SV2007002219A - Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas ref. 501872-122418/9615-245-122 - Google Patents

Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas ref. 501872-122418/9615-245-122

Info

Publication number
SV2007002219A
SV2007002219A SV2005002219A SV2005002219A SV2007002219A SV 2007002219 A SV2007002219 A SV 2007002219A SV 2005002219 A SV2005002219 A SV 2005002219A SV 2005002219 A SV2005002219 A SV 2005002219A SV 2007002219 A SV2007002219 A SV 2007002219A
Authority
SV
El Salvador
Prior art keywords
dioxopiperidin
processes
substituted
preparation
oxoisoindolins
Prior art date
Application number
SV2005002219A
Other languages
English (en)
Inventor
George W Muller
Roger Chen
Manohar Tukaram Saindane
Chuansheng Ge
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35385616&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SV2007002219(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of SV2007002219A publication Critical patent/SV2007002219A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LA PRESENTE INVENCION ESTA RELACIONADA CON NUEVOS PROCESOS PARA LA PREPARACION DE 2-(2, 6-DIOXOPPIPERIDIN-3-IL)-1-OXOISOINDOLINAS SUSTITUIDAS LAS CUALES SON ÚTILES PARA LA PREVENCIÓN O TRATAMIENTO DE ENFERMEDADES O CONDICIONES RELACIONADAS CON UN NIVEL O ACTIVIDAD ANORMALMENTE ALTOS DE TNFa. LA INVENCIÓN PROPORCIONA PROCESOS PARA LA PRODUCCIÓN COMERCIAL DE 2-(2, 6- DIOXOPIPERIDIN-3-IL)-1- OXOISOINDOLINAS SUSTITUIDAS QUE INCLUYEN, PERO NO SE LIMINTAN A, LA 3-(4-AMINO-1-OXOSOINDOLIN-2-IL)-PIPERIDIN-2,6-DIONA TERAPEUTICAMENTE ACTIVA
SV2005002219A 2004-09-03 2005-09-02 Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas ref. 501872-122418/9615-245-122 SV2007002219A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60740904P 2004-09-03 2004-09-03

Publications (1)

Publication Number Publication Date
SV2007002219A true SV2007002219A (es) 2007-03-20

Family

ID=35385616

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2005002219A SV2007002219A (es) 2004-09-03 2005-09-02 Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas ref. 501872-122418/9615-245-122

Country Status (22)

