 |
2006-08-22 |
Amgen Inc., |
IL-17 receptor like molecules and uses thereof
|
CZ20023203A3
(cs)
|
2000-03-24 |
2003-08-13 |
Micromet Ag |
Multifunkční polypeptidy obsahující vazebné místo k epitopu receptorového komplexu NKG2D
|
JP2003531588A
(ja)
|
2000-04-11 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
多価抗体とその用途
|
AU2001259432B2
(en)
|
2000-05-03 |
2005-04-21 |
Amgen Inc. |
Modified peptides, comprising an FC domain, as therapeutic agents
|
AU2001258567A1
(en)
|
2000-05-19 |
2001-11-26 |
Scancell Limited |
Humanised antibodies to the epidermal growth factor receptor
|
DK1297172T3
(da)
|
2000-06-28 |
2006-02-13 |
Glycofi Inc |
Fremgangsmåder til frembringelse af modificerede glucoproteiner
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
CZ2003291A3
(cs)
|
2000-06-29 |
2003-05-14 |
Abbott Laboratories |
Duálně specifické protilátky a způsoby jejich výroby a použití
|
US20040220388A1
(en)
|
2000-06-30 |
2004-11-04 |
Nico Mertens |
Novel heterodimeric fusion proteins
|
US20090081234A1
(en)
|
2000-08-07 |
2009-03-26 |
George Heavner |
Anti-tnf antibodies, compositions, methods and uses for treatment of depression and related conditions
|
GB0020685D0
(en)
|
2000-08-22 |
2000-10-11 |
Novartis Ag |
Organic compounds
|
US6699473B2
(en)
|
2000-10-13 |
2004-03-02 |
Uab Research Foundation |
Human anti-epidermal growth factor receptor single-chain antibodies
|
ATE338124T1
(de)
|
2000-11-07 |
2006-09-15 |
Hope City |
Cd19-spezifische umgezielte immunzellen
|
PE20020574A1
(es)
|
2000-12-06 |
2002-07-02 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido amiloideo beta
|
US6818392B2
(en)
|
2000-12-06 |
2004-11-16 |
Abbott Laboratories |
Monoclonal antibodies to human immunodeficiency virus and uses thereof
|
NZ526720A
(en)
|
2000-12-28 |
2007-11-30 |
Altus Pharmaceuticals Inc |
Crystallisation of whole antibodies or fragments thereof, on a large scale and a process allowing an alternative route for delivery of therapeutic antibodies
|
PE20020801A1
(es)
|
2001-01-05 |
2002-09-06 |
Pfizer |
Anticuerpos contra el receptor del factor de crecimiento similar a insulina
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
CA2448956C
(en)
|
2001-05-30 |
2017-10-03 |
Genentech, Inc. |
Anti-ngf antibodies for the treatment of various disorders
|
US20030157105A1
(en)
|
2001-05-30 |
2003-08-21 |
Carton Jill M. |
Anti-p40 immunglobulin derived proteins, compositions, methods and uses
|
JP4298498B2
(ja)
|
2001-06-13 |
2009-07-22 |
ゲンマブ エー/エス |
上皮成長因子受容体(egfr)に対するヒトモノクローナル抗体
|
ATE524495T1
(de)
|
2001-07-31 |
2011-09-15 |
Ono Pharmaceutical Co |
Pd-1-spezifische substanz
|
US20040192898A1
(en)
|
2001-08-17 |
2004-09-30 |
Jia Audrey Yunhua |
Anti-abeta antibodies
|
US7247304B2
(en)
|
2001-08-23 |
2007-07-24 |
Genmab A/S |
Methods of treating using anti-IL-15 antibodies
|
RU2305111C2
(ru)
|
2001-09-25 |
2007-08-27 |
Джуридикэл Фаундейшн Дзе Чемо-Серо-Терапьютик Рисерч Инститьют |
Рекомбинантное антитело против остеопонтина и его применение
|
DE60232672D1
(de)
|
2001-10-01 |
2009-07-30 |
Dyax Corp |
Mehrkettige eukaryontische display-vektoren und deren verwendungen
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
KR100988949B1
(ko)
|
2001-10-25 |
2010-10-20 |
제넨테크, 인크. |
당단백질 조성물
|
AU2002346373A1
(en)
|
2001-11-09 |
2003-05-19 |
Idec Pharmaceuticals Corporation |
Anti-cd80 antibody having adcc activity for adcc mediated killing of b cell lymphoma cells alone or in combination with other therapies
|
ES2624547T3
(es)
|
2001-11-14 |
2017-07-14 |
Janssen Biotech, Inc. |
Anticuerpos anti il 6, composiciones, métodos y usos
|
AU2002351353A1
(en)
|
2001-12-19 |
2003-09-02 |
Genentech, Inc. |
Stabilizing polypeptides which have been exposed to urea
|
DK1472275T3
(da)
|
2002-02-05 |
2009-04-14 |
Genentech Inc |
Proteinoprensning
|
MXPA04007583A
(es)
|
2002-02-11 |
2005-04-25 |
Genentech Inc |
Variantes de anticuerpo con tasas mas rapidas de asociacion a antigeno.
