CN1795926B - 治疗皮肤症状的制药用途 - Google Patents
治疗皮肤症状的制药用途 Download PDFInfo
- Publication number
- CN1795926B CN1795926B CN2004100942358A CN200410094235A CN1795926B CN 1795926 B CN1795926 B CN 1795926B CN 2004100942358 A CN2004100942358 A CN 2004100942358A CN 200410094235 A CN200410094235 A CN 200410094235A CN 1795926 B CN1795926 B CN 1795926B
- Authority
- CN
- China
- Prior art keywords
- sojae atricolor
- semen sojae
- skin
- compositions
- purposes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 claims abstract description 97
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 27
- 206010000496 acne Diseases 0.000 claims abstract description 24
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 21
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960003471 retinol Drugs 0.000 claims abstract description 13
- 235000020944 retinol Nutrition 0.000 claims abstract description 13
- 239000011607 retinol Substances 0.000 claims abstract description 13
- 210000000582 semen Anatomy 0.000 claims description 84
- 235000013336 milk Nutrition 0.000 claims description 54
- 239000008267 milk Substances 0.000 claims description 54
- 210000004080 milk Anatomy 0.000 claims description 54
- 238000002360 preparation method Methods 0.000 claims description 54
- 229960001727 tretinoin Drugs 0.000 claims description 47
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 46
- 229930002330 retinoic acid Natural products 0.000 claims description 45
- 239000000843 powder Substances 0.000 claims description 35
- 230000000694 effects Effects 0.000 claims description 33
- 239000003814 drug Substances 0.000 claims description 17
- 235000020712 soy bean extract Nutrition 0.000 claims description 13
- 230000007850 degeneration Effects 0.000 claims description 12
- 239000002753 trypsin inhibitor Substances 0.000 claims description 12
- 239000000284 extract Substances 0.000 abstract description 24
- 201000004700 rosacea Diseases 0.000 abstract description 5
- 230000032683 aging Effects 0.000 abstract description 4
- 102000004142 Trypsin Human genes 0.000 abstract description 3
- 108090000631 Trypsin Proteins 0.000 abstract description 3
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 239000012588 trypsin Substances 0.000 abstract description 3
- 206010040954 Skin wrinkling Diseases 0.000 abstract description 2
- 230000008832 photodamage Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 72
- 244000046052 Phaseolus vulgaris Species 0.000 description 47
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 37
- 150000004492 retinoid derivatives Chemical class 0.000 description 29
- 239000003795 chemical substances by application Substances 0.000 description 26
- 238000000034 method Methods 0.000 description 23
- 239000003001 serine protease inhibitor Substances 0.000 description 21
- 235000010469 Glycine max Nutrition 0.000 description 20
- 244000068988 Glycine max Species 0.000 description 20
- 108050000761 Serpin Proteins 0.000 description 20
- 102000008847 Serpin Human genes 0.000 description 20
- 241000699670 Mus sp. Species 0.000 description 18
- 239000002537 cosmetic Substances 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
- 230000000699 topical effect Effects 0.000 description 15
- 241000404317 Lindaconus Species 0.000 description 14
- 230000037303 wrinkles Effects 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 230000002421 anti-septic effect Effects 0.000 description 12
- 239000000839 emulsion Substances 0.000 description 12
- 210000002615 epidermis Anatomy 0.000 description 12
- 235000013322 soy milk Nutrition 0.000 description 12
- 230000001225 therapeutic effect Effects 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- 239000012071 phase Substances 0.000 description 11
- 239000003963 antioxidant agent Substances 0.000 description 10
- 230000003078 antioxidant effect Effects 0.000 description 10
- 235000006708 antioxidants Nutrition 0.000 description 10
- 238000005282 brightening Methods 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 10
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000002502 liposome Substances 0.000 description 10
- 239000000314 lubricant Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- 241000196324 Embryophyta Species 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 230000005855 radiation Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000002562 thickening agent Substances 0.000 description 9
- 239000000080 wetting agent Substances 0.000 description 9
- 229940122618 Trypsin inhibitor Drugs 0.000 description 8
- 101710162629 Trypsin inhibitor Proteins 0.000 description 8
- 239000003974 emollient agent Substances 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 210000003780 hair follicle Anatomy 0.000 description 8
- 239000003112 inhibitor Substances 0.000 description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 7
- 230000008859 change Effects 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- -1 retinoid chemical compound Chemical class 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 231100001274 therapeutic index Toxicity 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 241001597008 Nomeidae Species 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 239000006210 lotion Substances 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 230000007480 spreading Effects 0.000 description 6
- 238000003892 spreading Methods 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- NTQVODZUQIATFS-WAUHAFJUSA-N (2s)-2-[[(2s)-6-amino-2-[[2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-methylbutanoic acid Chemical compound OC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O NTQVODZUQIATFS-WAUHAFJUSA-N 0.000 description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 102100037132 Proteinase-activated receptor 2 Human genes 0.000 description 5
- 101710121435 Proteinase-activated receptor 2 Proteins 0.000 description 5
- 229920002125 Sokalan® Polymers 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 239000007854 depigmenting agent Substances 0.000 description 5
- 230000005251 gamma ray Effects 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000003349 gelling agent Substances 0.000 description 5
- 230000000813 microbial effect Effects 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 229940124597 therapeutic agent Drugs 0.000 description 5
- 229940042585 tocopherol acetate Drugs 0.000 description 5
- 230000000007 visual effect Effects 0.000 description 5
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 4
- 102000035195 Peptidases Human genes 0.000 description 4
- 108091005804 Peptidases Proteins 0.000 description 4
- 229960001631 carbomer Drugs 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000000017 hydrogel Substances 0.000 description 4
- 239000007764 o/w emulsion Substances 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 230000009759 skin aging Effects 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 3
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 3
- 239000005711 Benzoic acid Substances 0.000 description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 235000010233 benzoic acid Nutrition 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 210000004209 hair Anatomy 0.000 description 3
- 239000000138 intercalating agent Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000002480 mineral oil Substances 0.000 description 3
- 235000010446 mineral oil Nutrition 0.000 description 3
- 239000000419 plant extract Substances 0.000 description 3
- 235000008476 powdered milk Nutrition 0.000 description 3
- 235000019419 proteases Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- 239000007762 w/o emulsion Substances 0.000 description 3
- OQQOAWVKVDAJOI-UHFFFAOYSA-N (2-dodecanoyloxy-3-hydroxypropyl) dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCC OQQOAWVKVDAJOI-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- 206010011732 Cyst Diseases 0.000 description 2
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 2
- 206010048768 Dermatosis Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010051246 Photodermatosis Diseases 0.000 description 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 2
- 206010037888 Rash pustular Diseases 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 101710147108 Tyrosinase inhibitor Proteins 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 229920006037 cross link polymer Polymers 0.000 description 2
- 229940086555 cyclomethicone Drugs 0.000 description 2
- 208000031513 cyst Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229940074049 glyceryl dilaurate Drugs 0.000 description 2
- 150000002333 glycines Chemical class 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000003605 opacifier Substances 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
- 230000008845 photoaging Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 208000029561 pustule Diseases 0.000 description 2
- 238000012207 quantitative assay Methods 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 238000007390 skin biopsy Methods 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- 241000040710 Chela Species 0.000 description 1
- 240000009087 Crescentia cujete Species 0.000 description 1
- 235000005983 Crescentia cujete Nutrition 0.000 description 1
- 241000219104 Cucurbitaceae Species 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 101100381997 Danio rerio tbc1d32 gene Proteins 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 235000009797 Lagenaria vulgaris Nutrition 0.000 description 1
- 229920002884 Laureth 4 Polymers 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920003091 Methocel™ Polymers 0.000 description 1
- 241001490213 Milium Species 0.000 description 1
- 244000294411 Mirabilis expansa Species 0.000 description 1
- 235000015429 Mirabilis expansa Nutrition 0.000 description 1
- 101100381999 Mus musculus Tbc1d32 gene Proteins 0.000 description 1
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- SHGAZHPCJJPHSC-UHFFFAOYSA-N Panrexin Chemical compound OC(=O)C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-UHFFFAOYSA-N 0.000 description 1
- 244000100170 Phaseolus lunatus Species 0.000 description 1
- 235000010617 Phaseolus lunatus Nutrition 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 240000009134 Physalis philadelphica Species 0.000 description 1
- 235000002489 Physalis philadelphica Nutrition 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000882890 Renova Species 0.000 description 1
