JP5677646B2 - Hcvの治療に使用するためのdaaの(例えばabt−072もしくはabt−333との)併用治療 - Google Patents
Hcvの治療に使用するためのdaaの(例えばabt−072もしくはabt−333との)併用治療 Download PDFInfo
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- JP5677646B2 JP5677646B2 JP2014537304A JP2014537304A JP5677646B2 JP 5677646 B2 JP5677646 B2 JP 5677646B2 JP 2014537304 A JP2014537304 A JP 2014537304A JP 2014537304 A JP2014537304 A JP 2014537304A JP 5677646 B2 JP5677646 B2 JP 5677646B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Prostheses (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550360P | 2011-10-21 | 2011-10-21 | |
| US61/550,360 | 2011-10-21 | ||
| US201161562176P | 2011-11-21 | 2011-11-21 | |
| US61/562,176 | 2011-11-21 | ||
| US201261587197P | 2012-01-17 | 2012-01-17 | |
| US61/587,197 | 2012-01-17 | ||
| US201261600468P | 2012-02-17 | 2012-02-17 | |
| US61/600,468 | 2012-02-17 | ||
| US201261619883P | 2012-04-03 | 2012-04-03 | |
| US61/619,883 | 2012-04-03 | ||
| US201261656253P | 2012-06-06 | 2012-06-06 | |
| US61/656,253 | 2012-06-06 | ||
| US201261711793P | 2012-10-10 | 2012-10-10 | |
| US61/711,793 | 2012-10-10 | ||
| PCT/US2012/061085 WO2013059638A1 (en) | 2011-10-21 | 2012-10-19 | Combination treatment (eg. with abt-072 or abt -333) of daas for use in treating hcv |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014208264A Division JP2015071599A (ja) | 2011-10-21 | 2014-10-09 | Hcvの治療に使用するためのdaaの(例えばabt−072もしくはabt−333との)併用治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530874A JP2014530874A (ja) | 2014-11-20 |
| JP2014530874A5 JP2014530874A5 (enExample) | 2015-01-08 |
| JP5677646B2 true JP5677646B2 (ja) | 2015-02-25 |
Family
ID=47143548
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537304A Expired - Fee Related JP5677646B2 (ja) | 2011-10-21 | 2012-10-19 | Hcvの治療に使用するためのdaaの(例えばabt−072もしくはabt−333との)併用治療 |
| JP2014208264A Pending JP2015071599A (ja) | 2011-10-21 | 2014-10-09 | Hcvの治療に使用するためのdaaの(例えばabt−072もしくはabt−333との)併用治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014208264A Pending JP2015071599A (ja) | 2011-10-21 | 2014-10-09 | Hcvの治療に使用するためのdaaの(例えばabt−072もしくはabt−333との)併用治療 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8809265B2 (enExample) |
| EP (1) | EP2583680A3 (enExample) |
| JP (2) | JP5677646B2 (enExample) |
| CN (2) | CN104023726A (enExample) |
| AR (1) | AR088408A1 (enExample) |
| AU (1) | AU2013201532B2 (enExample) |
| BR (1) | BR112014005617A2 (enExample) |
| CA (1) | CA2811250C (enExample) |
| CH (1) | CH707030B1 (enExample) |
| CL (2) | CL2014000778A1 (enExample) |
| CY (1) | CY20152200002T2 (enExample) |
| DE (6) | DE202012012955U1 (enExample) |
| DK (1) | DK2583680T1 (enExample) |
| DO (1) | DOP2014000067A (enExample) |
| EA (1) | EA201490836A1 (enExample) |
| ES (1) | ES2527544T1 (enExample) |
| GB (4) | GB2506085A (enExample) |
| HK (2) | HK1199817A1 (enExample) |
| IL (1) | IL230862A0 (enExample) |
| MX (1) | MX2014004729A (enExample) |
| PH (2) | PH12014500833A1 (enExample) |
| PT (2) | PT107924A (enExample) |
| SE (2) | SE1450131A1 (enExample) |
| SG (1) | SG2014011670A (enExample) |
| TW (2) | TW201600087A (enExample) |
| UY (1) | UY34401A (enExample) |
| WO (1) | WO2013059638A1 (enExample) |
| ZA (1) | ZA201406352B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10201584B1 (en) * | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| HRP20180237T4 (hr) | 2011-09-16 | 2020-12-11 | Gilead Pharmasset Llc | Metode za liječenje hcv-a |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| CN104023726A (zh) | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如,与abt-072或abt-333) |
| DE112012003510T5 (de) | 2011-10-21 | 2015-03-19 | Abbvie Inc. | Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2897609A1 (en) * | 2012-09-18 | 2015-07-29 | AbbVie Inc. | Methods for treating hepatitis c |
| SMT201900683T1 (it) * | 2012-09-18 | 2020-01-14 | Abbvie Inc | Metodi per il trattamento di epatite c |
| EA032913B1 (ru) * | 2012-10-18 | 2019-08-30 | Эббви Инк. | Препараты производных пиримидиндиона |
| EP2950786B1 (en) | 2013-01-31 | 2019-11-27 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
| WO2014152514A1 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Combination of two antivirals for treating hepatitis c |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| EP3318258B1 (en) | 2013-03-14 | 2020-05-13 | AbbVie Inc. | Combination of direct acting antiviral agents and ribavirin for treating hcv patients |
| CN105451736A (zh) * | 2013-07-02 | 2016-03-30 | 艾伯维公司 | 用于治疗hcv的方法 |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| JP2016523924A (ja) * | 2013-07-02 | 2016-08-12 | アッヴィ・インコーポレイテッド | Hcvの治療方法 |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| JP2016527232A (ja) | 2013-07-17 | 2016-09-08 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Hcvの治療に使用するためのビフェニル誘導体を含む組み合わせ |
| EA201690473A1 (ru) | 2013-08-27 | 2017-03-31 | ГАЙЛИД ФАРМАССЕТ ЭлЭлСи | Комбинированный состав двух противовирусных соединений |
| US20150141351A1 (en) * | 2013-11-18 | 2015-05-21 | AbbVie Deutschland GmbH & Co. KG | Solid Pharmaceutical Compositions |
| US20150174194A1 (en) * | 2013-12-19 | 2015-06-25 | Abbvie Inc. | Methods for treating liver transplant recipients |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| BR112016022976A8 (pt) | 2014-04-02 | 2021-07-20 | Abbvie Inc | métodos para o tratamento de hcv |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| WO2016089814A1 (en) | 2014-12-02 | 2016-06-09 | Concert Pharmaceuticals, Inc. | Deuterated analogues of daclatasvir |
| JP2017536403A (ja) * | 2014-12-04 | 2017-12-07 | アイガー・バイオファーマシューティカルズ・インコーポレイテッドEiger Biopharmaceuticals, Inc. | デルタ肝炎ウイルス感染の治療 |
| CA2969307A1 (en) | 2014-12-04 | 2016-06-09 | Novartis Ag | Methods and compositions using klotho variant polypeptides |
| CN104546780A (zh) * | 2014-12-12 | 2015-04-29 | 安徽一灵药业有限公司 | 一种达卡他韦薄膜包衣片制剂及其制备方法 |
| HUE054068T2 (hu) | 2015-04-21 | 2021-08-30 | Eiger Biopharmaceuticals Inc | Lonafarnibot és Ritonavirt tartalmazó gyógyszerkészítmények |
| US20160375017A1 (en) | 2015-06-26 | 2016-12-29 | Abbvie Inc. | Solid Pharmaceutical Compositions for Treating HCV |
| EP3313398A4 (en) * | 2015-06-29 | 2019-03-27 | AbbVie Inc. | METHODS OF TREATING HCV |
| US20180177779A1 (en) | 2015-07-08 | 2018-06-28 | Abbvie Inc. | Methods for Treating HCV |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
| CA2994496A1 (en) | 2017-02-14 | 2018-08-14 | Abbvie Inc. | Methods for treating hcv |
| CA2981993A1 (en) | 2017-08-02 | 2019-02-02 | Abbvie Inc. | Methods for treating hcv |
| CA3078939A1 (en) | 2017-10-12 | 2019-04-18 | Abbvie Inc. | Methods for treating hcv |
Family Cites Families (403)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5026687A (en) | 1990-01-03 | 1991-06-25 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds |
| AU4671193A (en) | 1992-07-13 | 1994-01-31 | Kenneth E. Sherman | Composition and method of treating hepatitis b |
| US6107027A (en) | 1994-12-14 | 2000-08-22 | University Of Washington | Ribozymes for treating hepatitis C |
| GB9505025D0 (en) | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| US6387365B1 (en) | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| US5980884A (en) | 1996-02-05 | 1999-11-09 | Amgen, Inc. | Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon |
