FI990101A - Substituoituja 2-(2,6-dioksopiperidin-3-yyli) ftalimidejä ja -1-oksoisoindoliineja ja menetelmä TNF-alfa tasojen pienentämiseksi - Google Patents

Substituoituja 2-(2,6-dioksopiperidin-3-yyli) ftalimidejä ja -1-oksoisoindoliineja ja menetelmä TNF-alfa tasojen pienentämiseksi Download PDF

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Publication number
FI990101A
FI990101A FI990101A FI990101A FI990101A FI 990101 A FI990101 A FI 990101A FI 990101 A FI990101 A FI 990101A FI 990101 A FI990101 A FI 990101A FI 990101 A FI990101 A FI 990101A
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FI
Finland
Prior art keywords
dioxopiperidin
phthalimides
substituted
oxoisoindolines
alpha levels
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Application number
FI990101A
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English (en)
Swedish (sv)
Other versions
FI120687B (fi
FI990101A0 (fi
Inventor
George W Muller
David I Stirling
Roger Shen-Chu Chen
Original Assignee
Celgene Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367302&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI990101(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08690258 external-priority patent/US5635517B1/en
Priority claimed from US08/701,494 external-priority patent/US5798368A/en
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of FI990101A0 publication Critical patent/FI990101A0/fi
Publication of FI990101A publication Critical patent/FI990101A/fi
Application granted granted Critical
Publication of FI120687B publication Critical patent/FI120687B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
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    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
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  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI990101A 1996-07-24 1999-01-19 Substituoidut 2-(2,6-dioksopiperidin-3-yyli) ftalimidit ja -1-oksoisoindoliinit sekä menetelmä TNF-alfa tasojen laskemiseksi FI120687B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US08690258 US5635517B1 (en) 1996-07-24 1996-07-24 Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US69025896 1996-07-24
US08/701,494 US5798368A (en) 1996-08-22 1996-08-22 Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
US70149496 1996-08-22
US4827897P 1997-05-30 1997-05-30
US4827897 1997-05-30
US9713375 1997-07-24
PCT/US1997/013375 WO1998003502A1 (en) 1996-07-24 1997-07-24 Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and method of reducing tnf-alpha levels

Publications (3)

Publication Number Publication Date
FI990101A0 FI990101A0 (fi) 1999-01-19
FI990101A true FI990101A (fi) 1999-03-19
FI120687B FI120687B (fi) 2010-01-29

Family

ID=27367302

Family Applications (1)

Application Number Title Priority Date Filing Date
FI990101A FI120687B (fi) 1996-07-24 1999-01-19 Substituoidut 2-(2,6-dioksopiperidin-3-yyli) ftalimidit ja -1-oksoisoindoliinit sekä menetelmä TNF-alfa tasojen laskemiseksi

Country Status (22)

Country Link
EP (4) EP2305663B1 (fi)
JP (1) JP4065567B2 (fi)
KR (2) KR20050032629A (fi)
CN (1) CN1117089C (fi)
AT (4) ATE229521T3 (fi)
CA (3) CA2560523C (fi)
CZ (3) CZ295762B6 (fi)
DE (4) DE122007000079I2 (fi)
DK (2) DK0925294T6 (fi)
ES (4) ES2339425T3 (fi)
FI (1) FI120687B (fi)
FR (1) FR07C0056I2 (fi)
HK (5) HK1143360A1 (fi)
HU (1) HUS1300056I1 (fi)
LU (1) LU91359I2 (fi)
NL (1) NL300291I2 (fi)
NZ (1) NZ333903A (fi)
PL (2) PL191566B1 (fi)
PT (4) PT1285916E (fi)
SK (1) SK9199A3 (fi)
UA (1) UA60308C2 (fi)
WO (1) WO1998003502A1 (fi)

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