DE3607897A1 - Verfahren zur herstellung einer chemisch modifizierten hyaluronsaeurezubereitung - Google Patents
Verfahren zur herstellung einer chemisch modifizierten hyaluronsaeurezubereitungInfo
- Publication number
- DE3607897A1 DE3607897A1 DE19863607897 DE3607897A DE3607897A1 DE 3607897 A1 DE3607897 A1 DE 3607897A1 DE 19863607897 DE19863607897 DE 19863607897 DE 3607897 A DE3607897 A DE 3607897A DE 3607897 A1 DE3607897 A1 DE 3607897A1
- Authority
- DE
- Germany
- Prior art keywords
- hyaluronic acid
- water
- solvent
- chemically modified
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/710,929 US4713448A (en) | 1985-03-12 | 1985-03-12 | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3607897A1 true DE3607897A1 (de) | 1986-09-18 |
| DE3607897C2 DE3607897C2 (enExample) | 1992-02-27 |
Family
ID=24856100
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19863607897 Granted DE3607897A1 (de) | 1985-03-12 | 1986-03-10 | Verfahren zur herstellung einer chemisch modifizierten hyaluronsaeurezubereitung |
| DE3645226A Expired - Lifetime DE3645226C2 (enExample) | 1985-03-12 | 1986-03-10 | |
| DE3645191A Expired - Lifetime DE3645191C2 (enExample) | 1985-03-12 | 1986-03-10 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3645226A Expired - Lifetime DE3645226C2 (enExample) | 1985-03-12 | 1986-03-10 | |
| DE3645191A Expired - Lifetime DE3645191C2 (enExample) | 1985-03-12 | 1986-03-10 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4713448A (enExample) |
| JP (2) | JPS61207401A (enExample) |
| AU (1) | AU560956B2 (enExample) |
| BE (1) | BE904357A (enExample) |
| CA (1) | CA1276143C (enExample) |
| CH (1) | CH670092A5 (enExample) |
| DE (3) | DE3607897A1 (enExample) |
| FR (1) | FR2582002B1 (enExample) |
| GB (1) | GB2172295B (enExample) |
| IT (1) | IT1191981B (enExample) |
| NL (1) | NL186576C (enExample) |
| SE (1) | SE468830B (enExample) |
Families Citing this family (159)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| US5099013A (en) * | 1985-03-12 | 1992-03-24 | Biomatrix, Inc, | Hylan preparation and method of recovery thereof from animal tissues |
| US4879375A (en) * | 1985-05-09 | 1989-11-07 | Hill David Cullis | Preparation of hyaluronic acid from synovial fluid |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| EP0224987B1 (en) * | 1985-11-29 | 1992-04-15 | Biomatrix, Inc. | Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same |
| SE452469B (sv) * | 1986-06-18 | 1987-11-30 | Pharmacia Ab | Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma |
| IT1198449B (it) * | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| AU610512B2 (en) * | 1986-12-11 | 1991-05-23 | Biomatrix Incorporated | Improved hyaluronate-poly (ethylene oxide) mixtures |
| GB8713662D0 (en) * | 1987-06-11 | 1987-07-15 | Skandigen Ab | Hyaluronic acid derivatives |
| US6174999B1 (en) | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| US6610669B1 (en) | 1987-09-18 | 2003-08-26 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| AU619760B2 (en) * | 1987-12-10 | 1992-02-06 | Genzyme Biosurgery Corporation | Hylan preparation and method of recovery thereof from animal tissues |
| IT1219587B (it) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
| US5356883A (en) * | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
| US5143724A (en) * | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
| US5246698A (en) * | 1990-07-09 | 1993-09-21 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
