MX353482B - Metodos para el tratamiento del cancer y enfermedades inflamatorias utilizando cereblon como predictor. - Google Patents

Metodos para el tratamiento del cancer y enfermedades inflamatorias utilizando cereblon como predictor.

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Publication number
MX353482B
MX353482B MX2013012564A MX2013012564A MX353482B MX 353482 B MX353482 B MX 353482B MX 2013012564 A MX2013012564 A MX 2013012564A MX 2013012564 A MX2013012564 A MX 2013012564A MX 353482 B MX353482 B MX 353482B
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Mexico
Prior art keywords
predictor
cancer
inflammatory diseases
cereblon
treatment
Prior art date
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MX2013012564A
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English (en)
Other versions
MX2013012564A (es
Inventor
Gandhi Anita
Schafer Peter
Lopez-Girona Antonia
O Daniel Thomas
Mendy Derek
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Celgene Corp
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Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2013012564A publication Critical patent/MX2013012564A/es
Publication of MX353482B publication Critical patent/MX353482B/es

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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5751—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the skin, e.g. melanoma
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Immunology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

La presente invención se refiere a los usos de la proteína cereblon como predictor de la sensibilidad clínica para el cáncer, enfermedades inflamatorias y la respuesta del paciente al tratamiento farmacológico.
MX2013012564A 2011-04-29 2012-04-27 Metodos para el tratamiento del cancer y enfermedades inflamatorias utilizando cereblon como predictor. MX353482B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161481066P 2011-04-29 2011-04-29
US201161511986P 2011-07-26 2011-07-26
US201161579600P 2011-12-22 2011-12-22
PCT/US2012/035429 WO2012149299A2 (en) 2011-04-29 2012-04-27 Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor

Publications (2)

Publication Number Publication Date
MX2013012564A MX2013012564A (es) 2015-01-12
MX353482B true MX353482B (es) 2018-01-16

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MX2013012564A MX353482B (es) 2011-04-29 2012-04-27 Metodos para el tratamiento del cancer y enfermedades inflamatorias utilizando cereblon como predictor.

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US (2) US9365640B2 (es)
EP (2) EP3096142A3 (es)
JP (2) JP6016892B2 (es)
KR (1) KR20140024914A (es)
CN (1) CN103688176A (es)
AU (2) AU2012249491B2 (es)
CA (1) CA2834535A1 (es)
IL (1) IL229114B (es)
MX (1) MX353482B (es)
WO (1) WO2012149299A2 (es)
ZA (1) ZA201308111B (es)

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