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
US7419821B2
(en)
|
2002-03-05 |
2008-09-02 |
I-Stat Corporation |
Apparatus and methods for analyte measurement and immunoassay
|
EP2270049A3
(en)
|
2002-04-12 |
2011-03-09 |
Medimmune, Inc. |
Recombinant anti-interleukin-9-antibody
|
AU2003222664A1
(en)
|
2002-04-18 |
2003-11-03 |
Genencor International, Inc. |
Production of functional antibodies in filamentous fungi
|
SI1501369T1
(sl)
|
2002-04-26 |
2015-10-30 |
Genentech, Inc. |
Neafinitetno čiščenje proteinov
|
US20030206898A1
(en)
|
2002-04-26 |
2003-11-06 |
Steven Fischkoff |
Use of anti-TNFalpha antibodies and another drug
|
EP1505075B1
(en)
|
2002-04-30 |
2009-10-07 |
Kyowa Hakko Kirin Co., Ltd. |
Antibody to human insulin-like growth factor
|
NZ571508A
(en)
|
2002-05-24 |
2010-05-28 |
Schering Corp |
Neutralizing human anti-IGFR antibody
|
US9321832B2
(en)
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
ES2442615T5
(es)
|
2002-07-18 |
2023-03-16 |
Merus Nv |
Producción recombinante de mezclas de anticuerpos
|
US20040018577A1
(en)
|
2002-07-29 |
2004-01-29 |
Emerson Campbell John Lewis |
Multiple hybrid immunoassay
|
US20040033228A1
(en)
|
2002-08-16 |
2004-02-19 |
Hans-Juergen Krause |
Formulation of human antibodies for treating TNF-alpha associated disorders
|
US7202343B2
(en)
|
2002-08-19 |
2007-04-10 |
Abgenix, Inc. |
Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof
|
EP2332996B1
(en)
|
2002-09-11 |
2014-10-15 |
Genentech, Inc. |
Purification of anti-Her2 antibodies
|
US7820166B2
(en)
|
2002-10-11 |
2010-10-26 |
Micromet Ag |
Potent T cell modulating molecules
|
WO2004050683A2
(en)
|
2002-12-02 |
2004-06-17 |
Abgenix, Inc. |
Antibodies directed to tumor necrosis factor and uses thereof
|
PT1572744E
(pt)
|
2002-12-16 |
2010-09-07 |
Genentech Inc |
Variantes de imunoglobulina e utilizações destas
|
EP1575517B1
(en)
*
|
2002-12-24 |
2012-04-11 |
Rinat Neuroscience Corp. |
Anti-ngf antibodies and methods using same
|
US7569364B2
(en)
|
2002-12-24 |
2009-08-04 |
Pfizer Inc. |
Anti-NGF antibodies and methods using same
|
US7575893B2
(en)
|
2003-01-23 |
2009-08-18 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
JP3803790B2
(ja)
|
2003-02-17 |
2006-08-02 |
株式会社東北テクノアーチ |
新規なダイアボディ型二重特異性抗体
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
PT2177620E
(pt)
|
2003-03-05 |
2015-02-16 |
Halozyme Inc |
Glicoproteína hialuronidase solúvel (shasegp), processo para preparação da mesma, suas utilizações e composições farmacêuticas que a compreendem
|
US7638605B2
(en)
|
2003-05-01 |
2009-12-29 |
ImClone, LLC |
Fully human antibodies directed against the human insulin-like growth factor-1 receptor
|
AU2004242846A1
(en)
|
2003-05-31 |
2004-12-09 |
Micromet Ag |
Pharmaceutical compositions comprising bispecific anti-CD3, anti-CD19 antibody constructs for the treatment of B-cell related disorders
|
SI1648998T1
(sl)
|
2003-07-18 |
2015-01-30 |
Amgen Inc. |
Specifiäťna vezavna sredstva na hepatocitni rastni faktor
|
EP3722309A1
(en)
|
2003-07-28 |
2020-10-14 |
Genentech, Inc. |
Reducing protein a leaching during protein a affinity chromatography
|
US20050026881A1
(en)
|
2003-07-31 |
2005-02-03 |
Robinson Cynthia B. |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
|
WO2005044853A2
(en)
|
2003-11-01 |
2005-05-19 |
Genentech, Inc. |
Anti-vegf antibodies
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
US7662928B2