| GB9605293D0 (en) | 1996-03-13 | 1996-05-15 | Glaxo Group Ltd | Medicaments |
| US5922757A (en) | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
| AU5157998A (en) | 1996-11-01 | 1998-05-29 | Thomas Najarian | Methods and compositions for treatment of hepatitis c infection |
| IL119833A (en) | 1996-12-15 | 2001-01-11 | Lavie David | Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis |
| US6103706A (en) | 1997-04-29 | 2000-08-15 | New York Blood Center, Inc. | Methods for treating viral infections |
| US6010890A (en) | 1997-04-29 | 2000-01-04 | New York Blood Center, Inc. | Method for viral inactivation and compositions for use in same |
| US6143752A (en) | 1997-08-01 | 2000-11-07 | Oren; Ran | Method for preventing or arresting liver damage in humans |
| PT903148E (pt) | 1997-09-21 | 2002-02-28 | Schering Corp | Terapia de combinacao para a erradicacao de rna de hcv detectavel em doentes tendo infeccao cronica pelo virus da hepatite c |
| US6455051B1 (en) | 1997-10-13 | 2002-09-24 | Otsuka Pharmaceutical Co., Ltd. | Ameliorant for hepatitis C therapeutic effect and application thereof |
| FR2771637B1 (fr) | 1997-12-01 | 2003-10-24 | Hutchinson | Utilisation d'un halogenure de dialkyldialkylammonium par voie parenterale dans les infections bacteriennes et virales |
| AU761748B2 (en) | 1997-12-11 | 2003-06-12 | Chancellor, Masters And Scholars Of The University Of Oxford, The | Inhibition of membrane-associated viral replication |
| CA2313049A1 (en) | 1997-12-17 | 1999-06-24 | Cornell Research Foundation, Inc. | Cyclooxygenase-2 inhibition |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| US6475985B1 (en) | 1998-03-27 | 2002-11-05 | Regents Of The University Of Minnesota | Nucleosides with antiviral and anticancer activity |
| JP2000007578A (ja) | 1998-06-24 | 2000-01-11 | Hiroaki Okushin | C型肝炎ウイルスの陰性化のための投薬システム |
| PT1091975E (pt) | 1998-07-01 | 2006-05-31 | Debiopharm Sa | Nova ciclosporina com um perfil de actividade melhorado |
| RU2158604C2 (ru) | 1998-07-03 | 2000-11-10 | Толоконская Наталья Петровна | Способ лечения вирусного гепатита c |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| RU2001113268A (ru) | 1998-10-16 | 2003-09-27 | Шеринг Корпорейшн (US) | Сочетанная терапия рибавирином и интерфероном α для удаления определяемой рнк вируса гепатита с у пациентов с хроническим гепатитом с |
| US20080275005A1 (en) | 1998-11-25 | 2008-11-06 | Murphy Michael P | Mitochondrially targeted antioxidants |
| AU2156900A (en) | 1998-12-18 | 2000-07-12 | Schering Corporation | Ribavirin-interferon alfa induction hcv combination therapy |
| US6824768B2 (en) | 1998-12-18 | 2004-11-30 | Schering Corporation | Ribavirin-pegylated interferon alfa induction HCV combination therapy |
| CA2354536A1 (en) | 1998-12-18 | 2000-06-29 | Schering Corporation | Ribavirin-pegylated interferon alfa induction hcv combination therapy |
| JP2000212099A (ja) | 1999-01-19 | 2000-08-02 | Mochida Pharmaceut Co Ltd | ウイルス性肝炎治療剤 |
| ATE286407T1 (de) | 1999-02-13 | 2005-01-15 | Purepulse Technologies Inc | Verfahren zur inaktivierung von pathogenen mittels breitspektrum-pulslicht |
| GB2355932B (en) | 1999-04-12 | 2004-01-07 | Univ Madras | A pharmaceutical formulation suitable for the treatment of hepatitis B, hepatitis C and other viral infections of the liver and a process for its preparation |
| US6849254B1 (en) | 1999-04-19 | 2005-02-01 | Schering Corporation | HCV combination therapy |
| HK1053126A1 (zh) | 1999-07-22 | 2003-10-10 | 新生物生物公司 | 酶催化的治疗活化 |
| MXPA02001296A (es) | 1999-08-13 | 2002-07-22 | Hoffmann La Roche | Micofenolato mofetil en asociacion con peg-ifn-alfa. |
| US20050245502A1 (en) | 1999-08-23 | 2005-11-03 | Phoenix Biosciences | Treatments for viral infections |
| KR100392292B1 (ko) | 2000-01-07 | 2003-07-22 | 주식회사 펩트론 | 5원환 융합 방향족 헤테로사이클릭 화합물을 유효성분으로 하는 hcv 치료제 조성물 |
| WO2001077091A2 (en) | 2000-04-05 | 2001-10-18 | Tularik Inc. | Ns5b hcv polymerase inhibitors |
| WO2001077371A1 (fr) | 2000-04-07 | 2001-10-18 | Shionogi & Co., Ltd. | Procede de dosage de preincubation |
| WO2001079540A2 (en) | 2000-04-18 | 2001-10-25 | Virco Bvba | Methods for measuring drug resistance |
| US6415797B1 (en) | 2000-07-07 | 2002-07-09 | First Circle Medical, Inc. | Treatment of human herpesviruses using hyperthermia |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| US7012066B2 (en) | 2000-07-21 | 2006-03-14 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| EP1325324A4 (en) | 2000-08-02 | 2004-11-10 | Ortho Mcneil Pharm Inc | IMPROVED ANTIVIRAL AND ANTI-CANCER CHEMOTHERAPY USING ERYTHROPOIETIN ADMINISTRATION (EPO) |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| ES2272558T3 (es) | 2000-10-12 | 2007-05-01 | Viromics Gmbh | Inhibidores del proteasoma para el tratamiento de infecciones causadas por virus de la hepatitis. |
| CA2462681A1 (en) | 2000-10-13 | 2002-04-18 | Monash University | Disease prevention by reactivation of the thymus |
| AU2002213343A1 (en) | 2000-10-18 | 2002-04-29 | Schering Corporation | Ribavirin-pegylated interferon alfa HCV combination therapy |
| FR2815543B1 (fr) | 2000-10-19 | 2003-10-24 | Sedat | Seringue d'auto-injection d'un melange extemporane |
| EP1333850B1 (en) | 2000-10-20 | 2008-08-20 | Genetics Institute, Inc. | Use of il-13 inhibitors for the treatment of tumors |
| WO2002091989A2 (en) | 2000-11-08 | 2002-11-21 | Slil Biomedical Corporation | Antiviral therapies using polyamine or polyamine analog-amino acid conjugates |
| WO2002053096A2 (en) | 2000-12-06 | 2002-07-11 | The Trustees Of The University Of Pennsylvania | Single therapy and combination therapy involving drugs with target cellular proteins and drugs which target pathogen-encoded proteins |
| US7105499B2 (en) | 2001-01-22 | 2006-09-12 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| MXPA03006514A (es) | 2001-01-22 | 2004-12-02 | Merck & Co Inc | Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico. |
| CN1245215C (zh) | 2001-02-28 | 2006-03-15 | 四川省生物工程研究中心 | 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂 |
| GB0107924D0 (en) | 2001-03-29 | 2001-05-23 | Angeletti P Ist Richerche Bio | Inhibitor of hepatitis C virus NS3 protease |
| US6673775B2 (en) | 2001-04-18 | 2004-01-06 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| AU2002259130A1 (en) | 2001-05-03 | 2002-11-18 | Eli Lilly And Company | Agents for treatment of hcv and methods of use |
| US6833351B2 (en) | 2001-05-21 | 2004-12-21 | Douglas T. Dieterich | Method of treating anemia caused by ribavirin treatment of hepatitis C using erythropoietin alpha |
| US20030138403A1 (en) | 2001-06-29 | 2003-07-24 | Maxygen Aps | Interferon formulations |
| WO2003002152A2 (en) | 2001-06-29 | 2003-01-09 | Maxygen Aps | Stabilized formulations of interferons with sulfoalkyl ether cyclodextrins |
| CN1549724A (zh) | 2001-07-20 | 2004-11-24 | ����ͨѶ�ɷ�����˾ | 治疗肝纤维化的方法 |
| WO2003024461A1 (en) | 2001-09-20 | 2003-03-27 | Schering Corporation | Hcv combination therapy |
| PL369129A1 (en) | 2001-09-28 | 2005-04-18 | Intermune, Inc. | Method for treating hepatitis c virus infection in treatment failure patients |