- 241001303601 Rosacea Species 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000007230 Sorghum bicolor Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000005267 amalgamation Methods 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- JYXPOSFXHRXNSD-UHFFFAOYSA-N butanedioic acid;oct-1-ene Chemical compound CCCCCCC=C.OC(=O)CCC(O)=O JYXPOSFXHRXNSD-UHFFFAOYSA-N 0.000 description 1
- 239000001582 butter acid Substances 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 229960003949 dexpanthenol Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 210000004905 finger nail Anatomy 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229940062711 laureth-9 Drugs 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 235000013536 miso Nutrition 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 239000010742 number 1 fuel oil Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 230000003236 psychic effect Effects 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940059527 renova Drugs 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000008257 shaving cream Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229930193551 sterin Natural products 0.000 description 1
- 150000003431 steroids Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/51—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及治疗和改善皮肤症状的方法和组合物，所述皮肤症状包括由于光致损伤和和内源性老化引起的痤疮、酒糟鼻和皱纹。本发明特别涉及含有确定的天然提取物和天然或合成的类视黄醇的组合物。
Description
本申请系1998年7月6日提交的美国系列专利申请09/110409(AttorneyDocket No.JBP 430)和2000年10月27日提交的美国系列专利申请09/698454(Attorney Docket No.JBP 518)的部分继续申请案，此二申请并于文本进行参考。
发明领域
本发明涉及治疗和改善皮肤症状的方法和组合物，所述皮肤症状包括由于光致损伤和内源性老化引起的痤疮、酒糟鼻(rosacea)和皱纹。本发明特别涉及含有确定的天然提取物和天然或合成的类视黄醇的组合物。
发明背景
痤疮是一种炎性皮肤病，它通常发生于青春期，在成年人中也有一定规律。痤疮病况包括从皮脂腺毛囊中的粉刺到更为严重的多发的(como)炎性症状如脓疱、丘疹、囊肿和结节的皮肤病灶。该病况不仅使受害人感到不舒适，而且也使人感到困窘，并会引起使人变丑并留下疤痕。
人们认为寻常痤疮的病理涉及很多的因素：第一因素是粉刺的形成更为常见，如粟粒疹(封闭的粉刺)和黑头粉刺(暴露的粉刺)。这些是填塞毛囊并与皮脂产生增加有关的固体角质块。它们由紧紧挤压在一起的角质化的细胞和皮脂组成。粉刺的变大是由于角质化细胞的持续累积，导致毛囊中压力增加，最终毛囊破裂，清除掉包含角质材料、皮脂和进入皮肤的细菌的内含物。当破裂微小和囊肿完全破裂的时候，引起以脓包(疙瘩)形式显现的炎症反应。
过去已经尝试用许多不同的方法来改善该疾病，其中一些治疗较为有效。已经采用从简单洗涤和清洗到药物治疗进行处理。治疗痤疮的一类药物包括类视黄醇和视黄醇。尽管这些药物能有效地治疗痤疮，但它们出现不期望的副作用，从轻度到严重刺激、皮肤发红、脱屑、皮肤搔痒感和灼烧感。因此，人们渴望有一种单一局部治疗方法能预防或消除痤疮，该方法具有很小或没有不期望的副作用。
皮肤老化是一种复杂的现象，由几个内在和外在因素相互作用造成。与老化有关的皮肤变化通常表明化妆品没有作用。由于心理上的影响，皮肤老化已经成为社会普遍关注的话题和问题。随着生育高峰时期出生的人的老化，化妆品护理、化妆品保养和恢复年轻的时代意识有所提高。预防和治疗皮肤老化的方法是迫切需要的。内源性的老化是不可避免的受遗传上控制的过程。而在外在影响(风、热、香烟、化物物质等)中，紫外辐射是与皮肤老化有关的最重要的因素。持续接触紫外辐射(UVR)会引起光老化。在最近10年，接触日光的娱乐活动(包括过量的日光浴)，平流层臭氧的消耗以及在治疗各种皮肤疾病时使用UVR使得光老化变得流行。光致损伤可通过避免日光以及适当的日光防护来预防，并能通过使用外用类视黄醇来逆转，但是类视黄醇具有刺激性而且昂贵。过多接触紫外光和可见光辐射也引起晒伤。用阿斯匹林和其它非类固醇抗炎药、凉水澡和外用类固醇只能提供轻微的缓解作用。
在过去人们已经尝试了各种治疗痤疮、光损伤和其它皮肤症状方法，包括使用维A酸(也称“维甲酸”)，天然类视黄醇或者类视黄醇前体药物例如维生素A醇(也称为“视黄醇”)。(如参见US4877805和US4355028)但是使用类视黄醇进行局部治疗会对皮肤产生很强的刺激作用和引起患者的不舒服感。这种刺激作用能引起皮肤发红，让患者感到非常尴尬，特别是患有痤疮的青年人。口服类视黄醇治疗痤疮会产生致畸的副作用。
因此，人们渴望找到一种局部治疗痤疮、酒糟鼻、光损伤和其它皮肤症状的方法，又不引起皮肤发红。
发明概述
按照本发明，我们已经发现治疗和改善痤疮、酒糟鼻、皱纹和光损伤的组合物和方法，组合物中包含了未变性的植物提取物，所述提取物中包括具有抑制胰蛋白酶活性的豆类或植物的提取物和，天然或合成的类视黄醇或视黄醇类化合物。
优选实施方案详述
本发明的组合物优选包含未变性的豆类或植物的提取物，所述提取物中含有能抑制胰蛋白酶活性的化合物，例如：丝氨酸蛋白酶抑制剂。未变性的豆类提取物在本发明的方法中尤其有效。更优选的是未变性的黄豆、利马豆、黑豆的提取物和从这些豆类中得到其它天然产物，例如但不限于：豆奶、豆浆等，也通过这样的机理减少色素沉着。从豆类或植物中分离得到的丝氨酸蛋白酶抑制剂在本发明中也非常有用，例如但不限于：大豆中提取的蛋白质大豆胰蛋白酶抑制剂，“STI”和bowman-birk抑制剂。
本发明新的组合物优选包含豆类产品，更优选的是大豆产品，所述的组合物可以是流体(例如：大豆奶)或是固体(例如：大豆粉末或豆奶粉末)的形式。“大豆产品”是从大豆获得的物质，它含有大豆中天然发现的组份，它们的相对浓度与豆中所见浓度相当。大豆产品是一类从大豆中提取的物质。大豆产品可以只包含了大豆的一部分(例如：大豆的提取物如减脂的大豆粉或虑过的豆奶)或可以包含全部的大豆(如碾碎的豆粉)。大豆产品可以是流体(如豆奶)或是固体(如大豆粉或豆奶粉)。当是流体的形式时，术语“大豆产品，，是指由大豆制得的流体中的固体成分。
大豆产品可以是大豆粉通过碾磨干大豆制得大豆粉。大豆粉可以是冷冻干燥的。豆奶和豆奶粉也是有用的大豆产品。豆奶是由大豆制得的固体和水的混合物，混合中滤除全部或部分不溶物。豆奶粉是豆奶蒸干得到的。在一个实施方案中，豆奶粉是冷冻干燥或喷雾干燥的形式。制备豆奶的过程包括但不限于以下三个过程。首先，将大豆放入水中让其吸水，随后碾压膨胀的豆子，再加入水；过滤混合物除去不溶残渣。第二，豆奶可以通过大豆粉来制备。大豆粉与水充分地混合(如至少混合一小时)，接着过滤除去不溶残渣。第三，还可以通过加入水与豆奶粉重新制得豆奶。豆奶占来自大豆的固体物重量的约1％至约50％(如约5％至20％)。
豆类果实的表面通常含有高浓度的微生物。因此，早先人们应用时，豆类果实需要经过处理来减少或消除这些微生物。
本发明所用豆类产品的微生物总数小于每克10000个菌落单位(“cfu”)。优选地，本发明所用大豆产品的微生物总数约小于1000cfu/克(例如小于100cfu/克)
本发明所用豆类产品，不允许的微生物总数少于300cfu/g，例如少于150cfu/g。优选地，在本发明中所用豆类产品在至少每1克(如至少10克)产品中不允许的微生物总数达到测不出的水平。
可以将豆类产品暴露在伽马射线的辐射中。豆类产品是暴露在强度约2至约30kGy伽马射线的辐射下，例如伽马射线辐射强度约5至约10kGy。申请人发现这样的处理在降低豆类产品微生物含量的同时，保持了其生物活性(如丝氨酸蛋白酶抑制活性)。申请人还发现用伽马射线处理豆类产品可保持该产品的化妆品的优点，如保持天然色泽，且不带来明显的臭味。
其他同样保持豆类产品的蛋白酶抑制活性的微生物处理方法可以单独应用或联合伽马射线辐射使用，和加入具有抗微生物活性的化学试剂，它们的组合，所述辐射包括但不限于X射线、高能电子束或质子束、紫外线辐射、流体静压力。
在一个具体实施方案中，大豆产品是未变性的大豆产品。“未变性”在BANtam医药大词典(1990出版)中被定义为“由于X射线，热，化学物质引起的蛋白质物理和生理性质改变，包括丧失活性(就酶而言)和丧失(或改变)抗原性(就抗原而言)。”“未变性的植物提取物”是对植物进行衍生处理加工(例如：温度，提取介质)没有除去蛋白酶抑制活性的植物提取物。这样的一种酶是胰蛋白酶。在一个实施方案中，本发明的大豆产品的未变性状态可以通过完整的大豆胰蛋白酶抑制剂STI蛋白的存在或通过胰蛋白酶抑制剂的活性来测量。
其它的丝氨酸蛋白酶抑制剂来自下列植物属：茄科(如马铃薯、西红柿、粘果酸浆等)；禾本科(如稻谷、荞麦、高梁、小麦、大麦、燕麦等)；葫芦科(如黄瓜、南瓜、葫芦、丝瓜等)；优选的是豆科(如大豆、豌豆、小扁豆、花生等)。大豆中的组分，如异黄酮，或豆胰蛋白酶抑制剂，或未变性的大豆，以前未被认识或用来减少维甲酸诱发的刺激性或发红。令申请人惊奇的是，含有这些组分的组合物能减少类视黄醇诱发的刺激性或发红，却没有影响类视黄醇的活性。
本发明组合物和方法中的活性化合物通过本领域技术人员已知的技术可以被局部释放。如果局部活性药剂或化妆品的释放参数需要，本发明的局部活性组合物可以优选包含一种药剂和化妆品可接受载体，所述载体具有把局部活性成分渗透进皮肤的功能。
供局部输送本发明部分组合物特别是蛋白质如胰蛋白酶和豆胰蛋白酶抑制剂的一种可以接受的载体可含脂质体。该脂质体更优选是非离子型且含a)二月桂酸甘油酯(含量优选为约5％-约70％重量)；b)具有常见于胆固醇的类固醇骨架的化合物(含量优选为约5％-约45％重量)；和c)一种或多种含从约12至约18个碳原子的脂肪酸醚(总含量优选为约5％-约70％重量)，其中脂质体各成份化合物之比率优选是约37.5∶12.5∶33.3∶16.7，优选由二月桂酸甘油酯/胆固醇/聚氧乙烯-10-硬脂酰醚/聚氧乙烯-9-月桂基醚组成的脂质体(GDL脂质体)。以组合物的总体积为基准，脂质体的较佳存在量是从约10mg/ml至约100mg/ml，更优选从约20mg/ml至约50mg/ml。最优选的比率是约37.5∶12.5∶33.3∶16.7。适当的脂质体优选依据美国系列专利申请09/110409实施例1建立的实验设计制备得到，尽管本领域的其它一般制备方法也是可以接受的。以上描述的组合物可以通过在合适的容器里混合所需的成份，并在环境情形下在非离子脂质体制备领域所熟知的任何惯用高剪切力混合装置中将其混合，例如揭示于Niemiec等：“非离子脂质体组合物对肽类药物给毛囊皮脂腺单元局部给药的影响：用Hamstr耳模进行体内研究”，12 Pharm.Res.1184-88(1995)(″Niemiec″)，其全文并与文本供参考。我们已经发现在本发明中存在这些脂质体可以促进本发明组合物的治疗效果。
其它优选的制剂可含例如大豆奶或得自豆类或其它合适的植物的其它流体制剂。例如，此种制剂可含大比例的大豆奶，维持豆奶物理稳定性的乳化剂，及任选的螯和物、防腐剂、润滑剂、润湿剂和/或稠化剂或胶凝剂。
本领域技术人员已知的水包油乳剂、油包水乳剂、溶剂基制剂和水凝胶也可以用做释放本发明组合物的载体。
在本发明中有效的局部组合物，包括了适于局部应用于皮肤的制剂。该组合物可包含大豆产品和化妆品可接受的局部用载体，所述载体可占组合物重量约50％至约99.99％(如组合物重量的约80％至约95％)。
组合物可以制成各种不同的产品类型，包括但不限于固体和流体组合物，例如：洗剂、霜乳剂、凝胶剂、棒状剂、喷雾剂、剃须膏、软膏剂、清洗液、固体洗涤棒、香波、糊剂、粉剂、摩丝、粘性膏条(adhesive strips)、擦剂。这些产品类型可以包括几种化妆品可接受的局部用载体，包括但不限于溶液、乳液(如微乳液和毫微乳液)、凝胶、固体和脂质体。以下是这些载体的非限定性的实例。其他载体可以由本领域的常规技术制得。
本发明中应用的局部用组合物可以制成溶液。溶液通常包含含水溶剂(如从约50％至约99.99％或从约90％至约99％的化妆品可接受的含水溶剂)。
本发明中应用的局部组合物可以制成含有润滑(emollient)剂的溶液，这样的组合物优选含有从约2％至约50％的润滑剂。在这里，“润滑剂”是指那些可以用来防止或减轻干燥，达到保护皮肤效果的物质。许多适合的润滑剂都是已知的，并可以在此使用。参见估计化妆品活性成分辞典和手册，eds.Wenninger andMcEwen，pp.1656-61，1626，和1654-55(The Cosmetic，Toiletry，and FragranceAssoc.，Washington，D.C.，第7版，1997)(以下简称“INCI Handbook”)中记载了许多合适的上述物质的例子。
洗剂可以从上述溶液制备。洗剂通常含有大约1％至约20％(如，约5％至约10％)的一种润滑剂以及大约50％至约90％(如，约60％至约75％)的水。
可从溶液制得的产品的另一种剂型是乳剂。乳剂通常含有约5％至约50％(如约10％至约20％)的润滑剂，和大约45％至约85％(如，约50％至约75％)的水。
还有一种可从溶液制备的剂型是软膏。软膏通常可以含有简单的基质如动物油、植物油或半固体烃类。软膏可含有大约2％至约10％的润滑剂，加上约0.1％至约2％的增稠剂。常用的增稠剂或粘性剂都可以在INCI Handbook pp.1693-1697.中找到。
本发明的局部组合物可以制备成乳液。若载体是一种乳液，应该含有约1％至约10％(如，约2％至约5％)的乳化剂。乳化剂可以是非离子、阴离子或阳离子型的。合适的乳化剂在INCI Handbook，pp.1673-1686.中公开。
洗剂和霜剂可以制得乳剂，通常这样的洗剂含有大约0.5％至约5％的乳化剂。这样的霜剂通常含有大约1％至约20％(如约5％至约10％)的润滑剂；大约20％至约80％(如，约30％至约70％)的水；和大约1％至约10％(如，约2％至约5％)的乳化剂。
水包油型或油包水型的单相乳液护肤制剂，例如洗剂和乳剂，都是化妆品领域公知的，并在本发明中使用。多相乳液组合物，如水包油包水型，也在本发明中使用。通常，上述单一或多相乳液含有水、润滑剂和乳化剂作为必要的组分。
本发明的局部组合物也可以制备成凝胶(如，使用适当胶凝剂制得的水凝胶)。用于水凝胶的适当的胶凝剂包括但不限于天然树胶、丙烯酸和丙烯酸酯聚合物和共聚物，和纤维素衍生物(如羟甲基纤维素和羟丙基纤维素)。用于油(如矿物油)的适当的胶凝剂包括但不限于氢化丁烯/乙烯/苯乙烯共聚物和氢化乙烯/丙烯/苯乙烯共聚物。上述凝胶通常含有重量百分比约0.1％至约5％的上述胶凝剂。
本发明的局部组合物也可以制备成固体剂型(如蜡基棒状物、肥皂棒组合物、粉剂或含粉擦剂)。
本发明的局部组合物除上述制剂之外，可含有各种附加的油溶性物质和/或水溶性物质，它们可以以现有技术确立的按照常规方法用于皮肤、毛发和指甲的量用于组合物。
用于制剂的活性化合物来源通常取决化合物的特殊形式。对于小的有机分子和肽类片断可以化学合成，并以适合药剂/化妆品应用的纯品形式提供。天然提取物产品可通过本领域已知的技术纯化。本领域的普通技术人员还可应用重组来源的化合物。
在一个并列选择的具体实施方案中，局部使用的活性药剂或化妆品可任选地组合其它成分，诸如润湿剂、化妆佐剂、抗氧化剂、漂白剂、酪氨酸酶抑制剂、和其它已知的脱色剂、表面活性剂，发泡剂、调节剂、润湿剂、芳香剂、粘度剂、缓冲剂、防腐剂和遮光剂等等。本发明的组合物也可包含有效量的类视黄醇(如，结合一些维生素A受体的化合物)和维生素A前体如视黄醇，包括如维甲酸、视黄醇、视黄酸酯、和/或视黄醇、合成的类视黄醇(如在US4877805实施例中制备的)等等。
很多人使用含视黄酸产品遇到的一个问题就是由于刺激性引起的不断加深的红色，这是使用类视黄醇而常见的副作用。申请人惊奇地发现，维甲酸和具有胰蛋白酶活性抑制剂的大豆提取物的组合物，如未变性的豆奶粉，和维甲酸联合使用或同时使用能减轻皮肤的红色。局部组合物中使用的大豆产品优选含有约0.01％至约50％的大豆粉或豆奶粉，更优选含有约0.05％至20％的大豆粉或豆奶粉和最优选含有约0.5％至约5％的大豆粉或豆奶粉。
使用有效量的局部活性药剂或化妆品组合物可以减少类视黄醇诱发的哺乳动物皮肤刺激性作用。这里使用的“有效量”指的是用量足以覆盖希望减少类视黄醇引起的刺激性的局部皮肤表面的量。优选地，该组合物广泛地施加于皮肤表面，以公分皮肤表面为基准，按照希望减少的刺激性或红色使用约2/cm2至200μ/cm2的局部活性制剂。
直接从植物或植物性药材来源制得的天然提取物可以从约1％约99％浓度(W/V)用于本发明组合物。天然提取物的组分和从天然物质中得到的蛋白酶抑剂例如STI或BBI可以有从约0.01％至约20％的优选使用范围，更优选为组合物量的约0.05％至约10％，最优选为组合物量的约0.1％至约2.5％。当然，本发明活性制剂的混合物可以混合且同时用在同一剂型中，或依序使用不同的剂型。
申请人意外地发现，当局部活性制剂局部施用于动物的皮肤时，皮肤上有明显的变化。本发明的活性制剂较宜在相当高浓度及剂量(具有高治疗指数的化合物如天然和合成的类视黄醇衍生物和相似物是从约0.005％至约1％；植物的液体衍生物及提取物是从约20％至约99％；天然提取物及天然来源的蛋白酶抑制剂如STI或其混合物部分是从约0.1％至约20％)下每天一次或二次施用于哺乳动物的皮肤直到皮肤有明显的变化。此需要进行约四至十周或更久。随后，一旦皮肤有了改变，较低浓度和剂量(具有高治疗指数的化合物如天然和合成的类视黄醇衍生物和相似物是从约0.00001％至约0.005％；植物的液体衍生物及提取物是从约10％至约90％；天然提取物及天然来源的蛋白酶抑制剂如STI或其混合物部分是从约0.01％至约5％)的活性成份可在较不常用的时间表例如每天一次或约每周两次下使用，本发明活性制剂的效应为可逆性，因此为了维持这些效应，必须进行持续使用或用药。在此举例说明的本发明可在缺乏本文具体公开的任何成份、组份或步骤下进行。
在下述数个实施例以进一步说明本发明的本质及其实施方法，但是不能作为本发明方法及其组合物的范围限制。
实施例1制备含有STI的天然衍生产品
根据分析试验，豆奶和豆浆富含大豆胰蛋白酶抑制剂。
为了制备豆浆，大豆首先被浸入去离子水或纯水中历经数小时，于其完全水合后碾磨，添加少量的水。如果需要，可以使豆浆平整。制备豆奶，添加更多的水进行同样的步骤(碾磨过程允许豆奶滤去)。收集之后，过滤豆奶除去豆皮的残渣。
制备的豆奶，豆浆和豆酱(miso)作为含有STI的天然衍生物，该衍生物能使皮肤颜色变浅。
实施例2含有豆奶的护理制剂
在制备大豆奶中，申请人发现具有很好润肤作用的大豆奶适于皮肤保养剂。因为在任何水包油乳剂中水都是主要成分，在许多其他皮肤保养剂中，我们假定大豆奶可以作为这些制剂中去离子水的替代物。然而，我们预见由于大豆奶中油和水的不融合性，这种类型的剂型将是物理不稳定的。令申请人惊奇的是发现这种大豆奶取代水是物理稳定性的。使用大豆奶的制剂应当含有约1％到99％的大豆奶，更优选约80％到95％的大豆奶。这种以及类似的制剂优选含有约0％到5％(更优选，约0.1％到2％)的粘性助剂，约20％的一种或多种润滑剂和/或约0.1％到10％(更优选约3％到5％)的乳化剂，并可任选地含有约0％到5％(更优选1％到2％)的扩展剂、防腐剂、螯合剂或润湿剂。防腐剂应该以有效量存在以保持奶的完整性和维持组合物的活性。应加入足够量的增稠剂，以使制剂覆盖身体能又不使其过于粘稠而抑制阻碍了其覆盖性，例如，约0％到10％，更优选3％到5％。遮光剂、抗氧化剂、维生素和其它脱色剂和其它皮肤局部护理的组分也可以加入到本发明的组合物中。
以大豆奶代替水的一个特别优选治疗皮肤的剂型的实例示于下表A中。
表A
| 组分 | 功能 | ％W/W |
| 大豆奶 | 载体，脱色素剂 | 84.9％ |
| 丁二酸辛烯酯铝淀粉 | 粘性助剂 | 0.75％ |
| 环聚二甲基硅氧烷 | 扩展剂 | 2％ |
| PEG 6-癸/辛酸甘油三酯 | 润肤剂/乳化剂 | 3％ |
| 组分 | 功能 | ％W/W |
| 苯氧乙醇 | 防腐剂 | 0.75％ |
| 蔗糖椰子脂酸酯 | 润肤剂/乳化剂 | 1％ |
| Na2EDTA | 鳌合剂 | 0.1％ |
| 甘油 | 保湿剂 | 2.5％ |
| 聚丙烯酰胺；异链烷烃；7-聚乙二醇单十二醚 | 增稠剂 | 5％ |
所述制剂中可以添加STI，大豆糊和其他含有胰蛋白酶抑制剂的天然提取物来增加丝氨酸蛋白酶抑制剂的浓度。制剂中所用的活性成分的水平可以是约0.01％到约15％。其它脱色剂，包括蛋白酶激活受体-2抑制剂，酪氨酸酶抑制剂，氢醌，大豆产品，抗坏血酸和其衍生物，其它皮肤保养剂也可以加入到这种制剂中。
实施例3水包油的皮肤保养制剂
在表B是水包油皮肤保养制剂的2个具体实施例。在表B的第3栏描述了一种含有STI的制剂，其中STI可用任何天然衍生的丝氨酸蛋白酶抑制剂替代，或任何含有丝氨酸蛋白酶抑制剂的天然衍生物或成分替代。组合物中的治疗性组分可以用丝氨酸蛋白酶抑制剂或具有高治疗指数的PAR-2抑制剂替代，无论活性成分是通过合成得到还是天然得到。在这些制剂中，组分的推荐的含量范围列在表B中。制剂中去离子水可以用大豆奶来替代。
表B
| 相 | CTFA名称 | 功能 | ％W/W | ％W/W | 范围 |
| 油相 | Cetearyl葡萄糖苷 | 表面活性剂 | 1.4 | 1.4 | 0.1-2.8 |
| 苯甲酸C<sub>12-15</sub>烷基酯 | 表面活性剂 | 4.0 | 4.0 | 1-6 | |
| 羟基硬脂酸辛基酯 | 润肤剂 | 1.0 | 1.0 | 0-5 | |
| 环聚二甲硅氧烷 | 扩展剂 | 1.0 | 1.0 | 0.5 | |
| 环甲硅油 | 扩展剂 | 1.0 | 1.0 | 0-5 | |
| 十六烷醇 | 润肤剂 | 2.5 | 2.5 | 0-4 | |
| 丁化羟基甲苯 | 抗氧化剂 | 0.1 | 0.1 | 0-0.5 | |
| 甲氧剂桂皮酸辛基酯 | 防晒剂 | 6.0 | 6.0 | 0-10 |
| 相 | CTFA名称 | 功能 | ％W/W | ％W/W | 范围 |
| 对羟基苯甲酯 | 防腐剂 | 0.5 | 0.1 | 0-0.5 | |
| 维生素E醋酸酯 | 抗氧化剂 | 0.5 | 0.5 | 0-0.5 | |
| 生育酚醋酸酯 | 抗氧化剂 | 0.5 | 0.5 | 0-0.5 | |
| 水相 | 甘油 | 润湿剂 | 3.0 | 3.0 | 0-20 |
| D-泛醇 | 维生素前体 | 0.5 | 0.5 | 0-5 | |
| EDTA二钠 | 鳌合剂，增白剂 | 0.1 | 0.1 | 0.01-1 | |
| 对羟基苯甲酸甲酯 | 防腐剂 | 0.2 | 0.2 | 0-0.3 | |
| 卡波姆 | 增稠剂 | 0.35 | 0.35 | 0-3 | |
| 去离子水或大豆奶 | 载体/增白剂 | 76.35 | 77.5 | 50-80 | |
| STI和天然提取物 | 增白剂 | 1.0 | 0 | 0-15 | |
| 其它治疗组分 | 增白剂 | 0 | 0.25 | 0-1 |
为了制备此制剂，将脂质相组分合并并且在85℃混合，然后冷却到60℃。在一个单独的容器里面，将卡波姆缓慢加入到水或大豆奶中。混合10分钟后，加入剩余的水相组分，将组合物加热到60℃。然后合并两相，再混合10分钟，冷却至室温。当然，在本实施例和本发明下面的方法和组合物的其它实施方案中，在同一制剂中可以加入一种或多种脱色剂。
