DK2583680T1 - Mono (PSI-7977) eller kombinationsbehandling af DAA til anvendelse ved behandling af HCV - Google Patents

Mono (PSI-7977) eller kombinationsbehandling af DAA til anvendelse ved behandling af HCV Download PDF

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Publication number
DK2583680T1
DK2583680T1 DK12189195.6T DK12189195T DK2583680T1 DK 2583680 T1 DK2583680 T1 DK 2583680T1 DK 12189195 T DK12189195 T DK 12189195T DK 2583680 T1 DK2583680 T1 DK 2583680T1
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DK
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Prior art keywords
treatment
combination
compound
psi
hcv genotype
Prior art date
Application number
DK12189195.6T
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Danish (da)
English (en)
Inventor
Barry M Bernstein
Rajeev M Menon
Amit Khatri
Sven Mensing
Sandeep Dutta
Daniel E Cohen
Thomas Podsadecki
Scott C Brun
Walid M Awni
Emily O Dumas
Cheri E Klein
Original Assignee
Abbvie Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47143548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2583680(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of DK2583680T1 publication Critical patent/DK2583680T1/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Prostheses (AREA)
DK12189195.6T 2011-10-21 2012-10-19 Mono (PSI-7977) eller kombinationsbehandling af DAA til anvendelse ved behandling af HCV DK2583680T1 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161550360P 2011-10-21 2011-10-21
US201161562176P 2011-11-21 2011-11-21
US201261587197P 2012-01-17 2012-01-17
US201261600468P 2012-02-17 2012-02-17
US201261619883P 2012-04-03 2012-04-03
US201261656253P 2012-06-06 2012-06-06
US201261711793P 2012-10-10 2012-10-10

Publications (1)

Publication Number Publication Date
DK2583680T1 true DK2583680T1 (da) 2015-01-19

Family

ID=47143548

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12189195.6T DK2583680T1 (da) 2011-10-21 2012-10-19 Mono (PSI-7977) eller kombinationsbehandling af DAA til anvendelse ved behandling af HCV

Country Status (28)

Country Link
US (2) US8809265B2 (enExample)
EP (1) EP2583680A3 (enExample)
JP (2) JP5677646B2 (enExample)
CN (2) CN104023726A (enExample)
AR (1) AR088408A1 (enExample)
AU (1) AU2013201532B2 (enExample)
BR (1) BR112014005617A2 (enExample)
CA (1) CA2811250C (enExample)
CH (1) CH707030B1 (enExample)
CL (2) CL2014000778A1 (enExample)
CY (1) CY20152200002T2 (enExample)
DE (6) DE112012003457T5 (enExample)
DK (1) DK2583680T1 (enExample)
DO (1) DOP2014000067A (enExample)
EA (1) EA201490836A1 (enExample)
ES (1) ES2527544T1 (enExample)
GB (4) GB2506085A (enExample)
HK (2) HK1199817A1 (enExample)
IL (1) IL230862A0 (enExample)
MX (1) MX2014004729A (enExample)
PH (2) PH12014500833A1 (enExample)
PT (2) PT107924A (enExample)
SE (2) SE1450131A1 (enExample)
SG (1) SG2014011670A (enExample)
TW (2) TWI532485B (enExample)
UY (1) UY34401A (enExample)
WO (1) WO2013059638A1 (enExample)
ZA (1) ZA201406352B (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
ME03009B (me) 2011-09-16 2018-10-20 Gilead Pharmasset Llc Metode za lecenje hcv-a
US8466159B2 (en) * 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) * 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
PH12014500832A1 (en) 2011-10-21 2022-12-02 Abbvie Inc Methods for treating hcv
SG2014011670A (en) 2011-10-21 2014-10-30 Abbvie Inc Combination treatment (eg. with abt-072 or abt -333) of daas for use in treating hcv
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9326973B2 (en) 2012-01-13 2016-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
DK2897611T3 (da) * 2012-09-18 2019-11-04 Abbvie Inc Fremgangsmåder til behandling af hepatitis c
BR112015006058A2 (pt) * 2012-09-18 2017-07-04 Abbvie Inc métodos para tratamento de hcv
EP2908808A1 (en) * 2012-10-18 2015-08-26 Abbvie Inc. Formulations of pyrimidinedione derivative compounds
UA118256C2 (uk) 2013-01-31 2018-12-26 Гіліад Фармассет Елелсі Комбінований склад двох противірусних сполук
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
MX362616B (es) 2013-03-14 2019-01-28 Abbvie Inc Combinacion de dos agentes antivirales para el tratamiento de hepatitis c.
TW202002979A (zh) 2013-03-14 2020-01-16 美商艾伯維有限公司 治療hcv的方法
US9717712B2 (en) 2013-07-02 2017-08-01 Bristol-Myers Squibb Company Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus
MX2015017953A (es) * 2013-07-02 2016-10-28 Abbvie Inc Metodos para tratar el virus de hepatitis c.
US20150023913A1 (en) 2013-07-02 2015-01-22 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
CN105451736A (zh) * 2013-07-02 2016-03-30 艾伯维公司 用于治疗hcv的方法
WO2015009744A1 (en) 2013-07-17 2015-01-22 Bristol-Myers Squibb Company Combinations comprising biphenyl derivatives for use in the treatment of hcv
US20150064253A1 (en) 2013-08-27 2015-03-05 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
US20150141351A1 (en) * 2013-11-18 2015-05-21 AbbVie Deutschland GmbH & Co. KG Solid Pharmaceutical Compositions
US20150174194A1 (en) * 2013-12-19 2015-06-25 Abbvie Inc. Methods for treating liver transplant recipients
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
CN106413711A (zh) 2014-04-02 2017-02-15 艾伯维公司 治疗hcv的方法
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US10076512B2 (en) 2014-05-01 2018-09-18 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
WO2016089814A1 (en) 2014-12-02 2016-06-09 Concert Pharmaceuticals, Inc. Deuterated analogues of daclatasvir
MX2017007303A (es) 2014-12-04 2017-08-25 Novartis Ag Metodos y composiciones que utilizan polipeptidos variantes klotho.