(en)
|
2003-08-08 |
2010-02-16 |
The Research Foundation Of State University Of New York |
Anti-FcRn antibodies for treatment of auto/allo immune conditions
|
WO2005035575A2
(en)
|
2003-08-22 |
2005-04-21 |
Medimmune, Inc. |
Humanization of antibodies
|
AU2004266159A1
(en)
|
2003-08-22 |
2005-03-03 |
Biogen Idec Ma Inc. |
Improved antibodies having altered effector function and methods for making the same
|
US7682833B2
(en)
|
2003-09-10 |
2010-03-23 |
Abbott Point Of Care Inc. |
Immunoassay device with improved sample closure
|
US7723099B2
(en)
|
2003-09-10 |
2010-05-25 |
Abbott Point Of Care Inc. |
Immunoassay device with immuno-reference electrode
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
US20050180974A1
(en)
|
2003-10-24 |
2005-08-18 |
Medtronic, Inc. |
Extracellular TNF inhibitors for treating CNS disorders
|
US7968684B2
(en)
|
2003-11-12 |
2011-06-28 |
Abbott Laboratories |
IL-18 binding proteins
|
EP2264191A1
(en)
|
2003-11-21 |
2010-12-22 |
ANP Technologies, Inc. |
Asymmetrically branched polymer conjugates and microarray assays
|
CA2548817A1
(en)
|
2003-12-04 |
2005-06-23 |
Xencor, Inc. |
Methods of generating variant proteins with increased host string content and compositions thereof
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
ITRM20030601A1
(it)
|
2003-12-24 |
2005-06-25 |
Lay Line Genomics Spa |
Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
|
US7794713B2
(en)
|
2004-04-07 |
2010-09-14 |
Lpath, Inc. |
Compositions and methods for the treatment and prevention of hyperproliferative diseases
|
US7691379B2
(en)
|
2004-04-12 |
2010-04-06 |
Medimmune, Llc |
Anti-IL-9 antibody formulations
|
JP2007535317A
(ja)
|
2004-04-15 |
2007-12-06 |
グライコフィ, インコーポレイテッド |
下等真核生物におけるガラクトシル化された糖タンパク質の産生
|
CA2566647A1
(en)
|
2004-05-13 |
2005-12-22 |
Imclone Systems Incorporated |
Inhibition of macrophage-stimulating protein receptor (ron)
|
KR101266716B1
(ko)
|
2004-06-03 |
2013-05-31 |
노비뮨 에스 에이 |
항-cd3 항체 및 그의 사용 방법
|
EP1786918A4
(en)
|
2004-07-17 |
2009-02-11 |
Imclone Systems Inc |
NEW BISPECIFIC ANTIBODY TETRAVALENT
|
US7709611B2
(en)
|
2004-08-04 |
2010-05-04 |
Amgen Inc. |
Antibodies to Dkk-1
|
GB0417487D0
(en)
|
2004-08-05 |
2004-09-08 |
Novartis Ag |
Organic compound
|
ZA200701656B
(en)
|
2004-08-05 |
2008-09-25 |
Genentech Inc |
Humanized anti-cment antagonists
|
CN101052654A
(zh)
|
2004-08-19 |
2007-10-10 |
健泰科生物技术公司 |
具有改变的效应子功能的多肽变体
|
GB0419424D0
(en)
|
2004-09-02 |
2004-10-06 |
Viragen Scotland Ltd |
Transgene optimisation
|
SI2322556T1
(sl)
|
2004-09-03 |
2016-02-29 |
Genentech, Inc. |
Humanizirani antagonisti proti beta7 in njihove uporabe
|
DE602005026219D1
(de)
|
2004-10-01 |
2011-03-17 |
Max Planck Gesellschaft |
Gegen das säugetier-eag1-ionenkanalprotein gerichtete antikörper
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
JP5553963B2
(ja)
|
2004-10-22 |
2014-07-23 |
アムジエン・インコーポレーテツド |
組換え抗体をリフォールディングする方法
|
US20060253100A1
(en)
|
2004-10-22 |
2006-11-09 |
Medtronic, Inc. |
Systems and Methods to Treat Pain Locally
|
US7423128B2
(en)
|
2004-11-03 |
2008-09-09 |
Amgen Fremont Inc. |
Anti-properdin antibodies, and methods for making and using same
|
TW200635608A
(en)
|
2004-12-15 |
2006-10-16 |
Neuralab Ltd |
Aβ antibodies for use in improving cognition
|
ES2371083T3
(es)
|
2004-12-21 |
2011-12-27 |
Medimmune Limited |
Anticuerpos dirigidos contra la angiopoyetina-2 y usos de los mismos.