| US5824658A (en) * | 1990-09-18 | 1998-10-20 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| CA2061703C (en) * | 1992-02-20 | 2002-07-02 | Rudolf E. Falk | Formulations containing hyaluronic acid |
| US5990096A (en) * | 1990-09-18 | 1999-11-23 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US5910489A (en) * | 1990-09-18 | 1999-06-08 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| US5219360A (en) * | 1991-05-10 | 1993-06-15 | Fortis Research Corporation | Mammary prosthesis fill and method of making same |
| US5792753A (en) * | 1991-07-03 | 1998-08-11 | Hyal Pharmaceutical Corporation | Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs |
| US6103704A (en) * | 1991-07-03 | 2000-08-15 | Hyal Pharmaceutical Corporation | Therapeutic methods using hyaluronic acid |
| US5977088A (en) * | 1991-07-03 | 1999-11-02 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| CA2061567C (en) * | 1992-02-20 | 1998-02-03 | Rudolf E. Falk | Use of hyaluronic acid to repair ischemia reperfusion damage |
| US6218373B1 (en) | 1992-02-20 | 2001-04-17 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US5767106A (en) * | 1992-02-21 | 1998-06-16 | Hyal Pharmaceutical Corporation | Treatment of disease and conditions associated with macrophage infiltration |
| IT1260154B (it) * | 1992-07-03 | 1996-03-28 | Lanfranco Callegaro | Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) |
| US5616568A (en) * | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
| US5690961A (en) | 1994-12-22 | 1997-11-25 | Hercules Incorporated | Acidic polysaccharides crosslinked with polycarboxylic acids and their uses |
| US5612321A (en) * | 1995-06-22 | 1997-03-18 | Hercules Incorporated | Antioxidant grafted polysaccharides |
| CA2273852C (en) | 1996-12-06 | 2009-09-29 | Amgen Inc. | Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases |
| US6294170B1 (en) | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| US6630457B1 (en) | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
| IT1303738B1 (it) * | 1998-11-11 | 2001-02-23 | Aquisitio S P A | Processo di reticolazione di polisaccaridi carbossilati. |
| US20040048021A1 (en) * | 1999-03-19 | 2004-03-11 | Wan Barbara Y. F. | Surface modification of substrates |
| US6610666B1 (en) | 1999-11-08 | 2003-08-26 | Bio-Hyos Ab | Hyaluronan product and process for manufacturing thereof |
| US6521223B1 (en) | 2000-02-14 | 2003-02-18 | Genzyme Corporation | Single phase gels for the prevention of adhesions |
| KR100375299B1 (ko) | 2000-10-10 | 2003-03-10 | 주식회사 엘지생명과학 | 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법 |
| WO2002068383A2 (en) * | 2001-02-22 | 2002-09-06 | Anika Therapeutics, Inc. | Thiol-modified hyaluronan |
| KR100514582B1 (ko) * | 2001-09-05 | 2005-09-13 | 한스바이오메드 주식회사 | 생체복원물질의 제조방법 |
| MXPA01011542A (es) * | 2001-11-13 | 2003-05-22 | Alcon Inc | Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel. |
| US7186232B1 (en) * | 2002-03-07 | 2007-03-06 | Glaukoa Corporation | Fluid infusion methods for glaucoma treatment |
| US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
| CN101134119A (zh) | 2002-05-24 | 2008-03-05 | 血管技术国际股份公司 | 用于涂覆医用植入物的组合物和方法 |
| AU2003299509A1 (en) * | 2002-06-21 | 2004-05-13 | University Of Utah Research Foundation | Crosslinked compounds and methods of making and using thereof |
| CA2496121C (en) * | 2002-08-16 | 2010-03-30 | Yoshiaki Miyata | Stable formulations of hyaluronic acid for use in the therapeutic treatment of arthropathy |