Country Link
US (1) US7863451B2 (es)
EP (2) EP1797068B1 (es)
JP (2) JP2008512379A (es)
KR (1) KR20070057907A (es)
CN (1) CN101080400A (es)
AR (1) AR050724A1 (es)
AU (1) AU2005282728A1 (es)
BR (1) BRPI0514865A (es)
CA (1) CA2579291C (es)
ES (2) ES2438725T3 (es)
GT (1) GT200500242A (es)
HN (1) HN2005000508A (es)
IL (1) IL181674A0 (es)
MX (1) MX2007002521A (es)
NZ (1) NZ554068A (es)
PA (1) PA8643901A1 (es)
PE (1) PE20060648A1 (es)
SV (1) SV2007002219A (es)
TW (1) TW200621748A (es)
UY (1) UY29097A1 (es)
WO (1) WO2006028964A1 (es)
ZA (1) ZA200702382B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629360B2 (en) * 1999-05-07 2009-12-08 Celgene Corporation Methods for the treatment of cachexia and graft v. host disease
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
UA83504C2 (en) 2003-09-04 2008-07-25 Селджин Корпорейшн Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
ES2402204T3 (es) 2005-06-30 2013-04-29 Celgene Corporation Procedimientos para la preparación de compuestos de 4-amino-2-(2,6-dioxopiperidin-3-il)isoindolina-1,3-diona
CN101186611B (zh) * 2006-11-15 2011-05-18 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉-2-酮衍生物及其制备和应用
AU2009223014A1 (en) * 2008-03-11 2009-09-17 Dr. Reddy's Laboratories Ltd. Preparation of lenalidomide
DE102008057284A1 (de) 2008-11-14 2010-05-20 Ratiopharm Gmbh Tabletten enthaltend Lenalidomid und Adhäsionsverstärker
DE102008057335A1 (de) 2008-11-14 2010-05-20 Ratiopharm Gmbh Amorphes Lenalidomid
DE102008057285A1 (de) 2008-11-14 2010-05-20 Ratiopharm Gmbh 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidindion in Form einer festen Lösung
AU2009314512B2 (en) * 2008-11-17 2013-04-04 Dr. Reddy's Laboratories Ltd. Lenalidomide solvates and processes
WO2010093434A1 (en) 2009-02-11 2010-08-19 Celgene Corporation Isotopologues of lenalidomide
ES2487215T3 (es) 2009-03-02 2014-08-20 Generics [Uk] Limited Proceso mejorado
CN101580501B (zh) * 2009-06-01 2011-03-09 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
MX2012001890A (es) * 2009-08-12 2012-03-26 Synthon Bv Sales de lenalidomida.
PL2477973T3 (pl) * 2009-09-16 2015-04-30 Ranbaxy Laboratories Ltd Sposób wytwarzania krystalicznej formy lenalidomidu
TWI475014B (zh) * 2009-09-17 2015-03-01 Scinopharm Taiwan Ltd 固體形態的３－（４－胺基－１－側氧基－１，３－二氫－異吲哚－２－基）－哌啶－２，６－二酮及其製造方法
WO2011050962A1 (en) 2009-10-29 2011-05-05 Ratiopharm Gmbh Acid addition salts of lenalidomide
CN102127054B (zh) * 2009-11-02 2013-04-03 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
CN101696205B (zh) 2009-11-02 2011-10-19 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
CN102060842B (zh) * 2009-11-02 2013-05-08 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
WO2011069608A1 (en) * 2009-12-09 2011-06-16 Ratiopharm Gmbh S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide
CN101817813B (zh) * 2010-01-15 2013-04-10 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮晶体ⅳ及其药用组合物
LT3202460T (lt) 2010-02-11 2019-10-10 Celgene Corporation Arilmetoksi izoindolino dariniai ir kompozicijos, apimantys ir jų panaudojimo būdus
CN102453021A (zh) * 2010-10-22 2012-05-16 重庆医药工业研究院有限责任公司 来那度胺的新晶型及其制备方法
WO2012079075A1 (en) 2010-12-10 2012-06-14 Concert Pharmaceuticals, Inc. Deuterated phthalimide derivatives
WO2013012485A2 (en) * 2011-07-19 2013-01-24 Amplio Pharma, Llc Novel crystalline forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
ES2755748T3 (es) * 2012-07-27 2020-04-23 Celgene Corp Procedimientos para preparar compuestos de isoindolin-1,3-diona
WO2014025978A1 (en) 2012-08-09 2014-02-13 Celgene Corporation Processes for the preparation of (s)-3-4-((4-(morpholinomethyl) benzyl)oxy)-1-oxoisoindolin-2-yl) piperidine-2,6-dione and pharmaceutically acceptable forms thereof
WO2014110322A2 (en) 2013-01-11 2014-07-17 Concert Pharmaceuticals, Inc. Substituted dioxopiperidinyl phthalimide derivatives
CN103242215A (zh) * 2013-05-27 2013-08-14 合肥医工医药有限公司 一种来那度胺中间体的制备方法
WO2016024286A2 (en) 2014-08-11 2016-02-18 Avra Laboratories Pvt. Ltd. An improved process for synthesis of lenalidomide
PL3214081T3 (pl) 2014-10-30 2021-04-06 Kangpu Biopharmaceuticals, Ltd. Pochodna izoindoliny, półprodukt, sposób wytwarzania, kompozycja farmaceutyczna i ich zastosowanie
CN104447689B (zh) * 2014-12-22 2016-07-20 上海迈柏医药科技有限公司 来那度胺的晶型及其制备方法