EP3226973A4 (en) * 2014-12-04 2018-05-30 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
CN104546780A (zh) * 2014-12-12 2015-04-29 安徽一灵药业有限公司 一种达卡他韦薄膜包衣片制剂及其制备方法
DK3285768T3 (da) 2015-04-21 2021-01-25 Eiger Biopharmaceuticals Inc Farmaceutiske sammensætninger omfattende lonafarnib og ritonavir
US20160375017A1 (en) 2015-06-26 2016-12-29 Abbvie Inc. Solid Pharmaceutical Compositions for Treating HCV
AU2016285578A1 (en) * 2015-06-29 2018-01-25 Abbvie Inc. Methods for treating HCV
HK1255481A1 (zh) 2015-07-08 2019-08-16 Abbvie Inc. 用於治疗hcv的方法
US10617675B2 (en) 2015-08-06 2020-04-14 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
CA2994496A1 (en) 2017-02-14 2018-08-14 Abbvie Inc. Methods for treating hcv
CA2981993A1 (en) 2017-08-02 2019-02-02 Abbvie Inc. Methods for treating hcv
WO2019074507A1 (en) 2017-10-12 2019-04-18 Abbvie Inc. METHODS FOR THE TREATMENT OF HCV

Family Cites Families (403)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026687A (en) 1990-01-03 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
AU4671193A (en) 1992-07-13 1994-01-31 Kenneth E. Sherman Composition and method of treating hepatitis b
US6107027A (en) 1994-12-14 2000-08-22 University Of Washington Ribozymes for treating hepatitis C
GB9505025D0 (en) 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
US6387365B1 (en) 1995-05-19 2002-05-14 Schering Corporation Combination therapy for chronic hepatitis C infection
US5980884A (en) 1996-02-05 1999-11-09 Amgen, Inc. Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon
GB9605293D0 (en) 1996-03-13 1996-05-15 Glaxo Group Ltd Medicaments
US5922757A (en) 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
AU5157998A (en) 1996-11-01 1998-05-29 Thomas Najarian Methods and compositions for treatment of hepatitis c infection
IL119833A (en) 1996-12-15 2001-01-11 Lavie David Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
US6010890A (en) 1997-04-29 2000-01-04 New York Blood Center, Inc. Method for viral inactivation and compositions for use in same
US6103706A (en) 1997-04-29 2000-08-15 New York Blood Center, Inc. Methods for treating viral infections
US6143752A (en) 1997-08-01 2000-11-07 Oren; Ran Method for preventing or arresting liver damage in humans
EP1317929A3 (en) 1997-09-21 2003-07-02 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis c infection
JP3838034B2 (ja) 1997-10-13 2006-10-25 大塚製薬株式会社 Ｃ型肝炎治療効果の改善剤及びその応用
FR2771637B1 (fr) 1997-12-01 2003-10-24 Hutchinson Utilisation d'un halogenure de dialkyldialkylammonium par voie parenterale dans les infections bacteriennes et virales
CA2312423A1 (en) 1997-12-11 1999-06-17 The Chancellor, Masters And Scholars Of The University Of Oxford Inhibition of membrane-associated viral replication
CA2313049A1 (en) 1997-12-17 1999-06-24 Cornell Research Foundation, Inc. Cyclooxygenase-2 inhibition
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
US6475985B1 (en) 1998-03-27 2002-11-05 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
JP2000007578A (ja) 1998-06-24 2000-01-11 Hiroaki Okushin Ｃ型肝炎ウイルスの陰性化のための投薬システム
JP4350898B2 (ja) 1998-07-01 2009-10-21 デビオファーム・ソシエテ・アノニム 活性の特徴が改善された新規のシクロスポリン
RU2158604C2 (ru) 1998-07-03 2000-11-10 Толоконская Наталья Петровна Способ лечения вирусного гепатита c
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
US6403564B1 (en) 1998-10-16 2002-06-11 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
SK4742001A3 (en) 1998-10-16 2001-11-06 Schering Corp Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection
US20080275005A1 (en) 1998-11-25 2008-11-06 Murphy Michael P Mitochondrially targeted antioxidants
US6824768B2 (en) 1998-12-18 2004-11-30 Schering Corporation Ribavirin-pegylated interferon alfa induction HCV combination therapy
CA2354536A1 (en) 1998-12-18 2000-06-29 Schering Corporation Ribavirin-pegylated interferon alfa induction hcv combination therapy
AU2156900A (en) 1998-12-18 2000-07-12 Schering Corporation Ribavirin-interferon alfa induction hcv combination therapy
JP2000212099A (ja) 1999-01-19 2000-08-02 Mochida Pharmaceut Co Ltd ウイルス性肝炎治療剤
ATE286407T1 (de) 1999-02-13 2005-01-15 Purepulse Technologies Inc Verfahren zur inaktivierung von pathogenen mittels breitspektrum-pulslicht
AU5425400A (en) 1999-04-12 2000-11-14 University Of Madras A pharmaceutical formulation useful for the treatment of hepatitis B, hepatitis C and other viral infections of the liver and a process for its preparation
US6849254B1 (en) 1999-04-19 2005-02-01 Schering Corporation HCV combination therapy
EP1200455B1 (en) 1999-07-22 2009-04-22 Celmed Oncology (USA), Inc. Enzyme catalyzed therapeutic activation
JP2003507339A (ja) 1999-08-13 2003-02-25 エフ．ホフマン−ラ ロシュ アーゲー ＰＥＧ−ＩＦＮ−αと共同させたミコフェノラートモフェチル
US20050245502A1 (en) 1999-08-23 2005-11-03 Phoenix Biosciences Treatments for viral infections
KR100392292B1 (ko) 2000-01-07 2003-07-22 주식회사 펩트론 5원환 융합 방향족 헤테로사이클릭 화합물을 유효성분으로 하는 hcv 치료제 조성물
AU2001253206A1 (en) 2000-04-05 2001-10-23 Tularik, Inc. Ns5b hcv polymerase inhibitors
US7018796B2 (en) 2000-04-07 2006-03-28 Shionogi & Co., Ltd. Preincubation assay methods
DE60135366D1 (de) 2000-04-18 2008-09-25 Virco Bvba Methode zur bestimmung der resistenz gegen medikamente
US6415797B1 (en) 2000-07-07 2002-07-09 First Circle Medical, Inc. Treatment of human herpesviruses using hyperthermia
KR100939155B1 (ko) 2000-07-21 2010-01-28 쉐링 코포레이션 Ｃ형 간염 바이러스의 ｎｓ3-세린 프로테아제 억제제로서의신규한 펩티드
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
RU2003102887A (ru) 2000-08-02 2004-07-27 Орто-Макнейл Фармасьютикал, Инк. (Us) Усовершенствованная противовирусная и противоопухолевая химиотерапии путем введения эритропоэтина
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
PT1326632E (pt) 2000-10-12 2007-01-31 Viromics Gmbh Tratamento para o tratamento de infecções por vírus da hepatite
WO2002030259A2 (en) 2000-10-13 2002-04-18 Monash University Disease prevention by reactivation of the thymus
JP2004511513A (ja) 2000-10-18 2004-04-15 シェリング・コーポレーション リバビリン−ＰＥＧ化インターフェロンαＨＣＶ併用治療
FR2815543B1 (fr) 2000-10-19 2003-10-24 Sedat Seringue d'auto-injection d'un melange extemporane
EP2027867A1 (en) 2000-10-20 2009-02-25 Genetics Institute, LLC Method and composition for inhibition of tumor growth and enhancing an immune response
AU2002235126A1 (en) 2000-11-08 2002-05-21 Slil Biomedical Corporation Novel polyamine analog-amino acid conjugates useful as anticancer agents
AU2002245081A1 (en) 2000-12-06 2002-07-16 The Trustees Of The University Of Pennsylvania Single therapy and combination therapy involving drugs with target cellular proteins and drugs which target pathogen-encoded proteins
SI1355916T1 (sl) 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
US7105499B2 (en) 2001-01-22 2006-09-12 Merck & Co., Inc. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
CN1245215C (zh) 2001-02-28 2006-03-15 四川省生物工程研究中心 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
GB0107924D0 (en) 2001-03-29 2001-05-23 Angeletti P Ist Richerche Bio Inhibitor of hepatitis C virus NS3 protease
US6673775B2 (en) 2001-04-18 2004-01-06 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
AU2002259130A1 (en) 2001-05-03 2002-11-18 Eli Lilly And Company Agents for treatment of hcv and methods of use
US6833351B2 (en) 2001-05-21 2004-12-21 Douglas T. Dieterich Method of treating anemia caused by ribavirin treatment of hepatitis C using erythropoietin alpha
RU2004102500A (ru) 2001-06-29 2005-04-10 Максиген Апс (Dk) Композиции интерферонов
US20030138403A1 (en) 2001-06-29 2003-07-24 Maxygen Aps Interferon formulations
HUP0401156A2 (hu) 2001-07-20 2004-12-28 Intermune, Inc. Májfibrózis kezelésére szolgáló módszerek
WO2003024461A1 (en) 2001-09-20 2003-03-27 Schering Corporation Hcv combination therapy
PL369129A1 (en) 2001-09-28 2005-04-18 Intermune, Inc. Method for treating hepatitis c virus infection in treatment failure patients
MXPA04002915A (es) 2001-09-28 2004-07-05 Intermune Inc Metodo para tratar infeccion de virus de hepatitis c en pacientes que han fallado el tratamiento.
