CN1117089C - 取代的2－(2,6－二氧哌啶－3－基)－邻苯二甲酰亚胺和－1－氧异二氢吲哚及降低肿瘤坏死因子α的方法 - Google Patents

取代的2－(2,6－二氧哌啶－3－基)－邻苯二甲酰亚胺和－1－氧异二氢吲哚及降低肿瘤坏死因子α的方法 Download PDF

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Publication number
CN1117089C
CN1117089C CN97180299A CN97180299A CN1117089C CN 1117089 C CN1117089 C CN 1117089C CN 97180299 A CN97180299 A CN 97180299A CN 97180299 A CN97180299 A CN 97180299A CN 1117089 C CN1117089 C CN 1117089C
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Prior art keywords
oxo
dioxopiperidin
hydrogen
compound
dione
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Ceased
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CN97180299A
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Chinese (zh)
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CN1239959A (zh
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G·W·马勒
D·I·斯特林
R·Sc·陈
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Celgene Corp
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Celgene Corp
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Priority claimed from US08690258 external-priority patent/US5635517B1/en
Priority claimed from US08/701,494 external-priority patent/US5798368A/en
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of CN1239959A publication Critical patent/CN1239959A/zh
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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CN97180299A 1996-07-24 1997-07-24 取代的2－(2,6－二氧哌啶－3－基)－邻苯二甲酰亚胺和－1－氧异二氢吲哚及降低肿瘤坏死因子α的方法 Ceased CN1117089C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08690258 US5635517B1 (en) 1996-07-24 1996-07-24 Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US08/690,258 1996-07-24
US08/701,494 1996-08-22
US08/701,494 US5798368A (en) 1996-08-22 1996-08-22 Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
US4827897P 1997-05-30 1997-05-30
US60/048,278 1997-05-30

Publications (2)

Publication Number Publication Date
CN1239959A CN1239959A (zh) 1999-12-29
CN1117089C true CN1117089C (zh) 2003-08-06

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ID=27367302

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CN97180299A Ceased CN1117089C (zh) 1996-07-24 1997-07-24 取代的2－(2,6－二氧哌啶－3－基)－邻苯二甲酰亚胺和－1－氧异二氢吲哚及降低肿瘤坏死因子α的方法

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EP (4) EP2305663B1 (enExample)
JP (1) JP4065567B2 (enExample)
KR (2) KR20050032629A (enExample)
CN (1) CN1117089C (enExample)
AT (4) ATE530542T1 (enExample)
CA (3) CA2624949C (enExample)
CZ (3) CZ304569B6 (enExample)
DE (4) DE69739802D1 (enExample)
DK (2) DK1285916T3 (enExample)
ES (4) ES2187805T7 (enExample)
FI (1) FI120687B (enExample)
FR (1) FR07C0056I2 (enExample)
HU (1) HUS1300056I1 (enExample)
LU (1) LU91359I2 (enExample)
NL (1) NL300291I2 (enExample)
NZ (1) NZ333903A (enExample)
PL (2) PL195916B1 (enExample)
PT (4) PT1285916E (enExample)
SK (1) SK9199A3 (enExample)
UA (1) UA60308C2 (enExample)
WO (1) WO1998003502A1 (enExample)

Cited By (2)

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US9101620B2 (en) 2009-11-02 2015-08-11 Nanjing Cavendish Bio-Engineering Technology Co., Ltd. Polymorph of 3-(substituteddihydroisoindolinone-2-yl)-2,6-dioxopiperidine, and pharmaceutical compositions thereof
CN105440013A (zh) * 2014-08-29 2016-03-30 杭州和泽医药科技有限公司 一种泊马度胺的制备方法

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