TWI793151B (zh) * 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
CN108191826A (zh) * 2018-01-08 2018-06-22 浙江省医学科学院 一种来那度胺晶体及其制备方法
CA3096404A1 (en) 2018-04-23 2019-10-31 Celgene Corporation Substituted 4-aminoisoindoline-1,3-dione compounds and their use for treating lymphoma
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
WO2020012334A1 (en) 2018-07-10 2020-01-16 Novartis Ag 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases
JP7098825B2 (ja) * 2018-09-07 2022-07-11 メッドシャイン ディスカバリー インコーポレイテッド 三環式置換ピペリジンジオン類化合物
CN113423701A (zh) 2018-11-13 2021-09-21 拜欧斯瑞克斯公司 取代的异吲哚啉酮
CN109369504B (zh) * 2018-12-06 2020-05-12 温州大学 含硫3-亚甲基异吲哚啉-1-酮衍生物的制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
DE4236880A1 (de) * 1992-10-31 1994-05-05 Basf Ag N-Phenyl substituierte Glutarimide und N-Phenylglutarsäureamide, deren Herstellung und Verwendung
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US6114355A (en) 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US5698579A (en) * 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
DE19601303A1 (de) * 1996-01-16 1997-07-17 Boehringer Ingelheim Kg Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln
CZ295762B6 (cs) 1996-07-24 2005-10-12 Celgene Corporation 2,6-Dioxopiperidiny, jejich soli a optické izomery, farmaceutické kompozice obsahující tyto sloučeniny a léčiva pro snížení hladiny TNFalfa obsahující tyto sloučeniny
US5798368A (en) * 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US6281230B1 (en) * 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
ATE418536T1 (de) * 1996-08-12 2009-01-15 Celgene Corp Neue immunotherapeutische mittel und deren verwendung in der reduzierung von cytokinenspiegel
US5955476A (en) * 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
US5874448A (en) * 1997-11-18 1999-02-23 Celgene Corporation Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
DK1064277T3 (da) * 1998-03-16 2005-10-17 Celgene Corp 2-(2,6-dioxopiperidin-3-yl)isoindolinderivater, deres fremstilling og deres anvendelse som inhibitorer af inflammatoriske cytokiner
ES2250121T3 (es) * 1999-03-18 2006-04-16 Celgene Corporation 1-oxo- y 1,3-dioxoisoindolinas y su empleo en composiciones farmaceuticas para la reduccion de niveles de las citocinas inflamatorias.
EP1193248A1 (en) * 2000-09-30 2002-04-03 Aventis Pharma Deutschland GmbH Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation and their use
US6458810B1 (en) * 2000-11-14 2002-10-01 George Muller Pharmaceutically active isoindoline derivatives
ATE374609T1 (de) * 2000-11-30 2007-10-15 Childrens Medical Center Synthese von 4-aminothalidomid enantiomeren
US20030045552A1 (en) * 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
US7091353B2 (en) * 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
JP2002284761A (ja) * 2001-01-17 2002-10-03 Toray Ind Inc 光学活性３−アミノピロリジン−２，５−ジオン誘導体および光学活性３−アミノピロリジン誘導体の製造方法
DE60231989D1 (de) * 2001-08-06 2009-05-28 Childrens Medical Center Antiangiogenese wirkung von stickstoffsubstituierten thalidomid-analoga
US7091343B2 (en) * 2002-03-15 2006-08-15 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
US7968569B2 (en) * 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7189740B2 (en) * 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
US20040091455A1 (en) * 2002-10-31 2004-05-13 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration
US7563810B2 (en) * 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
CH696542A5 (de) * 2003-07-09 2007-07-31 Siegfried Ltd Verfahren zur Herstellung von substituierten 2,6-Dioxopiperidin-3-yl-Verbindungen.
ES2402204T3 (es) * 2005-06-30 2013-04-29 Celgene Corporation Procedimientos para la preparación de compuestos de 4-amino-2-(2,6-dioxopiperidin-3-il)isoindolina-1,3-diona
UA91560C2 (ru) * 2005-08-31 2010-08-10 Селджин Корпорэйшн Соединения ряда изоиндолимидов, их композиция и применение
ES2361584T3 (es) * 2006-09-15 2011-06-20 Celgene Corporation Compuestos de n-metilaminometil-isoindol y composiciones que los comprenden y métodos que usan los mismos.
AU2009223014A1 (en) 2008-03-11 2009-09-17 Dr. Reddy's Laboratories Ltd. Preparation of lenalidomide
WO2009111948A1 (zh) 2008-03-13 2009-09-17 天津和美生物技术有限公司 3-(4-氨基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮及其衍生物的盐或盐的多晶型物及其制备和应用