| KR20040022760A (ko) * | 2002-09-05 | 2004-03-18 | 주식회사 오스코텍 | 닭벼슬로부터 고순도 히아루론산의 추출방법 |
| US6946551B2 (en) * | 2003-03-12 | 2005-09-20 | New Life Resources, Llc | Preparation of hyaluronic acid from eggshell membrane |
| US20080063677A1 (en) * | 2004-03-10 | 2008-03-13 | New Life Resources, Llc | Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations |
| US20040180025A1 (en) * | 2003-03-12 | 2004-09-16 | New Life Resources, Llc | Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations |
| FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
| US20050158356A1 (en) * | 2003-11-20 | 2005-07-21 | Angiotech International Ag | Implantable sensors and implantable pumps and anti-scarring agents |
| US20080176205A1 (en) * | 2003-12-04 | 2008-07-24 | University Of Utah Research Foundation | Process and Formulation to Improve Viability of Stored Cells and Tissue |
| US7625581B2 (en) * | 2003-12-19 | 2009-12-01 | Ethicon, Inc. | Tissue scaffolds for use in muscoloskeletal repairs |
| US7091191B2 (en) * | 2003-12-19 | 2006-08-15 | Ethicon, Inc. | Modified hyaluronic acid for use in musculoskeletal tissue repair |
| US8524213B2 (en) * | 2003-12-30 | 2013-09-03 | Genzyme Corporation | Polymeric materials, their preparation and use |
| BRPI0418309B8 (pt) * | 2003-12-30 | 2021-05-25 | Genzyme Corp | "géis coesos de hialuronado e/ou hilano reticulados, processo para a preparação dos mesmos, bem como composições e dispositivos compreendendo os referidos géis". |
| DE102004002001A1 (de) * | 2004-01-14 | 2005-08-11 | Reinmüller, Johannes, Dr.med. | Mittel zur Behandlung von entzündlichen Erkrankungen |
| US8580315B2 (en) * | 2004-03-10 | 2013-11-12 | Esm Technologies, Llc | Anti-inflammatory activity of eggshell membrane and processed eggshell membrane preparations |
| CA2567532C (en) * | 2004-05-20 | 2013-10-01 | Mentor Corporation | Methods for making injectable polymer hydrogels |
| US7002007B2 (en) * | 2004-05-28 | 2006-02-21 | Calcigen Corporation | Production of high molecular weight hyaluronates |
| ITMI20041373A1 (it) | 2004-07-09 | 2004-10-09 | Lima Lto S P A | N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido |
| EP1817347B1 (en) * | 2004-11-24 | 2017-05-17 | Albumedix A/S | Method of cross-linking hyaluronic acid with divinylsulfone |
| CN103860582A (zh) | 2004-12-30 | 2014-06-18 | 建新公司 | 用于关节内粘弹性补充的方案 |
| ITPD20050056A1 (it) | 2005-03-02 | 2006-09-03 | Fidia Farmaceutici | Derivati ammidici del'acido ialuronico in osteoartrosi |
| CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| US20070202084A1 (en) | 2005-12-14 | 2007-08-30 | Anika Therapeutics, Inc. | Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects |
| WO2007070547A2 (en) * | 2005-12-14 | 2007-06-21 | Anika Therapeutics, Inc. | Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid |
| EP1991587B1 (en) | 2006-03-07 | 2013-07-24 | ProChon Biotech Ltd. | Hydrazido derivatives of hyaluronic acid |
| ITPD20060219A1 (it) | 2006-05-31 | 2007-12-01 | Fidia Farmaceutici | Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi |
| EP2107913B1 (en) * | 2006-12-22 | 2012-02-15 | Croma-Pharma Gesellschaft m.b.H. | Use of thiolated polysaccharides for tissue augmentation |
| WO2008081463A2 (en) * | 2007-01-04 | 2008-07-10 | Hepacore Ltd. | Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof |
| CA2687990A1 (en) | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Cross-linked collagen and uses thereof |
| US8658148B2 (en) | 2007-06-22 | 2014-02-25 | Genzyme Corporation | Chemically modified dendrimers |