| MXPA04002915A (es) | 2001-09-28 | 2004-07-05 | Intermune Inc | Metodo para tratar infeccion de virus de hepatitis c en pacientes que han fallado el tratamiento. |
| BR0213103A (pt) | 2001-10-05 | 2004-09-21 | Intermune Inc | Método para tratamento de infecção pelo vìrus da hepatite com um perfil de liberação de interferon multifásico |
| WO2003037908A1 (en) | 2001-10-31 | 2003-05-08 | Ribapharm Inc. | Antiviral combination therapy and compositions |
| AR037131A1 (es) | 2001-10-31 | 2004-10-20 | Schering Corp | Formulaciones de jarabe de ribavirina |
| US20030153073A1 (en) | 2001-11-07 | 2003-08-14 | Paul Rogers | Expansion of T cells in vitro and expanded T cell populations |
| AUPR879601A0 (en) | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
| AU2002346686A1 (en) | 2001-12-07 | 2003-06-23 | Intermune, Inc. | Compositions and method for treating hepatitis virus infection |
| US6936629B2 (en) | 2001-12-21 | 2005-08-30 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| US6906190B2 (en) | 2002-01-04 | 2005-06-14 | Ribapharm Inc. | Inhibitors for de novo-RNA polymerases and methods of identifying targets for same |
| RU2212248C1 (ru) | 2002-01-21 | 2003-09-20 | Государственное образовательное учреждение высшего профессионального образования Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова | Способ лечения больных хроническим вирусным гепатитом c |
| WO2003072135A2 (en) | 2002-02-26 | 2003-09-04 | North Shore-Long Island Jewish Research Insitute | Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors |
| US6649615B2 (en) | 2002-04-23 | 2003-11-18 | Institute National De La Sante Et De La Recherche Medicale (Inserm) | Method for inhibiting fibrogenesis |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| WO2003101199A1 (en) | 2002-05-31 | 2003-12-11 | Schering Corporation | Combination therapy for rna virus infections involving ribavirin and impdh inhibitors |
| TWI334785B (en) | 2002-06-03 | 2010-12-21 | Serono Lab | Use of recombinant ifn-β1a and pharmaceutical composition comprising recombinant ifn-β1a for the treatment of hcv infection in patients of asian race |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| DE60334303D1 (de) | 2002-07-03 | 2010-11-04 | Tasuku Honjo | Immunpotenzierende zusammensetzungen |
| ITMI20021860A1 (it) | 2002-08-28 | 2004-02-29 | Scalia Antonio Cassar | Impiego dei triptani come agenti antivirali. |
| EP1556498A1 (en) | 2002-11-01 | 2005-07-27 | Cadila Healthcare Ltd. | Method for producing recombinant human interferon alpha 2b polypeptide in pichia pastoris |
| AU2003287666A1 (en) | 2002-11-13 | 2004-06-03 | Control Delivery Systems, Inc. | Systemic delivery of antiviral agents |
| WO2004047673A2 (en) | 2002-11-21 | 2004-06-10 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| JP2006517960A (ja) | 2003-02-18 | 2006-08-03 | ファイザー インコーポレイテッド | C型肝炎ウイルスの阻害剤、それを使用する組成物および治療法 |
| AU2003225670A1 (en) | 2003-02-28 | 2004-09-28 | Intermune, Inc. | Interferon drug therapy for the treatment of viral diseases and liver fibrosis |
| EP1601368A2 (en) | 2003-02-28 | 2005-12-07 | Intermune, Inc. | Methods and compositions for treatment of viral diseases |
| US20070077225A1 (en) | 2003-02-28 | 2007-04-05 | Blatt Lawrence M | Continuous delivery methods for treating hepatitis virus infection |
| TWI269656B (en) | 2003-03-05 | 2007-01-01 | Original Image Co Ltd | Therapeutical composition for hepatitis C |
| UA64191A (en) | 2003-03-14 | 2004-02-16 | Yevhenii Mykhailovych Neiko | Method for treating chronic hepatitises of various etiology |
| US20040198840A1 (en) | 2003-04-02 | 2004-10-07 | Deloach Reuben Edwin | Hydrazide substrate safely shuts down disease activated protease to halt viral replication, cancerous cell division, and toxic protein generation |
| ATE422895T1 (de) | 2003-04-16 | 2009-03-15 | Bristol Myers Squibb Co | Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus |
| US20040258663A1 (en) | 2003-05-08 | 2004-12-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of interferon alpha |
| US20050009877A1 (en) | 2003-05-15 | 2005-01-13 | Henry Lu | Methods of identifying HCV NS5B polymerase inhibitors and their uses |
| CL2004001161A1 (es) | 2003-05-21 | 2005-04-08 | Boehringer Ingelheim Int | Compuestos describe compuestos derivados de quinolina; composicion farmaceutica; y su uso para tratar una enfermedad causada por el virus de la hepatitis c. |
| RU2358979C2 (ru) | 2003-05-30 | 2009-06-20 | Фармассет, Инк. | Модифицированные фторированные аналоги нуклеозида |
| US20050187170A1 (en) | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
| CN101014349A (zh) | 2003-06-20 | 2007-08-08 | 病毒基因混和公司 | 抗病毒组合物及其使用方法 |
| EP1648997A2 (en) | 2003-07-11 | 2006-04-26 | Oregon Health and Science University | Methods of treatment and disgnosis using modulators of virus-induced cellular gene sequences |
| MD2549G2 (ro) | 2003-07-18 | 2005-08-31 | Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова | Metodă de tratament a hepatitei virale cronice C. |
| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| WO2005018330A1 (en) | 2003-08-18 | 2005-03-03 | Pharmasset, Inc. | Dosing regimen for flaviviridae therapy |
| EP1667694B1 (en) | 2003-09-05 | 2010-04-28 | Anadys Pharmaceuticals, Inc. | Tlr7 ligands for the treatment of hepatitis c |
| WO2005023289A1 (ja) | 2003-09-08 | 2005-03-17 | Intellectual Property Consulting Incorporated | 慢性c型肝炎を治療するための医薬組成物 |
| AR045870A1 (es) | 2003-10-11 | 2005-11-16 | Vertex Pharma | Terapia de combinacion para la infeccion de virus de hepatitis c |
| WO2005037214A2 (en) | 2003-10-14 | 2005-04-28 | Intermune, Inc. | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication |
| WO2005038056A1 (en) | 2003-10-14 | 2005-04-28 | Intermune, Inc. | Combination therapy for the treatment of viral diseases |
| US7491794B2 (en) | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| US20050085528A1 (en) | 2003-10-17 | 2005-04-21 | Pfizer Inc. | Parmaceutical |
| BRPI0415533A (pt) | 2003-10-24 | 2006-12-26 | Immunaid Pty Ltd | método de terapia |
| WO2005043118A2 (en) | 2003-10-27 | 2005-05-12 | Vertex Pharmaceuticals Incorporated | Drug discovery method |
| CN1893978A (zh) | 2003-10-27 | 2007-01-10 | 沃泰克斯药物股份有限公司 | 用于hcv治疗的组合 |
| UA68233A (en) | 2003-11-25 | 2004-07-15 | Univ Zaporizhia State Medical | Method for treating chronic hepatitis c |
| US7078064B2 (en) | 2003-12-03 | 2006-07-18 | George Zabrecky | Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis |
| DK2161273T3 (en) | 2003-12-22 | 2015-07-20 | Leuven K U Res & Dev | Imidazo [4,5-C] pyridine compounds and methods for antiviral therapy |
| US20070258946A1 (en) | 2003-12-23 | 2007-11-08 | Blatt Lawrence M | Combination Therapy for Treating Hepatitis C Virus Infection |
| WO2005067963A1 (en) | 2003-12-23 | 2005-07-28 | Intermune, Inc. | Use of polyethylene glycol-modified interferon-alpha in therapeutic dosing regimens |
| WO2005062949A2 (en) | 2003-12-23 | 2005-07-14 | Intermune, Inc. | Method for treating hepatitis virus infection |
| DE10361944A1 (de) | 2003-12-31 | 2005-07-28 | Viromics Gmbh | Mittel zur Hemmung der Virusreplikation durch Regulation der Proteinfaltung |
