BRPI0514865A - processo para preparar um composto - Google Patents

processo para preparar um composto

Info

Publication number
BRPI0514865A
BRPI0514865A BRPI0514865-0A BRPI0514865A BRPI0514865A BR PI0514865 A BRPI0514865 A BR PI0514865A BR PI0514865 A BRPI0514865 A BR PI0514865A BR PI0514865 A BRPI0514865 A BR PI0514865A
Authority
BR
Brazil
Prior art keywords
oxo
preparing
compound
indolines
dioxo
Prior art date
Application number
BRPI0514865-0A
Other languages
English (en)
Inventor
George W Muller
Roger Chen
Manohar Tukaram Saindane
Chuansheng Ge
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35385616&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0514865(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BRPI0514865A publication Critical patent/BRPI0514865A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSO PARA PREPARAR UM COMPOSTO A presente invenção refere-se aos processos novos para a preparação de 2-(2,6-dioxo-piperidin-3-il)-1-oxo-indolinas substituídas que são úteis para a prevenção ou o tratamento de doenças ou condições relacionadas com uma atividade ou nível anormalmente alto de TNF<244>. A invenção proporciona processos para a produção comercial de 2-(2,6-dioxo-piperidin-3-il)-1-oxo-indolinas substituídas incluindo, mas não limitado a, 3-(4-amino-1-oxo-isoindolin-2-il)-piperidina-2,6-diona terapeuticamente ativa.
BRPI0514865-0A 2004-09-03 2005-08-31 processo para preparar um composto BRPI0514865A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60740904P 2004-09-03 2004-09-03
PCT/US2005/031318 WO2006028964A1 (en) 2004-09-03 2005-08-31 Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines

Publications (1)

Publication Number Publication Date
BRPI0514865A true BRPI0514865A (pt) 2008-06-24

Family

ID=35385616

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514865-0A BRPI0514865A (pt) 2004-09-03 2005-08-31 processo para preparar um composto

Country Status (22)

Country Link
US (1) US7863451B2 (pt)
EP (2) EP2479172B1 (pt)
JP (2) JP2008512379A (pt)
KR (1) KR20070057907A (pt)
CN (1) CN101080400A (pt)
AR (1) AR050724A1 (pt)
AU (1) AU2005282728A1 (pt)
BR (1) BRPI0514865A (pt)
CA (1) CA2579291C (pt)
ES (2) ES2437592T3 (pt)
GT (1) GT200500242A (pt)
HN (1) HN2005000508A (pt)
IL (1) IL181674A0 (pt)
MX (1) MX2007002521A (pt)
NZ (1) NZ554068A (pt)
PA (1) PA8643901A1 (pt)
PE (1) PE20060648A1 (pt)
SV (1) SV2007002219A (pt)
TW (1) TW200621748A (pt)
UY (1) UY29097A1 (pt)
WO (1) WO2006028964A1 (pt)
ZA (1) ZA200702382B (pt)

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ES2430545T3 (es) 2005-06-30 2013-11-21 Celgene Corporation Procedimientos para la preparación de compuestos de 4-amino-2-(2,6-dioxopiperidin-3-il)isoindolina-1,3-diona
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US8946265B2 (en) * 2009-03-02 2015-02-03 Generics [Uk] Limited Process for the preparation of lenalidomide
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PL2477973T3 (pl) * 2009-09-16 2015-04-30 Ranbaxy Laboratories Ltd Sposób wytwarzania krystalicznej formy lenalidomidu
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WO2011050962A1 (en) 2009-10-29 2011-05-05 Ratiopharm Gmbh Acid addition salts of lenalidomide
CN102060842B (zh) * 2009-11-02 2013-05-08 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
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CN102127054B (zh) * 2009-11-02 2013-04-03 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
WO2011069608A1 (en) * 2009-12-09 2011-06-16 Ratiopharm Gmbh S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide
CN101817813B (zh) * 2010-01-15 2013-04-10 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮晶体ⅳ及其药用组合物
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CN102453021A (zh) * 2010-10-22 2012-05-16 重庆医药工业研究院有限责任公司 来那度胺的新晶型及其制备方法
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CN103242215A (zh) * 2013-05-27 2013-08-14 合肥医工医药有限公司 一种来那度胺中间体的制备方法
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KR102191256B1 (ko) 2014-10-30 2020-12-15 강푸 바이오파마슈티칼즈 리미티드 이소인돌린 유도체, 이의 중간체, 제조방법, 약물 조성물 및 응용
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Also Published As

Publication number Publication date
WO2006028964A1 (en) 2006-03-16
ZA200702382B (en) 2008-08-27
NZ554068A (en) 2009-07-31
JP2008512379A (ja) 2008-04-24
PE20060648A1 (es) 2006-07-14
TW200621748A (en) 2006-07-01
SV2007002219A (es) 2007-03-20
PA8643901A1 (es) 2006-05-16
AU2005282728A1 (en) 2006-03-16
EP1797068A1 (en) 2007-06-20
CN101080400A (zh) 2007-11-28
JP5701824B2 (ja) 2015-04-15
ES2437592T3 (es) 2014-01-13
EP2479172B1 (en) 2013-10-09
EP1797068B1 (en) 2013-10-09
ES2438725T3 (es) 2014-01-20
AR050724A1 (es) 2006-11-15
IL181674A0 (en) 2007-07-04
US20060052609A1 (en) 2006-03-09
KR20070057907A (ko) 2007-06-07
MX2007002521A (es) 2007-05-09
CA2579291A1 (en) 2006-03-16
UY29097A1 (es) 2006-03-31
EP2479172A1 (en) 2012-07-25
HN2005000508A (es) 2010-10-08
JP2012207040A (ja) 2012-10-25
CA2579291C (en) 2011-11-29
US7863451B2 (en) 2011-01-04
GT200500242A (es) 2006-06-22

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