AR050724A1 - Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas - Google Patents

Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas

Info

Publication number
AR050724A1
AR050724A1 ARP050103695A ARP050103695A AR050724A1 AR 050724 A1 AR050724 A1 AR 050724A1 AR P050103695 A ARP050103695 A AR P050103695A AR P050103695 A ARP050103695 A AR P050103695A AR 050724 A1 AR050724 A1 AR 050724A1
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AR
Argentina
Prior art keywords
preparation
alkyl
steps
product
substituted
Prior art date
Application number
ARP050103695A
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English (en)
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35385616&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR050724(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of AR050724A1 publication Critical patent/AR050724A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas las cuales son utiles para la prevencion o tratamiento de enfermedades o condiciones relacionadas con un nivel o actividad anormalmente altos de TNFa. Reivindicacion 1: Un proceso para la preparacion de un compuesto de formula (1), o una sal, hidrato, solvato o polimorfo farmacéuticamente aceptable de éste, en donde: cada uno de R1', R2', R3', y R4' es en cada presencia independientemente hidrogeno, halo, alquilo, alcoxi, -CF3, -CN, -NO2, -NHProtG2 o -NR5R6; cada uno de R5 y R6 es en cada presencia independientemente hidrogeno o alquilo; R7 es hidrogeno, halo, alquilo o bencilo; y ProtG2 es un grupo de proteccion en N adecuado, caracterizado porque comprende las secuencias alternativas de los pasos de: 1a) el acoplamiento de un éster de glutamina o una sal de éste con un benzoato de 2-haloalquilo opcionalmente sustituido; b) ciclacion del producto acoplado; y c) la transformacion de uno o más sustituyentes benzo sobre el producto ciclado en otro(s) sustituyente(s) en uno o más pasos, o 2a) el acoplamiento de un éster de glutamina o una sal de éste con un benzoato de 2-haloalquilo opcionalmente sustituido; b) la transformacion de uno o más sustituyentes benzo sobre el producto acoplado en otro(s) sustituyente(s) en uno o más pasos; y c) ciclacion del producto transformado.
ARP050103695A 2004-09-03 2005-09-02 Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas AR050724A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60740904P 2004-09-03 2004-09-03

Publications (1)

Publication Number Publication Date
AR050724A1 true AR050724A1 (es) 2006-11-15

Family

ID=35385616

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103695A AR050724A1 (es) 2004-09-03 2005-09-02 Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas

Country Status (22)

Country Link
US (1) US7863451B2 (es)
EP (2) EP1797068B1 (es)
JP (2) JP2008512379A (es)
KR (1) KR20070057907A (es)
CN (1) CN101080400A (es)
AR (1) AR050724A1 (es)
AU (1) AU2005282728A1 (es)
BR (1) BRPI0514865A (es)
CA (1) CA2579291C (es)
ES (2) ES2438725T3 (es)
GT (1) GT200500242A (es)
HN (1) HN2005000508A (es)
IL (1) IL181674A0 (es)
MX (1) MX2007002521A (es)
NZ (1) NZ554068A (es)
PA (1) PA8643901A1 (es)
PE (1) PE20060648A1 (es)
SV (1) SV2007002219A (es)
TW (1) TW200621748A (es)
UY (1) UY29097A1 (es)
WO (1) WO2006028964A1 (es)
ZA (1) ZA200702382B (es)

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Publication number Publication date
HN2005000508A (es) 2010-10-08
KR20070057907A (ko) 2007-06-07
EP2479172B1 (en) 2013-10-09
PE20060648A1 (es) 2006-07-14
NZ554068A (en) 2009-07-31
IL181674A0 (en) 2007-07-04
GT200500242A (es) 2006-06-22
CN101080400A (zh) 2007-11-28
MX2007002521A (es) 2007-05-09
ES2438725T3 (es) 2014-01-20
JP2012207040A (ja) 2012-10-25
SV2007002219A (es) 2007-03-20
JP5701824B2 (ja) 2015-04-15
BRPI0514865A (pt) 2008-06-24
PA8643901A1 (es) 2006-05-16
ES2437592T3 (es) 2014-01-13
TW200621748A (en) 2006-07-01
CA2579291C (en) 2011-11-29
JP2008512379A (ja) 2008-04-24
ZA200702382B (en) 2008-08-27
US7863451B2 (en) 2011-01-04
CA2579291A1 (en) 2006-03-16
EP1797068A1 (en) 2007-06-20
EP2479172A1 (en) 2012-07-25
EP1797068B1 (en) 2013-10-09
AU2005282728A1 (en) 2006-03-16
WO2006028964A1 (en) 2006-03-16
UY29097A1 (es) 2006-03-31
US20060052609A1 (en) 2006-03-09

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