| US20080234182A1 (en) | 2007-03-22 | 2008-09-25 | Innovative Biologics, Inc. | Blockers of pore-forming virulence factors and their use as anti-infectives |
| WO2006003521A1 (en) | 2004-02-06 | 2006-01-12 | Monash University | High dose, short interval use of sulfated polysaccharides for the treatment of infections |
| CN1950393A (zh) | 2004-02-27 | 2007-04-18 | 先灵公司 | 丙型肝炎病毒ns3蛋白酶的抑制剂 |
| US7977326B2 (en) | 2004-04-22 | 2011-07-12 | Howard J Smith | Supportive treatment of liver disease |
| PT1747023E (pt) | 2004-05-04 | 2011-04-11 | Univ Leland Stanford Junior | Métodos e composições para reduzir quantidades de genoma viral numa célula alvo |
| CA2565658A1 (en) | 2004-05-06 | 2005-11-17 | Conjuchem Biotechnologies Inc. | Compounds for specific viral target |
| WO2005107745A1 (en) | 2004-05-06 | 2005-11-17 | Schering Corporation | An inhibitor of hepatitis c |
| WO2006016930A2 (en) | 2004-05-14 | 2006-02-16 | Intermune, Inc. | Methods for treating hcv infection |
| EP1753775B1 (en) | 2004-05-25 | 2012-12-26 | Boehringer Ingelheim International GmbH | Process for preparing acyclic hcv protease inhibitors |
| WO2005123076A2 (en) | 2004-06-08 | 2005-12-29 | Vertex Pharmaceuticals, Inc. | Pharmaceutical compositions |
| BRPI0513370A (pt) | 2004-07-14 | 2008-05-06 | Novartis Ag | uso de uma combinação de ciclosporina e interferonas peguilados para tratamento de hepatite c (hcv) |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| EP1627641A1 (en) | 2004-08-04 | 2006-02-22 | Victor Eluwa | Pharmaceutical compositions comprising metal oxides and uses thereof |
| US7348425B2 (en) | 2004-08-09 | 2008-03-25 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| EP1799866A4 (en) | 2004-09-27 | 2010-12-01 | Us Gov Health & Human Serv | MODULAR MXA EXPRESSION |
| US20080267915A1 (en) | 2004-10-01 | 2008-10-30 | Vertex Pharmaceuticals | Hcv Ns3-Ns4a Protease Inhibition |
| ATE490778T1 (de) | 2004-10-01 | 2010-12-15 | Debiopharm Sa | Verwendung von äd-mealaü3-äetvalü4-ciclosporin zur behandlung von hepatitis-c-infektion |
| US7723310B2 (en) | 2004-10-18 | 2010-05-25 | Three Rivers Pharmaceuticals, Llc | Large dose ribavirin formulations |
| WO2006043153A2 (en) | 2004-10-20 | 2006-04-27 | Michel Xilinas | Use of zinc and copper chelators for the treatment of viral diseases |
| US20060228333A1 (en) | 2004-10-20 | 2006-10-12 | Kye-Hyung Paik | Methods for control of tumors and chronic infections by modulating immunologically informed carriers homing to tolerogenic organs or tissues |
| RU2007119562A (ru) | 2004-10-26 | 2008-12-10 | Институто Ди Ричерке Ди Биолоджиа Молеколаре П Анджелетти Спа (It) | Тетрациклические производные индолов в качестве противовирусных агентов |
| MY141025A (en) | 2004-10-29 | 2010-02-25 | Vertex Pharma | Dose forms |
| US7592315B2 (en) | 2004-11-02 | 2009-09-22 | Schering Corporation | Peptide viral entry inhibitors |
| WO2006055711A1 (en) | 2004-11-18 | 2006-05-26 | Kent Hann | Compositions containing aloe vera isolate and a prebiotic and their therapeutic application |
| EP1827460A4 (en) | 2004-12-09 | 2012-03-14 | Univ Minnesota | NUCLEOSIDE WITH ANTIVIRAL AND ANTI-CANCER EFFECT |
| TW200633718A (en) | 2004-12-16 | 2006-10-01 | Applied Research Systems | Treatment of hepatitis c in the asian population |
| DE102004061746A1 (de) | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| EP1674104A1 (en) | 2004-12-24 | 2006-06-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Uridine derivatives as antiviral drugs against a flaviviridae, especially HCV |
| EP1679065A1 (en) | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Controlled release compositions for interferon based on PEGT/PBT block copolymers |
| BRPI0606647A2 (pt) | 2005-01-17 | 2009-07-14 | Jerini Ag | antagonistas do receptor de c5a |
| EP1877077A2 (en) | 2005-02-03 | 2008-01-16 | Intarcia Therapeutics, Inc. | An implantable interferon-containing device |
| AU2006221080A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| WO2006089113A2 (en) | 2005-02-18 | 2006-08-24 | Intermune, Inc. | Biomarkers for predicting liver fibrosis treatment efficacy |
| US8232240B2 (en) | 2005-02-23 | 2012-07-31 | The Brigham And Women's Hospital, Inc. | Inhibitors of enveloped virus infectivity |
| US20090156545A1 (en) | 2005-04-01 | 2009-06-18 | Hostetler Karl Y | Substituted Phosphate Esters of Nucleoside Phosphonates |
| US20060229293A1 (en) | 2005-04-06 | 2006-10-12 | Addiction Research Institute, Inc. | Compositions for the treatment of hepatitis C and methods for using compositions for the treatment of hepatitis C |
| JP2008538354A (ja) | 2005-04-08 | 2008-10-23 | キメリクス,インコーポレイテッド | ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法 |
| US20060293267A1 (en) | 2005-04-13 | 2006-12-28 | University Of Massachusetts | Dual functional oligonucleotides for use as anti-viral agents |
| US20060241144A1 (en) | 2005-04-20 | 2006-10-26 | Albert Cha | Method for treating apathy syndrome |
| JP5030947B2 (ja) | 2005-05-13 | 2012-09-19 | ヴァイロケム・ファーマ・インコーポレーテッド | フラビウイルス感染の治療及び予防のための化合物及び方法 |
| WO2006127482A1 (en) | 2005-05-20 | 2006-11-30 | Bioenvision, Inc. | Methylene blue therapy of viral disease |
| EP1881828A4 (en) | 2005-05-20 | 2009-06-03 | Valeant Res & Dev | TREATMENT OF HEPATITIS C (HCV) USING SUB-THERAPEUTIC DOSES OF RIBAVIRIN |
| CN101184771A (zh) | 2005-05-26 | 2008-05-21 | 先灵公司 | 干扰素-IgG融合体 |
| CA2608709A1 (en) | 2005-05-31 | 2006-12-07 | Novartis Ag | Treatment of liver diseases in which iron plays a role in pathogenesis |
| US7793040B2 (en) | 2005-06-01 | 2010-09-07 | Microsoft Corporation | Content addressable memory architecture |
| US8119602B2 (en) | 2005-06-02 | 2012-02-21 | Schering Corporation | Administration of HCV protease inhibitors in combination with food to improve bioavailability |
| US20060281689A1 (en) | 2005-06-02 | 2006-12-14 | Schering Corporation | Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period |
| WO2006130552A2 (en) | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis c virus |
| US20070004635A1 (en) | 2005-06-02 | 2007-01-04 | Schering Corporation | Method of treating interferon non-responders using HCV protease inhibitor |
| US20060287248A1 (en) | 2005-06-02 | 2006-12-21 | Schering Corporation | Asymmetric dosing methods |
| US7772178B2 (en) | 2005-06-02 | 2010-08-10 | Schering Corporation | Pharmaceutical formulations and methods of treatment using the same |
| US20060275366A1 (en) | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation |
| WO2006130666A2 (en) | 2005-06-02 | 2006-12-07 | Schering Corporation | Medicaments and methods combining a hcv protease inhibitor and an akr competitor |
| US20070232527A1 (en) | 2005-06-02 | 2007-10-04 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
| US20070237818A1 (en) | 2005-06-02 | 2007-10-11 | Malcolm Bruce A | Controlled-release formulation of HCV protease inhibitor and methods using the same |
| US20070207949A1 (en) | 2005-06-02 | 2007-09-06 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
| US20070021351A1 (en) | 2005-06-02 | 2007-01-25 | Schering Corporation | Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor |
| US20060276407A1 (en) | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis C virus |