BR0213103A (pt) 2001-10-05 2004-09-21 Intermune Inc Método para tratamento de infecção pelo vìrus da hepatite com um perfil de liberação de interferon multifásico
PE20030545A1 (es) 2001-10-31 2003-06-19 Schering Corp Formulaciones de jarabe de ribavirina
WO2003037908A1 (en) 2001-10-31 2003-05-08 Ribapharm Inc. Antiviral combination therapy and compositions
WO2003042377A1 (en) 2001-11-07 2003-05-22 Kirin Beer Kabushiki Kaisha Expansion of t cells in vitro and expanded t cell populations
AUPR879601A0 (en) 2001-11-09 2001-12-06 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
WO2003049760A1 (en) 2001-12-07 2003-06-19 Intermune, Inc. Compositions and method for treating hepatitis virus infection
EP1321463B1 (en) 2001-12-21 2007-08-08 Virochem Pharma Inc. Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections
US6906190B2 (en) 2002-01-04 2005-06-14 Ribapharm Inc. Inhibitors for de novo-RNA polymerases and methods of identifying targets for same
RU2212248C1 (ru) 2002-01-21 2003-09-20 Государственное образовательное учреждение высшего профессионального образования Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Способ лечения больных хроническим вирусным гепатитом c
JP2005522457A (ja) 2002-02-26 2005-07-28 ノース ショア−ロング アイランド ジューイッシュ リサーチ インスティチュート 脳ムスカリン性レセプターの刺激による炎症性サイトカイン産生の阻害
CA2383243A1 (en) 2002-04-23 2003-10-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for inhibiting fibrogenesis
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
WO2003101199A1 (en) 2002-05-31 2003-12-11 Schering Corporation Combination therapy for rna virus infections involving ribavirin and impdh inhibitors
TWI334785B (en) 2002-06-03 2010-12-21 Serono Lab Use of recombinant ifn-β1a and pharmaceutical composition comprising recombinant ifn-β1a for the treatment of hcv infection in patients of asian race
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
ES2350687T3 (es) 2002-07-03 2011-01-26 Ono Pharmaceutical Co., Ltd. Composiciones de inmunopotenciación.
ITMI20021860A1 (it) 2002-08-28 2004-02-29 Scalia Antonio Cassar Impiego dei triptani come agenti antivirali.
EP1556498A1 (en) 2002-11-01 2005-07-27 Cadila Healthcare Ltd. Method for producing recombinant human interferon alpha 2b polypeptide in pichia pastoris
AU2003287666A1 (en) 2002-11-13 2004-06-03 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
AU2003295773A1 (en) 2002-11-21 2004-06-18 Novacea, Inc. Treatment of liver disease with active vitamin d compounds
EP1596846A2 (en) 2003-02-18 2005-11-23 Pfizer Inc. Inhibitors of hepatitis c virus, compositions and treatments using the same
US20070077225A1 (en) 2003-02-28 2007-04-05 Blatt Lawrence M Continuous delivery methods for treating hepatitis virus infection
WO2004078194A1 (en) 2003-02-28 2004-09-16 Intermune, Inc. Interferon drug therapy for the treatment of viral diseases and liver fibrosis
WO2005016288A2 (en) 2003-02-28 2005-02-24 Intermune, Inc. Methods and compositions for treatment of viral diseases
TWI269656B (en) 2003-03-05 2007-01-01 Original Image Co Ltd Therapeutical composition for hepatitis C
UA64191A (en) 2003-03-14 2004-02-16 Yevhenii Mykhailovych Neiko Method for treating chronic hepatitises of various etiology
US20040198840A1 (en) 2003-04-02 2004-10-07 Deloach Reuben Edwin Hydrazide substrate safely shuts down disease activated protease to halt viral replication, cancerous cell division, and toxic protein generation
ES2320771T3 (es) 2003-04-16 2009-05-28 Bristol-Myers Squibb Company Inhibidores peptidicos de isoquinolina macrociclicos del virus de la hepatitis c.
US20040258663A1 (en) 2003-05-08 2004-12-23 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of interferon alpha
US20050009877A1 (en) 2003-05-15 2005-01-13 Henry Lu Methods of identifying HCV NS5B polymerase inhibitors and their uses
AU2004240704B9 (en) 2003-05-21 2009-10-22 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor compounds
ES2726998T3 (es) 2003-05-30 2019-10-11 Gilead Pharmasset Llc Análogos de nucleósidos fluorados modificados
US20050187170A1 (en) 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
CN101014349A (zh) 2003-06-20 2007-08-08 病毒基因混和公司 抗病毒组合物及其使用方法
EP1648997A2 (en) 2003-07-11 2006-04-26 Oregon Health and Science University Methods of treatment and disgnosis using modulators of virus-induced cellular gene sequences
MD2549G2 (ro) 2003-07-18 2005-08-31 Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова Metodă de tratament a hepatitei virale cronice C.
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
WO2005018330A1 (en) 2003-08-18 2005-03-03 Pharmasset, Inc. Dosing regimen for flaviviridae therapy
BRPI0414045A (pt) 2003-09-05 2006-10-24 Anadys Pharmaceuticals Inc administração de ligantes de tlr7 e pró-medicamentos dos mesmos para tratamento de infecção por vìrus de hepatite c
WO2005023289A1 (ja) 2003-09-08 2005-03-17 Intellectual Property Consulting Incorporated 慢性ｃ型肝炎を治療するための医薬組成物
AR045870A1 (es) 2003-10-11 2005-11-16 Vertex Pharma Terapia de combinacion para la infeccion de virus de hepatitis c
CN103145715B (zh) 2003-10-14 2016-08-03 F·霍夫曼-罗须公司 作为hcv复制抑制剂的巨环羧酸和酰基磺酰胺
US7491794B2 (en) 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
WO2005038056A1 (en) 2003-10-14 2005-04-28 Intermune, Inc. Combination therapy for the treatment of viral diseases
US20050085528A1 (en) 2003-10-17 2005-04-21 Pfizer Inc. Parmaceutical
CN1898569A (zh) 2003-10-24 2007-01-17 伊缪因艾德有限公司 治疗方法
WO2005043118A2 (en) 2003-10-27 2005-05-12 Vertex Pharmaceuticals Incorporated Drug discovery method
DE602004018363D1 (de) 2003-10-27 2009-01-22 Vertex Pharma Kombinationen für die hcv-behandlung
UA68233A (en) 2003-11-25 2004-07-15 Univ Zaporizhia State Medical Method for treating chronic hepatitis c
US7078064B2 (en) 2003-12-03 2006-07-18 George Zabrecky Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis
EP2546254A1 (en) 2003-12-22 2013-01-16 K.U.Leuven Research & Development Imidazo[4,5-C]pyridine compounds and methods of antiviral treatment
WO2005062949A2 (en) 2003-12-23 2005-07-14 Intermune, Inc. Method for treating hepatitis virus infection
US20070258946A1 (en) 2003-12-23 2007-11-08 Blatt Lawrence M Combination Therapy for Treating Hepatitis C Virus Infection
WO2005067963A1 (en) 2003-12-23 2005-07-28 Intermune, Inc. Use of polyethylene glycol-modified interferon-alpha in therapeutic dosing regimens
DE10361944A1 (de) 2003-12-31 2005-07-28 Viromics Gmbh Mittel zur Hemmung der Virusreplikation durch Regulation der Proteinfaltung
US20080234182A1 (en) 2007-03-22 2008-09-25 Innovative Biologics, Inc. Blockers of pore-forming virulence factors and their use as anti-infectives
US20080004236A1 (en) 2004-02-06 2008-01-03 Comper Wayne D High Dose, Short Interval Use of Sulfated Polysaccharides for Treatment of Infections
CA2557322A1 (en) 2004-02-27 2005-09-15 Schering Corporation Inhibitors of hepatitis c virus ns3 protease
US7977326B2 (en) 2004-04-22 2011-07-12 Howard J Smith Supportive treatment of liver disease