| US20110077737A1 (en) * | 2007-07-30 | 2011-03-31 | Allergan, Inc. | Tunably Crosslinked Polysaccharide Compositions |
| US8318695B2 (en) | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
| US8697044B2 (en) | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
| RU2501811C2 (ru) * | 2007-11-13 | 2013-12-20 | Био-Текнолоджи Дженерал (Изрейел) Лтд. | Способ стерилизации посредством фильтрации разбавленных вязкоэластичных биополимеров (варианты) |
| PT2818184T (pt) | 2007-11-16 | 2019-01-28 | Aclaris Therapeutics Inc | Composições e métodos para o tratamento de púrpura |
| US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| US8394784B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having multi-stage bioactive agent delivery |
| US9044477B2 (en) | 2007-12-12 | 2015-06-02 | Allergan, Inc. | Botulinum toxin formulation |
| US9161970B2 (en) | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
| WO2009077399A1 (en) * | 2007-12-19 | 2009-06-25 | Evonik Goldschmidt Gmbh | Crosslinked hyaluronic acid in emulsion |
| US8357795B2 (en) | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| CA2735173C (en) | 2008-09-02 | 2017-01-10 | Tautona Group Lp | Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof |
| WO2010038231A1 (en) | 2008-10-02 | 2010-04-08 | L.R.R.& D. Ltd. | Interface layer wound dressing |
| CN101721349B (zh) | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
| CZ301555B6 (cs) | 2008-11-06 | 2010-04-14 | Cpn S. R. O. | Zpusob prípravy DTPA sítovaných derivátu kyseliny hyaluronové a jejich modifikace |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US8273725B2 (en) | 2009-09-10 | 2012-09-25 | Genzyme Corporation | Stable hyaluronan/steroid formulation |
| CZ2009836A3 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace |
| CZ302503B6 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace |
| US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
| US20110172180A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| US8586562B2 (en) | 2010-03-12 | 2013-11-19 | Allergan Industrie, Sas | Fluid compositions for improving skin conditions |
| EP4062950A1 (en) | 2010-03-22 | 2022-09-28 | Allergan, Inc. | Syringe comprising dermal filler for soft tissue augmentation |
| US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| CZ302994B6 (cs) | 2010-12-31 | 2012-02-08 | Cpn S.R.O. | Hyaluronová vlákna, zpusob jejich prípravy a použití |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| RU2624239C2 (ru) | 2011-06-03 | 2017-07-03 | Аллерган, Инк. | Составы кожного наполнителя, включая антиоксиданты |
| US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
| US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
| US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| DE102011077393A1 (de) * | 2011-06-10 | 2012-12-13 | Johannes Reinmüller | Antiinfektives Mittel |
| US10865383B2 (en) | 2011-07-12 | 2020-12-15 | Lineage Cell Therapeutics, Inc. | Methods and formulations for orthopedic cell therapy |
| RU2613887C2 (ru) | 2011-08-10 | 2017-03-21 | Гликорес 2000 С.Р.Л. | Устойчивый к расщеплению сшитый низкомолекулярный гиалуронат |
| US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
| FR2983483B1 (fr) | 2011-12-02 | 2014-11-14 | Vivacy Lab | Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles |
| CZ303879B6 (cs) | 2012-02-28 | 2013-06-05 | Contipro Biotech S.R.O. | Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití |
| KR101240518B1 (ko) | 2012-03-26 | 2013-03-11 | 주식회사 제네웰 | 생체 적합성 고분자를 이용한 이식용 재료 |
