KR100534498B1 - 치환된 2-(2,6-디옥소피페리딘-3-일)-프탈이미드와 치환된 2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린과 ＴＮＦα농도를 감소시키는 방법 - Google Patents
치환된 2-(2,6-디옥소피페리딘-3-일)-프탈이미드와 치환된 2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린과 ＴＮＦα농도를 감소시키는 방법 Download PDFInfo
- Publication number
- KR100534498B1 KR100534498B1 KR10-1999-7000565A KR19997000565A KR100534498B1 KR 100534498 B1 KR100534498 B1 KR 100534498B1 KR 19997000565 A KR19997000565 A KR 19997000565A KR 100534498 B1 KR100534498 B1 KR 100534498B1
- Authority
- KR
- South Korea
- Prior art keywords
- dioxopiperidin
- oxo
- hydrogen
- aminoisoindolin
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- -1 1-oxo-4-aminoisoindolin-2-yl Chemical group 0.000 claims description 43
- 239000001257 hydrogen Substances 0.000 claims description 40
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8/690,258 | 1996-07-24 | ||
| US08/690,258 | 1996-07-24 | ||
| US08690258 US5635517B1 (en) | 1996-07-24 | 1996-07-24 | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US08/701,494 US5798368A (en) | 1996-08-22 | 1996-08-22 | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
| US8/701,494 | 1996-08-22 | ||
| US08/701,494 | 1996-08-22 | ||
| US4827897P | 1997-05-30 | 1997-05-30 | |
| US60/048,278 | 1997-05-30 | ||
| PCT/US1997/013375 WO1998003502A1 (en) | 1996-07-24 | 1997-07-24 | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and method of reducing tnf-alpha levels |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057004561A Division KR20050032629A (ko) | 1996-07-24 | 1997-07-24 | 치환된 2-(2,6-디옥소피페리딘-3-일)-프탈이미드와 치환된2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린과 ＴＮＦα농도를 감소시키는 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20000068008A KR20000068008A (ko) | 2000-11-25 |
| KR100534498B1 true KR100534498B1 (ko) | 2005-12-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-1999-7000565A Expired - Lifetime KR100534498B1 (ko) | 1996-07-24 | 1997-07-24 | 치환된 2-(2,6-디옥소피페리딘-3-일)-프탈이미드와 치환된 2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린과 ＴＮＦα농도를 감소시키는 방법 |
| KR1020057004561A Ceased KR20050032629A (ko) | 1996-07-24 | 1997-07-24 | 치환된 2-(2,6-디옥소피페리딘-3-일)-프탈이미드와 치환된2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린과 ＴＮＦα농도를 감소시키는 방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057004561A Ceased KR20050032629A (ko) | 1996-07-24 | 1997-07-24 | 치환된 2-(2,6-디옥소피페리딘-3-일)-프탈이미드와 치환된2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린과 ＴＮＦα농도를 감소시키는 방법 |
Country Status (21)
| Country | Link |
|---|---|
| EP (4) | EP0925294B3 (enExample) |
| JP (1) | JP4065567B2 (enExample) |
| KR (2) | KR100534498B1 (enExample) |
| CN (1) | CN1117089C (enExample) |
| AT (4) | ATE500240T1 (enExample) |
| CA (3) | CA2560523C (enExample) |
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| FI (1) | FI120687B (enExample) |
| FR (1) | FR07C0056I2 (enExample) |
| HU (1) | HUS1300056I1 (enExample) |
| LU (1) | LU91359I2 (enExample) |
| NL (1) | NL300291I2 (enExample) |
| NZ (1) | NZ333903A (enExample) |
| PL (2) | PL195916B1 (enExample) |
| PT (4) | PT2177517E (enExample) |
| SK (1) | SK9199A3 (enExample) |
| UA (1) | UA60308C2 (enExample) |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190120094A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 레날리도마이드를 포함하는 약제학적 조성물 |
| KR20190120093A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 레날리도마이드의 경구용 코팅 정제 조성물 |
| KR20190120092A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 다양한 용량의 레날리도마이드의 경구용 정제 조성물 |
| KR20190120096A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 붕해가 개선된 레날리도마이드의 경구용 정제 조성물 |
| KR20190120095A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 레날리도마이드를 포함하는 경구용 고형제제의 제조방법 |
Families Citing this family (205)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6228879B1 (en) | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
| US6429221B1 (en) | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
| HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| DE69739802D1 (de) * | 1996-07-24 | 2010-04-22 | Celgene Corp | Substituierte 2-(2,6-Dioxopiperidine-3-yl)-phthalimide -1-oxoisoindoline und Verfahren zur Reduzierung des TNF-alpha Spiegels |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| DE19703763C1 (de) * | 1997-02-01 | 1998-10-01 | Gruenenthal Gmbh | Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione |
| ES2262753T3 (es) * | 1997-11-18 | 2006-12-01 | Celgene Corporation | 2-(2.6-dioxo-3-fluorpiperidin-3-il)-isoindolinas substituidas y su empleo para reducir los niveles de tnfalfa. |
| US5955476A (en) * | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
| ES2243052T3 (es) * | 1998-03-16 | 2005-11-16 | Celgene Corporation | Derivados de la 2- (2,6-dioxopiperidin-3-il) isoindolina, su preparacion y su empleo como inhibidores de las citocinas inflamatorias. |
| TR200102688T2 (tr) | 1999-03-18 | 2002-01-21 | Celgene Corporation | İkameli 1-okso ve 1,3-dioksoizoindolinler ve enflamatuar sitokin seviyelerinin azaltılması için farmasötik bileşimlerde kullanımları. |
| DE19917195B4 (de) * | 1999-04-16 | 2006-09-28 | Immatics Biotechnologies Gmbh | Peptid zur Auslösung einer Immunreaktion gegen Tumorzellen, diese enthaltende pharmzeutische Zusammensetzungen, dessen Verwendungen, dafür codierende Nukleinsäure und diese Nukleinsäure enthaltender Expressionsvektor |
| US7629360B2 (en) | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
| US7182953B2 (en) * | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| CA2430669C (en) * | 2000-11-30 | 2011-06-14 | The Children's Medical Center Corporation | Synthesis of 3-amino-thalidomide and its enantiomers |
| CA2431319A1 (en) * | 2000-12-11 | 2002-06-20 | Hiroto Bando | Pharmaceutical composition having an improved water solubility |
| US20030045552A1 (en) * | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| EP1389203B8 (en) * | 2001-02-27 | 2010-03-10 | The Governement of the United States of America, represented by The Secretary Department of Health and Human services | Analogs of thalidomide as angiogenesis inhibitors |
| WO2003014315A2 (en) * | 2001-08-06 | 2003-02-20 | The Children's Medical Center Corporation | Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| USRE48890E1 (en) | 2002-05-17 | 2022-01-11 | Celgene Corporation | Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation |
| CN1981761B (zh) | 2002-05-17 | 2011-10-12 | 细胞基因公司 | 使用免疫调节性化合物用于制备治疗和控制癌症和其它疾病药物中的应用及组合物 |
| US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20190120094A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 레날리도마이드를 포함하는 약제학적 조성물 |
| KR20190120093A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 레날리도마이드의 경구용 코팅 정제 조성물 |
| KR20190120092A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 다양한 용량의 레날리도마이드의 경구용 정제 조성물 |
| KR20190120096A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 붕해가 개선된 레날리도마이드의 경구용 정제 조성물 |
| KR20190120095A (ko) | 2018-04-13 | 2019-10-23 | 주식회사 삼양바이오팜 | 레날리도마이드를 포함하는 경구용 고형제제의 제조방법 |
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