CY1115091T1 - Διειδικες πρωτεϊνες προσδεσης αντιγονων - Google Patents

Διειδικες πρωτεϊνες προσδεσης αντιγονων

Info

Publication number
CY1115091T1
CY1115091T1 CY20141100178T CY141100178T CY1115091T1 CY 1115091 T1 CY1115091 T1 CY 1115091T1 CY 20141100178 T CY20141100178 T CY 20141100178T CY 141100178 T CY141100178 T CY 141100178T CY 1115091 T1 CY1115091 T1 CY 1115091T1
Authority
CY
Cyprus
Prior art keywords
protection
proteins
antigen
specific
specific protection
Prior art date
Application number
CY20141100178T
Other languages
English (en)
Inventor
Sabine Imhof-Jung
Christian Klein
Jörg Thomas Regula
Wolfgang Schaefer
Jürgen Michael Schanzer
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of CY1115091T1 publication Critical patent/CY1115091T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Διειδικές πρωτεΐνες πρόσδεσης αντιγόνων, μέθοδοι για την παραγωγή τους, φαρμακευτικές συνθέσεις που περιέχουν τα εν λόγω αντισώματα και χρήσεις αυτών.
CY20141100178T 2009-06-16 2014-03-06 Διειδικες πρωτεϊνες προσδεσης αντιγονων CY1115091T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09007857 2009-06-16
EP10725615.8A EP2443154B1 (en) 2009-06-16 2010-06-14 Bispecific antigen binding proteins

Publications (1)

Publication Number Publication Date
CY1115091T1 true CY1115091T1 (el) 2016-12-14

Family

ID=41168518

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100178T CY1115091T1 (el) 2009-06-16 2014-03-06 Διειδικες πρωτεϊνες προσδεσης αντιγονων

Country Status (26)

Country Link
US (3) US9676845B2 (el)
EP (2) EP2443154B1 (el)
JP (1) JP5689463B2 (el)
KR (1) KR101431345B1 (el)
CN (1) CN102459345B (el)
AR (1) AR077088A1 (el)
AU (1) AU2010262129A1 (el)
BR (1) BRPI1008145B8 (el)
CA (1) CA2764392C (el)
CL (1) CL2011003148A1 (el)
CY (1) CY1115091T1 (el)
DK (1) DK2443154T3 (el)
ES (1) ES2449623T3 (el)
HK (1) HK1170506A1 (el)
HR (1) HRP20140258T1 (el)
IL (1) IL216266A0 (el)
MX (1) MX2011013615A (el)
PE (1) PE20120549A1 (el)
PL (1) PL2443154T3 (el)
PT (1) PT2443154E (el)
RU (1) RU2573914C2 (el)
SG (1) SG176886A1 (el)
SI (1) SI2443154T1 (el)
TW (1) TW201102087A (el)
WO (1) WO2010145792A1 (el)
ZA (1) ZA201108536B (el)

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