| ITPD20120098A1 (it) | 2012-03-30 | 2013-10-01 | Fidia Farmaceutici | "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico" |
| EP2831237B1 (en) | 2012-03-30 | 2017-11-29 | The Board of Regents of the University of Oklahoma | High molecular weight heparosan polymers and methods of production and use thereof |
| ITPD20120173A1 (it) | 2012-05-31 | 2013-12-01 | Fidia Farmaceutici | "nuovo sistema di rilascio di proteine idrofobiche" |
| IN2014DN10147A (enExample) * | 2012-06-15 | 2015-08-21 | Merz Pharma Gmbh & Co Kgaa | |
| CZ304512B6 (cs) | 2012-08-08 | 2014-06-11 | Contipro Biotech S.R.O. | Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití |
| CN102863631B (zh) * | 2012-09-29 | 2013-11-13 | 杭州嘉伟生物制品有限公司 | 外科整形用组织填充剂交联透明质酸钠凝胶及其制备方法 |
| CZ304654B6 (cs) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
| HK1214618A1 (zh) | 2013-01-11 | 2016-07-29 | Carbylan Therapeutics, Inc. | 含有透明質酸的穩定化組合物 |
| US9714361B2 (en) | 2013-03-15 | 2017-07-25 | Lake Region Manfacturing, Inc. | Oxirane (ethylene oxide) polyurethane coatings |
| US9255173B2 (en) | 2013-03-15 | 2016-02-09 | Lake Region Manufacturing, Inc. | Oxirane (ethylene oxide) polyurethane coatings |
| CZ2014150A3 (cs) | 2014-03-11 | 2015-05-20 | Contipro Biotech S.R.O. | Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití |
| CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| WO2016051219A1 (en) | 2014-09-30 | 2016-04-07 | Allergan Industrie, Sas | Stable hydrogel compositions including additives |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
| RU2715234C2 (ru) | 2015-02-13 | 2020-02-26 | Аллерган Эндюстри, Сас | Имплантаты для моделирования, увеличения или коррекции частей лица, например подбородка |
| CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| CZ2015398A3 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
| KR20170090965A (ko) * | 2016-01-29 | 2017-08-08 | 한미약품 주식회사 | 복합 히알루론산 가교물 및 그 제조방법 |
| EP3415586B1 (en) | 2016-02-12 | 2022-11-30 | Laimu Corporation | Wound treatment agent and method for producing same |
| CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| AU2018216540B2 (en) | 2017-02-02 | 2021-02-18 | Amtixbio Co., Ltd. | Hydrogel using, as substrate, hyaluronic acid derivative modified with gallol group and use thereof |
| BR112021004771A2 (pt) | 2018-09-13 | 2021-11-09 | Allergan Inc | Composições de ácido hialurônico-toxina clostridial |
| US10899944B2 (en) | 2018-10-29 | 2021-01-26 | Lake Region Manufacturing, Inc. | Polyurethane urea-containing adipic acid dihydrazide where active hydrogens react with the epoxy group found on glycidol to form a diol |
| KR102400586B1 (ko) | 2018-12-07 | 2022-05-23 | 한미약품 주식회사 | 히알루론산 가교물, 히알루론산 수화 겔 및 이들의 제조방법 |
| US12090248B2 (en) | 2018-12-07 | 2024-09-17 | Hanmi Pharm. Co., Ltd. | Crosslinked hyaluronic acid, hyaluronic acid hydrogel, and method for producing crosslinked hyaluronic acid and hyaluronic acid hydrogel |
| WO2022147084A1 (en) | 2020-12-30 | 2022-07-07 | Convatec Technologies Inc. | Surface treatment system and method for subcutaneous device |
| KR20220106283A (ko) | 2021-01-22 | 2022-07-29 | (주)앰틱스바이오 | 자가 가교형 히알루론산 유도체 기반 창상피복재 |
| WO2023104843A1 (de) | 2021-12-09 | 2023-06-15 | Beiersdorf Ag | Topisch applizierbare zubereitung zur verbesserung des hautzustandes |
| DE102022202547A1 (de) | 2021-12-09 | 2023-06-15 | Beiersdorf Aktiengesellschaft | Topisch applizierbare Zubereitung zur Verbesserung des Hautzustandes |
