JP2017514834A5 - - Google Patents
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- Publication number
- JP2017514834A5 JP2017514834A5 JP2016565327A JP2016565327A JP2017514834A5 JP 2017514834 A5 JP2017514834 A5 JP 2017514834A5 JP 2016565327 A JP2016565327 A JP 2016565327A JP 2016565327 A JP2016565327 A JP 2016565327A JP 2017514834 A5 JP2017514834 A5 JP 2017514834A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic combination
- combination according
- day
- administered
- sofosbuvir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001225 therapeutic effect Effects 0.000 claims description 16
- 241000711549 Hepacivirus C Species 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- TTZHDVOVKQGIBA-IQWMDFIBSA-N sofosbuvir Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@]2(F)C)O)CO[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC=2C=CC=CC=2)C=CC(=O)NC1=O TTZHDVOVKQGIBA-IQWMDFIBSA-N 0.000 claims description 15
- 229960002063 sofosbuvir Drugs 0.000 claims description 15
- 208000015181 infectious disease Diseases 0.000 claims description 10
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 8
- 229960000329 ribavirin Drugs 0.000 claims description 8
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 8
- 239000002552 dosage form Substances 0.000 claims description 4
- LLGDPTDZOVKFDU-XUHJSTDZSA-N faldaprevir Chemical compound N([C@H](C(=O)N1[C@@H](C[C@H](C1)OC=1C2=CC=C(C(=C2N=C(C=1)C=1N=C(NC(=O)C(C)C)SC=1)Br)OC)C(=O)N[C@]1([C@@H](C1)C=C)C(O)=O)C(C)(C)C)C(=O)OC1CCCC1 LLGDPTDZOVKFDU-XUHJSTDZSA-N 0.000 claims description 3
- 229960003777 faldaprevir Drugs 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- -1 Rejipasubiru Chemical compound 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 150000001875 compounds Chemical class 0.000 description 3
- 239000003443 antiviral agent Substances 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 238000011295 triple combination therapy Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461987682P | 2014-05-02 | 2014-05-02 | |
| US61/987,682 | 2014-05-02 | ||
| PCT/EP2015/059557 WO2015166071A1 (en) | 2014-05-02 | 2015-04-30 | Combination therapy for treating hcv infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017514834A JP2017514834A (ja) | 2017-06-08 |
| JP2017514834A5 true JP2017514834A5 (enExample) | 2018-06-14 |
Family
ID=53052853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565327A Pending JP2017514834A (ja) | 2014-05-02 | 2015-04-30 | Ｈｃｖ感染症を治療するための組合せ療法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20170049797A1 (enExample) |
| EP (1) | EP3137075A1 (enExample) |
| JP (1) | JP2017514834A (enExample) |
| WO (1) | WO2015166071A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ2015443A3 (cs) * | 2015-06-26 | 2017-01-04 | Zentiva, K.S. | Farmaceutická formulace sofosbuviru |
-
2015
- 2015-04-30 JP JP2016565327A patent/JP2017514834A/ja active Pending
- 2015-04-30 EP EP15720697.0A patent/EP3137075A1/en not_active Withdrawn
- 2015-04-30 WO PCT/EP2015/059557 patent/WO2015166071A1/en not_active Ceased
- 2015-04-30 US US15/307,428 patent/US20170049797A1/en not_active Abandoned
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