实施例4皮肤护理组合物(水包油乳剂)
皮肤护理组合物的水包油乳剂的另外2个实施例示于表C。在表C的第3栏描述了一种含有STI的制剂，其中STI能用任何天然衍生得到的丝氨酸蛋白酶抑制剂，或任何含有丝氨酸蛋白酶抑制剂的天然衍生物或成分替代。组合物中的治疗性组分可以用丝氨酸蛋白酶抑制剂或具有高治疗指数的PAR-2抑制剂替代，无论活性成分是通过合成得到还是天然得到。在些制剂中，组分的推荐的含量范围也列在表C中。制剂中去离子水可以用大豆奶来替代。
表C
| CFA名称 | 功能 | ％W/W | ％W/W | 优选的含量范围 |
| 乙醇 | 溶剂 | 12.0 | 12.0 | 5-20 |
| 丙二醇 | 溶剂 | 3.0 | 3.0 | 1-10 |
| 羟乙基纤维素 | 增稠剂/聚合物 | 0.2 | 0.2 | 0-3 |
| 丙烯酸酯/丙烯酸C<sub>10-30</sub>烷基酯交联聚合物 | 增稠剂/聚合物 | 1.0 | 1.0 | 0-3 |
| 泛醇(98％) | 维生素前体/润湿剂 | 1.5 | 1.5 | 0.1-3 |
| 香料 | 香料 | 0.5 | 0.5 | 0-0.5 |
| 异十六烷 | 扩展剂 | 4.0 | 4.0 | 0-5 |
| 维生素E醋酸酯 | 抗氧化剂 | 1.0 | 1.0 | 0-2 |
| 氢氧化钠 | 中和剂 | 0.35 | 0.35 | 0.1-0.5 |
| 甘油 | 润湿剂 | 3.0 | 3.0 | 0-20 |
| 去离子水或大豆奶 | 载体/增白剂 | 72.2 | 71.95 | 60-80 |
| 治疗成分 | 增白剂 | 0 | 0.25 | 0-1 |
| STI或天然提取物 | 增白剂 | 1.0 | 0 | 0-15 |
为了制备此制剂，将羟乙基纤维素缓慢地加入水或大豆奶中，并且搅拌直到完全溶解。在一个单独的容器中，加入丙烯酸酯/丙烯酸C10-30烷基酯交联聚合物并且搅拌到完全溶解。将两个容器中的组分合并并且混合20分钟。然后加入维生素E醋酸酯并且混合，再加入异十六烷和泛醇(98％)。混合5分钟后，将STI或天然提取物与丙二醇一起加入，搅拌5分种。然后加入甘油并且将制剂搅拌20分钟。最后，用氢氧化钠调节PH值(对STI是6-8.5)。
实施例5皮肤护理组合物(油包水乳剂)
表D显示的是油包水型乳剂的皮肤护理制剂的一个实施例。在表D的第4栏描述了一种含有STI的制剂，其中STI能用任何天然衍生得到的丝氨酸蛋白酶抑制剂，或任何含有丝氨酸蛋白酶抑制剂的天然衍生物或成分替代。表D的第5栏是含有治疗组分的相似制剂。组合物中的治疗性组分可以用丝氨酸蛋白酶抑制剂或具有高治疗指数的PAR-2抑制剂替代，无论活性成分是通过合成得到还是天然得到。在些制剂中，组分的推荐的含量范围也列在表D中。制剂中去离子水可以用大豆奶来替代。
表D
| 相 | CTFA名称 | 功能 | ％W/W | ％W/W | 优选的含量范围 |
| 油相 | 矿物油 | 润肤剂 | 25.0 | 25.0 | 40-80 |
| 脱水山梨糖醇-油酸酯 | 表面活性剂 | 5.0 | 5.0 | 1-6 | |
| 硬脂酸 | 润肤剂 | 25.0 | 25.0 | 20-60 | |
| 二甲聚硅氧烷 | 扩展剂 | 1.0 | 1.0 | 1-5 | |
| 十六烷醇 | 润肤剂 | 2.0 | 2.0 | 0.1-10 | |
| 氢化卵磷脂 | 抗氧化剂 | 3.0 | 3.0 | 0-10 | |
| Parsol MCX | 防晒剂 | 3.0 | 3.0 | 0-10 | |
| 对羟基苯甲酸丙酯 | 防腐剂 | 0.5 | 0.5 | 0.01-0.5 | |
| 维生素E醋酸酯 | 抗氧化剂 | 0.5 | 0.5 | 0.01-0.5 | |
| 水相 | 甘油 | 润湿剂 | 3.0 | 3.0 | 0-20 |
| 对羟基苯甲酸甲酯 | 防腐剂 | 0.2 | 0.2 | 0.01-0.3 | |
| 水或大豆奶 | 载体/增白剂 | 30.8 | 31.55 | 20-45 | |
| STI | 增白剂 | 1.0 | 0 | 0-10 | |
| 治疗组分 | 增白剂 | 0 | 0.25 | 0-1 |
为了制备此制剂，硬脂醇和矿物油在在70℃熔化。加入其它的油相组分并且加热到75℃。然后，加入已经预先溶于水或大豆奶体相(bulk phase)且加热到70℃的水相组分，然后将混合物搅拌直到其凝固。
实施例6皮肤护理组合物(水凝胶)
表E显示是含水凝胶皮肤护理制剂的两个实例。在表E的第3栏描述了一种含有STI的制剂，其中STI能用任何天然衍生得到的丝氨酸蛋白酶抑制剂，或任何含有丝氨酸蛋白酶抑制剂的天然衍生物或成分替代。组合物中的治疗性组分可以用丝氨酸蛋白酶抑制剂或具有高治疗指数的PAR-2抑制剂替代，无论活性成分是通过合成得到还是天然得到。在些制剂中，组分的推荐的含量范围也列在表E中。制剂中去离子水可以用大豆奶来替代。
表E
| CTFA名称 | 功能 | ％W/W | ％W/W | 范围 |
| 辛苯昔酸-13 | 表面活性剂 | 0.2 | 0.2 | 0.05-0.5 |
| 2，4-己二烯酸 | 防腐剂 | 0.1 | 0.1 | 0-0.3 |
| 苯甲酸 | 防腐剂 | 1.0 | 1.0 | 0-2 |
| EDTA二钠 | 鳌合剂/防腐剂 | 0.05 | 0.05 | 0.01-0.2 |
| 抗坏血酸 | 抗氧化剂 | 0.1 | 0.1 | 0-0.2 |
| 焦亚硫酸钠 | 抗氧化剂 | 0.2 | 0.2 | 0-0.3 |
| 卡波姆 | 增稠剂 | 1.5 | 1.5 | 0-3.0 |
| 20％NaOH溶液 | 中和剂 | 2.45 | 2.45 | 0.1-5 |
| 去离子水或大豆奶 | 载体/治疗剂 | 93.4 | 94.15 | 85-98 |
| STI或天然提取物 | 治疗剂 | 1.0 | 0 | 0-15 |
| 治疗性组分 | 治疗剂 | 0 | 0.25 | 0-1 |
为了制备此制剂，将EDTA二钠、焦亚硫酸钠和抗坏血酸缓慢地加入到水或大豆奶中，并且搅拌直到完全溶解。加入STI、天然提取物或治疗组分，缓慢搅拌5分钟。然后加快搅拌速度并加入卡波姆。组合物搅拌30分钟直到气泡完全分散，没有聚集在一起的团，接着加热到50℃。在一个单独的容器中，在40℃～50℃的条件下不停搅拌辛苯昔酸-13、2，4-己二烯酸和苯甲酸制得浆体相。将浆体缓慢加入到水相中，混合并冷却到45℃。加入20％的氢氧化钠溶液调节组合物的PH值到7.0(范围是5.5～8.5)。通过搅拌和震荡容器使混合物匀一。
实施例7溶剂基皮肤护理组合物
表F例出了含有溶剂的皮肤护理制剂的一个实施例。在表F的第3栏描述了一种含有STI的制剂，其中STI能用任何天然衍生得到的丝氨酸蛋白酶抑制剂，或任何含有丝氨酸蛋白酶抑制剂的天然衍生物或成分替代。组合物中的治疗性组分可以用丝氨酸蛋白酶抑制剂或具有高治疗指数的PAR-2抑制剂替代，无论活性成分是通过合成得到还是天然得到。在此制剂中，组分的推荐的含量范围也列在表F中。制剂中去离子水可以用大豆奶来替代。
表F
| CTFA名称 | 功能 | ％W/W | 范围 |
| 乙醇 | 溶剂(1) | 70 | 40-90 |
| 丙二醇 | 溶剂(2) | 29 | 1-40 |
| 去离子水 | 载体 | 适量 | 1-40 |
| STI | 治疗剂 | 0 | 0.01-50％ |
| 治疗组份 | 治疗剂 | 1um | 0.00001-1 |
参照美国系列申请09/110409，将丝氨酸蛋白酶抑制剂溶解于水中制备此制剂。将乙醇和丙二醇混合，加入含有丝氨酸蛋白酶抑制剂的水溶液中。
实施例8用未变性的大豆和视黄酸治疗小鼠能减少红色
从杰克森实验室(Bar Harbor，Me.)获得5-7周龄大的RHJ/LE无毛(Rhino)雄性小鼠。小鼠先适应一个星期，再治疗14天，每天用一次试验材料。试验材料包括(0.05％维甲酸，Ortho Neutrogena CA)有或没有2.5％的豆奶粉。在2000年10月27日提交的美国系列专利申请09/698454中描述了不变性的大豆奶的豆奶粉。从DevonSoy Farms(Carroll，Iowa)购得的豆奶粉，使用Polytron LS10-35匀化器加入到维甲酸产品中。未治疗的组作为研究对照组。每个试验组有5只小鼠。
在处理阶段结束，观察小鼠的皮肤发红和皱纹的减少。目视观测表明，用维甲酸处理的小鼠皮肤变红，而对照组，没有处理过的小鼠皮肤略带粉色。令人惊讶的是，豆奶粉末和维甲酸的组合物能减少皮肤的红色，如表G所示。
表G
处理 皮肤红色
没有处理 1
维甲酸 4
维甲酸+大豆 2
关键字：1＝浅粉色，2＝粉色，3＝粉红色，4＝红色
目视观测也表明用维甲酸处理的小鼠皱纹减少。向维甲酸中添加大豆也不改变此效果，并不干扰维甲酸减少小鼠皮肤的皱纹。(见表E)
表E
处理 皱纹
处理 3
维甲酸 2
维甲酸+大豆 2
这个实施例证明加入到含维甲酸产品的未变性的大豆提取物能消退类视黄醇处理产生的红色，却对类视黄醇的活性没有消极作用。
实施例9使用不变性的大豆和维甲酸处理小鼠
在随后的目测观察中，处死实施例8中的小鼠，对它们的皮肤标本进行组织结构学上的评价。依据Sheehand和Hrapchak，1980描述的技术标准对其进行H&E染色法和组织学上的分析。对皮肤切片H&E染色的检测结果显示了下列的结论：未处理过的Rhino小鼠的皮肤有很大的椭圆囊，表皮很薄，分散围绕着椭圆囊。没有观察到毛囊。接着用维甲酸进行处理，表皮增厚，椭圆囊消失。表皮产生像毛囊样的组织结构。用维甲酸和大豆处理过的皮肤和只用维甲酸处理过的皮肤有相似的解剖构造。椭圆囊消失，表皮增厚，可以看见上皮的囊泡结构。更有趣的是，和仅用维甲酸处理过的相比，这些上皮囊泡结果看起来更“光滑”和更健康。这个实例证明在加入维甲酸产品的大豆提取物确实没有减少维甲酸的活性，而且还可能增强其处理皮肤的质量。
实施例10用未变性的大豆和视黄酸来处理小鼠
依照文献Mezick J A，Bhatia M C，Capetola R J，rhino小鼠中类视黄醇对角状物填充的椭圆囊大小的局部和全身：定量测定类视黄醇“抗角质化”作用的模型，J Invest Dermatol 83：2，110-3，Aug，1984.，处理从实施例8取得的皮肤标本。表皮皮肤照所描述的那样进行分离，通过计算机图像分析软件(Image Pro Plus4.5版from Media Cybernetics，Silver Spring，Md.)，日立公司CCD照相机KP-D50，Olympus BH-2的显微镜来测量椭圆囊的直径。对每个试验组，要测量50个表皮椭圆囊的直径。与对照组相比，椭圆囊直径的减少表明了维甲酸的生物学活性。表I中展示了用维甲酸处理过的椭圆囊的面积减少了约63％。大豆和维甲酸联合处理组也表现了相似的结果，其结果再次证明了添加的大豆不会抑制维甲酸类的活性，就像随着大豆的加入，(实施例8)红色的消退也同样有效果。
表I
处理 椭圆囊直径(μM+/-STD) ％减少(相对于对照组)
对照 94.7+/-6.9 -
维甲酸 34.6+/-1.6 63.4
维甲酸+大豆 34.8+/-1.2 63.2
实施例11对人的刺激性研究
已经实施和完成对人的6周的刺激性和过敏性的研究。结果表明用于皮肤的大豆/视黄醇组合物能减少对皮肤34％的刺激。没有观察到过敏。
方法：
大约200个受试者间隙地斑片样使用制剂，一周三次，共计三周九次使用该制剂。在移除每个斑片以后，对原来的皮肤点进行每周三次的等级评估。在剩下的2周，不再使用试验制剂，将制剂的刺激性斑片用于受试者完好的皮肤上。在移除斑片后的24、74、96小时对试验点进行等级评估，结果见表J。
表J
制剂 刺激分数 刺激性％
载体+0.1％视黄醇 381 100％
大豆5％+0.1％视黄醇 255 66％
实施例12
在Jackson Laboratories(Bar Harbor，Me.)获得的5-7周龄的RHJ/LE(Rhino)无毛雄性小鼠，用试验材料处理14天，每天一次。试验材料包含了的维甲酸产品(0.05％维甲酸，商购自Ortho Neutrogena CA)，有或没有0.1％STI(大豆胰蛋白酶抑制剂，Sigma-Aldrich Corp.，St.Louis，Mo.)。STI以重量/重量形式通过Polytron LS10-35匀化器混入产品。载体试验组作为研究对照组。每个试验组有5只小鼠。
在试验阶段结束，观察小鼠的皮肤红色和减少的皱纹状态。目视观测表明，用处理的小鼠皮肤发红，而对照组，载体处理的小鼠皮肤略带粉色。令人惊讶的是，
和STI的组合物能减少皮肤的红色，如表K所示。
表K
处理 皮肤红色
载体 1
4
1
关键字：1＝浅粉色，2＝粉色，3＝粉红色，4＝红色
目视观察也表处理的小鼠能减少皱纹。加入Renova的STI并不改变此效果，也不干扰减少皱纹的作用(见表L)。
表L
处理 皱纹
未处理 3
关键字：0＝没有皱纹，1＝少许皱纹，2＝轻微的皱纹，3＝严重的皱纹。
这个实施例证明加入到含维甲酸产品的STI能消退维甲酸类治疗产生的红色，却对类视黄醇的活性没有消极作用。
实施例13
在随后的目测观察中，处死实施例12中的小鼠，对它们的皮肤标本进行组织结构学上的评价。依据Sheehand和Hrapchak，1980描述的技术标准对其进行H&E染色法和组织学上的分析。对皮肤切片H&E染色的检测结果显示了下列的结论：未处理过的Rhino小鼠的皮肤有很大的椭圆囊，表皮很薄，分散围绕椭圆囊。没有观察到毛囊。接着用维甲酸进行处理，表皮增厚，椭圆囊消失。表皮产生像毛囊样的组织结构。用混合STI的维甲酸处理过的皮肤和只用维甲酸处理过的皮肤有相似的解剖构造。用维甲酸和STI联合处理过的皮肤与使用维甲酸处理过的皮肤具有非常类似的组织学表象。椭圆囊消失，表皮增厚，可以看见上皮的囊泡结构。这个实例表明加入维甲酸产品的STI并没有减少类视黄醇的活性。
实施例14
依照文献Mezick J A，BhatiaMC，CapetolaRJ，rhino小鼠中类视黄醇对角状物填充的椭圆囊大小的局部和全身：定量测定类视黄醇“抗角质化”作用的模型，J Invest Dermatol 83：2，110-3，Aug，1984.，处理从实施例12取得的皮肤标本。表皮皮肤照所描述的那样进行分离，通过计算机图像分析软件(Image Pro Plus4.5版from Media Cybernetics，Silver Spring，Md.)，日立公司CCD照相机KP-D50，Olympus BH-2的显微镜来测量椭圆囊的直径。对每个试验组，要测量50个表皮椭圆囊的直径。与对照组相比，椭圆囊直径的减少表明了类视黄醇的生物学活性。表M中展示了用
处理的椭圆囊的面积减少了约70％。维甲酸和STI联合处理组也表现了相似的结果，其结果再次证明了加入的STI不会抑制类视黄醇的活性，就像随着STI的加入，(实施例12)红色的消退也同样有效果。
表M
处理 椭圆囊直径(μM+/-STD) ％减少(相对于对照)
对照 94.7+/-6.9 -
维甲酸 34.6+/-1.6 63.4
29.4+/-0.6 68.9
Claims (14)
1.一种组合物在制备治疗痤疮的药物中的用途，所述组合物含有(a)维甲酸，和(b)具有胰蛋白酶抑制活性的未变性的大豆提取物。
2.如权利要求1所述的用途，其中所述未变性大豆提取物选自大豆奶和未变性大豆糊。
3.一种组合物在制备治疗痤疮的药物中的用途，所述组合物含有(a)视黄醇，和(b)具有胰蛋白酶抑制活性的未变性大豆提取物。
4.如权利要求3所述的用途，其特征在于所述未变性大豆提取物选自大豆奶和未变性大豆糊。
5.如权利要求1所述的用途，其特征在于所述未变性大豆提取物是大豆粉。
6.如权利要求3所述的用途，其特征在于所述未变性大豆提取物是大豆粉。
7.一种组合物在制备治疗痤疮的药物中的用途，所述组合物含有(a)0.01-0.3重量％的维甲酸和(b)0.01-50重量％的具有胰蛋白酶抑制活性的未变性大豆提取物。
8.如权利要求7所述的用途，其特征在于所述未变性大豆提取物是大豆粉。
9.如权利要求8所述的用途，其特征在于所述大豆粉的含量为0.05-20重量％。
10.如权利要求9所述的用途，其特征在于所述大豆粉的含量为0.5-5重量％。
11.一种组合物在治疗痤疮中的用途，所述组合物含有(a)0.1-1重量％的视黄醇和(b)0.01-50重量％的具有胰蛋白酶抑制活性的未变性大豆提取物。
12.如权利要求11所述的用途，其特征在于所述未变性大豆提取物是大豆粉。
13.如权利要求12所述的用途，其特征在于所述大豆粉的含量为0.05-20重量％。
14.如权利要求13所述的用途，其特征在于所述大豆粉的含量为0.5-5重量％。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/659,598 US8093293B2 (en) | 1998-07-06 | 2003-09-10 | Methods for treating skin conditions |
| US10/659,598 | 2003-09-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1795926A CN1795926A (zh) | 2006-07-05 |
| CN1795926B true CN1795926B (zh) | 2010-05-26 |
Family
ID=34136761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004100942358A Expired - Fee Related CN1795926B (zh) | 2003-09-10 | 2004-09-10 | 治疗皮肤症状的制药用途 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8093293B2 (zh) |
| EP (1) | EP1514536B1 (zh) |
| JP (1) | JP2005082600A (zh) |
| KR (2) | KR101151317B1 (zh) |
| CN (1) | CN1795926B (zh) |
| AT (1) | ATE427776T1 (zh) |
| AU (2) | AU2004208740A1 (zh) |
| BR (1) | BRPI0405445A8 (zh) |
| CA (1) | CA2480925C (zh) |
| DE (1) | DE602004020432D1 (zh) |
| ES (1) | ES2322851T3 (zh) |
| TW (1) | TW200526259A (zh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
| US7192615B2 (en) | 2001-02-28 | 2007-03-20 | J&J Consumer Companies, Inc. | Compositions containing legume products |
| WO2005067691A2 (en) * | 2004-01-07 | 2005-07-28 | E-L Management Corporation | Cosmetic composition containing a protein and an enzyme inhibitor |
| US20070048246A1 (en) * | 2005-09-01 | 2007-03-01 | Biophysica Research, Inc. | Novel skin care compositions |
| US7547434B2 (en) * | 2005-09-09 | 2009-06-16 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for mitigating skin irritation |
| KR101286782B1 (ko) | 2005-09-20 | 2013-07-17 | 디에스엠 아이피 어셋츠 비.브이. | 신규 카복실산 유도체 |
| KR100720381B1 (ko) | 2005-12-14 | 2007-05-22 | 이금희 | 클렌징 화장료 조성물 |
| WO2008139124A2 (fr) * | 2007-05-11 | 2008-11-20 | Galderma Research & Development | Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations |
| EP2260831A1 (en) * | 2009-06-12 | 2010-12-15 | L V M H Recherche | Plant extracts modulating Myo-X for use in compositions |
| US8409633B2 (en) | 2008-09-10 | 2013-04-02 | L V M H Recherche | Methods useful in studying or modulating skin or hair pigmentation, plant extracts for use in compositions and cosmetic care method |
| EP3578178A1 (en) * | 2011-02-15 | 2019-12-11 | Aclaris Therapeutics, Inc. | Pharmaceutical composition comprising oxymetazoline |
| ITMI20112048A1 (it) * | 2011-11-11 | 2013-05-12 | Difa Cooper S P A | Composizione per uso topico |
| WO2013175507A1 (en) * | 2012-05-22 | 2013-11-28 | Laila Pharmaceuticals Pvt. Ltd. | Novel highly bioavailable, water soluble and sustained release nanoformulations of hydrophobic plant derived compounds and extracts |
| KR102157407B1 (ko) * | 2013-08-15 | 2020-09-17 | 마리 케이 인코포레이티드 | 주름 치료를 위한 국소 피부 조성물 |
| MX2016016123A (es) * | 2014-06-06 | 2017-07-20 | Archer Daniels Midland Co | Microemulsiones y sus usos. |
| KR102299276B1 (ko) * | 2014-07-16 | 2021-09-09 | (주)아모레퍼시픽 | 납떼기콩 오일을 포함하는 조성물 |
| US9765026B2 (en) | 2015-08-28 | 2017-09-19 | Scinopharm Taiwan, Ltd. | Forms of apremilast and the process of making the same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1342064A (zh) * | 1999-11-05 | 2002-03-27 | 强生消费者公司 | 大豆脱色素和护肤组合物 |
Family Cites Families (377)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2924525A (en) | 1957-06-03 | 1960-02-09 | Central Soya Co | Poultry treatment for skin pigmentation |
| US2876164A (en) | 1957-08-01 | 1959-03-03 | Dome Chemicals Inc | Dermatological preparation containing defatted soy bean flour |
| US3097947A (en) | 1961-01-30 | 1963-07-16 | Mend Johnson & Company | Nutritional composition and process |