|
EP2361933A3
(en)
|
2005-01-26 |
2012-05-02 |
Amgen Fremont Inc. |
Antibodies against interleukin-1 beta
|
EP2548575A1
(en)
|
2005-02-15 |
2013-01-23 |
Duke University |
Anti-CD19 antibodies that mediate ADCC for use in treating autoimmune diseases
|
WO2006090750A1
(ja)
|
2005-02-28 |
2006-08-31 |
Institute For Antibodies Co., Ltd. |
抗IgSF4抗体及びその利用
|
ZA200707258B
(en)
|
2005-03-24 |
2008-06-25 |
Thromb X N V |
Novel anti-PLGF antibody
|
CN101484182B
(zh)
|
2005-04-06 |
2014-06-11 |
Ibc药品公司 |
由同二聚体、同四聚体或二聚体的二聚体组成的稳定连接复合体的生产方法及用途
|
DOP2006000093A
(es)
|
2005-04-25 |
2007-01-31 |
Pfizer |
Anticuerpos contra miostatina
|
US7592429B2
(en)
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
WO2006121852A2
(en)
|
2005-05-05 |
2006-11-16 |
Duke University |
Anti-cd19 antibody therapy for autoimmune disease
|
CA2607697C
(en)
|
2005-05-10 |
2015-01-06 |
Biogen Idec Ma Inc. |
Treating and evaluating inflammatory disorders
|
KR20080023317A
(ko)
|
2005-05-27 |
2008-03-13 |
바이오겐 아이덱 엠에이 인코포레이티드 |
Tweak 결합 항체
|
WO2006130429A2
(en)
|
2005-05-27 |
2006-12-07 |
Biogen Idec Ma Inc. |
Treatment of cancer
|
ITRM20050290A1
(it)
|
2005-06-07 |
2006-12-08 |
Lay Line Genomics Spa |
Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
|
EP1896577A2
(en)
|
2005-06-24 |
2008-03-12 |
Novozymes A/S |
Lipases for pharmaceutical use
|
JP2009501006A
(ja)
|
2005-06-30 |
2009-01-15 |
セントカー・インコーポレーテツド |
抗il−23抗体、組成物、方法および用途
|
US20070041905A1
(en)
|
2005-08-19 |
2007-02-22 |
Hoffman Rebecca S |
Method of treating depression using a TNF-alpha antibody
|
US20090215992A1
(en)
|
2005-08-19 |
2009-08-27 |
Chengbin Wu |
Dual variable domain immunoglobulin and uses thereof
|
MY169746A
(en)
|
2005-08-19 |
2019-05-14 |
Abbvie Inc |
Dual variable domain immunoglobulin and uses thereof
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
AU2006290433B2
(en)
|
2005-08-26 |
2012-06-07 |
Roche Glycart Ag |
Modified antigen binding molecules with altered cell signaling activity
|
US7906116B2
(en)
|
2005-09-01 |
2011-03-15 |
Parkash Gill |
Methods for using and identifying modulators of Delta-like 4
|
CA2862540C
(en)
|
2005-09-21 |
2018-07-31 |
The Regents Of The University Of California |
Systems, compositions, and methods for local imaging and treatment of pain
|
WO2007038392A2
(en)
|
2005-09-23 |
2007-04-05 |
Walter Reed Army Institute Of Research (Wrair) |
Antibodies with simultaneous subsite specificities to protein and lipid epitopes
|
WO2007042261A2
(en)
|
2005-10-11 |
2007-04-19 |
Micromet Ag |
Compositions comprising cross-species-specific antibodies and uses thereof
|
EP1945771A1
(en)
|
2005-10-28 |
2008-07-23 |
Novo Nordisk A/S |
Fusion proteins that bind effector lymphocytes and target cells
|
UA96139C2
(uk)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Антитіло до нейропіліну-1 (nrp1)
|
AR056806A1
(es)
|
2005-11-14 |
2007-10-24 |
Amgen Inc |