| IT202100032111A1 (it) | 2021-12-22 | 2023-06-22 | Fidia Farm Spa | Nuovi sostituti biocompatibili dell’umor vitreo |
| DE102023201536A1 (de) | 2023-02-21 | 2024-08-22 | Beiersdorf Aktiengesellschaft | Körpermilch |
| DE102023201528A1 (de) | 2023-02-21 | 2024-08-22 | Beiersdorf Aktiengesellschaft | Körpermilch |
| EP4701742A1 (de) | 2023-04-27 | 2026-03-04 | Beiersdorf AG | Retinolhaltige kosmetische zubereitung mit guter hautverträglichkeit |
| DE102023203936A1 (de) | 2023-04-27 | 2024-10-31 | Beiersdorf Aktiengesellschaft | Retinolhaltige kosmetische Zubereitung mit guter Hautverträglichkeit |
| WO2024223515A1 (de) | 2023-04-27 | 2024-10-31 | Beiersdorf Ag | Retinolhaltige kosmetische zubereitung mit guter stabilität und hautverträglichkeit |
| EP4701743A1 (de) | 2023-04-27 | 2026-03-04 | Beiersdorf AG | Retinolhaltige kosmetische zubereitung mit guter stabilität, hautverträglichkeit und wirksamkeit |
| CN118812877B (zh) * | 2024-06-17 | 2025-02-14 | 弘知生物科技(浙江)有限公司 | 一种含聚胍类高分子聚合物的长效抑菌水凝胶及制备方法 |
| DE102024003493A1 (de) | 2024-10-24 | 2026-04-30 | Beiersdorf Aktiengesellschaft | Kombination aus Retinol, Alkylamidothiazolen und Flavonoiden zur Verbesserung der Wirkstoffstabilisierung |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2627125A1 (de) * | 1975-06-18 | 1976-12-30 | Hayashibara Biochem Lab | Vernetztes pullulan |
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| US4303676A (en) | 1980-03-21 | 1981-12-01 | Balazs Endre A | Hyaluronate based compositions and cosmetic formulations containing same |
| DE3434104A1 (de) * | 1983-12-15 | 1985-08-29 | Biomatrix Inc., Ridgefield, N.J. | Wasserunloesliche zubereitung von hyaluronsaeure und verfahren dazu |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT252264B (de) * | 1965-03-17 | 1967-02-10 | Etapharm Chem Pharm Lab Ges M | Verfahren zur Herstellung eines reinen hochviskosen Hyaluronsäurepräparates |
| US4048435A (en) * | 1976-07-12 | 1977-09-13 | National Starch And Chemical Corporation | Method for the preparation of highly substituted granular starches |
| US4272522A (en) * | 1979-10-15 | 1981-06-09 | Balazs Endre A | Method for stimulating phagocytic activity and synergistic compositions therefor |
| SU950735A1 (ru) * | 1980-10-28 | 1982-08-15 | Саратовский Ордена Трудового Красного Знамени Государственный Университет Им.Н.Г.Чернышевского | Способ получени гиалуроновой кислоты |
| US4517295A (en) * | 1983-02-18 | 1985-05-14 | Diagnostic, Inc. | Hyaluronic acid from bacterial culture |
| US4500676A (en) * | 1983-12-15 | 1985-02-19 | Biomatrix, Inc. | Hyaluronate modified polymeric articles |
| US4487865A (en) * | 1983-12-15 | 1984-12-11 | Biomatrix, Inc. | Polymeric articles modified with hyaluronate |
| US4629623A (en) * | 1984-06-11 | 1986-12-16 | Biomatrix, Inc. | Hyaluronate-poly (ethylene oxide) compositions and cosmetic formulations thereof |
| US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| US4605691A (en) * | 1984-12-06 | 1986-08-12 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
-
1985
- 1985-03-12 US US06/710,929 patent/US4713448A/en not_active Expired - Lifetime
-
1986
- 1986-01-07 CA CA000499104A patent/CA1276143C/en not_active Expired - Lifetime
- 1986-01-20 GB GB08601304A patent/GB2172295B/en not_active Expired
- 1986-01-31 AU AU52891/86A patent/AU560956B2/en not_active Expired
- 1986-02-28 JP JP61045134A patent/JPS61207401A/ja active Granted
- 1986-03-06 BE BE0/216373A patent/BE904357A/fr not_active IP Right Cessation
