CN1239959A - 取代的2-(2,6-二氧哌啶-3-基)-邻苯二甲酰亚胺和-1-氧异二氢吲哚及降低肿瘤坏死因子α的方法 - Google Patents
取代的2-(2,6-二氧哌啶-3-基)-邻苯二甲酰亚胺和-1-氧异二氢吲哚及降低肿瘤坏死因子α的方法 Download PDFInfo
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- CN1239959A CN1239959A CN97180299A CN97180299A CN1239959A CN 1239959 A CN1239959 A CN 1239959A CN 97180299 A CN97180299 A CN 97180299A CN 97180299 A CN97180299 A CN 97180299A CN 1239959 A CN1239959 A CN 1239959A
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Description
Claims (8)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08690258 US5635517B1 (en) | 1996-07-24 | 1996-07-24 | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
US08/690,258 | 1996-07-24 | ||
US08/701,494 | 1996-08-22 | ||
US08/701,494 US5798368A (en) | 1996-08-22 | 1996-08-22 | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
US4827897P | 1997-05-30 | 1997-05-30 | |
US60/048,278 | 1997-05-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1239959A true CN1239959A (zh) | 1999-12-29 |
CN1117089C CN1117089C (zh) | 2003-08-06 |
Family
ID=27367302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97180299A Ceased CN1117089C (zh) | 1996-07-24 | 1997-07-24 | 取代的2-(2,6-二氧哌啶-3-基)-邻苯二甲酰亚胺和-1-氧异二氢吲哚及降低肿瘤坏死因子α的方法 |
Country Status (22)
Country | Link |
---|---|
EP (4) | EP2305663B1 (zh) |
JP (1) | JP4065567B2 (zh) |
KR (2) | KR20050032629A (zh) |
CN (1) | CN1117089C (zh) |
AT (4) | ATE229521T3 (zh) |
CA (3) | CA2560523C (zh) |
CZ (3) | CZ295762B6 (zh) |
DE (4) | DE69740140D1 (zh) |
DK (2) | DK0925294T6 (zh) |
ES (4) | ES2339425T3 (zh) |
FI (1) | FI120687B (zh) |
FR (1) | FR07C0056I2 (zh) |
HK (5) | HK1050893A1 (zh) |
HU (1) | HUS1300056I1 (zh) |
LU (1) | LU91359I2 (zh) |
NL (1) | NL300291I2 (zh) |
NZ (1) | NZ333903A (zh) |
PL (2) | PL195916B1 (zh) |
PT (4) | PT1285916E (zh) |
SK (1) | SK9199A3 (zh) |
UA (1) | UA60308C2 (zh) |
WO (1) | WO1998003502A1 (zh) |
Cited By (13)
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CN1984657B (zh) * | 2004-05-05 | 2010-12-15 | 细胞基因公司 | 用于治疗和控制骨髓增生性疾病的包含免疫调节化合物的组合物和使用方法 |
CN101959856A (zh) * | 2008-03-11 | 2011-01-26 | 雷迪博士实验室有限公司 | 来那度胺的制备 |
CN102127054A (zh) * | 2009-11-02 | 2011-07-20 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物 |
CN1871003B (zh) * | 2003-09-04 | 2012-03-14 | 细胞基因公司 | 3-(4-氨基-1-氧代-1,3二氢-异吲哚-2-基)-哌啶-2,6-二酮的多晶型物 |
CN103497174A (zh) * | 2013-07-29 | 2014-01-08 | 杭州派臣医药科技有限公司 | 泊利度胺的制备和精制方法 |
CN101531653B (zh) * | 2008-03-13 | 2014-07-09 | 峡江和美药业有限公司 | 3-(4-氨基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮及其衍生物的盐或盐的多晶型物及其制备和应用 |
CN104016967A (zh) * | 2014-04-04 | 2014-09-03 | 南京工业大学 | 一种泊利度胺的合成方法 |
CN104072476A (zh) * | 2013-03-27 | 2014-10-01 | 江苏豪森药业股份有限公司 | 泊马度胺晶型及其制备方法和用途 |
CN104447689A (zh) * | 2014-12-22 | 2015-03-25 | 上海迈柏医药科技有限公司 | 来那度胺的新晶型及其制备方法 |
CN104557858A (zh) * | 2013-10-29 | 2015-04-29 | 上海医药工业研究院 | 一种泊利度胺的制备方法 |
CN107188884A (zh) * | 2013-10-29 | 2017-09-22 | 上海医药工业研究院 | 一种泊利度胺的纯化方法 |
CN110343063A (zh) * | 2019-08-09 | 2019-10-18 | 新乡双鹭药业有限公司 | 一种泊马度胺合成中杂质的制备方法 |
CN111205268A (zh) * | 2014-10-30 | 2020-05-29 | 康朴生物医药技术(上海)有限公司 | 异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用 |
Families Citing this family (185)
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US6228879B1 (en) | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
US6429221B1 (en) | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
ES2339425T3 (es) * | 1996-07-24 | 2010-05-20 | Celgene Corporation | 2-(2,6-dioxopiperidin-3-il)-ftalimidas y -1-oxoisoindolinas sustituidas y procedimiento para reducir los niveles de tnf-alfa. |
DE19703763C1 (de) * | 1997-02-01 | 1998-10-01 | Gruenenthal Gmbh | Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione |
US5955476A (en) * | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
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TR200101501T2 (tr) * | 1998-03-16 | 2002-06-21 | Celgene Corporation | 2-(2,6-dioksopiperidin-3-il)izoindolin türevleri, bunların hazırlanması ve enflamatuar sitokinlerin inhibitörleri olarak kullanımı. |
RU2001121987A (ru) | 1999-03-18 | 2004-02-27 | Селджин Корпорейшн (Us) | Замещенные 1-оксо- и 1,3-диоксоизоиндолины и их применение в фармацевтических композициях для снижения уровней воспалительных цитокинов |
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