| BRPI0613796A2 (pt) | 2005-06-07 | 2011-02-15 | Univ Yale | composicões farmacêuticas e seus usos, e métodos de tratamento de cáncer e outras condições ou estados patológicos, por meio do uso de clevudina (lfmau) e telbivudina (ldt) |
| RU2293572C1 (ru) | 2005-07-18 | 2007-02-20 | Гюнтер Хаазе | Способ лечения хронического вирусного гепатита с генотип-2 с умеренной активностью |
| AR057456A1 (es) | 2005-07-20 | 2007-12-05 | Merck & Co Inc | Inhibidores de la proteasa ns3 del vhc |
| PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| ES2401661T3 (es) | 2005-08-02 | 2013-04-23 | Vertex Pharmaceuticals Incorporated | Inhibidores de serina proteasas |
| CA2618476A1 (en) | 2005-08-12 | 2007-02-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| DE102005038768A1 (de) | 2005-08-16 | 2007-02-22 | Toximed Gmbh | Pharmazeutischer Wirkstoff gegen Borreliose |
| RU2446171C2 (ru) | 2005-08-19 | 2012-03-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способы и промежуточные продукты |
| US8193328B2 (en) | 2005-09-08 | 2012-06-05 | Philadelphia Health & Education Corporation | Identification of modulators of serine protease inhibitor Kazal and their use as anti-cancer and anti-viral agents |
| US7531164B2 (en) | 2005-10-21 | 2009-05-12 | Duke University | Preventing bacterial or viral infectivity and composition containing infection preventing additive |
| IE20050723A1 (en) | 2005-10-28 | 2007-05-30 | Patrick T Prendergast | Anti-mineralocorticoid therapy of infection |
| WO2007056016A2 (en) | 2005-11-02 | 2007-05-18 | Kemia, Inc. | Bisamide cytokine inhibitors |
| RU2306134C2 (ru) | 2005-11-07 | 2007-09-20 | Государственное образовательное учреждение высшего профессионального образования "Самарский Государственный медицинский университет" | Способ базисного лечения хронического вирусного гепатита c |
| NZ568324A (en) | 2005-11-11 | 2012-01-12 | Vertex Pharma | Hepatitis C virus variants |
| WO2007058384A1 (en) | 2005-11-17 | 2007-05-24 | Osaka University | Method of suppressing replication of hepatitis c virus, inhibitor of replication of the virus and method of screening for the same |
| RU2326115C2 (ru) | 2005-11-21 | 2008-06-10 | Ефаг АО | Соли 1-алкиламино-1-дезоксиполиолов с 9-оксоакридин-10-уксусной кислотой, лекарственные препараты на их основе, применение, способы профилактики и лечения |
| AR057623A1 (es) | 2005-11-28 | 2007-12-05 | Omega Bio Pharma H K Ltd | Materiales y metodos para el tratamiento de las infecciones virales |
| US8293726B2 (en) | 2005-12-02 | 2012-10-23 | Vianova Labs, Inc. | Treatment of cancer and other diseases |
| BRPI0619563A2 (pt) | 2005-12-09 | 2011-10-04 | Pharmasset Inc | nucleosìdeos antivirais |
| WO2007075896A2 (en) | 2005-12-22 | 2007-07-05 | Kemia, Inc. | Heterocyclic cytokine inhibitors |
| RU2306934C1 (ru) | 2005-12-28 | 2007-09-27 | ГОУ ВПО Омская Государственная Медицинская Академия | Способ лечения больных хроническим вирусным гепатитом c |
| MX2008008723A (es) | 2006-01-09 | 2008-09-26 | Romark Lab Lc | Tratamiento de la hepatitis viral. |
| MD20060037A (ro) | 2006-01-24 | 2007-07-31 | Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова | Metodă de tratament al hepatitei virale acute C |
| MX2008010355A (es) | 2006-02-09 | 2008-10-31 | Schering Corp | Combinaciones que comprenden inhibidores de proteasa del virus de la hepatitis c e inhibidores de polimerasa del virus de la hepatitis c, y metodos de tratamiento relacionados con los mismos. |
| AR059430A1 (es) | 2006-02-09 | 2008-04-09 | Schering Corp | Novedosas combinaciones y metodos de inhibidores del vhc |
| EP1991229A2 (en) | 2006-02-27 | 2008-11-19 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| JP2009531315A (ja) | 2006-03-16 | 2009-09-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | 重水素化c型肝炎プロテアーゼインヒビター |
| JP2009530415A (ja) | 2006-03-20 | 2009-08-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | 医薬組成物 |
| WO2007109605A2 (en) | 2006-03-20 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
| MX2008012225A (es) | 2006-03-23 | 2008-12-03 | Schering Corp | Combinaciones de inhibidores de proteasa de virus de hepatitis c e inhibidores de isoenzima 3a4 del citocromo p450, y metodos de tratamiento relacionados con las mismas. |
| US8895531B2 (en) | 2006-03-23 | 2014-11-25 | Rfs Pharma Llc | 2′-fluoronucleoside phosphonates as antiviral agents |
| WO2007130646A2 (en) | 2006-05-04 | 2007-11-15 | The Rockefeller University | Hcv coreceptor and methods of use thereof |
| WO2008060695A2 (en) | 2006-05-22 | 2008-05-22 | The Trustees Of The University Of Pennsylvania | Antiviral inhibition of casein kinase ii |
| DE102006026464A1 (de) | 2006-06-01 | 2007-12-06 | Virologik Gmbh Innovationszentrum Medizintechnik Und Pharma | Pharmazeutische Zusammensetzung zur Behandlung von Virusinfektionen und / oder Tumorerkrankungen durch Inhibition der Proteinfaltung und des Proteinabbaus |
| WO2007143164A1 (en) | 2006-06-02 | 2007-12-13 | San Diego State University Research Foundation | Compositions and methods for ameliorating hyperlipidemia |
| JP2009539358A (ja) | 2006-06-04 | 2009-11-19 | セルアーティス アーベー | hBS細胞に由来する新規な肝細胞様細胞及び肝芽細胞様細胞 |
| EP2035005A4 (en) | 2006-06-09 | 2011-07-06 | Kemia Inc | THERAPY BASED ON CYTOKINE INHIBITORS |
| WO2007149382A2 (en) | 2006-06-19 | 2007-12-27 | The Cleveland Clinic Foundation | Therapeutic compositions and methods useful in treating hepatitis |
| RU2008152171A (ru) | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
| US20080081791A1 (en) | 2006-07-06 | 2008-04-03 | Weida Huang | Methods of using combinations of siRNAs for treating a disease or a disorder, and for enhancing siRNA efficacy in RNAi |
| US7893264B2 (en) | 2006-07-07 | 2011-02-22 | Gilead Sciences, Inc. | Antiviral phosphinate compounds |
| ES2448494T3 (es) | 2006-07-13 | 2014-03-14 | Achillion Pharmaceuticals, Inc. | Péptidos de 4-amino-4-oxobutanoilo en calidad de inhibidores de la replicación viral |
| US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US20100158862A1 (en) | 2006-08-11 | 2010-06-24 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| EP1886685A1 (en) | 2006-08-11 | 2008-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition |
| WO2008022006A2 (en) | 2006-08-11 | 2008-02-21 | Enanta Pharmaceuticals, Inc. | Arylalkoxyl hepatitis c virus protease inhibitors |
| CA2666814A1 (en) | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| US7655419B2 (en) | 2006-08-25 | 2010-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for identifying anti-HCV agents |
| TW200815384A (en) | 2006-08-25 | 2008-04-01 | Viropharma Inc | Combination therapy method for treating hepatitis C virus infection and pharmaceutical compositions for use therein |
| AU2007286754A1 (en) | 2006-08-25 | 2008-02-28 | Viropharma Incorporated | Identification and characterization of HCV replicon variants with reduced susceptibility to HCV-796, and methods related thereto |
| WO2008032227A2 (en) | 2006-09-11 | 2008-03-20 | Biomas, Ltd. | Topical formulations of tellurium-containing compounds |
| WO2008033413A2 (en) | 2006-09-14 | 2008-03-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20080161324A1 (en) | 2006-09-14 | 2008-07-03 | Johansen Lisa M | Compositions and methods for treatment of viral diseases |