| US3395214A (en) | 1964-01-09 | 1968-07-30 | Scholl Mfg Co Inc | Antiperspirant composition providing a readily collapsible sprayable foam |
| US4007266A (en) | 1968-05-03 | 1977-02-08 | Choay S.A. | Pharmaceutical composition containing vitamin B12, process of making the same and method of treatment |
| FR2041594A5 (zh) | 1969-04-30 | 1971-01-29 | Expanscience | |
| US3625976A (en) | 1969-12-09 | 1971-12-07 | Int Flavors & Fragrances Inc | Coumarin ether sun-screening compounds |
| US3755560A (en) | 1971-06-30 | 1973-08-28 | Dow Chemical Co | Nongreasy cosmetic lotions |
| US4331692A (en) | 1971-07-23 | 1982-05-25 | Ulla Drevici | Cocoa fruits and products |
| GB1541463A (en) | 1975-10-11 | 1979-02-28 | Lion Dentifrice Co Ltd | Process for prparing a multiple emulsion having a dispersing form of water-phase/oil-phase/water-phase |
| US4056637A (en) | 1976-06-08 | 1977-11-01 | Japan Natural Food Co. Ltd. | Process for preparing food products containing a lactic acid bacteria-fermented product of a cereal germ |
| US4151304A (en) | 1976-11-05 | 1979-04-24 | Lever Brothers Company | Method and composition for moisturizing the skin |
| FR2380775A1 (fr) | 1977-02-22 | 1978-09-15 | Sederma Sarl | Composition " apres-epilation " favorisant un ralentissement progressif de la repousse des poils |
| US4190671A (en) | 1977-03-17 | 1980-02-26 | Biorex Laboratories Limited | Chalcone derivatives |
| US4219569A (en) | 1978-10-10 | 1980-08-26 | The Upjohn Company | Process for treating inflammation |
| US4279930A (en) | 1978-10-10 | 1981-07-21 | The Upjohn Company | Process for treating inflammation |
| US4223018A (en) | 1979-02-09 | 1980-09-16 | Jimmie Belle | Bath composition |
| IT8021120A0 (it) | 1979-04-02 | 1980-04-01 | Inst Organicheskogo Sinteza Ak | Analogo ciclico del peptide naturale stimolante la fagocitosi: treonile-ciclo (n-lisile-prolile-arginile). |
| DE3040246C2 (de) | 1979-10-29 | 1985-01-10 | Osaka Chemical Laboratory Co., Ltd., Osaka | Sojasaponine A↓1↓ und A↓2↓ und ihre Verwendung |
| JPS56135416A (en) | 1980-03-27 | 1981-10-22 | Mitsubishi Chem Ind Ltd | Pharmaceutical preparation for skin |
| US4297348A (en) | 1980-04-11 | 1981-10-27 | Rush-Hampton Industries, Inc. | Composition and method for the treatment of acne |
| US5439672A (en) | 1980-07-01 | 1995-08-08 | L'oreal | Cosmetic composition based on an aqueous dispersion of small lipid spheres |
| US4272544A (en) | 1980-08-20 | 1981-06-09 | Eli Lilly And Company | Skin cell renewal regime |
| US4278570A (en) | 1980-08-20 | 1981-07-14 | Eli Lilly And Company | Cosmetic cleanser formulation |
| LU83020A1 (fr) | 1980-12-19 | 1982-07-07 | Oreal | Composition huileuse destinee au traitement des matieres keratiniques et de la peau |
| DE3109420A1 (de) | 1981-03-12 | 1982-09-23 | Kastell, Wolfgang, 2000 Hamburg | Mittel zum anhalten des haarausfalls und zum foerdern des haarwuchses |
| FR2509988B1 (fr) | 1981-07-23 | 1986-05-30 | Oreal | Melange d'huiles vegetales a base d'huile de jojoba comme agent de stabilisation a l'oxydation et compositions cosmetiques le contenant |
| DE3129867A1 (de) | 1981-07-29 | 1983-02-17 | Henkel Kgaa | "ungesaettigte arylketone als antiseborrhoische zusaetze fuer kosmetische mittel" |
| US4368187A (en) | 1981-08-03 | 1983-01-11 | Eli Lilly And Company | Sensitive-skin care regime |
| US4382960A (en) | 1981-08-03 | 1983-05-10 | Eli Lilly And Company | Cosmetic cleanser formulation |
| US4603146A (en) | 1984-05-16 | 1986-07-29 | Kligman Albert M | Methods for retarding the effects of aging of the skin |
| US4578267A (en) | 1981-09-15 | 1986-03-25 | Morton Thiokol, Inc. | Skin conditioning polymer containing alkoxylated nitrogen salts of sulfonic acid |
| US4859458A (en) | 1981-09-15 | 1989-08-22 | Morton Thiokol, Inc. | Hair conditioning polymers containing alkoxylated nitrogen salts of sulfonic acid |
| US4421769A (en) | 1981-09-29 | 1983-12-20 | The Procter & Gamble Company | Skin conditioning composition |
| FR2514643B1 (fr) | 1981-10-20 | 1986-07-04 | Oreal | Lanolate de cuivre et compositions cosmetiques anti-acneiques le contenant |
| FR2520253A1 (fr) | 1982-01-28 | 1983-07-29 | Oreal | Nouveau systeme emulsionnant a base d'un condensat de proteines, d'un sterol polyoxyethylene et de phosphatide et son utilisation en cosmetique |
| US4477434A (en) | 1982-05-29 | 1984-10-16 | Reiko Kosaka | Medicinal compositions, foods and beverages having therapeutic effects on diseases of circulatory system and digestive system |
| JPS58225003A (ja) | 1982-06-23 | 1983-12-27 | Ichimaru Fuarukosu Kk | 納豆抽出物含有化粧料 |
| JPS6019885B2 (ja) | 1982-06-23 | 1985-05-18 | 一丸フアルコス株式会社 | イソフラボン化合物含有美白化粧料 |
| US4462981A (en) | 1982-12-10 | 1984-07-31 | Creative Products Resource, Associates Ltd. | Cosmetic applicator useful for skin moisturizing and deodorizing |
| US4550035A (en) | 1982-12-10 | 1985-10-29 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing and deodorizing |
| US4604281A (en) | 1983-03-21 | 1986-08-05 | Charles Of The Ritz Group Ltd. | Cosmetic and skin treatment compositions containing acetylated sterols |
| JPS59187756A (ja) | 1983-04-08 | 1984-10-24 | Erika Kk | 粉末豆乳 |
| DE3326455A1 (de) | 1983-07-22 | 1985-01-31 | Henkel Kgaa | Kosmetisch-pharmazeutische oelkomponenten |
| US4512973A (en) | 1983-10-12 | 1985-04-23 | Genentech, Inc. | Method for overcoming trypsin inhibition |
| US5192332A (en) | 1983-10-14 | 1993-03-09 | L'oreal | Cosmetic temporary coloring compositions containing protein derivatives |
| JPS60109544A (ja) | 1983-11-17 | 1985-06-15 | Kao Corp | 新規カルコン誘導体及びこれを含有する紫外線吸収剤 |
| IT1180156B (it) | 1984-01-09 | 1987-09-23 | Crinos Industria Farmaco | Composizione cosmetica a base di glicoproteine per il trattamento della pelle |
| US4678663A (en) | 1984-02-06 | 1987-07-07 | Nuetrogena Corporation | Hydroquinone composition having enhanced bio-availability and percutaneous adsorption |
| US4690821A (en) | 1984-02-10 | 1987-09-01 | Creative Products Resource Associates, Ltd. | Towel for skin moisturizing and drying |
| DE3586747D1 (de) | 1984-03-05 | 1992-11-19 | Tonfer Inc | Reinigungsmittel. |
| AU580645B2 (en) | 1984-12-21 | 1989-01-19 | Kibun Company Limited | Process of producing soy bean milk |
| FR2580478B1 (fr) | 1985-04-17 | 1989-05-12 | Christian Chapoton | Dispositif de traitement capillaire liberant une substance active et procede de fabrication |
| JPS6236304A (ja) | 1985-06-05 | 1987-02-17 | Kashiwa Kagaku Kogyo:Kk | 化粧料 |
| US4760096A (en) | 1985-09-27 | 1988-07-26 | Schering Corporation | Moisturizing skin preparation |
| FR2591105B1 (fr) * | 1985-12-11 | 1989-03-24 | Moet Hennessy Rech | Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide. |
| US4793991A (en) | 1986-01-31 | 1988-12-27 | Slimak Karen M | Hypoallergenic cosmetics, lip balms and lip sticks |
| US4970216A (en) | 1986-03-17 | 1990-11-13 | Richardson Vicks, Inc. | Skin treatment composition and method |
| US4847267A (en) | 1986-03-17 | 1989-07-11 | Charles Of The Ritz Group Ltd. | Skin treatment composition and method |
| LU86361A1 (fr) | 1986-03-19 | 1987-11-11 | Oreal | Composition cosmetique aqueuse a moussage differe pour le traitement des cheveux et de la peau |
| FR2596986B1 (fr) | 1986-04-11 | 1988-09-23 | Sederma Sa | Utilisation de la lactoferrine dans des preparations cosmetiques, antiradicaux libres |
| FR2641696B2 (fr) | 1986-04-11 | 1991-03-08 | Sederma Sa | Utilisation d'un melange renfermant de la lactoferrine dans des preparations cosmetiques anti-radicaux libres |
| FR2600250B1 (fr) | 1986-06-23 | 1989-11-24 | Bio Serae | Procede pour conditionner une composition antibacterienne et composition antibacterienne conditionnee |
| JPS6368512A (ja) | 1986-09-09 | 1988-03-28 | Iwase Kosufua Kk | 皮膚外用剤 |
| JPS6396120A (ja) | 1986-10-14 | 1988-04-27 | Matsuura Yakugiyou Kk | 日焼け止め化粧品 |
| JPS63135310A (ja) | 1986-11-27 | 1988-06-07 | Lion Corp | 化粧料 |
| LU86715A1 (fr) | 1986-12-16 | 1988-07-14 | Oreal | Composition cosmetique contenant des derives hydroxyles de chalcone et son utilisation pour la protection de la peau et des cheveux contre les radiations lumineuses,nouveaux derives hydroxyles de chalcone utilises et leur procede de preparation |
| AU618517B2 (en) | 1986-12-23 | 1992-01-02 | Eugene J. Van Scott | Additives enhancing topical actions of therapeutic agents |
| IT1201149B (it) | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche |
| US5166139A (en) | 1987-02-26 | 1992-11-24 | Indena, S.P.A. | Complexes of saponins and their aglycons with phospholipids and pharmaceutical and cosmetic compositions containing them |
| IT1203515B (it) | 1987-02-26 | 1989-02-15 | Indena Spa | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono |
| US4960764A (en) | 1987-03-06 | 1990-10-02 | Richardson-Vicks Inc. | Oil-in-water-in-silicone emulsion compositions |
| JP2554873B2 (ja) | 1987-03-17 | 1996-11-20 | 新日本化工株式会社 | 無菌化粧品の製造方法 |
| US5057417A (en) | 1987-06-12 | 1991-10-15 | Genentech, Inc. | Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein |
| US5688763A (en) | 1987-06-12 | 1997-11-18 | Hammonds, Jr.; R. Glenn | Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein |
| US4824662A (en) | 1987-06-15 | 1989-04-25 | Vi-Jon Laboratories, Inc. | Nail polish remover |
| JPS63316711A (ja) | 1987-06-17 | 1988-12-26 | Nonogawa Shoji:Kk | 美白化粧料 |
| IT1222012B (it) | 1987-07-10 | 1990-08-31 | Indena Spa | Composizioni farmaceutiche e cosmetiche contenenti complessi di flavonolignani con fosfolipidi |
| IT1223290B (it) | 1987-07-27 | 1990-09-19 | Indena Spa | Acidi poliinsaturi ad azione vasocinetica e relative formulazioni farmaceutiche e cosmetiche |
| LU86997A1 (fr) | 1987-09-21 | 1989-04-06 | Oreal | Composition cosmetique filtrante photostable contenant de la bixine associee a un filtre uv liposoluble et son utilisation pour la protection de l'epiderme humain contre les radiations ultraviolettes |
| JP2618657B2 (ja) | 1987-10-02 | 1997-06-11 | 株式会社資生堂 | 抗色素沈着外用剤 |
| JPH0196106A (ja) | 1987-10-09 | 1989-04-14 | Shiseido Co Ltd | 皮膚外用剤 |
| CH676470A5 (zh) | 1988-02-03 | 1991-01-31 | Nestle Sa | |
| FR2628317B1 (fr) | 1988-03-09 | 1991-11-08 | Lvmh Rech | Composition a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un extrait de scutellaria, ou au moins un flavonoide tel que baicaleine ou baicaline et composition cosmetique ou pharmaceutique, notamment dermatologique, a activite anti-allergique, anti-inflammatoire ou anti-vieillissement, l'incorporant |
| DE3814839A1 (de) | 1988-05-02 | 1989-11-16 | Henkel Kgaa | Haarbehandlungsmittel mit natuerlichen inhaltsstoffen |
| IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US4906457A (en) | 1988-09-06 | 1990-03-06 | Washington State University Research Foundation, Inc. | Compositions and methods for reducing the risk of sunlight and ultraviolet induced skin cancer |
| US4851214A (en) | 1988-09-07 | 1989-07-25 | Ici Americas Inc. | Deodorants containing N-soya-N-ethyl morpholinium ethosulfate |
| US4960588A (en) | 1988-11-16 | 1990-10-02 | Helene Curtis, Inc. | Hair treatment compositions to impart durable hair set retention properties |
| US4943462A (en) | 1989-01-17 | 1990-07-24 | Semex Medical, Inc. | Nail treatment device |
| LU87449A1 (fr) | 1989-02-09 | 1990-09-19 | Oreal | Procede de fabrication de mousses utilisables dans les domaines cosmetique et pharmaceutique et mousses obtenues par ce procede |
| US5116605A (en) | 1989-03-09 | 1992-05-26 | Alt John P | Composition and skin treatment method therewith for mitigating acne and male-pattern baldness |
| EP0393532B1 (en) | 1989-04-14 | 1996-06-19 | Wesley Jessen Corporation | Color binding mechanism for contact lenses |
| MY105521A (en) | 1989-04-17 | 1994-10-31 | Healthpoint Ltd | Moisturizing vehicle for topical application of vitamin a acid. |
| US5194252A (en) | 1989-07-27 | 1993-03-16 | Vijon Laboratories, Inc. | Moisture retaining aftershave |
| US5077038A (en) | 1989-07-27 | 1991-12-31 | Vi-Jon Laboratories, Inc. | Nail polish remover |
| JPH04501882A (ja) | 1989-09-14 | 1992-04-02 | チヤン，シン―シウン | 改良された臨床的性能を有する柔軟なガス透過性コンタクトレンズ |
| JP2832848B2 (ja) | 1989-10-21 | 1998-12-09 | 株式会社林原生物化学研究所 | 結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途 |
| EP0421021A1 (de) | 1989-10-06 | 1991-04-10 | MUCOS EMULSIONSGESELLSCHAFT m.b.H. | Verwendung katabolischer Enzyme zur Aktivierung von Makrophagen und/oder NK-Zellen, ein diese Enzyme enthaltendes Arzneimittel sowie durch diese Enzyme aktivierte Makrophage und/oder NK-zelle |
| JP2804312B2 (ja) | 1989-10-09 | 1998-09-24 | 三省製薬株式会社 | 化粧料 |
| US5554647A (en) | 1989-10-12 | 1996-09-10 | Perricone; Nicholas V. | Method and compositions for treatment and/or prevention of skin damage and aging |
| US5032400A (en) | 1989-11-02 | 1991-07-16 | Erie Laboratories | Shark liver oil and garlic oil topical analgesic |
| WO1991007166A1 (en) | 1989-11-16 | 1991-05-30 | Washington State University Research Foundation, Inc | Compositions and methods for reducing the risk of sunlight and ultraviolet induced skin cancer |
| US5834312A (en) | 1990-01-29 | 1998-11-10 | Hy-Gene, Inc. | Process and media for the growth of human epithelia |
| US5622690A (en) | 1990-04-05 | 1997-04-22 | Nurture, Inc. | Seed-derived proteinaceous compositions for reduction of sunburn cell formation |
| US5077040A (en) | 1990-04-30 | 1991-12-31 | Helene Curtis, Inc. | Hair-treating microemulsion composition and method of preparing and using the same |
| FR2663633B1 (fr) | 1990-06-22 | 1994-06-17 | Adir | Nouvelles chalcones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5332758A (en) | 1990-07-13 | 1994-07-26 | Kanebo, Ltd. | Collagen metabolism ameliorant and its use |
| CA2047160C (en) | 1990-07-25 | 2002-06-25 | Masahiro Ito | Reactive hot-melt elastic sealant composition |
| US5231090A (en) | 1990-07-30 | 1993-07-27 | University Of Miami | Treatment for hypercholesterolemia |
| US5407675A (en) | 1990-08-10 | 1995-04-18 | Etemad-Moghadam; Parviz | Method and composition for use on the scalp and eyebrow region of a subject |
| CA2049728A1 (en) | 1990-08-24 | 1992-02-25 | Kenji Kitamura | Washing composition capable of preventing and ameliorating skin irritation |
| FR2666474B1 (fr) | 1990-08-28 | 1992-11-06 | De Stoutz Jean | Dispositif pour le chauffage de fluides par effet joule. |
| US5338547A (en) * | 1990-09-06 | 1994-08-16 | Trustees Of The Univ. Of Pennsylvania | Bowman-Birk inhibitor product for use as an anticarcinogenesis agent |
| US5217717A (en) | 1990-09-06 | 1993-06-08 | Central Soya Company, Inc. | Method of making soybean Bowman-Birk inhibitor concentrate and use of same as a human cancer preventative and therapy |
| US5130142A (en) | 1990-10-31 | 1992-07-14 | The Practer & Gamble Company | Hair growth regulating composition comprising epithelium cell supernatant-derived growth factor |
| JP3032566B2 (ja) | 1990-11-01 | 2000-04-17 | 株式会社資生堂 | 皮膚外用剤 |
| EP0510165B1 (fr) | 1990-11-14 | 1995-01-25 | L'oreal | Composes amphiphiles non-ioniques derives du glycerol, leur procede de preparation, composes intermediaires correspondants et compositions contenant lesdits composes |
| US5135297A (en) | 1990-11-27 | 1992-08-04 | Bausch & Lomb Incorporated | Surface coating of polymer objects |
| BR9107133A (pt) | 1990-11-27 | 1994-03-22 | Bausch & Lomb | Marcromonomeros tensoativos |
| US5110603A (en) | 1991-01-31 | 1992-05-05 | Kao Corporation | Bathing preparation for colloidal material |
| US5188823A (en) | 1991-02-07 | 1993-02-23 | Stepan Company | Antiperspirant formulations |
| US5449794A (en) | 1991-02-15 | 1995-09-12 | Jasmine Fockerman | Benzopyran phenol derivatives for use as antibacterial agents |
| GB9104286D0 (en) | 1991-02-28 | 1991-04-17 | Phytopharm Ltd | Pharmaceutical compositions for the treatment of skin disorders |
| US5807543A (en) | 1993-08-27 | 1998-09-15 | The Procter & Gamble Co. | Cosmetic compositions containing hydrophobically modified nonionic polymer and unsaturated quaternary ammonium surfactant |
| JPH05114905A (ja) | 1991-04-08 | 1993-05-07 | Digital Equip Corp <Dec> | 単一アドレス及びプロトコール・テーブル・ブリツジを使用したメツセージの処置フイルタリング |
| US5498420A (en) | 1991-04-12 | 1996-03-12 | Merz & Co. Gmbh & Co. | Stable small particle liposome preparations, their production and use in topical cosmetic, and pharmaceutical compositions |
| US5229104A (en) | 1991-04-29 | 1993-07-20 | Richardson-Vicks Inc. | Artificial tanning compositions containing positively charged paucilamellar vesicles |
| EP0514576A1 (fr) | 1991-05-24 | 1992-11-25 | Societe Des Produits Nestle S.A. | Mélange antioxydant liposoluble |
| US5310734A (en) | 1991-07-05 | 1994-05-10 | Rhone-Poulenc Rorer | Phospholipid composition |
| JP3320430B2 (ja) | 1991-07-10 | 2002-09-03 | 日本原子力研究所 | 放射線滅菌による無菌リン脂質、リン脂質水分散液又はリポソーム水分散液の製造法 |
| FR2679446B1 (fr) | 1991-07-24 | 1993-10-29 | Oreal | Procede de fabrication d'une composition cosmetique pour application sur les cheveux, composition obtenue par ce procede et procede de traitement cosmetique a l'aide de ladite composition. |
| FR2679904A1 (fr) | 1991-08-01 | 1993-02-05 | Lvmh Rech | Utilisation d'un phosphate de tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, ou pharmaceutiques et compositions ainsi obtenues. |
| US5254331A (en) | 1991-09-12 | 1993-10-19 | Chanel, Inc. | Skin cream composition |
| ES2179038T3 (es) | 1991-09-13 | 2003-01-16 | Pentapharm Ag | Fraccion porteinica para el tratamiento cosmetico y dermatologico de la piel. |
| US5260065A (en) | 1991-09-17 | 1993-11-09 | Micro Vesicular Systems, Inc. | Blended lipid vesicles |
| WO1993010755A1 (en) | 1991-11-25 | 1993-06-10 | Richardson-Vicks, Inc. | Compositions for regulating skin wrinkles and/or skin atrophy |
| DE69233039T2 (de) | 1991-11-25 | 2004-03-11 | Richardson-Vicks Inc., Cincinnati | VERWENDUNG VON SALICYLSÄURE ZUR KONTROLLE von Hautfalten und/oder HAUTATROPHIE |
| US5780459A (en) | 1991-11-25 | 1998-07-14 | The Procter & Gamble Company | Compositions for regulating skin wrinkles and or skin atrophy |
| FR2685202B1 (fr) | 1991-12-24 | 1995-03-24 | Sederma Sa | Nouvelle methode de traitement pharmaceutique et cosmetique pour la regulation de la seborrhee, de l'acne et de la flore cutanee. |
| JPH05213729A (ja) | 1992-01-31 | 1993-08-24 | Kao Corp | メラニン抑制剤 |
| FR2687314A1 (fr) | 1992-02-18 | 1993-08-20 | Oreal | Dispersion de vesicules lipidiques, composition cosmetique et/ou pharmaceutique la contenant et procede de preparation de ladite dispersion. |
| US5766628A (en) | 1992-02-24 | 1998-06-16 | Merz + Co. Gmbh & Co. | Bath and shower composition having vesicle-forming properties and method for the production and use thereof |
| DE4206090C2 (de) | 1992-02-27 | 1998-02-05 | Perycut Chemie Ag | Insektenabwehrmittel |
| JPH05246932A (ja) | 1992-03-04 | 1993-09-24 | Nippon High Potsukusu:Kk | ３，４−ジヒドロキシカルコン誘導体 |
| US5393519A (en) | 1992-03-27 | 1995-02-28 | Helene Curtis, Inc. | Shampoo compositions |
| US5248495A (en) | 1992-04-16 | 1993-09-28 | The Procter & Gamble Company | Post foaming shaving gel composition |
| JPH05320061A (ja) | 1992-05-19 | 1993-12-03 | Soken Kk | 豆類からの活性酸素消去剤 |
| JP3236347B2 (ja) | 1992-05-21 | 2001-12-10 | 同和鉱業株式会社 | 美白化粧料 |
| US6030612A (en) | 1994-11-22 | 2000-02-29 | Phairson Medical Inc. | Antimicrobial uses of multifunctional enzyme |
| JPH0649251A (ja) | 1992-06-09 | 1994-02-22 | Ciba Geigy Ag | 表面特性を改質するための、予め成形した基材表面へのグラフト重合法 |
| US5352443A (en) | 1992-06-15 | 1994-10-04 | Shiseido Co., Ltd. | Permanent waving composition |
| US5641509A (en) | 1992-06-26 | 1997-06-24 | Lancaster Group Ag | Preparation for topical use |
| US5643601A (en) | 1992-06-26 | 1997-07-01 | Lancaster Group Ag | Phospholipid-and fluorocarbon-containing cosmetic |
| DE4221256C2 (de) | 1992-06-26 | 1997-07-10 | Lancaster Group Ag | Galenische Zusammensetzung für die topische Anwendung |
| US5438044A (en) | 1992-06-30 | 1995-08-01 | Rhone-Poulenc Rorer | Phospholipid composition |
| US5252604A (en) | 1992-07-10 | 1993-10-12 | Hoffmann-La Roche Inc. | Compositions of retinoic acids and tocopherol for prevention of dermatitis |
| DE4226173A1 (de) | 1992-08-07 | 1994-02-10 | Solvay Fluor & Derivate | Badezusatzpräparat |
| FR2694934B1 (fr) | 1992-08-24 | 1994-11-10 | Oreal | Composition pour le traitement de l'acné contenant un dérivé d'acide salicylique et dérivés d'acide salicylique. |
| JPH06192085A (ja) | 1992-08-31 | 1994-07-12 | Yuji Inada | ダニアレルギー治療剤 |
| IL106922A (en) | 1992-09-14 | 1998-08-16 | Novartis Ag | Complex materials with one or more wettable surfaces and a process for their preparation |
| US6048520A (en) | 1992-09-24 | 2000-04-11 | Helene Curtis, Inc. | Clear leave-on hair treatment composition and method |
| US5753612A (en) | 1992-10-27 | 1998-05-19 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Pharmaceutical composition and method for inhibiting hair growth by administration of activin or activin agonists |
| JP3257091B2 (ja) | 1992-11-06 | 2002-02-18 | 不二製油株式会社 | 抗皮膚癌剤又は食品 |
| US5565439A (en) | 1992-11-24 | 1996-10-15 | The Procter & Gamble Company | Methods of using lysophosphatidic acid for treating hyperproliferative conditions |
| JP2580942B2 (ja) | 1992-12-24 | 1997-02-12 | ティアック株式会社 | 磁気テ−プ装置及びこの磁気ヘッドの移動方法 |
| US5270042A (en) | 1993-02-23 | 1993-12-14 | Juanita Whitham | Medicinal salve composition |
| RU2066992C1 (ru) | 1993-03-01 | 1996-09-27 | Надежда Михайловна Остроумова | Средство для удаления волос "пластилин каприз" и способ его получения |