ATE494373T2 (de) 2004-05-04 2011-01-15 Univ Leland Stanford Junior Verfahren und zusammensetzungen zur verringerung von hcv virusgenommengen in einer zielzelle
CA2565658A1 (en) 2004-05-06 2005-11-17 Conjuchem Biotechnologies Inc. Compounds for specific viral target
PE20060309A1 (es) 2004-05-06 2006-04-13 Schering Corp (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil]-3-[(2s)-2[[[(1,1-dimetiletil)amino]carbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3.1.o]hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de l
WO2006016930A2 (en) 2004-05-14 2006-02-16 Intermune, Inc. Methods for treating hcv infection
WO2005116054A1 (en) 2004-05-25 2005-12-08 Boehringer Ingelheim International, Gmbh Process for preparing acyclic hcv protease inhibitors
KR101370580B1 (ko) 2004-06-08 2014-03-06 버텍스 파마슈티칼스 인코포레이티드 약학 조성물
WO2006005610A1 (en) 2004-07-14 2006-01-19 Novartis Ag Use of a combination of cyclosporine and pegylated interferon for treating hepatitis c (hcv)
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
EP1627641A1 (en) 2004-08-04 2006-02-22 Victor Eluwa Pharmaceutical compositions comprising metal oxides and uses thereof
US7348425B2 (en) 2004-08-09 2008-03-25 Bristol-Myers Squibb Company Inhibitors of HCV replication
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
WO2006037052A2 (en) 2004-09-27 2006-04-06 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Modulating mxa expression
RU2007116265A (ru) 2004-10-01 2008-11-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Ингибирование протеазы ns3-ns4a вируса hcv
EP1793844B1 (en) 2004-10-01 2010-12-08 Debiopharm S.A. Use of [d-meala]3-[etval]4-cyclosporin for the treatment of hepatitis c infection
US7723310B2 (en) 2004-10-18 2010-05-25 Three Rivers Pharmaceuticals, Llc Large dose ribavirin formulations
US20060228333A1 (en) 2004-10-20 2006-10-12 Kye-Hyung Paik Methods for control of tumors and chronic infections by modulating immunologically informed carriers homing to tolerogenic organs or tissues
WO2006043153A2 (en) 2004-10-20 2006-04-27 Michel Xilinas Use of zinc and copper chelators for the treatment of viral diseases
WO2006046039A2 (en) 2004-10-26 2006-05-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Tetracyclic indole derivatives as antiviral agents
MY141025A (en) 2004-10-29 2010-02-25 Vertex Pharma Dose forms
US7592315B2 (en) 2004-11-02 2009-09-22 Schering Corporation Peptide viral entry inhibitors
WO2006055711A1 (en) 2004-11-18 2006-05-26 Kent Hann Compositions containing aloe vera isolate and a prebiotic and their therapeutic application
EP1827460A4 (en) 2004-12-09 2012-03-14 Univ Minnesota NUCLEOSIDE WITH ANTIVIRAL AND ANTI-CANCER EFFECT
TW200633718A (en) 2004-12-16 2006-10-01 Applied Research Systems Treatment of hepatitis c in the asian population
DE102004061746A1 (de) 2004-12-22 2006-07-06 Bayer Healthcare Ag Alkinyl-substituierte Thiophene
EP1674104A1 (en) 2004-12-24 2006-06-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Uridine derivatives as antiviral drugs against a flaviviridae, especially HCV
EP1679065A1 (en) 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
MX2007008640A (es) 2005-01-17 2007-09-12 Jerini Ag Antagonistas del receptor de c5a.
CA2596966A1 (en) 2005-02-03 2006-08-10 Intarcia Therapeutics, Inc. Implantable osmotic device for continuous delivery of suspension formulations
EA200701669A1 (ru) 2005-02-09 2008-02-28 Мидженикс Инк. Композиции и способы лечения или предотвращения инфекций, вызванных вирусами семейства flaviviridae
WO2006089113A2 (en) 2005-02-18 2006-08-24 Intermune, Inc. Biomarkers for predicting liver fibrosis treatment efficacy
US8232240B2 (en) 2005-02-23 2012-07-31 The Brigham And Women's Hospital, Inc. Inhibitors of enveloped virus infectivity
US20090156545A1 (en) 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
US20060229293A1 (en) 2005-04-06 2006-10-12 Addiction Research Institute, Inc. Compositions for the treatment of hepatitis C and methods for using compositions for the treatment of hepatitis C
JP2008538354A (ja) 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
WO2006113431A2 (en) 2005-04-13 2006-10-26 University Of Massachusetts Dual functional oligonucleotides for use as anti-viral agents
US20060241144A1 (en) 2005-04-20 2006-10-26 Albert Cha Method for treating apathy syndrome
SG161315A1 (en) 2005-05-13 2010-05-27 Virochem Pharma Inc Compounds and methods for the treatment or prevention of flavivirus infections
WO2006127482A1 (en) 2005-05-20 2006-11-30 Bioenvision, Inc. Methylene blue therapy of viral disease
EP1881828A4 (en) 2005-05-20 2009-06-03 Valeant Res & Dev TREATMENT OF HEPATITIS C (HCV) USING SUB-THERAPEUTIC DOSES OF RIBAVIRIN
JP2008545409A (ja) 2005-05-26 2008-12-18 シェーリング コーポレイション インターフェロン−ＩｇＧ融合体
AU2006252718B2 (en) 2005-05-31 2010-04-15 Novartis Ag Treatment of liver diseases in which iron plays a role in pathogenesis
US7793040B2 (en) 2005-06-01 2010-09-07 Microsoft Corporation Content addressable memory architecture
PE20070011A1 (es) 2005-06-02 2007-03-08 Schering Corp Formulaciones farmaceuticas de compuestos inhibidores de proteasa del vhc o catepsina
US20070232527A1 (en) 2005-06-02 2007-10-04 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
PL1891089T3 (pl) 2005-06-02 2015-05-29 Merck Sharp & Dohme Inhibitory proteazy HCV w połączeniu z pokarmem
US20070021351A1 (en) 2005-06-02 2007-01-25 Schering Corporation Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor
US20060281689A1 (en) 2005-06-02 2006-12-14 Schering Corporation Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
WO2006130553A2 (en) 2005-06-02 2006-12-07 Schering Corporation Hcv protease inhibitors
US20060275366A1 (en) 2005-06-02 2006-12-07 Schering Corporation Controlled-release formulation
WO2006130554A2 (en) 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis c virus
US20060276406A1 (en) 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis C virus
US20070237818A1 (en) 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
WO2006130688A2 (en) 2005-06-02 2006-12-07 Schering Corporation Compounds for inhibiting cathepsin activity
US20060276404A1 (en) 2005-06-02 2006-12-07 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
US20070207949A1 (en) 2005-06-02 2007-09-06 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
ES2392544T3 (es) 2005-06-07 2012-12-11 Yale University Métodos de tratamiento del cáncer y otras enfermedades o estados patológicos usando LFMAU y LDT
RU2293572C1 (ru) 2005-07-18 2007-02-20 Гюнтер Хаазе Способ лечения хронического вирусного гепатита с генотип-2 с умеренной активностью
US7470664B2 (en) 2005-07-20 2008-12-30 Merck & Co., Inc. HCV NS3 protease inhibitors
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP2402331A1 (en) 2005-08-02 2012-01-04 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
MX2008001865A (es) 2005-08-12 2008-04-15 Human Genome Sciences Inc Proteinas de fusion de albumina.