| EP2083825A4 (en) | 2006-09-26 | 2009-11-04 | Addiction Res Inst Inc | HEPATITIS C TREATMENT COMPOSITIONS AND METHODS OF USING HEPATITIS C TREATMENT COMPOSITIONS |
| WO2008045419A1 (en) | 2006-10-10 | 2008-04-17 | Pharmasset, Inc. | Preparation of nucleosides ribofuranosyl pyrimidines |
| US7777395B2 (en) | 2006-10-12 | 2010-08-17 | Eastman Kodak Company | Continuous drop emitter with reduced stimulation crosstalk |
| JP5268927B2 (ja) | 2006-10-27 | 2013-08-21 | メルク・シャープ・アンド・ドーム・コーポレーション | Hcvns3プロテアーゼ阻害剤 |
| SG176488A1 (en) | 2006-11-15 | 2011-12-29 | Virochem Pharma Inc | Thiophene analogues for the treatment or prevention of flavivirus infections |
| WO2008143647A2 (en) | 2006-11-29 | 2008-11-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating viral infection |
| US20100081672A1 (en) | 2006-12-07 | 2010-04-01 | Schering Corporation | Ph sensitive matrix formulation |
| RU2336096C1 (ru) | 2006-12-14 | 2008-10-20 | ООО Медицинский центр "Столица" | Способ лечения гепатита с |
| RU2345787C2 (ru) | 2006-12-25 | 2009-02-10 | Государственное образовательное учреждение высшего профессионального образования "Самарский Государственный медицинский университет" | Способ лечения хронического вирусного гепатита с |
| US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| US20100323953A1 (en) | 2007-01-08 | 2010-12-23 | Phenomix Corporation | Macrocyclic hepatitis c protease inhibitors |
| WO2008089034A2 (en) | 2007-01-11 | 2008-07-24 | Kemia, Inc. | Cytokine inhibitors |
| US7645732B2 (en) | 2007-01-24 | 2010-01-12 | Board Of Regents, The University Of Texas System | Treating hepatitis C virus infection |
| SI2118098T1 (sl) | 2007-02-01 | 2015-01-30 | Janssen R&D Ireland | Polimorfne oblike makrocikličnega inhibitorja HCV |
| TWI426918B (zh) | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Il-23拮抗劑於治療感染之用途 |
| AU2008218275B2 (en) | 2007-02-21 | 2013-06-20 | Allaccem, Incorporated | Bridged polycyclic compound based compositions for the inhibition and amelioration of disease |
| EA200970806A1 (ru) | 2007-02-27 | 2010-08-30 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы и содержащие их фармацевтические композиции |
| WO2008106167A1 (en) | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases |
| MD3477G2 (ro) | 2007-03-21 | 2008-08-31 | Николае БОДРУГ | Metodă de tratament al hepatitei virale cronice C |
| WO2008118013A2 (en) | 2007-03-23 | 2008-10-02 | To-Bbb Holding B.V. | Targeted intracellular delivery of antiviral agents |
| US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| WO2008124384A2 (en) | 2007-04-03 | 2008-10-16 | Aegerion Pharmaceuticals, Inc. | Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c |
| US20080269205A1 (en) | 2007-04-27 | 2008-10-30 | Ondine International, Ltd. | Methods to prevent vertical transmission of infectious diseases |
| CN101678122A (zh) | 2007-04-27 | 2010-03-24 | 奇默里克斯公司 | 在核苷给药的受体中降低肾中毒性的方法 |
| WO2008137779A2 (en) | 2007-05-03 | 2008-11-13 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| MX2009011930A (es) | 2007-05-04 | 2009-11-18 | Vertex Pharma | Terapia de combinacion para el tratamiento de infeccion de virus de hepatitis c. |
| CA2686546A1 (en) | 2007-05-10 | 2008-11-20 | Intermune, Inc. | Novel peptide inhibitors of hepatitis c virus replication |
| EP2157974A1 (en) | 2007-05-21 | 2010-03-03 | Vertex Pharmceuticals Incorporated | Dose forms comprising vx- 950 and their dosage regimen |
| RU2348412C1 (ru) | 2007-06-01 | 2009-03-10 | Лариса Леонидовна Попова | Способ профилактики рецидива хронического вирусного гепатита с после достижения вирусологической ремиссии |
| WO2008154248A1 (en) | 2007-06-06 | 2008-12-18 | Inova Health System | Prognostic chronic hepatitis c biomarkers |
| NZ582096A (en) | 2007-06-29 | 2012-05-25 | Gilead Sciences Inc | Antiviral compounds that inhibit hepatitis c virus (hcv) |
| CN100532388C (zh) | 2007-07-16 | 2009-08-26 | 郑州大学 | 2’-氟-4’-取代-核苷类似物、其制备方法及应用 |
| CA2694440A1 (en) | 2007-07-25 | 2009-01-29 | Biolex Therapeutics, Inc. | Controlled release interferon drug products and treatment of hcv infection using same |
| CA2698038A1 (en) | 2007-07-26 | 2009-01-29 | Entra Pharmaceuticals Inc. | Systems and methods for delivering drugs |
| ES2614269T3 (es) | 2007-08-03 | 2017-05-30 | Biotron Limited | Procedimientos y composiciones antivíricas frente a la hepatitis C |
| US7728027B2 (en) | 2007-08-08 | 2010-06-01 | Bristol-Myers Squibb Company | Process for synthesizing compounds useful for treating hepatitis C |
| US8629171B2 (en) | 2007-08-08 | 2014-01-14 | Bristol-Myers Squibb Company | Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt |
| WO2009026292A1 (en) | 2007-08-20 | 2009-02-26 | Anadys Pharmaceuticals, Inc. | Dosing methods for treating disease |
| EP2436682A1 (en) | 2007-08-30 | 2012-04-04 | Vertex Pharmceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| WO2009033183A2 (en) | 2007-09-08 | 2009-03-12 | University Of Florida Research Foundation | Compounds and methods for treatment of hcv and conditions associated with cd81 binding |
| US20090076100A1 (en) | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched gsk625433 |
| CA2699280A1 (en) | 2007-09-14 | 2009-03-26 | Schering Corporation | Method of treating hepatitis c patients |
| WO2009039134A1 (en) * | 2007-09-17 | 2009-03-26 | Abbott Laboratories | Anti-infective pyrimidines and uses thereof |
| AR070027A1 (es) * | 2007-09-17 | 2010-03-10 | Abbott Lab | Agentes anti-infecciosos contra el virus hcv |
| WO2009039248A2 (en) | 2007-09-18 | 2009-03-26 | Stanford University | Methods of treating a flaviviridae family viral infection and compositions for treating a flaviviridae family viral infection |
| US20090082414A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched viramidine |
| US20090082366A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched telaprevir |
| JP5486744B2 (ja) | 2007-10-03 | 2014-05-07 | サベル コーポレーション | ムユヨの花、トゲバンレイシの葉、及びウコンの根の抽出物を含む、肝炎を治療するための組成物 |
| WO2009046369A2 (en) | 2007-10-05 | 2009-04-09 | Medtronic, Inc. | Use of a specific dosage regimen of ifn-alpha and ribavirin for treating hepatitis c |
| EP2214682A2 (en) | 2007-11-05 | 2010-08-11 | Vertex Pharmaceuticals Incorporated | Hcv combination therapies comprising vx-950, peg-ifn and ribavirin |
| AU2008323156B2 (en) | 2007-11-15 | 2012-05-31 | Madaus Gmbh | Silibinin component for the treatment of hepatitis |
| AU2008340430B2 (en) | 2007-12-21 | 2013-01-24 | F. Hoffmann-La Roche Ag | Process for the preparation of a macrocycle |
| CN104557880A (zh) | 2007-12-21 | 2015-04-29 | 阿维拉制药公司 | Hcv蛋白酶抑制剂和其用途 |
| US8202996B2 (en) * | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
| WO2009085267A1 (en) | 2007-12-27 | 2009-07-09 | Epiphany Biosciences | Antiviral compounds |
| EP2268811A1 (en) | 2008-03-07 | 2011-01-05 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| JP5283106B2 (ja) | 2008-03-14 | 2013-09-04 | 国立大学法人 熊本大学 | C型肝炎ウイルス阻害剤 |
| US20100009970A1 (en) | 2008-03-19 | 2010-01-14 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| US20110045001A1 (en) | 2008-03-28 | 2011-02-24 | Biontex Laboratories Gmbh | Transfection results of non-viral gene delivery systems by influencing of the innate immune system |
