DE10199024I2 - Sulfonamid inhibitoren von Hiv-Aspartyl protease - Google Patents

Sulfonamid inhibitoren von Hiv-Aspartyl protease

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Publication number
DE10199024I2
DE10199024I2 DE2001199024 DE10199024C DE10199024I2 DE 10199024 I2 DE10199024 I2 DE 10199024I2 DE 2001199024 DE2001199024 DE 2001199024 DE 10199024 C DE10199024 C DE 10199024C DE 10199024 I2 DE10199024 I2 DE 10199024I2
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Germany
Prior art keywords
hiv
aspartyl protease
sulfonamide inhibitors
sulfonamide
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE2001199024
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English (en)
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DE10199024I1 (de
Inventor
Roger D Tung
Mark A Murcko
Govinda Rao Bhisetti
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Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
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Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE10199024I1 publication Critical patent/DE10199024I1/de
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Publication of DE10199024I2 publication Critical patent/DE10199024I2/de
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
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    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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AU6135294A (en) * 1993-02-12 1994-08-29 Merck & Co., Inc. Piperazine derivatives as hiv protease inhibitors
JP3419539B2 (ja) * 1993-02-17 2003-06-23 中外製薬株式会社 インドリン−２−オン誘導体

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US6372778B1 (en) 2002-04-16
ATE178598T1 (de) 1999-04-15
LT3302B (en) 1995-06-26
MXPA03010538A (es) 2011-12-16
HUT71892A (en) 1996-02-28
ATE241602T1 (de) 2003-06-15
DE10199024I1 (de) 2001-07-12
DE69333012D1 (de) 2003-07-03
CN1087347A (zh) 1994-06-01
FI951059A0 (fi) 1995-03-07
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US20100210603A1 (en) 2010-08-19
IL106927A0 (en) 1993-12-28
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NO950876D0 (no) 1995-03-07
CZ58795A3 (en) 1995-12-13
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AU691160B2 (en) 1998-05-14
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