| JP3091045B2 (ja) | 1993-03-04 | 2000-09-25 | 丸善製薬株式会社 | 皮膚化粧料 |
| CA2119064A1 (en) | 1993-03-17 | 1994-09-18 | Richard A. Berg | Dermal-epidermal in vitro test system |
| CN1094279A (zh) | 1993-04-22 | 1994-11-02 | 王能强 | 纯天然药物型理疗保健护发洗头素 |
| US5276058A (en) | 1993-06-09 | 1994-01-04 | Nippon Hypox Laboratories Incorporated | 3,4-dihydroxychalcone derivatives |
| TW253849B (zh) | 1993-08-09 | 1995-08-11 | Ciba Geigy | |
| ES2185638T3 (es) | 1993-08-30 | 2003-05-01 | Unilever Nv | Composicion de champu acondicionador. |
| FR2709756B1 (fr) | 1993-09-10 | 1995-10-20 | Essilor Int | Matériau hydrophile, transparent à haute perméabilité à l'oxygène, à base d'un polymère à réseaux interpénétrés, son mode de préparation et fabrication de lentilles de contact souples à haute perméabilité à l'oxygène. |
| FR2710264B1 (fr) | 1993-09-21 | 1995-12-08 | Rocher Yves Biolog Vegetale | Utilisation pour le traitement des peaux mixtes d'une quantité efficace de substances actives. |
| FR2710524B1 (fr) | 1993-09-28 | 1995-11-17 | Oreal | Composition de vernis à ongles contenant une huile époxydée comme plastifiant. |
| IL111105A (en) | 1993-09-30 | 2009-05-04 | Univ Pennsylvania | Use of a molecule capable of inhibiting the expression of syk kinase to prepare a pharmaceutical composition for inhibiting phagocytosis |
| US5641863A (en) | 1993-09-30 | 1997-06-24 | University Of Pennsylvania | Chimeric IgG Fc receptors |
| US5681571A (en) | 1993-10-08 | 1997-10-28 | Duotol Ab | Immunological tolerance-inducing agent |
| JPH07121869B2 (ja) | 1993-10-12 | 1995-12-25 | 浩 前田 | 炎症性浮腫亢進抑制剤 |
| US5510391A (en) | 1993-10-22 | 1996-04-23 | Mayapple Holdings, Llc | Method of treating blood vessel disorders of the skin using vitamin K |
| GB9322007D0 (en) | 1993-10-26 | 1993-12-15 | Unilever Plc | Cosmetic composition |
| US5681852A (en) | 1993-11-12 | 1997-10-28 | The Procter & Gamble Company | Desquamation compositions |
| US5712356A (en) | 1993-11-26 | 1998-01-27 | Ciba Vision Corporation | Cross-linkable copolymers and hydrogels |
| EP0655470B1 (de) | 1993-11-26 | 1999-05-12 | Novartis AG | Vernetzbare Copolymere und Hydrogele |
| DE4343431C1 (de) | 1993-12-18 | 1995-05-04 | Henkel Kgaa | Kosmetische und/oder pharamzeutische Zubereitungen |
| EP0664112B1 (fr) | 1993-12-22 | 1997-03-26 | L'oreal | Poudre cosmétique ou dermatologique, son procédé de préparation et utilisations |
| US5620692A (en) | 1993-12-23 | 1997-04-15 | Nurture, Inc. | Oat oil compositions with useful cosmetic and dermatological properties |
| JPH07196529A (ja) | 1993-12-29 | 1995-08-01 | Morinaga Milk Ind Co Ltd | 創傷治癒剤、化粧料および養毛剤 |
| JPH07196527A (ja) | 1993-12-29 | 1995-08-01 | Morinaga Milk Ind Co Ltd | ペプチドまたはその誘導体と、細胞増殖賦活化剤 |
| FR2714601B1 (fr) | 1993-12-30 | 1996-02-09 | Oreal | Composition dépigmentante pour le traitement simultané des couches superficielles et profondes, son utilisation. |
| FR2714599B1 (fr) | 1993-12-30 | 1996-02-09 | Oreal | Composition pour lutter contre le vieillissement, agissant siimultanément sur les couches superficielles et profondes de la peau, son utilisation. |
| FR2714602B1 (fr) | 1993-12-30 | 1996-02-09 | Oreal | Composition antiacnéique pour le traitement simultané des couches superficielles et profondes de la peau, son utilisation. |
| FR2714604B1 (fr) | 1993-12-30 | 1996-01-26 | Oreal | Utilisation d'un accepteur de spin dans une composition cosmétique ou dermatologique. |
| FR2714600B1 (fr) | 1993-12-30 | 1996-02-09 | Oreal | Composition protectrice, nutritive et/ou raffermissante pour le traitement simultané des couches superficielles et profondes de la peau, son utilisation. |
| FR2714596B1 (fr) | 1993-12-30 | 1996-02-09 | Oreal | Composition cosmétique pour le traitement simultané des couches superficielles et profondes de la peau, son utilisation. |
| FR2714597B1 (fr) | 1993-12-30 | 1996-02-09 | Oreal | Composition hydratante pour le traitement simultané des couches superficielles et profondes de la peau, son utilisation. |
| FR2714598B1 (fr) | 1993-12-30 | 1996-02-09 | Oreal | Composition amincissante à deux types de liposomes pour traitement topique, son utilisation. |
| JPH0899891A (ja) | 1994-01-21 | 1996-04-16 | Pola Chem Ind Inc | 皮膚外用剤 |
| US5468473A (en) | 1994-02-09 | 1995-11-21 | Innova Products, Inc. | Antiperspirant for hands and feet |
| FR2716079B1 (fr) | 1994-02-15 | 1996-05-03 | Stoutz Jean Christian De | Procédé d'extraction de matières solubles de fèves ou graines d'oléagineux, notamment procédé de production de "lait" de soja. |
| DE4405127A1 (de) | 1994-02-18 | 1995-08-31 | Henkel Kgaa | Haarbehandlungsmittel |
| US5547661A (en) | 1994-02-22 | 1996-08-20 | Helene Curtis, Inc. | Antiperspirant deodorant compositions |
| IL112649A (en) | 1994-02-22 | 1999-12-22 | Curtis Helene Ind Inc | Topically effective compositions for application to the skin or hair |
| FR2717075B1 (fr) | 1994-03-14 | 1996-04-05 | Oreal | Gel aqueux de maquillage à organopolysiloxane. |
| US5455234A (en) | 1994-03-16 | 1995-10-03 | Ahluwalia; Gurpreet S. | Inhibition of hair growth |
| US5505946A (en) | 1994-04-01 | 1996-04-09 | Trustees Of Univ Of Pa | Bowman-birk inhibitor concentrate compositions and methods for the treatment of pre-malignant tissue |
| US6013255A (en) | 1994-04-18 | 2000-01-11 | Gist-Brocades B.V. | Stable water-in-oil emulsions |
| FR2719219B1 (fr) | 1994-05-02 | 1996-06-21 | Rocher Yves Biolog Vegetale | Composition cosmétique ou pharmaceutique à usage topique comprenant des vésicules lipidiques. |
| JPH07304655A (ja) | 1994-05-13 | 1995-11-21 | Kikkoman Corp | 入浴剤及びその製造法 |
| FR2720937B1 (fr) | 1994-06-08 | 1997-03-28 | Oreal | Composition cosmétique ou dermatologique sous forme de dispersion, aqueuse et stable, de particules de gel cubique à base de phytantriol et contenant un agent tensioactif à chaîne grasse en tant qu'agent dispersant et stabilisant. |
| JPH0812560A (ja) | 1994-06-29 | 1996-01-16 | Shiseido Co Ltd | 皮膚外用剤 |
| JPH0820597A (ja) | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
| US6080393A (en) | 1994-07-09 | 2000-06-27 | Johnson & Johnson Consumer Products, Inc. | Skin care composition comprising a retinoid |
| DE4424210C2 (de) | 1994-07-09 | 1997-12-04 | Beiersdorf Ag | Verwendung von Zusammensetzungen mit einem Gehalt an Tensiden sowie einem Gehalt an Ölkomponenten, die im übrigen wasserfrei sind, als kosmetische oder dermatologische Duschöle |
| GB9414045D0 (en) | 1994-07-12 | 1994-08-31 | Berwind Pharma Service | Moisture barrier film coating composition, method, and coated form |
| JPH0859450A (ja) | 1994-08-18 | 1996-03-05 | Kose Corp | 皮膚外用剤 |
| US5534265A (en) * | 1994-08-26 | 1996-07-09 | The Procter & Gamble Company | Thickened nonabrasive personal cleansing compositions |
| DE4433071C1 (de) | 1994-09-16 | 1995-12-21 | Henkel Kgaa | Milde Detergensgemische |
| US5554608A (en) | 1994-09-28 | 1996-09-10 | Ahluwalia; Gurpreet S. | Inhibition of hair growth |
| JPH08143442A (ja) | 1994-11-16 | 1996-06-04 | Kikkoman Corp | 皮膚外用剤及びその製造法 |
| US5567420A (en) | 1994-11-16 | 1996-10-22 | Mceleney; John | Lotion which is temporarily colored upon application |
| JP3647093B2 (ja) | 1994-11-17 | 2005-05-11 | 株式会社メニコン | 親水性化酸素透過性コンタクトレンズ及びその製造法 |
| DE69509554T2 (de) | 1994-12-06 | 1999-12-23 | The Procter & Gamble Co., Cincinnati | Lagerbeständige flüssige hautreinigungszusammensetzung mit gelbindenden polymeren, lipiden und athylenglykolfettsäureestern |
| EP0796083A1 (en) | 1994-12-06 | 1997-09-24 | The Procter & Gamble Company | Shelf stable skin cleansing liquid with gel forming polymer and lipid |
| DE4444238A1 (de) | 1994-12-13 | 1996-06-20 | Beiersdorf Ag | Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden |
| EP0799240A1 (en) | 1994-12-22 | 1997-10-08 | Biochem Pharma Inc | Heterocyclic keto arginine peptides as thrombin inhibitors |
| AP9701004A0 (en) | 1994-12-22 | 1997-07-31 | Iaf Biochem Int | Low molecular weight bicyclic thrombin inhibitors. |
| GB9500116D0 (en) | 1995-01-05 | 1995-03-01 | Ciba Geigy Ag | Pharmaceutical compositions |
| US5618522A (en) | 1995-01-20 | 1997-04-08 | The Procter & Gamble Company | Emulsion compositions |
| ATE219381T1 (de) | 1995-02-07 | 2002-07-15 | Fidia Advanced Biopolymers Srl | Verfahren zur beschichtung von gegenständen mit hyaluronsäure, dessen derivaten und halbsynthetischen polymeren |
| WO1996025144A1 (en) | 1995-02-15 | 1996-08-22 | The Procter & Gamble Company | Crystalline hydroxy waxes as oil in water stabilizers for skin cleansing liquid composition |
| FR2730928B1 (fr) | 1995-02-23 | 1997-04-04 | Oreal | Composition a base de vesicules lipidiques a ph acide et son utilisation en application topique |
| CA2210524A1 (en) | 1995-03-23 | 1996-09-26 | Lancaster Group Gmbh | Cosmetic with condensates of plant and animal decomposition products |
| FR2731907B1 (fr) | 1995-03-23 | 1997-06-20 | Fabre Pierre Dermo Cosmetique | Composition dermatologique et/ou cosmetique depigmentante et utilisation dans une methode cosmetique |
| WO1996030396A1 (en) | 1995-03-24 | 1996-10-03 | Molecumetics Ltd. | β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS |
| CA2215695C (en) | 1995-03-24 | 2003-09-16 | Molecumetics, Ltd | .beta.-sheet mimetics and use thereof as protease inhibitors |
| EP0818988A2 (en) | 1995-04-03 | 1998-01-21 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Skin care compositions containing retinoids and liposomes |
| JPH08301760A (ja) * | 1995-05-10 | 1996-11-19 | Shiseido Co Ltd | 皮膚外用剤 |
| GB9510264D0 (en) | 1995-05-22 | 1995-07-19 | Iaf Biochem Int | Low molecular weight bicyclic-urea type thrombin inhibitors |
| US5942479A (en) | 1995-05-27 | 1999-08-24 | The Proctor & Gamble Company | Aqueous personal cleansing composition with a dispersed oil phase comprising two specifically defined oil components |
| US5985809A (en) | 1995-05-27 | 1999-11-16 | The Procter & Gamble Company | Aqueous personal cleansing compositions comprising specific nonocclusive liquid polyol fatty acid polyester |
| GB9510833D0 (en) | 1995-05-27 | 1995-07-19 | Procter & Gamble | Cleansing compositions |
| JP3911642B2 (ja) | 1995-06-06 | 2007-05-09 | 株式会社加美乃素本舗 | 皮膚外用剤 |
| IL122338A0 (en) | 1995-06-07 | 1998-04-05 | Univ Pennsylvania Center For T | Methods of inhibiting phagocytosis |
| CA2223747A1 (en) | 1995-06-07 | 1996-12-19 | Taisho Pharmaceutical Co., Ltd. | Antifungal compositions |
| US5639785A (en) | 1995-06-07 | 1997-06-17 | Global Pharma, Ltd. | Methods for the treatment of baldness and gray hair using isoflavonoid derivatives |
| US5523308A (en) | 1995-06-07 | 1996-06-04 | Costanzo; Michael J. | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| DK0749746T3 (da) | 1995-06-21 | 1998-02-23 | Oreal | Kosmetisk sammensætning omfattende en dispersion af polymerpartikler |