- 1986-03-06 FR FR8603144A patent/FR2582002B1/fr not_active Expired
- 1986-03-10 DE DE19863607897 patent/DE3607897A1/de active Granted
- 1986-03-10 DE DE3645226A patent/DE3645226C2/de not_active Expired - Lifetime
- 1986-03-10 DE DE3645191A patent/DE3645191C2/de not_active Expired - Lifetime
- 1986-03-10 IT IT19684/86A patent/IT1191981B/it active
- 1986-03-11 SE SE8601135A patent/SE468830B/sv not_active IP Right Cessation
- 1986-03-11 CH CH992/86A patent/CH670092A5/fr not_active IP Right Cessation
- 1986-03-12 NL NLAANVRAGE8600644,A patent/NL186576C/xx not_active IP Right Cessation
-
1988
- 1988-12-21 JP JP63324696A patent/JPH01198602A/ja not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2627125A1 (de) * | 1975-06-18 | 1976-12-30 | Hayashibara Biochem Lab | Vernetztes pullulan |
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| US4141973B1 (enExample) * | 1975-10-17 | 1989-08-08 | ||
| US4303676A (en) | 1980-03-21 | 1981-12-01 | Balazs Endre A | Hyaluronate based compositions and cosmetic formulations containing same |
| DE3434104A1 (de) * | 1983-12-15 | 1985-08-29 | Biomatrix Inc., Ridgefield, N.J. | Wasserunloesliche zubereitung von hyaluronsaeure und verfahren dazu |
Non-Patent Citations (23)
| Title |
|---|
| Analyt.Biochem. 1965, 12, 547-558 |
| Annals Rheumatic Diseases, 1955, 15, 67-68 |
| Arkiv for Kemi, Mineral.Geol.,1945,19A,1 |
| BALAZS, E.A.: Healon, Wiley and Son, New York 1983,5-28 |
| Biochem.J., 1952, 62, 31 |
| Biochem.J., 1968, 109, 43-50 |
| Biochem.J., 1972, 128, 1255-1263 |
| Biochim.Biophys. Acta, 1960, 42, 472-485 |
| Biochim.Biophys. Acta, 1962, 58, 120-122 |
| Biochim.Biophys. Acta, 1966, 130, 112-129 |
| Biochim.Biophys. Acta, 1981, 673, 192-196 |
| Biopolymers, 1970, 9, 799 |
| Carbohydr.Res., 1974, 32, 386-395 |
| Fed.Proceed., 1958, 17, 1086-1093 |
| Fed.Proceed., 1966, 25, 1817-1822 |
| J.Biol.Chem., 1942, 146, 279 |
| J.Biol.Chem., 1951, 193, 265-275 |
| J.Biol.Chem., 1955, 216, 263-271 |
| J.Biol.Chem., 1981, 256, 8463-8469 |
| J.Mol.Biol., 1983, 169, 861-872 |
| Naturforsch., 1979, 34c, 508-511 |
| Science, 1972, 179, 560-562 |
| WALKER, J.F.: Formaldehyde, Reinhold Publ.Corp., New York 1953, 312-317 |
Also Published As
| Publication number | Publication date |
|---|---|
| CH670092A5 (enExample) | 1989-05-12 |
| NL8600644A (nl) | 1986-10-01 |
| SE8601135D0 (sv) | 1986-03-11 |
| SE8601135L (sv) | 1986-09-13 |
| AU5289186A (en) | 1986-09-18 |
| JPS61207401A (ja) | 1986-09-13 |
| AU560956B2 (en) | 1987-04-30 |
| CA1276143C (en) | 1990-11-13 |
| SE468830B (sv) | 1993-03-29 |
| IT8619684A1 (it) | 1987-09-10 |
| AU583464B2 (en) | 1989-04-27 |
| DE3607897C2 (enExample) | 1992-02-27 |
| AU7618087A (en) | 1987-10-29 |
| NL186576C (nl) | 1991-01-02 |
| IT1191981B (it) | 1988-03-31 |
| US4713448A (en) | 1987-12-15 |
| DE3645226C2 (enExample) | 1993-07-15 |
| GB2172295B (en) | 1989-01-05 |
| GB2172295A (en) | 1986-09-17 |
| FR2582002A1 (fr) | 1986-11-21 |
| DE3645191C2 (enExample) | 1992-12-10 |
| FR2582002B1 (fr) | 1988-01-15 |
| JPH0353321B2 (enExample) | 1991-08-14 |
| JPH01198602A (ja) | 1989-08-10 |
| BE904357A (fr) | 1986-06-30 |
| IT8619684A0 (it) | 1986-03-10 |
| NL186576B (nl) | 1990-08-01 |
| GB8601304D0 (en) | 1986-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3645191C2 (enExample) | ||
| DE69632313T2 (de) | Desorbierbare extrazelluläre matrix für rekonstruktion eines knorpelgewebes | |
| DE3546811C2 (enExample) | ||
| DE3750793T2 (de) | Verfahren zur Behandlung von Kollagen zur Erleichterung seiner Vernetzung und das so erhaltene Kollagen. | |