DE102005038768A1 (de) 2005-08-16 2007-02-22 Toximed Gmbh Pharmazeutischer Wirkstoff gegen Borreliose
SI1934179T1 (sl) 2005-08-19 2010-08-31 Vertex Pharma Postopki in intermediati
WO2007030560A2 (en) 2005-09-08 2007-03-15 Philadelphia Health & Education Corporation, D/B/A Drexel University College Of Medicine Identification of modulators of serine protease inhibitor kazal and their use as anti-cancer and anti-viral agents
US7531164B2 (en) 2005-10-21 2009-05-12 Duke University Preventing bacterial or viral infectivity and composition containing infection preventing additive
IE20050723A1 (en) 2005-10-28 2007-05-30 Patrick T Prendergast Anti-mineralocorticoid therapy of infection
WO2007056016A2 (en) 2005-11-02 2007-05-18 Kemia, Inc. Bisamide cytokine inhibitors
RU2306134C2 (ru) 2005-11-07 2007-09-20 Государственное образовательное учреждение высшего профессионального образования "Самарский Государственный медицинский университет" Способ базисного лечения хронического вирусного гепатита c
CA2629343A1 (en) 2005-11-11 2007-05-24 Vertex Pharmaceuticals, Inc. Hepatitis c virus variants
WO2007058384A1 (en) 2005-11-17 2007-05-24 Osaka University Method of suppressing replication of hepatitis c virus, inhibitor of replication of the virus and method of screening for the same
RU2326115C2 (ru) 2005-11-21 2008-06-10 Ефаг АО Соли 1-алкиламино-1-дезоксиполиолов с 9-оксоакридин-10-уксусной кислотой, лекарственные препараты на их основе, применение, способы профилактики и лечения
AR057623A1 (es) 2005-11-28 2007-12-05 Omega Bio Pharma H K Ltd Materiales y metodos para el tratamiento de las infecciones virales
WO2007064691A1 (en) 2005-12-02 2007-06-07 Nabil Habib Lab Treatment of cancer and other diseases
WO2007065829A1 (en) 2005-12-09 2007-06-14 F. Hoffmann-La Roche Ag Antiviral nucleosides
WO2007075896A2 (en) 2005-12-22 2007-07-05 Kemia, Inc. Heterocyclic cytokine inhibitors
RU2306934C1 (ru) 2005-12-28 2007-09-27 ГОУ ВПО Омская Государственная Медицинская Академия Способ лечения больных хроническим вирусным гепатитом c
EA015560B1 (ru) 2006-01-09 2011-08-30 Ромарк Лэборетериз, Эл.Си. Способ лечения вирусного гепатита
MD20060037A (ro) 2006-01-24 2007-07-31 Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова Metodă de tratament al hepatitei virale acute C
US20070224167A1 (en) 2006-02-09 2007-09-27 Schering Corporation Novel HCV inhibitor combinations and methods
AR059429A1 (es) 2006-02-09 2008-04-09 Schering Corp Combinaciones que involucran el (los) inhibidor(es) de la protesa hcv y metodos de tratamiento relacionados al (los) mismo (s)
CN101489557B (zh) 2006-02-27 2013-12-18 弗特克斯药品有限公司 包含vx-950的共晶体和包含所述共晶体的药物组合物
NZ571280A (en) 2006-03-16 2011-10-28 Vertex Pharma Deuterated hepatitis C protease inhibitors
CA2645566A1 (en) 2006-03-20 2007-09-27 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
TWI428125B (zh) 2006-03-20 2014-03-01 Vertex Pharma 對包括vx-950之藥物實施噴霧乾燥之方法及由此方法製備之產物
EP1998759A2 (en) 2006-03-23 2008-12-10 Schering Corporation Combinations of hcv protease inhibitor(s) and cyp3a4 inhibitor(s), and methods of treatment related thereto
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
WO2007130646A2 (en) 2006-05-04 2007-11-15 The Rockefeller University Hcv coreceptor and methods of use thereof
WO2008060695A2 (en) 2006-05-22 2008-05-22 The Trustees Of The University Of Pennsylvania Antiviral inhibition of casein kinase ii
DE102006026464A1 (de) 2006-06-01 2007-12-06 Virologik Gmbh Innovationszentrum Medizintechnik Und Pharma Pharmazeutische Zusammensetzung zur Behandlung von Virusinfektionen und / oder Tumorerkrankungen durch Inhibition der Proteinfaltung und des Proteinabbaus
WO2007143164A1 (en) 2006-06-02 2007-12-13 San Diego State University Research Foundation Compositions and methods for ameliorating hyperlipidemia
EP2029730A1 (en) 2006-06-04 2009-03-04 Cellartis AB Novel hepatocyte-like cells and hepatoblast-like cells derived from hbs cells
AU2007257959A1 (en) 2006-06-09 2007-12-21 Kemia, Inc. Therapy using cytokine inhibitors
WO2007149382A2 (en) 2006-06-19 2007-12-27 The Cleveland Clinic Foundation Therapeutic compositions and methods useful in treating hepatitis
KR20090024834A (ko) 2006-07-05 2009-03-09 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규 억제제
US20080081791A1 (en) 2006-07-06 2008-04-03 Weida Huang Methods of using combinations of siRNAs for treating a disease or a disorder, and for enhancing siRNA efficacy in RNAi
ATE554776T1 (de) 2006-07-07 2012-05-15 Gilead Sciences Inc Antivirale phosphinatverbindungen
EP2374812B1 (en) 2006-07-13 2015-04-15 Achillion Pharmaceuticals, Inc. 4-amino-4-oxobutanoyl Peptides as Inhibitors of Viral Replication
US8329159B2 (en) 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2008022006A2 (en) 2006-08-11 2008-02-21 Enanta Pharmaceuticals, Inc. Arylalkoxyl hepatitis c virus protease inhibitors
US20100158862A1 (en) 2006-08-11 2010-06-24 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
EP1886685A1 (en) 2006-08-11 2008-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition
EP2054076A2 (en) 2006-08-21 2009-05-06 United Therapeutics Corporation Combination therapy for treatment of viral infections
WO2008024763A2 (en) 2006-08-25 2008-02-28 Wyeth Identification and characterization of hcv replicon variants with reduced susceptibility to hcv-796, and methods related thereto
TW200815384A (en) 2006-08-25 2008-04-01 Viropharma Inc Combination therapy method for treating hepatitis C virus infection and pharmaceutical compositions for use therein
US7655419B2 (en) 2006-08-25 2010-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for identifying anti-HCV agents
WO2008032227A2 (en) 2006-09-11 2008-03-20 Biomas, Ltd. Topical formulations of tellurium-containing compounds
US20080161324A1 (en) 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
JP2010503396A (ja) 2006-09-14 2010-02-04 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド アルブミン融合タンパク質
WO2008039179A1 (en) 2006-09-26 2008-04-03 Addiction Research Institute, Inc. Compositions for the treatment of hepatitis c and methods for using compositions for the treatment of hepatitis c
WO2008045419A1 (en) 2006-10-10 2008-04-17 Pharmasset, Inc. Preparation of nucleosides ribofuranosyl pyrimidines