Also Published As

Publication number Publication date
CN101080400A (zh) 2007-11-28
US7863451B2 (en) 2011-01-04
AR050724A1 (es) 2006-11-15
JP2008512379A (ja) 2008-04-24
EP2479172A1 (en) 2012-07-25
PA8643901A1 (es) 2006-05-16
CA2579291C (en) 2011-11-29
JP5701824B2 (ja) 2015-04-15
JP2012207040A (ja) 2012-10-25
HN2005000508A (es) 2010-10-08
UY29097A1 (es) 2006-03-31
EP1797068B1 (en) 2013-10-09
KR20070057907A (ko) 2007-06-07
MX2007002521A (es) 2007-05-09
TW200621748A (en) 2006-07-01
WO2006028964A1 (en) 2006-03-16
GT200500242A (es) 2006-06-22
EP1797068A1 (en) 2007-06-20
BRPI0514865A (pt) 2008-06-24
EP2479172B1 (en) 2013-10-09
ES2438725T3 (es) 2014-01-20
ES2437592T3 (es) 2014-01-13
PE20060648A1 (es) 2006-07-14
US20060052609A1 (en) 2006-03-09
AU2005282728A1 (en) 2006-03-16
NZ554068A (en) 2009-07-31
IL181674A0 (en) 2007-07-04
ZA200702382B (en) 2008-08-27
CA2579291A1 (en) 2006-03-16

Similar Documents

Publication Publication Date Title
SV2007002219A (es) Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas ref. 501872-122418/9615-245-122
ATE412414T1 (de) 3,11b-cis-dihydrotetrabenazin zur behandlung von proliferativen krankheiten oder entzündungen
IS8505A (is) (S)-2-N-própýlamínó-5-hýdroxýetralín sem D3-gerandefni
NO20081527L (no) Anvendelse av flibanserin for behandling av pre-menopausal seksuell lyst forstyrrelser
SV2006002187A (es) Indazoles utiles para tratamientos de enfermedades cardiovasculares ref.wyth0089-504(am101590)
NO20083561L (no) Forbindelser for behandling av inflammatoriske forstyrrelser
HN1998000172A (es) Compuestos terapeuticamente activos basados en el reemplazo bioisostero del catecol por el indazol en inhibidores de pde4.
BR0318383A (pt) derivados de pirazoloisoquinolina como inibidores de cinase
PA8487201A1 (es) Moduladores de ccr5
DK1438310T3 (da) Beta-carbolin-derivater som PTP-inhibitorer
UY30723A1 (es) Compuestos de biciclocarboxiamida sustituidos
AR056682A1 (es) COMPUESTOS MULTICíCLICOS DERIVADOS DE LA SULFONAMIDA COMO INHIBIDORES DE LA HISTONA DESACETILASA Y COMPOSICIoN FARMACÉUTICA
EP3986863A4 (en) GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
MXPA04006031A (es) Compuestos para el tratamiento de trastornos inflamatorios.
MX2019015741A (es) Tratamiento con plasminogeno de afecciones asociadas a la sobreexpresion de pai-1.
GT200500291A (es) Nuevos heterociclos
DK1817033T3 (da) Behandling af inflammatorisk tarmsygdom
CR11272A (es) Enzimas de aciltranferasa de lecitina-colesterol, modificadas
ATE338036T1 (de) Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate
ECSP056106A (es) Compuestos novedosos de acido fosfonico como inhibidores de las serina proteasas
DE60015508D1 (de) C-16 ungesätigte fp-selektive prostaglandin analoge
CR10038A (es) Analogo de la diazonamida a
PA8607501A1 (es) N-[3-(3-sustituidas-pirazolo[1,5-a]pirimidin-7-il)fenil]-sulfonamidas y composiciones y metodos relacionados
CR8825A (es) Metabolitos de indolilalquilamina como ligandos 5- hidroxitriptamina-6
DOP2005000175A (es) Procesos para la preparacion de 2-(2, 6-dioxopiperidin-3-il)-1-oxoisoidolinas sustituidas

Legal Events

Date Code Title Description
FA Abandonment
FD Lapse