| CA2720846A1 (en) | 2008-04-15 | 2009-11-05 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| EP2280709A1 (en) | 2008-04-23 | 2011-02-09 | Vertex Pharmaceuticals Incorporated | Treatment of hepatitis c virus infections with telaprevir (vx-950) in patients non-responsive to treatment with pegylated interfer0n-alpha-2a/2b and ribavirin |
| PL2280973T3 (pl) * | 2008-04-23 | 2013-05-31 | Gilead Sciences Inc | Analogi karba-nukleozydowe do leczenia przeciwwirusowego |
| DE102008029669A1 (de) | 2008-05-16 | 2009-11-19 | Schlaak, Jörg Friedrich, Prof. Dr. med. | Neue Therapeutika für die Hepatitis-Therapie |
| US20110218512A1 (en) | 2008-06-03 | 2011-09-08 | Aethlon Medical, Inc. | Enhanced antiviral therapy methods and devices |
| RU2496514C2 (ru) | 2008-06-05 | 2013-10-27 | Займоджинетикс, Инк. | Применение пэгилированных интерферонов типа iii для лечения гепатита с |
| JP2011522862A (ja) | 2008-06-10 | 2011-08-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | テラプレビル(Telaprevir)投薬養生法 |
| EP2349257B1 (en) | 2008-06-17 | 2013-11-27 | Universidade Federal de Minas Gerais-UFMG | Use of paf receptor for treating infections caused by flaviviridae |
| ES2392611T3 (es) | 2008-07-22 | 2012-12-12 | Merck Sharp & Dohme Corp. | Compuestos de quinoxalina macrocíclica como inhibidores de la proteasa NS3 del VHC |
| US20100034839A1 (en) | 2008-07-25 | 2010-02-11 | Martha Karen Newell | Methods for treating viral disorders |
| RU2373952C1 (ru) | 2008-07-30 | 2009-11-27 | Юрий Михайлович Амбалов | Способ лечебного питания больных хроническим гепатитом с, получающих комплексную противовирусную терапию |
| JP2011530519A (ja) | 2008-08-06 | 2011-12-22 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | 免疫調節化合物を用いたc型肝炎の治療または予防の方法 |
| EP2323981B1 (en) | 2008-08-07 | 2014-03-12 | F. Hoffmann-La Roche AG | Process for the preparation of a macrocycle |
| EP2323631A1 (en) | 2008-08-07 | 2011-05-25 | Schering Corporation | Pharmaceutical formulations of an hcv protease inhibitor in a solid molecular dispersion |
| US20100092479A1 (en) | 2008-08-18 | 2010-04-15 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| WO2010020676A1 (en) | 2008-08-20 | 2010-02-25 | Vib Vzw | The use of topoisomerase type i inhibitors to treat viral infections |
| WO2010025380A2 (en) | 2008-08-28 | 2010-03-04 | Vertex Pharmaceuticals Incorporated | Analysis of hcv genotypes |
| CN102137682B (zh) | 2008-08-29 | 2014-07-02 | 国立大学法人大阪大学 | 抗丙型肝炎病毒组合物 |
| AU2009288200A1 (en) | 2008-09-03 | 2010-03-11 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical formulations comprising the same |
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| AU2009293494B2 (en) | 2008-09-16 | 2014-04-24 | Boehringer Ingelheim International Gmbh | Crystalline forms of a 2-thiazolyl- 4-quinolinyl-oxy derivative, a potent HCV inhibitor |
| AU2009293493B2 (en) | 2008-09-17 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Combination of HCV NS3 protease inhibitor with interferon and ribavirin |
| WO2010031832A2 (en) | 2008-09-18 | 2010-03-25 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Synergistic combinations of a macrocyclic inhibitor of hcv and a thiophene-2-carboxylic acid derivative |
| KR20110074870A (ko) | 2008-09-24 | 2011-07-04 | 버텍스 파마슈티칼스 인코포레이티드 | 간염을 치료하기 위한 peg-인터페론, 리바비린 및 vx-950을 포함하는 치료 요법 |
| CN102227237A (zh) | 2008-09-26 | 2011-10-26 | 国家健康与医学研究院 | 作为针对hcv感染的抗病毒治疗的靶标的宿主细胞激酶 |
| US9006285B2 (en) | 2008-09-30 | 2015-04-14 | Mochida Pharmaceutical Co., Ltd. | Therapeutic agent for hepatitis C |
| EP2341924A4 (en) | 2008-10-02 | 2013-01-23 | David Gladstone Inst | METHOD FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTIONS |
| BRPI0914060A2 (pt) | 2008-10-08 | 2015-11-17 | Charlotte Mecklenburg Hospital | formulação para o tratamento de células que expressem proteínas do hcv e de mamíferos portadores de hepatite c, método para o tratamento de células infectadas pela cepa pj6/jfh1 do hcv genótipo 2a e uso de uma formulação |
| WO2010045266A1 (en) | 2008-10-15 | 2010-04-22 | Intermune, Inc. | Therapeutic antiviral peptides |
| WO2010049438A2 (en) | 2008-10-30 | 2010-05-06 | Innate Pharma | Improved methods of using phosphoantigens for the treatment of diseases |
| EP2358439A1 (en) | 2008-11-05 | 2011-08-24 | Vertex Pharmaceuticals Incorporated | Methods for treating hepatitis c virus infection |
| EP2358355B1 (en) | 2008-11-21 | 2013-11-06 | Boehringer Ingelheim International GmbH | Pharmaceutical composition of a potent hcv inhibitor for oral administration |
| ES2527166T3 (es) | 2008-12-10 | 2015-01-21 | Achillion Pharmaceuticals, Inc. | Nuevos péptidos de 4-amino-4-oxobutanoílo como inhibidores de la replicación viral |
| WO2010066112A1 (en) | 2008-12-11 | 2010-06-17 | The University Of Hong Kong | siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION |
| WO2010069809A1 (en) | 2008-12-18 | 2010-06-24 | F. Hoffmann-La Roche Ag | Biomarkers for hcv treatment response |
| MX2011006890A (es) | 2008-12-23 | 2011-07-20 | Pharmasset Inc | Analogos de nucleosidos. |
| US20120009148A1 (en) | 2008-12-29 | 2012-01-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection |
| US8840934B2 (en) | 2009-01-02 | 2014-09-23 | Rainbow Pharmaceutical Sa | Uses of ammonium chloride |
| BRPI1004575A2 (pt) | 2009-01-09 | 2016-04-05 | Inhibitex Inc | composto, composição farmacêutica, método de tratamento de infecções virais, método de separação dos diaestereômeros de fósforo |
| RU2398582C1 (ru) | 2009-01-19 | 2010-09-10 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.М. Мечникова Федерального агентства по здравоохранению и социальному развитию" | Способ лечения хронического вирусного гепатита с 1-генотипа с умеренной активностью и репликативностью |
| EP2396028A2 (en) | 2009-02-12 | 2011-12-21 | Vertex Pharmceuticals Incorporated | Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir |
| AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| WO2010101649A2 (en) | 2009-03-05 | 2010-09-10 | Pablo Gastaminza | Sigma 1 receptor inhibition as a novel therapeutical approach against hepatitis c virus infection |
| CN102413843A (zh) | 2009-03-05 | 2012-04-11 | 阿森迪斯药物股份有限公司 | 干扰素α载体前药 |
| US9034837B2 (en) | 2009-04-24 | 2015-05-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical compositions for treatment of HCV patients that are poor-responders to interferon |
| LT2421527T (lt) | 2009-04-25 | 2018-09-10 | F. Hoffmann-La Roche Ag | Farmakokinetinių savybių pagerinimo būdai |
| SG176015A1 (en) * | 2009-05-13 | 2011-12-29 | Gilead Sciences Inc | Antiviral compounds |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI576352B (zh) * | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| AU2010249379B2 (en) | 2009-05-21 | 2013-09-26 | Merck Sharp & Dohme Corp. | Genetic markers associated with interferon-alpha response |
| EP2853531A3 (en) | 2009-06-11 | 2015-08-12 | AbbVie Bahamas Ltd. | Antiviral compounds |
| TW201111381A (en) | 2009-06-23 | 2011-04-01 | Gilead Sciences Inc | Pharmaceutical combinations useful for treating HCV |