Moleculas quimericas de anticuerpo rankl- pth/ pthrp
|
JP2009516513A
(ja)
|
2005-11-21 |
2009-04-23 |
ラボラトワール セローノ ソシエテ アノニム |
ハイブリッド抗原結合分子の組成物及び製造方法並びにその使用
|
DK1954718T3
(en)
|
2005-11-30 |
2014-12-15 |
Abbvie Inc |
Anti-A-globulomer antibodies antigenbindingsgrupper thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods for producing said antibodies,
|
CN105753983A
(zh)
|
2005-12-13 |
2016-07-13 |
阿斯利康(瑞典)有限公司 |
胰岛素样生长因子特异性结合蛋白及其用途
|
AR056857A1
(es)
|
2005-12-30 |
2007-10-24 |
U3 Pharma Ag |
Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
|
CN101415415A
(zh)
|
2006-01-23 |
2009-04-22 |
约瑟夫·P·埃里科 |
定向药物开发的方法和组合物
|
KR20080099290A
(ko)
|
2006-01-31 |
2008-11-12 |
노파르티스 아게 |
암 치료용 il-17 길항 항체
|
CN103073639A
(zh)
|
2006-03-17 |
2013-05-01 |
比奥根艾迪克Ma公司 |
稳定的多肽组合物
|
MX2008012023A
(es)
|
2006-03-21 |
2008-10-01 |
Wyeth Corp |
Metodos para prevenir y tratar enfermedades amiloidogenicas.
|
US20070232556A1
(en)
|
2006-03-31 |
2007-10-04 |
Montine Thomas J |
Methods and compositions for the treatment of neurological diseases and disorders
|
EP2010213A4
(en)
|
2006-04-10 |
2010-08-11 |
Abbott Biotech Ltd |
USE AND COMPOSITIONS FOR THE TREATMENT OF JUVENIL RHEUMATOID ARTHRITIS
|
CA2648223A1
(en)
|
2006-04-14 |
2007-10-25 |
Novartis Ag |
Use of il-i antibodies for treating ophthalmic disorders
|
US8945564B2
(en)
|
2006-04-21 |
2015-02-03 |
Novartis Ag |
Antagonist anti-CD40 antibody pharmaceutical compositions
|
US20080118978A1
(en)
|
2006-04-28 |
2008-05-22 |
Takashi Sato |
Anti-tumor agent
|
CN101058609B
(zh)
|
2006-05-26 |
2011-04-13 |
神州细胞工程有限公司 |
人源抗体及其表达
|
EP2029627B1
(en)
|
2006-06-02 |
2011-11-16 |
Aveo Pharmaceuticals, Inc. |
Hepatocyte growth factor (hgf) binding proteins
|
CA2654000A1
(en)
|
2006-06-06 |
2008-05-22 |
Genentech, Inc. |
Anti-dll4 antibodies and methods using same
|
AU2007256617A1
(en)
|
2006-06-06 |
2007-12-13 |
Genentech, Inc. |
Compositions and methods for modulating vascular development
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
ATE537450T1
(de)
|
2006-06-30 |
2011-12-15 |
Schering Corp |
Igfbp2-biomarker
|
WO2008011348A2
(en)
|
2006-07-14 |
2008-01-24 |
Ac Immune S.A. |
Humanized antibody against amyloid beta
|
PL2383297T3
(pl)
|
2006-08-14 |
2013-06-28 |
Xencor Inc |
Zoptymalizowane przeciwciała ukierunkowane na CD19
|
SG10201508485UA
(en)
|
2006-09-08 |
2015-11-27 |
Abbvie Bahamas Ltd |
Interleukin - 13 binding proteins
|
DK2066694T3
(en)
|
2006-09-29 |
2016-02-08 |
Oncomed Pharm Inc |
Compositions and Methods for Diagnosing and Treating Cancer
|
ES2442258T3
(es)
|
2006-10-27 |
2014-02-10 |
Abbvie Biotechnology Ltd |
Anticuerpos cristalinos anti-hTNF alfa
|
TWI472535B
(zh)
|
2006-11-02 |
2015-02-11 |
Genentech Inc |
人類化之抗-因子d抗體及其用途
|
WO2008079326A2
(en)
|
2006-12-20 |
2008-07-03 |
Vasgene Therapeutics, Inc. |
Methods for using and identifying modulators of delta-like 4
|
US7919594B2
