CN104557858B - 一种泊利度胺的制备方法 - Google Patents
一种泊利度胺的制备方法 Download PDFInfo
- Publication number
- CN104557858B CN104557858B CN201310526299.XA CN201310526299A CN104557858B CN 104557858 B CN104557858 B CN 104557858B CN 201310526299 A CN201310526299 A CN 201310526299A CN 104557858 B CN104557858 B CN 104557858B
- Authority
- CN
- China
- Prior art keywords
- solvent
- water
- formula
- compound
- dimethyl acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310526299.XA CN104557858B (zh) | 2013-10-29 | 2013-10-29 | 一种泊利度胺的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310526299.XA CN104557858B (zh) | 2013-10-29 | 2013-10-29 | 一种泊利度胺的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104557858A CN104557858A (zh) | 2015-04-29 |
CN104557858B true CN104557858B (zh) | 2018-06-01 |
Family
ID=53075031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310526299.XA Active CN104557858B (zh) | 2013-10-29 | 2013-10-29 | 一种泊利度胺的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104557858B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106565668B (zh) * | 2016-10-27 | 2020-01-10 | 扬子江药业集团有限公司 | 一种高纯度泊马度胺的制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015075694A1 (en) * | 2013-11-25 | 2015-05-28 | Mylan Laboratories Limited | Improved process for the preparation of pomalidomide and its purification |
CN105348257A (zh) * | 2014-08-20 | 2016-02-24 | 河北菲尼斯生物技术有限公司 | 泊马度胺的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE530542T1 (de) * | 1996-07-24 | 2011-11-15 | Celgene Corp | Amino substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide zur verringerung der tnf-alpha-stufen |
AU2002323063B2 (en) * | 2001-08-06 | 2007-11-08 | Entremed, Inc. | Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs |
MX2007008903A (es) * | 2005-01-25 | 2007-09-07 | Celgene Corp | Metodos y composiciones que usan 4-amino-2-(3-metil-2,6- dioxopiperidin-3-il)-isoindol-1,3-diona. |
KR101342241B1 (ko) * | 2005-06-30 | 2013-12-16 | 셀진 코포레이션 | 4-아미노-2-(2,6-디옥소피페리딘-3-일)이소인돌린-1,3-디온 화합물의 제조 방법 |
US8927725B2 (en) * | 2011-12-02 | 2015-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
-
2013
- 2013-10-29 CN CN201310526299.XA patent/CN104557858B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015075694A1 (en) * | 2013-11-25 | 2015-05-28 | Mylan Laboratories Limited | Improved process for the preparation of pomalidomide and its purification |
CN105348257A (zh) * | 2014-08-20 | 2016-02-24 | 河北菲尼斯生物技术有限公司 | 泊马度胺的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104557858A (zh) | 2015-04-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101921205B (zh) | 阿戈美拉汀ⅰ晶型的制备方法 | |
CN109678840A (zh) | 泊马度胺的制备方法 | |
CN108276414B (zh) | 一种枸橼酸托法替尼的制备方法 | |
CN104557858B (zh) | 一种泊利度胺的制备方法 | |
CN101270124B (zh) | 一种提纯制备高纯度荧光素及荧光素盐的新方法 | |
CN105693603A (zh) | 改良的马来酸茚达特罗制备工艺 | |
CN107698651B (zh) | 一种高纯度度他雄胺的生产工艺 | |
CN107188884A (zh) | 一种泊利度胺的纯化方法 | |
CN102391126A (zh) | 一种同时生产2,4-二硝基苯甲醚和2,4-二硝基苯酚的方法 | |
CN102964336B (zh) | 质子泵抑制剂的精制方法及其n-氧化物的还原方法 | |
CN105873898A (zh) | 纯化在非离子x-射线造影剂的合成中的中间体的供选方法 | |
CN105884746B (zh) | 氟马替尼的合成方法 | |
CN104876812B (zh) | 制备盐酸舍曲林中间体及杂质的方法 | |
CN113402502B (zh) | 一种parp抑制剂中间体制备的物料组合体系 | |
CN103172530A (zh) | 一种托芬那酸的制备方法 | |
CN104774150B (zh) | 一种双醋瑞因晶体及其制备方法 | |
CN104119240A (zh) | (S)-(-)-α-甲胺基苯丙酮的制备方法 | |
CN107089942B (zh) | 替吉奥杂质bcb的制备方法 | |
CN113980012A (zh) | 恩曲他滨的纯化方法 | |
CN103360275A (zh) | 一种制备阿戈美拉汀ⅰ型晶体的方法 | |
CN108409648B (zh) | 一种甲苯磺酸索拉非尼相关中间体的制备方法 | |
JP6764998B2 (ja) | ヒドロニドンの製造方法 | |
CN101696185A (zh) | 6-硝基-s-(-)-吲哚啉-2-甲酸的合成方法 | |
CN103408447B (zh) | 氟他胺的合成工艺 | |
CN107021928B (zh) | 艾曲波帕新的中间体及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Liu Hang Inventor after: Yuan Zhedong Inventor after: Yang Yulei Inventor after: Hu Zhi Inventor after: Zhang Hao Inventor after: Gu Hongmei Inventor after: Wang Xiangjian Inventor before: Liu Hang Inventor before: Yuan Zhedong Inventor before: Yang Yulei Inventor before: Hu Zhi Inventor before: Zhang Hao |
|
COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160408 Address after: 200040 Beijing West Road, Shanghai, No. 1320, No. Applicant after: Shanghai Institute of pharmaceutical industry Applicant after: China State Institute of Pharmaceutical Industry Applicant after: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Address before: 200040 Beijing West Road, Shanghai, No. 1320, No. Applicant before: Shanghai Institute of pharmaceutical industry Applicant before: China State Institute of Pharmaceutical Industry |
|
GR01 | Patent grant | ||
GR01 | Patent grant |