| DE69711540T3 (de) | Lösungsmittel-getrocknete Polysaccharidschwämme | |
| US5099013A (en) | Hylan preparation and method of recovery thereof from animal tissues | |
| DE69129391T2 (de) | Bioverträgliche, viskoelastische Gelschlämme, ihre Herstellung und Verwendung | |
| DE68917009T2 (de) | Sulfaminoderivate von Chondroitinsulfat, Dermatansulfat und Hyaluronsäure und ihre pharmakologischen Eigenschaften. | |
| DE3125260C2 (de) | Wasserhaltiges, viscoelastisches Gemisch enthaltend Hyaluronat und kosmetische Mittel enthaltend diese Gemische | |
| US6610810B2 (en) | Biopolymers obtained by solid state irradiation in an unsaturated gaseous atmosphere | |
| WO1996030411A1 (de) | Verfahren zur aktivierung von polysacchariden, danach hergestellte polysaccharide und deren verwendung | |
| DE69115181T2 (de) | Polysaccharid enthaltende Zusammensetzung oder Polysaccharid mit heparinoidaler Aktivität, Verfahren zu ihrer Herstellung und Antikoagulans welche dieses als aktives Ingredienz enthält. | |
| DD212969A1 (de) | Verfahren zur modifizierung von carboxymethylcellulose | |
| DE3852992T2 (de) | Verfahren zur Herstellung von Hylan und Hylanverbindungen. | |
| DE212020000715U1 (de) | Hydrogel auf der Basis eines vernetzten Hydroxyphenylderivats der Hyaluronsäure | |
| DE102021209820B4 (de) | Verfahren zur Herstellung eines flüssigen Cellulose-Komposits aus bakterieller Nanocellulose und Carboxymethylcellulose, Cellulose-Komposit und dessen Verwendung | |
| DE60017802T2 (de) | Hyaluronan enthaltende zusammensetzung und verfahren zu ihrer herstellung | |
| DE918532C (de) | Verfahren zur Herstellung von Polymerhomologen von Dextran | |
| DE19954357C2 (de) | Zusammensetzung, enthaltend Heteropolysaccharid und perlenförmiges quervernetztes Polysaccharid, sowie deren Verwendung für medizinische/kosmetische Zwecke | |
| DE4242813A1 (enExample) | ||
| DE4121115B4 (de) | Gemische sulfatierter Polysaccharide mit der Grundstruktur der das Heparin bildenden Polysaccharide und mit niedrigem Molekulargewicht, deren Herstellungsverfahren und Verwendung | |
| CH254105A (de) | Verfahren zur Herstellung eines völlig wasserlöslichen Polymerhomologen von Dextran. | |
| HK1001897B (en) | Method for preparing hylan and novel hylan product | |
| CH282873A (de) | Verfahren zur Herstellung von hochmolekularen Dextranabbauprodukten praktisch einheitlicher Molekülgrösse für pharmazeutische Zwecke. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8172 | Supplementary division/partition in: |
Ref country code: DE Ref document number: 3645191 Format of ref document f/p: P |
|
| Q171 | Divided out to: |
Ref country code: DE Ref document number: 3645191 |
|
| 8172 | Supplementary division/partition in: |
Ref country code: DE Ref document number: 3645226 Format of ref document f/p: P |
|
| Q171 | Divided out to: |
Ref country code: DE Ref document number: 3645226 |
|
| AH | Division in |
Ref country code: DE Ref document number: 3645191 Format of ref document f/p: P Ref country code: DE Ref document number: 3645226 Format of ref document f/p: P |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| AH | Division in |
Ref country code: DE Ref document number: 3645191 Format of ref document f/p: P |
|
| AH | Division in |
Ref country code: DE Ref document number: 3645226 Format of ref document f/p: P |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: GENZYME BIOSURGERY CORPORATION, CAMBRIDGE, MASS., |