(en)
|
2007-02-14 |
2011-04-05 |
Vaccinex, Inc. |
Human anti-CD100 antibodies
|
JP5564266B2
(ja)
|
2007-02-16 |
2014-07-30 |
メリマック ファーマシューティカルズ インコーポレーティッド |
Erbb3に対する抗体およびその使用
|
CN103214577B
(zh)
|
2007-03-22 |
2015-09-02 |
生物基因Ma公司 |
特异性结合cd154的包括抗体、抗体衍生物和抗体片段在内的结合蛋白及其用途
|
US20090068195A1
(en)
|
2007-04-23 |
2009-03-12 |
Wyeth |
Methods and compositions for treating and monitoring treatment of il-13-associated disorders
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
EP1997832A1
(en)
|
2007-05-29 |
2008-12-03 |
Ganymed Pharmaceuticals AG |
Monoclonal antibodies against Claudin-18 for treatment of cancer
|
US8158124B2
(en)
|
2007-05-30 |
2012-04-17 |
Lpath, Inc. |
Compositions and methods for binding lysophosphatidic acid
|
WO2009003142A1
(en)
|
2007-06-27 |
2008-12-31 |
The Board Of Trustees Of The Leland, Stanford Junior University |
Beta2-microglobulin and c reactive protein (crp) as biomarkers for peripheral artery disease
|
WO2009018386A1
(en)
|
2007-07-31 |
2009-02-05 |
Medimmune, Llc |
Multispecific epitope binding proteins and uses thereof
|
MX2010001488A
(es)
*
|
2007-08-08 |
2010-03-01 |
Abbott Lab |
Composiciones y metodos para cristalizar anticuerpos.
|
JP5485152B2
(ja)
|
2007-08-15 |
2014-05-07 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
単一特異性および多特異性抗体ならびに使用方法
|
JP5848006B2
(ja)
|
2007-10-19 |
2016-01-27 |
アボット・ラボラトリーズAbbott Laboratories |
Ngalの検出用イムノアッセイ及びキット
|
CN102216329A
(zh)
|
2007-12-17 |
2011-10-12 |
辉瑞有限公司 |
间质性膀胱炎的治疗
|
CA2709847C
(en)
|
2008-01-07 |
2018-07-10 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
EP2784089A1
(en)
|
2008-01-15 |
2014-10-01 |
AbbVie Inc. |
Improved mammalian expression vectors and uses thereof
|
US8962803B2
(en)
|
2008-02-29 |
2015-02-24 |
AbbVie Deutschland GmbH & Co. KG |
Antibodies against the RGM A protein and uses thereof
|
US20100260668A1
(en)
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
KR20110014607A
(ko)
|
2008-04-29 |
2011-02-11 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
KR101649168B1
(ko)
|
2008-05-09 |
2016-08-18 |
애브비 인코포레이티드 |
최종 당화 산물의 수용체(rage)에 대한 항체 및 이의 용도
|
CN102112494A
(zh)
|
2008-06-03 |
2011-06-29 |
雅培制药有限公司 |
双重可变结构域免疫球蛋白及其用途
|
WO2009149189A2
(en)
*
|
2008-06-03 |
2009-12-10 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
US8741287B2
(en)
|
2008-06-18 |
2014-06-03 |
Abbott Laboratories |
PlGF-1 assay and kits and components thereof
|
BRPI0915448A2
(pt)
|
2008-07-08 |
2015-11-10 |
Abbott Lab |
imunoglobulinas de domínio variável duplo para prostaglandina e2 e usos das mesmas
|
CN102143760B
(zh)
|
2008-07-08 |
2015-06-17 |
Abbvie公司 |
前列腺素e2结合蛋白及其用途
|
US9273136B2
(en)
|
2008-08-04 |
2016-03-01 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Fully human anti-human NKG2D monoclonal antibodies
|
MX2011003381A
(es)
*
|
2008-09-30 |
2011-04-21 |
Abbott Lab |
Metodo mejorado para despliegue de arn.