| AR077138A1 (es) | 2009-06-23 | 2011-08-03 | Gilead Sciences Inc | Composiciones farmaceuticas utiles para tratar el vhc |
| TW201105323A (en) | 2009-06-23 | 2011-02-16 | Gilead Sciences Inc | Pharmaceutical compositions useful for treating HCV |
| BRPI1014322A2 (pt) | 2009-06-26 | 2015-08-25 | Romark Lab Lc | Método para tratar infecção, e para interromper ou evitar a produção de partículas virais infecciosas, combinação, e, composição farmacêutica. |
| PE20120322A1 (es) | 2009-07-07 | 2012-04-14 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende faldaprevir o una sal del mismo en un vehiculo auto-emulsionante |
| RU2400229C1 (ru) | 2009-07-13 | 2010-09-27 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" | СПОСОБ ЛЕЧЕНИЯ БОЛЬНЫХ ХРОНИЧЕСКИМ ВИРУСНЫМ ГЕПАТИТОМ С, ГЕНОТИПОМ 3а |
| EP2467144A1 (en) | 2009-07-24 | 2012-06-27 | ViroLogik GmbH | Combination of proteasome inhibitors and anti-hepatitis medication for treating hepatitis |
| JP2013500713A (ja) | 2009-07-31 | 2013-01-10 | サントル オスピタリエ ウニヴェルシテール ヴォドア | Hcv感染患者においてc型肝炎の転帰を診断又は予測する方法 |
| US20110027229A1 (en) | 2009-07-31 | 2011-02-03 | Medtronic, Inc. | Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients |
| EP2470189A4 (en) | 2009-08-27 | 2013-01-23 | Merck Sharp & Dohme | METHOD FOR PRODUCING PROTEASE INHIBITORS OF HEPATITIS C VIRUS |
| US20110086869A1 (en) | 2009-09-24 | 2011-04-14 | The Trustees Of Boston University | Methods for treating viral disorders |
| TW201116540A (en) | 2009-10-01 | 2011-05-16 | Intermune Inc | Therapeutic antiviral peptides |
| US8415374B2 (en) | 2009-10-12 | 2013-04-09 | Bristol-Myers Squibb Company | Combinations of hepatitis C virus inhibitors |
| WO2011056650A2 (en) | 2009-10-27 | 2011-05-12 | Michael Zasloff | Methods and compositions for treating and preventing viral infections |
| US9174988B2 (en) | 2009-10-27 | 2015-11-03 | Trustees Of Boston University | Small molecule inhibitors of hepatitis C virus |
| KR20120106942A (ko) | 2009-10-30 | 2012-09-27 | 베링거 인겔하임 인터내셔날 게엠베하 | Bi201335, 인터페론 알파 및 리바비린을 포함하는 hcv 병용 치료요법을 위한 투여 용법 |
| CA2779404A1 (en) | 2009-11-09 | 2011-06-03 | Schering Corporation | Markers associated with ribavirin-induced anemia |
| WO2011063076A1 (en) | 2009-11-19 | 2011-05-26 | Itherx Pharmaceuticals, Inc. | Methods of treating hepatitis c virus with oxoacetamide compounds |
| WO2011066260A2 (en) | 2009-11-25 | 2011-06-03 | Michael Zasloff | Formulations comprising aminosterols |
| US8653070B2 (en) * | 2009-12-14 | 2014-02-18 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| MX2012007076A (es) | 2009-12-18 | 2012-07-20 | Boehringer Ingelheim Int | Terapia combinada de hcv. |
| US20110150836A1 (en) | 2009-12-22 | 2011-06-23 | Gilead Sciences, Inc. | Methods of treating hbv and hcv infection |
| WO2011076807A2 (en) | 2009-12-23 | 2011-06-30 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| RU2424794C1 (ru) | 2009-12-30 | 2011-07-27 | Государственное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО УГМА Росздрава) | Способ лечения врожденного гепатита с у детей первого года жизни |
| EA201201031A1 (ru) * | 2010-01-25 | 2013-02-28 | Энанта Фармасьютиклз, Инк. | Ингибиторы вируса гепатита с |
| AU2011210795A1 (en) | 2010-01-29 | 2012-08-02 | Vertex Pharmaceuticals Incorporated | Therapies for treating Hepatitis C virus infection |
| US20110312973A1 (en) * | 2010-03-10 | 2011-12-22 | Bernd Liepold | Solid compositions |
| US8530497B2 (en) | 2010-03-11 | 2013-09-10 | Boehringer Ingelheim International Gmbh | Crystalline salts of a potent HCV inhibitor |
| AP2012006535A0 (en) * | 2010-03-31 | 2012-10-31 | Gilead Pharmasset Llc | Stereoselective synthesis of phosphorous containing actives |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| US20110306541A1 (en) | 2010-06-10 | 2011-12-15 | Gilead Sciences, Inc. | Methods for treating hcv |
| CA2745102A1 (en) | 2010-06-29 | 2011-12-29 | Medicorp Institute Of Canada | Pharmaceutical composition and method of use to improve organ function |
| RU2429877C1 (ru) | 2010-06-30 | 2011-09-27 | Общество с ограниченной ответственностью "ИНГИЛС" | Способ лечения хронического вирусного гепатита с |
| EP2593105A1 (en) | 2010-07-14 | 2013-05-22 | Vertex Pharmaceuticals Incorporated | Palatable pharmaceutical composition comprising vx-950 |
| US20140162942A1 (en) | 2010-07-30 | 2014-06-12 | Anima Ghosal | Inhibition of cyp3a drug metabolism |
| US20120196272A1 (en) | 2010-08-05 | 2012-08-02 | Roche Molecular Systems, Inc. | Prediction of HCV Viral Kinetics in Interferon-Free Treatment |
| US20120196794A1 (en) | 2010-08-06 | 2012-08-02 | Bristol-Myers Squibb Company | Combinations of Hepatitis C Virus Inhibitors |
| WO2012040127A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| CA2811752A1 (en) | 2010-09-29 | 2012-04-19 | Merck Sharp & Dohme Corp. | Polycyclic heterocycle derivatives and methods of use thereof for the treatment of viral diseases |
| WO2012041771A1 (en) | 2010-09-30 | 2012-04-05 | Boehringer Ingelheim International Gmbh | Combination therapy for treating hcv infection |
| CN103269586B (zh) * | 2010-10-26 | 2015-07-15 | 普雷西迪奥制药公司 | 丙型肝炎病毒抑制剂 |
| US20120107278A1 (en) | 2010-10-29 | 2012-05-03 | Pharmasset, Inc. | Abbreviated hcv therapy for hcv infected patients with il28b c/c genotype |
| TW201306841A (zh) | 2010-12-20 | 2013-02-16 | Gilead Sciences Inc | 治療c型肝炎病毒(hcv)之方法 |
| WO2012139028A2 (en) | 2011-04-06 | 2012-10-11 | The Trustees Of Princeton University | Anti-viral combination therapy |
| WO2012175733A1 (en) | 2011-06-23 | 2012-12-27 | Santaris Pharma A/S | Hcv combination therapy |
| EP2726610A1 (en) | 2011-06-30 | 2014-05-07 | Stella ApS | Hcv combination therapy |
| KR20140058536A (ko) | 2011-06-30 | 2014-05-14 | 스텔라 에이피에스 | Hcv 조합 치료 |
| WO2013024158A1 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection |
| WO2013025975A1 (en) | 2011-08-17 | 2013-02-21 | Glaxosmithkline Llc | Combination treatments for hepatitis c |
| WO2013024155A1 (en) | 2011-08-17 | 2013-02-21 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Combinations of anti-hcv-entry factor antibodies and direct acting antivirals for the treatment and the prevention of hcv infection |
| EA201490254A1 (ru) | 2011-08-24 | 2014-07-30 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Комбинированное лечение гепатита с |
| HRP20180237T4 (hr) * | 2011-09-16 | 2020-12-11 | Gilead Pharmasset Llc | Metode za liječenje hcv-a |
| US8466159B2 (en) * | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| US8492386B2 (en) * | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| DE112012003510T5 (de) | 2011-10-21 | 2015-03-19 | Abbvie Inc. | Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon |
| CN104023726A (zh) | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如,与abt-072或abt-333) |
| WO2013066753A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Compositions useful for the treatment of viral diseases |
| US20130137084A1 (en) | 2011-11-28 | 2013-05-30 | Roche Molecular Systems, Inc. | Single Nucleotide Polymorphism on Chromosome 15 That Predicts HCV Treatment Responses |
| EP2794630A4 (en) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE |
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