US7777395B2 (en) 2006-10-12 2010-08-17 Eastman Kodak Company Continuous drop emitter with reduced stimulation crosstalk
EP2086982B1 (en) 2006-10-27 2018-08-29 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
EP2559691A1 (en) 2006-11-15 2013-02-20 Virochem Pharma Inc. Thiophene analogues for the treatment or prevention of Flavivirus infections
WO2008143647A2 (en) 2006-11-29 2008-11-27 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating viral infection
EP2099430A2 (en) 2006-12-07 2009-09-16 Schering Corporation Ph sensitive matrix formulation
RU2336096C1 (ru) 2006-12-14 2008-10-20 ООО Медицинский центр "Столица" Способ лечения гепатита с
RU2345787C2 (ru) 2006-12-25 2009-02-10 Государственное образовательное учреждение высшего профессионального образования "Самарский Государственный медицинский университет" Способ лечения хронического вирусного гепатита с
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
EP2111227A1 (en) 2007-01-08 2009-10-28 Phenomix Corporation Macrocyclic hepatitis c protease inhibitors
WO2008089034A2 (en) 2007-01-11 2008-07-24 Kemia, Inc. Cytokine inhibitors
US7645732B2 (en) 2007-01-24 2010-01-12 Board Of Regents, The University Of Texas System Treating hepatitis C virus infection
CN104230918B (zh) 2007-02-01 2018-01-26 爱尔兰詹森科学公司 Hcv巨环抑制剂的多晶形
TWI426918B (zh) 2007-02-12 2014-02-21 Merck Sharp & Dohme Ｉｌ-２３拮抗劑於治療感染之用途
CA2683383C (en) 2007-02-21 2016-01-05 Allaccem, Incorporated Bridged polycyclic compound based compositions for the inhibition and amelioration of disease
HRP20120330T1 (hr) 2007-02-27 2012-05-31 Vertex Pharmaceuticals Incorporated Sukristali i farmaceutski pripravci koji ih sadrže
WO2008106167A1 (en) 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
MD3477G2 (ro) 2007-03-21 2008-08-31 Николае БОДРУГ Metodă de tratament al hepatitei virale cronice C
DK2308514T3 (da) 2007-03-23 2013-09-02 To Bbb Holding B V Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren
US7964580B2 (en) * 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
WO2008124384A2 (en) 2007-04-03 2008-10-16 Aegerion Pharmaceuticals, Inc. Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c
WO2008133966A1 (en) 2007-04-27 2008-11-06 Chimerix, Inc. Methods of reducing nephrotoxicity in subjects administered with nucleoside
US20080269205A1 (en) 2007-04-27 2008-10-30 Ondine International, Ltd. Methods to prevent vertical transmission of infectious diseases
CN101784549A (zh) 2007-05-03 2010-07-21 因特蒙公司 丙型肝炎病毒复制的新颖大环抑制剂
US8258116B2 (en) 2007-05-04 2012-09-04 Vertex Pharmaceuticals Incorporated Combination therapy for the treatment of HCV infection
AU2008251425A1 (en) 2007-05-10 2008-11-20 Array Biopharma, Inc. Novel peptide inhibitors of hepatitis C virus replication
MX2009012598A (es) 2007-05-21 2009-12-07 Vertex Pharma Formas de dosis que comprenden vx-950 y su regimen de dosificacion.
RU2348412C1 (ru) 2007-06-01 2009-03-10 Лариса Леонидовна Попова Способ профилактики рецидива хронического вирусного гепатита с после достижения вирусологической ремиссии
WO2008154248A1 (en) 2007-06-06 2008-12-18 Inova Health System Prognostic chronic hepatitis c biomarkers
KR101596524B1 (ko) 2007-06-29 2016-02-22 길리애드 사이언시즈, 인코포레이티드 항바이러스 화합물
CN100532388C (zh) 2007-07-16 2009-08-26 郑州大学 2’-氟-4’-取代-核苷类似物、其制备方法及应用
EP2175865A4 (en) 2007-07-25 2012-01-11 Biolex Therapeutics Inc INTERFERON DRUG PRODUCTS WITH CONTROLLED RELEASE AND TREATMENT OF HCV INFECTIONS THEREWITH
CA2698038A1 (en) 2007-07-26 2009-01-29 Entra Pharmaceuticals Inc. Systems and methods for delivering drugs
CN101827589B (zh) 2007-08-03 2016-08-17 拜伊特朗有限公司 抗丙型肝炎病毒的组合物及方法
US7728027B2 (en) 2007-08-08 2010-06-01 Bristol-Myers Squibb Company Process for synthesizing compounds useful for treating hepatitis C
US8629171B2 (en) 2007-08-08 2014-01-14 Bristol-Myers Squibb Company Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt
US20110166092A1 (en) 2007-08-20 2011-07-07 Anadys Pharmaceuticals, Inc. Dosing methods for treating disease
NZ583699A (en) 2007-08-30 2012-04-27 Vertex Pharma Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same
WO2009033183A2 (en) 2007-09-08 2009-03-12 University Of Florida Research Foundation Compounds and methods for treatment of hcv and conditions associated with cd81 binding
US20090076100A1 (en) 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched gsk625433
EP2061513B1 (en) 2007-09-14 2011-08-10 Schering Corporation Method of treating hepatitis c patients
WO2009039127A1 (en) 2007-09-17 2009-03-26 Abbott Laboratories Uracil or thymine derivative for treating hepatitis c
CA2699986C (en) * 2007-09-17 2014-06-17 Abbott Laboratories Anti-infective pyrimidines and uses thereof
WO2009039248A2 (en) 2007-09-18 2009-03-26 Stanford University Methods of treating a flaviviridae family viral infection and compositions for treating a flaviviridae family viral infection
US20090082366A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched telaprevir
US20090082414A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched viramidine
CA2701190C (en) 2007-10-03 2017-12-05 Sabell Corporation Herbal compositions and methods for treating hepatic disorders
EP2211895A2 (en) 2007-10-05 2010-08-04 Medtronic, Inc. Use of a specific dosage regimen of ifn-alpha and ribavirin for treating hepatitis c
WO2009061395A2 (en) 2007-11-05 2009-05-14 Vertex Pharmaceuticals Incorporated Hcv combination therapies
PL2219642T3 (pl) 2007-11-15 2012-02-29 Madaus Gmbh Komponent sylibininy do leczenia zapalenia wątroby
EP2237666A4 (en) 2007-12-21 2012-05-16 Avila Therapeutics Inc HCV PROTEASE INHIBITORS AND USES THEREOF
US8202996B2 (en) * 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
CA2709032C (en) 2007-12-21 2016-02-23 F. Hoffmann-La Roche Ag Process for the preparation of a macrocycle
WO2009085267A1 (en) 2007-12-27 2009-07-09 Epiphany Biosciences Antiviral compounds
EP2268811A1 (en) 2008-03-07 2011-01-05 Santaris Pharma A/S Pharmaceutical compositions for treatment of microrna related diseases
JP5283106B2 (ja) 2008-03-14 2013-09-04 国立大学法人 熊本大学 Ｃ型肝炎ウイルス阻害剤
US20100009970A1 (en) 2008-03-19 2010-01-14 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US20110045001A1 (en) 2008-03-28 2011-02-24 Biontex Laboratories Gmbh Transfection results of non-viral gene delivery systems by influencing of the innate immune system