| JPH0840824A (ja) | 1995-06-21 | 1996-02-13 | Nonogawa Shoji Kk | 化粧料 |
| US6126933A (en) | 1995-06-27 | 2000-10-03 | Genetics Institute | Methods of treating inflammatory bowel diseases by administering IL-11 |
| US6013250A (en) | 1995-06-28 | 2000-01-11 | L'oreal S. A. | Composition for treating hair against chemical and photo damage |
| JP3410870B2 (ja) | 1995-07-13 | 2003-05-26 | 株式会社資生堂 | 皮膚外用剤 |
| JPH0925213A (ja) | 1995-07-13 | 1997-01-28 | Shiseido Co Ltd | 皮膚外用剤 |
| JPH0925212A (ja) | 1995-07-13 | 1997-01-28 | Shiseido Co Ltd | 皮膚外用剤 |
| US5571503A (en) | 1995-08-01 | 1996-11-05 | Mausner; Jack | Anti-pollution cosmetic composition |
| US5874127A (en) | 1995-08-16 | 1999-02-23 | Ciba Vision Corporation | Method and apparatus for gaseous treatment |
| JP3302535B2 (ja) | 1995-08-17 | 2002-07-15 | キッコーマン株式会社 | 上皮細胞増殖促進剤 |
| DE19533175A1 (de) | 1995-09-08 | 1997-03-13 | Nordbeton Gmbh | Belüftete Mehrkammer-Kleinkläranlage zur biologischen Behandlung von Abwasser |
| JPH0977638A (ja) | 1995-09-19 | 1997-03-25 | Art Beauty Clinic Kk | 化粧用ファンデーション |
| US6063398A (en) | 1995-09-20 | 2000-05-16 | L'oreal | Cosmetic or dermopharmaceutical patch containing, in an anhydrous polymeric matrix, at least one active compound which is, in particular, unstable in oxidizing mediums, and at least one water-absorbing agent |
| US5683683A (en) | 1995-09-21 | 1997-11-04 | Helene Curtis, Inc. | Body wash composition to impart conditioning properties to skin |
| US5635165A (en) | 1995-09-27 | 1997-06-03 | Helene Curtis, Inc. | Antiperspirant deodorant compositions |
| US5885593A (en) | 1995-09-28 | 1999-03-23 | The Andrew Jergens Company | Skin care composition including cyclodextrin materials and method for treating skin therewith |
| NZ299379A (en) | 1995-10-27 | 1997-04-24 | Unilever Plc | Topical flavanone-containing composition |
| US6019962A (en) | 1995-11-07 | 2000-02-01 | The Procter & Gamble Co. | Compositions and methods for improving cosmetic products |
| US6509098B1 (en) | 1995-11-17 | 2003-01-21 | Massachusetts Institute Of Technology | Poly(ethylene oxide) coated surfaces |
| KR100246702B1 (ko) | 1995-11-24 | 2000-03-15 | 이시하라 소이치 | 히드로칼콘유도체, 히드로칼콘유도체를 함유하는 화장품조성물 및 이들의 제조방법 |
| JP3945544B2 (ja) | 1995-12-27 | 2007-07-18 | ピジョン株式会社 | ダイズエキスの製造方法 |
| US5961980A (en) | 1996-01-18 | 1999-10-05 | The Trustees Of The University Of Pennsylvania | Bowman-birk inhibitor compositions and methods for the treatment of genitourinary diseases |
| US5643587A (en) | 1996-02-15 | 1997-07-01 | Avon Products, Inc. | Composition and method for under-eye skin lightening |
| BR9708390A (pt) | 1996-03-28 | 2000-01-04 | Trustees O Boston University | Método para identificar uma substância que altera a pigmentação nos melanócitos epidérmicos de vertebrados, substância que inibe, intensifica ou modula a fosforização da tirosinase mediada pela proteìna c-beta quinase, uso de um agente que modula ou inibe a fosforização de um resìduo de serina ou de treonina mediada pela proteìna c-beta quinase, uso em peptìdeo que especificamente interfere na fosforização de resìduos de serina/treonina mediada pela proteìna c-beta quinase, uso de uma construção de dna ou de um peptìdeo para fabricar um medicamento para diminuir a pigmentação na pela, cabelo, lã ou pelo de vertebrados e uso de uma substância que modula a fosforização da tirosinase mediada pela proteìna c-beta quinase. |
| AU1793397A (en) | 1996-03-29 | 1997-10-22 | S.W. Patentverwertungs Ges. M.B.H. Edelsbacher U. Partner | Cosmetic or cosmetic preparation for smoothing and tightening the skin in the case of subcutaneous fatty tissue problems, particularly cellulite |
| FR2747568B1 (fr) | 1996-04-17 | 1999-09-17 | Oreal | Utilisation d'au moins un inhibiteur de lipoxygenase et d'au moins un inhibiteur de cyclo-oxygenase pour modifier la pousse des poils et/ou des cheveux |
| KR100357848B1 (ko) | 1996-04-23 | 2002-12-18 | 더 프록터 앤드 갬블 캄파니 | 비타민비3화합물을포함하는피부외관을조절하기위한국소용조성물 |
| US5834513A (en) | 1996-04-25 | 1998-11-10 | Avon Products, Inc. | Oxa diacids and related compounds for treating skin conditions |
| US5885595A (en) | 1996-05-13 | 1999-03-23 | Elizabeth Arden Co., Division Of Conopco, Inc. | Cosmetic composition with a retinol fatty acid ester |
| US5824702A (en) | 1996-06-07 | 1998-10-20 | Mount Sinai School Of Medicine Of The City University Of New York | Genistein as a preventive against ultraviolet induced skin photodamage and cancer |
| US5821361A (en) | 1996-06-11 | 1998-10-13 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
| EP0814116A1 (de) | 1996-06-19 | 1997-12-29 | Hüls Aktiengesellschaft | Hydrophile Beschichtung von Oberflächen polymerer Substrate |
| BR9602991A (pt) | 1996-07-05 | 1998-04-28 | Cosmeticos Natural Ind Com | Composições cosméticas hidratantes e protetoras da pele contra as radiações ultravioleta e infravermelha |
| IL127806A0 (en) | 1996-07-12 | 1999-10-28 | Johnson & Johnson Consumer | Composition for altering hair growth and hair pigmentation |
| BR9603084A (pt) | 1996-07-12 | 1998-05-05 | Cosmeticos Natural Ind Com | Composição secativa em forma de emulsão para a pele |
| AU732174B2 (en) | 1996-08-05 | 2001-04-12 | Myriad Genetics, Inc. | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
| US5888522A (en) | 1996-08-23 | 1999-03-30 | Skin Biology, Inc. | Tissue protective and regenerative compositions |
| JPH10120560A (ja) | 1996-08-26 | 1998-05-12 | Sankyo Co Ltd | ロキソプロフェン含有外用製剤 |
| AUPO203996A0 (en) | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| WO1998009987A1 (en) | 1996-09-06 | 1998-03-12 | Biochem Pharma, Inc. | Lactam inhibitors of thrombin |
| US5804234A (en) | 1996-09-13 | 1998-09-08 | Suh; John D. | Plant protein for nutritional products and method of making same |
| DE19638534A1 (de) | 1996-09-20 | 1998-03-26 | Beiersdorf Ag | Verwendung von Tocopherylferulat zur Hautaufhellung oder zur Verhinderung der Hautbräunung, insbesondere der durch UV-Strahlung hervorgerufenen Hautbräunung |
| US5665367A (en) | 1996-09-27 | 1997-09-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Skin care compositions containing naringenin and/or quercetin and a retinoid |
| FR2754713B1 (fr) | 1996-10-22 | 1999-01-08 | Roc Sa | Utilisation de complexes pour la preparation de compositions pour le traitement des peaux sensibles, procede de preparation et compositions hypoallergeniques |
| IL119535A (en) | 1996-10-31 | 2001-01-11 | Chajuss Daniel | Soy molasses and modified soy molasses for topical application |
| US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
| JPH10139654A (ja) | 1996-11-08 | 1998-05-26 | Lion Corp | 皮膚外用組成物 |
| FR2757767B1 (fr) | 1996-12-27 | 1999-02-05 | Oreal | Composition topique contenant au moins une proteine d'origine vegetale et/ou une proteine d'origine animale et une poly(acide 2-acrylamido 2-methylpropane sulfonique) reticule |
| WO1998033089A1 (fr) | 1997-01-23 | 1998-07-30 | Menicon Co., Ltd. | Procede de production de lentilles de contact a surface hydrophile et lentille de contact ainsi obtenue |
| US5863546A (en) | 1997-03-02 | 1999-01-26 | Swinehart; James M | Cosmetic composition |
| US5885600A (en) | 1997-04-01 | 1999-03-23 | Burlington Bio-Medical & Scientific Corp. | Natural insect repellent formula and method of making same |
| AUPO644897A0 (en) | 1997-04-28 | 1997-05-22 | Novogen Inc | Preparation of isoflavones from legumes |
| US5962015A (en) | 1997-05-02 | 1999-10-05 | Kobo Products S.A.R.L. | Stabilized liposomes |
| US6183762B1 (en) | 1997-05-27 | 2001-02-06 | Sembiosys Genetics Inc. | Oil body based personal care products |
| US6060070A (en) | 1997-06-11 | 2000-05-09 | Gorbach; Sherwood L. | Isoflavonoids for treatment and prevention of aging skin and wrinkles |
| US5885596A (en) | 1997-07-23 | 1999-03-23 | Bristol-Myers Squibb Company | Methods and compositions for fine lines and/or wrinkles |
| US8039026B1 (en) | 1997-07-28 | 2011-10-18 | Johnson & Johnson Consumer Companies, Inc | Methods for treating skin pigmentation |
| DE19735587B4 (de) | 1997-08-16 | 2012-03-22 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Peptid mit radioprotektiver Wirkung, dieses enthaltende kosmetische oder pharmazeutische Zusammensetzung, für dieses kodierende Nukleinsäure, Herstellungsverfahren für dieses Peptid und die Verwendung als radioprotektives Agens |
| US6017893A (en) | 1997-08-29 | 2000-01-25 | Natures Sunshine Products, Inc. | Use of isoflavones to prevent hair loss and preserve the integrity of existing hair |
| AU9627298A (en) | 1997-09-23 | 1999-04-12 | Novartis Ag | Method for hydrogel surface treatment and article formed therefrom |
| US5972355A (en) | 1997-09-30 | 1999-10-26 | E-L Management Corp. | Stable compositions containing biologically active components |
| US6017549A (en) | 1997-09-30 | 2000-01-25 | E-L Management Corp. | Non-irritating cosmetic and pharmaceutical compositions |
| JP2001522787A (ja) | 1997-11-10 | 2001-11-20 | ザ、プロクター、エンド、ギャンブル、カンパニー | 液状ポリオール脂肪酸ポリエステルと液状油を共に含む組成物 |
| US5928658A (en) | 1997-12-05 | 1999-07-27 | U.S. Cosmetics | Oil-free wax-free solid cosmetic composition |
| DE69835832T2 (de) | 1997-12-16 | 2007-04-05 | Johnson & Johnson Consumer Companies, Inc. | Zusammensetzungen und methoden zur regulierung der phagozytose und icam-1 expression |
| FR2772613B1 (fr) | 1997-12-19 | 2003-05-09 | Oreal | Utilisation du phloroglucinol dans une composition cosmetique |
| AUPP112497A0 (en) | 1997-12-24 | 1998-01-22 | Novogen Research Pty Ltd | Compositions and method for protecting skin from UV induced immunosupression and skin damage |
| US6030931A (en) | 1998-02-03 | 2000-02-29 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Foaming cleansing skin product |
| US5928889A (en) | 1998-02-13 | 1999-07-27 | S.C. Johnson & Son, Inc. | Protocol for simulated natural biofilm formation |
| US6051602A (en) | 1998-03-16 | 2000-04-18 | The Procter & Gamble Company | Methods for regulating skin appearance |
| ATE259215T1 (de) | 1998-03-16 | 2004-02-15 | Procter & Gamble | Zusammensetzung zur regulierung des hauterscheinungsbildes |
| US5965153A (en) | 1998-03-24 | 1999-10-12 | Stabar Enterprises, Inc. | Dietary supplement for preventing or reducing shedding by animals |
| US6323219B1 (en) | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
| WO1999057178A1 (en) | 1998-05-05 | 1999-11-11 | Bausch & Lomb Incorporated | Plasma surface treatment of silicone hydrogel contact lenses |
| JPH11346695A (ja) | 1998-06-03 | 1999-12-21 | Natl Food Res Inst | 豆乳の製造方法 |