|
US20100233079A1
(en)
|
2008-12-04 |
2010-09-16 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
TWI541021B
(zh)
|
2009-03-05 |
2016-07-11 |
艾伯維有限公司 |
Il-17結合蛋白
|
CN102458459A
(zh)
|
2009-05-01 |
2012-05-16 |
雅培制药有限公司 |
双重可变结构域免疫球蛋白及其用途
|
AR076508A1
(es)
|
2009-05-01 |
2011-06-15 |
Abbott Lab |
Inmunoglobulina con dominio variable dual y usos de la misma
|
TW201109438A
(en)
|
2009-07-29 |
2011-03-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
TWI465250B
(zh)
|
2009-08-29 |
2014-12-21 |
Abbvie Inc |
治療用之dll4結合蛋白質
|
JP2013503607A
(ja)
|
2009-09-01 |
2013-02-04 |
アボット・ラボラトリーズ |
二重可変ドメイン免疫グロブリンおよびその使用
|
US20110172398A1
(en)
|
2009-10-02 |
2011-07-14 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules for anti-angiogenesis therapy
|
BR112012007365A2
(pt)
|
2009-10-15 |
2016-11-22 |
Abbott Lab |
proteínas de ligação à il-1
|
RU2012119756A
(ru)
*
|
2009-10-15 |
2013-11-20 |
Эбботт Лэборетриз |
Иммуноглобулины с двумя вариабельными доменами и их применение
|
UY32979A
(es)
*
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
WO2011084714A2
(en)
|
2009-12-17 |
2011-07-14 |
Biogen Idec Ma Inc. |
STABILIZED ANTI-TNF-ALPHA scFv MOLECULES OR ANTI-TWEAK scFv MOLECULES AND USES THEREOF
|
PE20130580A1
(es)
|
2010-03-02 |
2013-06-02 |
Abbvie Inc |
Proteinas terapeuticas de union a dll4
|
KR20130010123A
(ko)
*
|
2010-04-07 |
2013-01-25 |
아비에 인코포레이티드 |
TNF-α 결합 단백질
|
AU2011252883B2
(en)
|
2010-05-14 |
2015-09-10 |
Abbvie Inc. |
IL-1 binding proteins
|
US20110318349A1
(en)
|
2010-06-24 |
2011-12-29 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
EP3252072A3
(en)
|
2010-08-03 |
2018-03-14 |
AbbVie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
RU2013125479A
(ru)
|
2010-11-02 |
2014-12-10 |
Эбботт Лэборетриз |
Иммуноглобулины с двумя вариабельными доменами и их применение
|
AR083705A1
(es)
|
2010-11-04 |
2013-03-13 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
EP2771360A1
(en)
|
2011-10-24 |
2014-09-03 |
AbbVie Inc. |
Immunobinders directed against sclerostin
|
JP2015508994A
(ja)
|
2011-12-30 |
2015-03-26 |
アッヴィ・インコーポレイテッド |
Il−13および/またはil−17に対する二重可変ドメイン免疫グロブリン
|
WO2013101972A2
(en)
|
2011-12-30 |
2013-07-04 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
EP2797956A2
(en)
|
2011-12-30 |
2014-11-05 |
Abbvie Inc. |
Dual variable domain immunoglobulins against receptors
|
EP2914625A2
(en)
|
2012-11-01 |
2015-09-09 |
AbbVie Inc. |
Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof
|
US20140213772A1
(en)
|
2012-12-28 |
2014-07-31 |
Abbvie, Inc. |
Cross-over dual variable domain immunoglobulin constructs
|
RU2015143833A
(ru)
|
2013-03-15 |
2017-04-21 |
Эббви Инк. |
СВЯЗЫВАЮЩИЕ БЕЛКИ С ДВОЙНОЙ СПЕЦИФИЧНОСТЬЮ, НАПРАВЛЕННЫЕ ПРОТИВ TNFα
|
US9062108B2
(en)
|
2013-03-15 |
2015-06-23 |
Abbvie Inc. |
Dual specific binding proteins directed against IL-1 and/or IL-17
|