AU2009241514A1 (en) 2008-04-15 2009-11-05 Intermune, Inc. Novel inhibitors of hepatitis C virus replication
US8008264B2 (en) * 2008-04-23 2011-08-30 Gilead Sciences, Inc. 1′-substituted carba-nucleoside analogs for antiviral treatment
NZ588655A (en) 2008-04-23 2012-12-21 Vertex Pharma Treatment of hepatitis c virus infections with telaprevir (vx-950) in patients non-responsive to treatment with pegylated interfer0n-alpha-2a/2b and ribavirin
DE102008029669A1 (de) 2008-05-16 2009-11-19 Schlaak, Jörg Friedrich, Prof. Dr. med. Neue Therapeutika für die Hepatitis-Therapie
US20110218512A1 (en) 2008-06-03 2011-09-08 Aethlon Medical, Inc. Enhanced antiviral therapy methods and devices
JP2011522834A (ja) 2008-06-05 2011-08-04 ザイモジェネティクス リミテッド ライアビリティ カンパニー Ｃ型肝炎の治療のためのペグ化ｉｉｉ型インターフェロンの使用
AU2009256623A1 (en) 2008-06-10 2009-12-17 Janssen Pharmaceutica Nv Telaprevir dosing regimen
CN102123706B (zh) 2008-06-17 2013-08-14 米纳斯吉拉斯联合大学 血小板活化因子受体在治疗黄病毒科病毒引起的感染中的用途
SI2310095T1 (sl) 2008-07-22 2013-01-31 Merck Sharp & Dohme Corp. Makrocikliäśne kuinoksalinske spojine kot hcv ns3 proteazni inhibitorji
US20100034839A1 (en) 2008-07-25 2010-02-11 Martha Karen Newell Methods for treating viral disorders
RU2373952C1 (ru) 2008-07-30 2009-11-27 Юрий Михайлович Амбалов Способ лечебного питания больных хроническим гепатитом с, получающих комплексную противовирусную терапию
US20110200558A1 (en) 2008-08-06 2011-08-18 Sciclone Pharmaceuticals, Inc. Treatment or Prevention of Hepatitis C with Immunomodulator Compounds
WO2010015545A1 (en) 2008-08-07 2010-02-11 F. Hoffmann-La Roche Ag Process for the preparation of a macrocycle
JP2011530532A (ja) 2008-08-07 2011-12-22 シェーリング コーポレイション 固体分子分散物中のｈｃｖプロテアーゼインヒビターの薬学的処方物
US20100092479A1 (en) 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
WO2010020676A1 (en) 2008-08-20 2010-02-25 Vib Vzw The use of topoisomerase type i inhibitors to treat viral infections
CN102307589A (zh) 2008-08-28 2012-01-04 沃泰克斯药物股份有限公司 Hcv的基因型分析
CN102137682B (zh) 2008-08-29 2014-07-02 国立大学法人大阪大学 抗丙型肝炎病毒组合物
KR20110050549A (ko) 2008-09-03 2011-05-13 버텍스 파마슈티칼스 인코포레이티드 공-결정 및 이를 포함하는 제약 제제
UY32099A (es) * 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
PE20110388A1 (es) 2008-09-16 2011-07-01 Boehringer Ingelheim Int Formas cristalinas de un derivado de peptido como inhibidores de hcv
JP5539363B2 (ja) 2008-09-17 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インターフェロンおよびリバビリンとのｈｃｖｎｓ３プロテアーゼ阻害剤の組合せ
WO2010031832A2 (en) 2008-09-18 2010-03-25 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Synergistic combinations of a macrocyclic inhibitor of hcv and a thiophene-2-carboxylic acid derivative
EP2328656A1 (en) 2008-09-24 2011-06-08 Vertex Pharmaceuticals Incorporated Therapeutic regimen comprising peg- interferon, ribavirin and vx-950 for the treatment of hepatitis "
WO2010034670A2 (en) 2008-09-26 2010-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Host cell kinases as targets for antiviral therapies against hcv infection
EP2343066A4 (en) 2008-09-30 2012-08-29 Mochida Pharm Co Ltd THERAPEUTIC AGENT FOR HEPATITIS C
WO2010039801A2 (en) 2008-10-02 2010-04-08 The J. David Gladstone Institutes Methods of treating hepatitis c virus infection
WO2010042683A1 (en) 2008-10-08 2010-04-15 The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Medical Center Treating hepatitis c virus infection with over-expression of microrna-196
KR20110075019A (ko) 2008-10-15 2011-07-05 인터뮨, 인크. 치료용 항바이러스성 펩티드
WO2010049438A2 (en) 2008-10-30 2010-05-06 Innate Pharma Improved methods of using phosphoantigens for the treatment of diseases
WO2010053942A1 (en) 2008-11-05 2010-05-14 Vertex Pharmaceuticals Incorporated Methods for treating hepatitis c virus infection
SI2358355T1 (sl) 2008-11-21 2014-02-28 Boehringer Ingelheim Gmbh Farmacevtski sestavek potentnega inhibitorja HCV za oralno dajanje
CA2746264C (en) 2008-12-10 2017-11-14 Achillion Pharmaceuticals, Inc. New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
EP2356236B1 (en) 2008-12-11 2015-07-29 Xiangxue Group (Hong Kong) Company Limited siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION
WO2010069809A1 (en) 2008-12-18 2010-06-24 F. Hoffmann-La Roche Ag Biomarkers for hcv treatment response
KR20110098849A (ko) 2008-12-23 2011-09-01 파마셋 인코포레이티드 뉴클레오시드 유사체
EP2376653A2 (en) 2008-12-29 2011-10-19 Yissum Research Development Company of The Hebrew University of Jerusalem Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection
US8840934B2 (en) 2009-01-02 2014-09-23 Rainbow Pharmaceutical Sa Uses of ammonium chloride
MX2011007364A (es) * 2009-01-09 2012-02-28 Univ Cardiff Derivados de fosforamidato de compuestos de nuecleosido de guanosina para tratamiento de infecciones virales.
RU2398582C1 (ru) 2009-01-19 2010-09-10 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.М. Мечникова Федерального агентства по здравоохранению и социальному развитию" Способ лечения хронического вирусного гепатита с 1-генотипа с умеренной активностью и репликативностью
EP2396028A2 (en) 2009-02-12 2011-12-21 Vertex Pharmceuticals Incorporated Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir
US8101643B2 (en) 2009-02-27 2012-01-24 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
AR075584A1 (es) 2009-02-27 2011-04-20 Intermune Inc COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
BRPI1013227A2 (pt) 2009-03-05 2016-03-29 Ascendis Pharma As pró-fármacos transportadores de interferon alfa
WO2010101649A2 (en) 2009-03-05 2010-09-10 Pablo Gastaminza Sigma 1 receptor inhibition as a novel therapeutical approach against hepatitis c virus infection
EP2421970B1 (en) 2009-04-24 2016-09-07 Roche Innovation Center Copenhagen A/S Pharmaceutical compositions for treatment of hcv patients that are non-responders to interferon
AU2010240893B2 (en) 2009-04-25 2015-02-05 F. Hoffmann-La Roche Ag Methods for improving pharmacokinetics
EP3002281B1 (en) * 2009-05-13 2017-09-13 Gilead Pharmasset LLC Antiviral compounds
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
MX2011012311A (es) 2009-05-21 2011-12-14 Schering Corp Marcadores geneticos asociados con la respuesta al interferon alfa.
ES2565536T3 (es) 2009-06-11 2016-04-05 Abbvie Bahamas Ltd. Heterociclos trisustituidos como inhibidores de la replicación del virus de la Hepatitis C VHC
US20100323989A1 (en) 2009-06-23 2010-12-23 Gilead Sciences, Inc. Pharmaceutical combinations useful for treating hcv
WO2010151487A1 (en) 2009-06-23 2010-12-29 Gilead Sciences, Inc. Combination of telaprevir with 5- ({6- [2,4-bis (trifluoromethyl) phenyl] pyridazin-3 -yl)methyl) -2- (2 -fluorophenyl) -5h- imidazo [4, 5-c]pyridine for the treatment of hcv
TW201105323A (en) 2009-06-23 2011-02-16 Gilead Sciences Inc Pharmaceutical compositions useful for treating HCV
BR122020003634B8 (pt) 2009-06-26 2021-07-27 Romark Laboratories Lc uso de nitazoxanida, tizoxanida ou sal farmaceuticalmente aceitável do mesmo no tratamento de uma doença semelhante a influenza
NZ596928A (en) 2009-07-07 2013-05-31 Boehringer Ingelheim Int A liquid- or semi-solid pharmaceutical composition of a hepatitis C viral protease inhibitor
RU2400229C1 (ru) 2009-07-13 2010-09-27 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" СПОСОБ ЛЕЧЕНИЯ БОЛЬНЫХ ХРОНИЧЕСКИМ ВИРУСНЫМ ГЕПАТИТОМ С, ГЕНОТИПОМ 3а
US20110020272A1 (en) 2009-07-24 2011-01-27 Ulrich Schubert Combination therapy for treating hepatitis viral infection
JP2013500713A (ja) 2009-07-31 2013-01-10 サントル オスピタリエ ウニヴェルシテール ヴォドア Ｈｃｖ感染患者においてｃ型肝炎の転帰を診断又は予測する方法
US20110027229A1 (en) 2009-07-31 2011-02-03 Medtronic, Inc. Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients
AU2010286681A1 (en) 2009-08-27 2012-02-09 Merck Sharp & Dohme Corp. Processes for preparing protease inhibitors of hepatitis C virus
US20110086869A1 (en) 2009-09-24 2011-04-14 The Trustees Of Boston University Methods for treating viral disorders
TW201116540A (en) 2009-10-01 2011-05-16 Intermune Inc Therapeutic antiviral peptides
US8415374B2 (en) 2009-10-12 2013-04-09 Bristol-Myers Squibb Company Combinations of hepatitis C virus inhibitors
US9174988B2 (en) 2009-10-27 2015-11-03 Trustees Of Boston University Small molecule inhibitors of hepatitis C virus
US8729058B2 (en) 2009-10-27 2014-05-20 Michael Zasloff Methods and compositions for treating and preventing viral infections
PH12012500827A1 (en) 2009-10-30 2013-01-07 Boehringer Ingelheim Int Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
EP2499263A2 (en) 2009-11-09 2012-09-19 Merck Sharp & Dohme Corp. Markers associated with ribavirin-induced anemia
WO2011063076A1 (en) 2009-11-19 2011-05-26 Itherx Pharmaceuticals, Inc. Methods of treating hepatitis c virus with oxoacetamide compounds
US8623416B2 (en) 2009-11-25 2014-01-07 Michael Zasloff Formulations comprising aminosterols
WO2011081918A1 (en) * 2009-12-14 2011-07-07 Enanta Pharmaceuticals, Inc Hepatitis c virus inhibitors
CA2784646A1 (en) 2009-12-18 2011-06-23 Boehringer Ingelheim International Gmbh Hcv combination therapy
WO2011079016A1 (en) 2009-12-22 2011-06-30 Gilead Sciences, Inc. Methods of treating hbv and hcv infection
CN102905763B (zh) 2009-12-23 2015-06-17 诺华股份有限公司 脂质、脂质组合物和使用它们的方法
RU2424794C1 (ru) 2009-12-30 2011-07-27 Государственное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО УГМА Росздрава) Способ лечения врожденного гепатита с у детей первого года жизни
CA2787309A1 (en) * 2010-01-25 2011-07-28 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
RU2012136824A (ru) 2010-01-29 2014-03-10 Вертекс Фармасьютикалз Инкорпорейтед Способы лечения вирусной инфекции гепатита с
UA104517C2 (uk) * 2010-03-10 2014-02-10 Ебботт Леборетріз Тверда композиція, що є корисною в лікуванні інфекції вірусу гепатиту с, та способи її одержання
US8530497B2 (en) 2010-03-11 2013-09-10 Boehringer Ingelheim International Gmbh Crystalline salts of a potent HCV inhibitor
PL2552930T3 (pl) 2010-03-31 2016-02-29 Gilead Pharmasset Llc Krystaliczny 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1-(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian (S)-izopropylu
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
AR084393A1 (es) 2010-06-10 2013-05-15 Gilead Sciences Inc Metodos para tratar el virus de la hepatitis c, composicion, uso, combinacion, kit y uno o mas compuestos anti vhc
CA2745102A1 (en) 2010-06-29 2011-12-29 Medicorp Institute Of Canada Pharmaceutical composition and method of use to improve organ function
RU2429877C1 (ru) 2010-06-30 2011-09-27 Общество с ограниченной ответственностью "ИНГИЛС" Способ лечения хронического вирусного гепатита с
AR082215A1 (es) 2010-07-14 2012-11-21 Vertex Pharma Composicion farmaceutica agradable al paladar
EP2598159A4 (en) 2010-07-30 2014-01-08 Merck Sharp & Dohme INHIBITION OF THE CYP3A DRUG MIXTURE EXCHANGE
US20120196272A1 (en) * 2010-08-05 2012-08-02 Roche Molecular Systems, Inc. Prediction of HCV Viral Kinetics in Interferon-Free Treatment
US20120196794A1 (en) 2010-08-06 2012-08-02 Bristol-Myers Squibb Company Combinations of Hepatitis C Virus Inhibitors
KR20130110170A (ko) 2010-09-22 2013-10-08 앨리오스 바이오파마 인크. 치환된 뉴클레오타이드 유사체
RU2013119607A (ru) 2010-09-29 2014-11-10 Мерк Шарп Энд Домэ Корп. Полициклические гетероциклические соединения и способы их применения для лечения вирусных заболеваний
CA2813093A1 (en) 2010-09-30 2012-04-05 Boehringer Ingelheim International Gmbh Combination therapy for treating hcv infection
US20130302282A1 (en) * 2010-10-26 2013-11-14 Presidio Pharmaceuticals, Inc. Inhibitors of Hepatitis C Virus
US20120107278A1 (en) 2010-10-29 2012-05-03 Pharmasset, Inc. Abbreviated hcv therapy for hcv infected patients with il28b c/c genotype
AU2011349844B2 (en) 2010-12-20 2017-06-01 Gilead Sciences, Inc. Combinations for treating HCV
JP2014510155A (ja) 2011-04-06 2014-04-24 ザ トラスティーズ オブ プリンストン ユニバーシティ 抗ウイルス組み合わせ治療薬
KR20140051271A (ko) 2011-06-23 2014-04-30 스텔라 에이피에스 Hcv 조합 치료
US20140113958A1 (en) 2011-06-30 2014-04-24 Stella Aps HCV Combination Therapy
JP2014523429A (ja) 2011-06-30 2014-09-11 ステラ・アンパルトセルスカブ Ｈｃｖ併用療法
WO2013024158A1 (en) 2011-08-17 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection
WO2013024155A1 (en) 2011-08-17 2013-02-21 Inserm (Institut National De La Sante Et De La Recherche Medicale) Combinations of anti-hcv-entry factor antibodies and direct acting antivirals for the treatment and the prevention of hcv infection
WO2013025975A1 (en) 2011-08-17 2013-02-21 Glaxosmithkline Llc Combination treatments for hepatitis c
PH12014500386A1 (en) 2011-08-24 2019-10-07 Glaxosmithkline Llc Combination treatment for hepatitis c
ME03009B (me) * 2011-09-16 2018-10-20 Gilead Pharmasset Llc Metode za lecenje hcv-a
PH12014500832A1 (en) 2011-10-21 2022-12-02 Abbvie Inc Methods for treating hcv
SG2014011670A (en) 2011-10-21 2014-10-30 Abbvie Inc Combination treatment (eg. with abt-072 or abt -333) of daas for use in treating hcv
US8492386B2 (en) * 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) * 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
WO2013066753A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Compositions useful for the treatment of viral diseases
US20130137084A1 (en) 2011-11-28 2013-05-30 Roche Molecular Systems, Inc. Single Nucleotide Polymorphism on Chromosome 15 That Predicts HCV Treatment Responses
AU2012358804B2 (en) 2011-12-22 2018-04-19 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs

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