| US6087415A (en) | 1998-06-11 | 2000-07-11 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with hydrophilic coatings |
| US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
| US6750229B2 (en) | 1998-07-06 | 2004-06-15 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin pigmentation |
| US8106094B2 (en) * | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
| FR2783169B1 (fr) | 1998-09-15 | 2001-11-02 | Sederma Sa | Utilisation cosmetique ou dermopharmaceutique de peptides pour la cicatrisation et pour l'amelioration de l'aspect cutane lors du vieillissement naturel ou accelere (heliodermie, pollution) |
| KR100577914B1 (ko) | 1998-10-09 | 2006-05-10 | 가부시키가이샤 야쿠루트 혼샤 | 피부 외용제 |
| US6096327A (en) | 1998-11-05 | 2000-08-01 | Protease Sciences Inc. | Cosmetic compositions containing human type serine protease inhibitors for revitalizing the skin |
| US20020197244A1 (en) | 1998-12-07 | 2002-12-26 | Miri Seiberg | Compositions and methods for regulating phagocytosis and ICAM-1 expression |
| CA2355894C (en) | 1999-01-19 | 2006-10-10 | Pharmacia & Upjohn Company | Gamma-irradiation sterilized polyethylene packaging |
| AU3390400A (en) | 1999-03-05 | 2000-09-21 | Johns Hopkins University, The | Regulating skin appearance and composition with a fluorinated vitamin d3 analog compound |
| US7393548B2 (en) | 1999-03-22 | 2008-07-01 | J.P. M.E.D. Ltd. | Nano oil in glycerin emulsion |
| WO2000062741A2 (en) | 1999-04-19 | 2000-10-26 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
| US6444647B1 (en) | 1999-04-19 | 2002-09-03 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
| US6492326B1 (en) | 1999-04-19 | 2002-12-10 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
| JP2002542179A (ja) | 1999-04-19 | 2002-12-10 | ザ、プロクター、エンド、ギャンブル、カンパニー | スキンケア活性物質の組合せを含有するスキンケア組成物 |
| AU4647300A (en) | 1999-04-19 | 2000-11-02 | Procter & Gamble Company, The | Skin care compositions containing combination of skin care actives |
| JP2000302678A (ja) | 1999-04-21 | 2000-10-31 | Kuressendo Corporation:Kk | 大豆由来のイソフラボンによる毛髪活性 |
| US6447809B1 (en) | 1999-05-11 | 2002-09-10 | Metagenics, Inc. | Composition for promoting healthy bone structure |
| US6261603B1 (en) | 1999-05-11 | 2001-07-17 | Mcelwain Elizena A. | Skin cream |
| CN1177580C (zh) | 1999-05-17 | 2004-12-01 | 宝洁公司 | 植物甾醇组合物及其应用 |
| WO2000069408A1 (en) | 1999-05-18 | 2000-11-23 | The Procter & Gamble Company | Methods of regulating the condition of mammalian keratinous tissue |
| AU5026700A (en) | 1999-05-18 | 2000-12-05 | Procter & Gamble Company, The | Methods for upregulating and/or modulating kgf production and increasing receptivity of keratinocytes to kgf |
| AU5026600A (en) | 1999-05-18 | 2000-12-05 | Procter & Gamble Company, The | Methods of regulating the condition of mammalian keratinous tissue |
| JP3661981B2 (ja) | 1999-06-09 | 2005-06-22 | 株式会社ノエビア | 制汗剤 |
| GB9913408D0 (en) | 1999-06-10 | 1999-08-11 | Albright & Wilson Uk Ltd | Personal care formulations |
| US6762158B2 (en) | 1999-07-01 | 2004-07-13 | Johnson & Johnson Consumer Companies, Inc. | Personal care compositions comprising liquid ester mixtures |
| US7985404B1 (en) | 1999-07-27 | 2011-07-26 | Johnson & Johnson Consumer Companies, Inc. | Reducing hair growth, hair follicle and hair shaft size and hair pigmentation |
| US7309688B2 (en) | 2000-10-27 | 2007-12-18 | Johnson & Johnson Consumer Companies | Topical anti-cancer compositions and methods of use thereof |
| JP2003514001A (ja) | 1999-11-16 | 2003-04-15 | ユニリーバー・ナームローゼ・ベンノートシヤープ | ヒヨコマメ抽出物とレチノイドを含む美容組成物 |
| FR2803747B1 (fr) | 2000-01-18 | 2003-12-26 | Pharmascience Lab | Utilisation d'isoflavones et/ou d'extraits de prunier d'afrique en pharmacie, cosmetique et en tant qu'additif alimentaire. |
| JP3610278B2 (ja) | 2000-03-28 | 2005-01-12 | 有限会社テイ・ケイ・シイ▲高▼橋コンピュータ会計 | 米糠加工物 |
| US6433025B1 (en) | 2000-04-13 | 2002-08-13 | Cyanotech Corporation | Method for retarding and preventing sunburn by UV light |
| US6558656B2 (en) | 2000-04-20 | 2003-05-06 | Morris Mann | Oral and topical compositions and methods related thereto in the treatment of acne |
| FR2811226B1 (fr) | 2000-06-05 | 2003-06-20 | Clarins Laboratoires S A S | Composition cosmetique hydratante comprenant un inhibiteur de trypsine vegetal |
| DE50109707D1 (de) | 2000-07-26 | 2006-06-08 | Cognis France Sas | Verwendung eines mittels welches das haarwachstum inhibiert |
| CA2357998A1 (en) | 2000-09-29 | 2002-03-29 | Johnson & Johnson Consumer Companies, Inc. | Composition to enhance permeation of topical skin agents |
| US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
| JP4612180B2 (ja) * | 2000-12-19 | 2011-01-12 | 株式会社ヤクルト本社 | 皮膚外用剤 |
| US7090875B2 (en) * | 2000-12-19 | 2006-08-15 | Kabushiki Kaisha Yakult Honsha | External skin preparations and process for producing the same |
| JP2005506285A (ja) | 2001-02-27 | 2005-03-03 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | 表皮成長因子受容体を活性化するレチノイド療法、石鹸および他の刺激物による副作用を防止する目的での天然ｅｇｆｒ阻害剤の使用 |
| US7192615B2 (en) | 2001-02-28 | 2007-03-20 | J&J Consumer Companies, Inc. | Compositions containing legume products |
| ES2387717T3 (es) | 2001-02-28 | 2012-09-28 | Johnson & Johnson Consumer Companies, Inc. | Composiciones que contienen productos leguminosos |
| US20020160061A1 (en) | 2001-02-28 | 2002-10-31 | Claude Saliou | Use of legume products for the treatment of external aggressions |
| US6555143B2 (en) | 2001-02-28 | 2003-04-29 | Johnson & Johnson Consumer Products, Inc. | Legume products |
| AU2002305054B2 (en) | 2001-03-16 | 2006-09-07 | Johnson & Johnson Consumer Inc. | Composition containing feverfew extract and use thereof |
| WO2003032941A2 (de) | 2001-10-13 | 2003-04-24 | Beiersdorf Ag | Kosmetische und/oder dermatologische wirkstoffkombination |
| EP1448157A1 (de) | 2001-11-09 | 2004-08-25 | Beiersdorf AG | Kosmetische und/ oder dermatologische zubereitung enthaltend octadecendicarbons aeure und uv-filtersubstanzen |
| US20030224075A1 (en) | 2002-02-21 | 2003-12-04 | Jue-Chen Liu | Soy composition for balancing combination skin |
| JP2004000019A (ja) | 2002-03-27 | 2004-01-08 | Ikeda Shokken Kk | 変性防止剤および液体組成物 |
| EP1510200B1 (en) | 2003-08-26 | 2006-10-11 | Johnson & Johnson Consumer France SAS | Stabilized antiperspirant compositions containing soy products |
| KR20060125746A (ko) | 2003-10-29 | 2006-12-06 | 죤슨 앤 죤슨 컨슈머 프랑스 에스에이에스 | 대두 제품과 이산을 포함한 조성물 |
| EP1543823A1 (en) | 2003-12-19 | 2005-06-22 | Johnson & Johnson Consumer France SAS | Gingko containing formulations for the improvement of skin radiance |
| AU2005203059B2 (en) | 2004-07-16 | 2011-11-24 | Johnson & Johnson Consumer Companies, Inc. | Use of legume products for the treatment and prevention of radiotherapy-induced skin damage |
-
2003
- 2003-09-10 US US10/659,598 patent/US8093293B2/en not_active Expired - Fee Related
-
2004
- 2004-09-07 AU AU2004208740A patent/AU2004208740A1/en not_active Abandoned
- 2004-09-09 DE DE602004020432T patent/DE602004020432D1/de not_active Expired - Lifetime
- 2004-09-09 AT AT04255470T patent/ATE427776T1/de not_active IP Right Cessation
- 2004-09-09 ES ES04255470T patent/ES2322851T3/es not_active Expired - Lifetime
- 2004-09-09 KR KR1020040072136A patent/KR101151317B1/ko not_active IP Right Cessation
- 2004-09-09 JP JP2004262607A patent/JP2005082600A/ja active Pending
- 2004-09-09 TW TW093127223A patent/TW200526259A/zh unknown
- 2004-09-09 EP EP04255470A patent/EP1514536B1/en not_active Expired - Lifetime
- 2004-09-09 CA CA2480925A patent/CA2480925C/en not_active Expired - Fee Related
- 2004-09-10 CN CN2004100942358A patent/CN1795926B/zh not_active Expired - Fee Related
- 2004-09-10 BR BRPI0405445A patent/BRPI0405445A8/pt not_active Application Discontinuation
-
2010
- 2010-11-26 AU AU2010246469A patent/AU2010246469B2/en not_active Ceased
-
2012
- 2012-03-21 KR KR1020120028997A patent/KR101364470B1/ko not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1342064A (zh) * | 1999-11-05 | 2002-03-27 | 强生消费者公司 | 大豆脱色素和护肤组合物 |
Non-Patent Citations (2)
| Title |
|---|
| 卢忠.暴发性酒糟鼻的治疗.国外医学皮肤性病学分册21 2.1995,21(2),107. |
| 卢忠.暴发性酒糟鼻的治疗.国外医学皮肤性病学分册21 2.1995,21(2),107. * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010246469B2 (en) | 2011-12-22 |
| EP1514536A1 (en) | 2005-03-16 |
| KR20120042806A (ko) | 2012-05-03 |
| EP1514536B1 (en) | 2009-04-08 |
| BRPI0405445A (pt) | 2005-11-08 |
| US8093293B2 (en) | 2012-01-10 |
| AU2010246469A1 (en) | 2010-12-16 |
| ES2322851T3 (es) | 2009-06-30 |
| KR20050026889A (ko) | 2005-03-16 |
| KR101364470B1 (ko) | 2014-02-19 |
| CA2480925C (en) | 2013-07-16 |
| US20040131710A1 (en) | 2004-07-08 |
| ATE427776T1 (de) | 2009-04-15 |
| DE602004020432D1 (de) | 2009-05-20 |
| BRPI0405445A8 (pt) | 2017-10-10 |
| CN1795926A (zh) | 2006-07-05 |
| AU2004208740A1 (en) | 2005-03-24 |
| JP2005082600A (ja) | 2005-03-31 |
| TW200526259A (en) | 2005-08-16 |
| KR101151317B1 (ko) | 2012-06-08 |
| CA2480925A1 (en) | 2005-03-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2010246469B2 (en) | Methods for treating skin conditions | |
| US20040254245A1 (en) | Cosmetic and dermopharmaceutical compositions for skin prone to acne | |
| EP1216696A2 (en) | Method for reducing the appearance of dark circles under the eyes | |
| EP1762241A1 (en) | Compositions and methods for mitigating skin irritation | |
| US8106094B2 (en) | Compositions and methods for treating skin conditions | |
| EP1192939A2 (en) | Methods for reduction of inflammation and erythema | |
| EP1192940A1 (en) | Compositions and methods for promoting clear skin using an alkanolamine | |
| KR100258612B1 (ko) | 여드름 예방 및 치료용 팩조성물 | |
| EP1569629A1 (en) | Topical antiinflammatory preparations of g(g)-terpinene | |
| EP1080719A2 (en) | Methods for potentiation of efficacy of topical actives by mono-acyl-(lyso)-glycerophosholipids | |
| JPH08259423A (ja) | 化粧料 | |
| CA2513936C (en) | Compositions and methods for treating skin conditions | |
| JP2003137798A (ja) | 皮膚外用剤 | |
| KR20130016929A (ko) | 박하잎 추출물, 밀싹 추출물 및 길경 추출물을 유효성분으로 포함하는 모공 축소 또는 피지분비 억제용 화장료 조성물 | |
| JPS63284110A (ja) | 菟糸子抽出物 | |
| JPH11124313A (ja) | 美白用皮膚外用剤 | |
| EP1752129A1 (en) | Compositions and methods for treating skin conditions | |
| JP2003306440A (ja) | 皮膚外用剤 | |
| WO2020178830A1 (en) | Argan extracts for the treatment of dermatological conditions | |
| JP2002255780A (ja) | 皮膚外用剤 | |
| AU2011253594A1 (en) | Compositions and methods for treating skin conditions | |
| JP2004043348A (ja) | 皮膚外用剤 | |
| JP2003277249A (ja) | 皮膚外用剤、並びに表皮細胞賦活剤，真皮線維芽細胞賦活剤，コラーゲン産生促進剤 | |
| KR19990052470A (ko) | 면포 용해효과를 갖는 조성물 | |
| AU2004242563A1 (en) | Method for promoting clear skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100526 Termination date: 20170910 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |