CR11272A - Enzimas de aciltranferasa de lecitina-colesterol, modificadas - Google Patents

Enzimas de aciltranferasa de lecitina-colesterol, modificadas

Info

Publication number
CR11272A
CR11272A CR11272A CR11272A CR11272A CR 11272 A CR11272 A CR 11272A CR 11272 A CR11272 A CR 11272A CR 11272 A CR11272 A CR 11272A CR 11272 A CR11272 A CR 11272A
Authority
CR
Costa Rica
Prior art keywords
cholesterol
aciltranpherase
lecitine
enzymes
modified
Prior art date
Application number
CR11272A
Other languages
English (en)
Inventor
Mingyue Zhou
Thomas Boone
David Park Meininger
Margrit Schwartz
Bei Shan
Shen Wenyan
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CR11272A publication Critical patent/CR11272A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01043—Phosphatidylcholine-sterol O-acyltransferase (2.3.1.43), i.e. lecithin-cholesterol acyltransferase or LCAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)

Abstract

La invencion proporciona los compuestos, las composiciones farmaceuticas y los metodos para tratar la ateroesclerosis, la enfermedad cardiaca coronaria, la trombosis y para la disminucion o prevencion de la acumulacion de colesterol en un sujeto, mediante la modificacion del polipeptido LCAT.
CR11272A 2007-07-26 2010-02-12 Enzimas de aciltranferasa de lecitina-colesterol, modificadas CR11272A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95200707P 2007-07-26 2007-07-26

Publications (1)

Publication Number Publication Date
CR11272A true CR11272A (es) 2010-05-26

Family

ID=39864722

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11272A CR11272A (es) 2007-07-26 2010-02-12 Enzimas de aciltranferasa de lecitina-colesterol, modificadas

Country Status (26)

Country Link
US (3) US8168416B2 (es)
EP (4) EP2489730B1 (es)
JP (5) JP5643643B2 (es)
KR (1) KR20100040937A (es)
CN (1) CN101855344B (es)
AU (1) AU2008279065B2 (es)
BR (1) BRPI0814310A2 (es)
CA (1) CA2694590A1 (es)
CR (1) CR11272A (es)
CY (2) CY1114857T1 (es)
DK (2) DK2181190T3 (es)
EA (1) EA201070187A1 (es)
ES (3) ES2559353T3 (es)
HK (1) HK1138039A1 (es)
HR (1) HRP20140315T1 (es)
IL (1) IL203399A0 (es)
MX (1) MX348799B (es)
MY (1) MY159075A (es)
NZ (2) NZ597885A (es)
PL (2) PL2489731T3 (es)
PT (2) PT2181190E (es)
RS (1) RS53237B (es)
SG (1) SG186016A1 (es)
SI (2) SI2489731T1 (es)
UA (1) UA103304C2 (es)
WO (1) WO2009015314A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201070187A1 (ru) * 2007-07-26 2010-08-30 Эмджен Инк. Модифицированные ферменты лецитин-холестерин ацилтрансферазы
BRPI1012910A2 (pt) * 2009-06-12 2020-06-02 Alphacore Pharma Llc Uso de um agente que leva a atividade de lcat ou eleva o nível de plasma do lcat ou ambos e composição farmacêutica compreendendo tal agente
DK2566505T3 (da) 2010-05-06 2020-01-20 Alphacore Pharma Llc Fremføring af kolesterylester til steroidogene væv
WO2012114131A1 (en) * 2011-02-25 2012-08-30 University Of Patras Lecithin:cholesterol acyltransferase (lcat) and its role in nonalcoholic fatty liver disease (nafld)
BR112013028271B1 (pt) * 2011-05-05 2020-11-24 Wellstat Immuno Therapeutics, Llc Polipeptideo, acido nucleico, vetor viral, preparação farmaceutica, bem como uso dos mesmos no tratamento de doenqa mediada por complemento
CN104220460A (zh) 2011-12-08 2014-12-17 安姆根有限公司 激动人lcat抗原结合蛋白和它们在疗法中的用途
WO2016123569A2 (en) * 2015-01-29 2016-08-04 Plantvax, Inc. Highly expressed protective plant-derived broadly neutralizing hiv monoclonal antibodies for use in passive immunotherapy
WO2018022511A1 (en) 2016-07-25 2018-02-01 The Trustees Of The University Of Pennsylvania Compositions comprising a lecithin cholesterol acyltransferase variant and uses thereof
CA3082070A1 (en) * 2017-11-07 2019-05-16 Alphacore Pharma Llc Methods of treating and protecting against cardiac disease, cardiovascular disease and related conditions and symptoms
US20210115412A1 (en) * 2018-05-22 2021-04-22 Dsm Ip Assets B.V. Modified sterol acyltransferases
US11612619B2 (en) 2018-11-01 2023-03-28 National Institute Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Compostions and methods for enabling cholesterol catabolism in human cells
KR200493485Y1 (ko) * 2019-08-27 2021-04-07 주식회사 서원기술 배관용 고무링

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3691016A (en) 1970-04-17 1972-09-12 Monsanto Co Process for the preparation of insoluble enzymes
CA1023287A (en) 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
US4195128A (en) 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
US4330440A (en) 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
CA1093991A (en) 1977-02-17 1981-01-20 Hideo Hirohara Enzyme immobilization with pullulan gel
US4229537A (en) 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
JPS63167409A (ja) 1986-12-27 1988-07-11 Yamaha Corp 磁気記録体
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
NL8720442A (nl) 1986-08-18 1989-04-03 Clinical Technologies Ass Afgeefsystemen voor farmacologische agentia.
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
EP0842925A1 (en) 1987-09-04 1998-05-20 Beecham Group Plc Substituted thiazolidinedione derivatives
US6288095B1 (en) 1987-09-04 2001-09-11 Beecham Group P.L.C. Compounds
DE3889853D1 (de) 1987-11-05 1994-07-07 Hybritech Inc Polysaccharidmodifizierte Immunglobuline mit reduziertem immunogenem Potential oder verbesserter Pharmakokinetik.
GB8824591D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Fractionation process
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
NZ241954A (en) 1991-03-15 1994-01-26 Amgen Inc Compositions of g-csf for pulmonary administration.
HU217629B (hu) 1991-12-12 2000-03-28 Novartis Ag. Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására
ATE156158T1 (de) 1992-04-14 1997-08-15 Cornell Res Foundation Inc Makromoleküle auf basis von dendritischen polymeren und verfahren zur herstellung
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5741803A (en) 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
WO1994016693A1 (en) 1993-01-19 1994-08-04 Warner-Lambert Company Stable oral ci-981 formulation and process of preparing same
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
TWI238064B (en) 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
DE69616808T2 (de) 1995-07-17 2002-05-29 Warner Lambert Co Kristallines (r-(r*,r*))-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrol-1-heptancarbonsäure hemi calcium salz (atorvastatin)
EP0871713B1 (en) * 1995-11-09 2007-02-14 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES The use of lecithin-cholesterol acyltransferase (lcat) in the treatment of atherosclerosis
WO1997034631A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
FR2758459B1 (fr) 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
DE69836626T2 (de) * 1997-04-11 2007-04-05 Takeda Pharmaceutical Co. Ltd. Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung
DK0974356T3 (da) 1998-07-15 2003-10-27 Merck Sante Sas Tabletter omfattende en kombination af metformin og glibenclamid
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
AU5931600A (en) 1999-07-14 2001-02-05 Betagene, Inc. Lcat recombinant cell line compositions and methods
EP2452683A3 (en) 2006-06-26 2012-08-22 Amgen Inc. Methods for treating atherosclerosis
EA201070187A1 (ru) * 2007-07-26 2010-08-30 Эмджен Инк. Модифицированные ферменты лецитин-холестерин ацилтрансферазы

Also Published As

Publication number Publication date
US9006408B2 (en) 2015-04-14
AU2008279065B2 (en) 2013-12-12
PL2489731T3 (pl) 2015-01-30
RS53237B (en) 2014-08-29
WO2009015314A3 (en) 2009-03-12
JP2016182136A (ja) 2016-10-20
JP2020058366A (ja) 2020-04-16
JP2014198047A (ja) 2014-10-23
EP2489730A1 (en) 2012-08-22
EP2522721A2 (en) 2012-11-14
PT2181190E (pt) 2014-02-24
CY1115573T1 (el) 2017-01-04
JP5643643B2 (ja) 2014-12-17
EA201070187A1 (ru) 2010-08-30
DK2181190T3 (da) 2014-03-31
BRPI0814310A2 (pt) 2015-01-06
HK1138039A1 (en) 2010-08-13
ES2559353T3 (es) 2016-02-11
EP2489731B1 (en) 2014-08-27
US8168416B2 (en) 2012-05-01
CA2694590A1 (en) 2009-01-29
CN101855344A (zh) 2010-10-06
JP2010534479A (ja) 2010-11-11
EP2181190B1 (en) 2014-01-08
AU2008279065A1 (en) 2009-01-29
CY1114857T1 (el) 2016-12-14
DK2489731T3 (en) 2014-11-17
EP2181190A2 (en) 2010-05-05
CN101855344B (zh) 2015-12-09
MX348799B (es) 2017-06-29
ES2449483T3 (es) 2014-03-19
JP2018161134A (ja) 2018-10-18
NZ597885A (en) 2013-08-30
NZ582794A (en) 2012-09-28
PL2181190T3 (pl) 2014-06-30
PT2489731E (pt) 2014-09-15
IL203399A0 (en) 2011-07-31
UA103304C2 (ru) 2013-10-10
ES2513716T3 (es) 2014-10-27
HRP20140315T1 (hr) 2014-05-09
KR20100040937A (ko) 2010-04-21
US20090081182A1 (en) 2009-03-26
WO2009015314A2 (en) 2009-01-29
EP2489730B1 (en) 2015-12-30
MY159075A (en) 2016-12-15
EP2522721A3 (en) 2013-01-23
EP2522721B1 (en) 2016-05-04
SG186016A1 (en) 2012-12-28
SI2489731T1 (sl) 2014-12-31
JP6033258B2 (ja) 2016-11-30
EP2489731A1 (en) 2012-08-22
US8703926B1 (en) 2014-04-22
SI2181190T1 (sl) 2014-04-30
US20140287479A1 (en) 2014-09-25

Similar Documents

Publication Publication Date Title
CR11272A (es) Enzimas de aciltranferasa de lecitina-colesterol, modificadas
CY1121593T1 (el) Προφαρμακα της τετραϋδροκανναβινολης, συνθεσεις οι οποιες περιλαμβανουν προφαρμακα της τετραϋδροκανναβινολης και μεθοδοι χρησης των ιδιων
CY1118452T1 (el) Ενωσεις και συνθεσεις ως αναστολεις πρωτεϊνικης κινασης
EA200901166A1 (ru) Соединения и композиции в качестве модуляторов активности gpr 119
SG10201805670QA (en) Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
ECSP10010042A (es) Compuestos y composiciones como moduladores de la actividad de gpr119
TWI372061B (en) Use of il-23 and il-17 antagonists to treat autoimmune ocular inflammatory disease
CY1115236T1 (el) Ενωσεις για την προληψη και τη θεραπεια των καρδιαγγειακων παθησεων
ECSP10010548A (es) Composiciones y metodos de preparacion y uso de las mismas
BR112015009948A2 (pt) antagonistas de ativina-actriia e usos para tratamento ósseos e outros disturbios
ITRM20050265A1 (it) Protesi modulare perfezionata per osteosintesi, in particolare per l'osteosintesi dell'omero.
AR050717A1 (es) Composiciones farmaceuticas
CR9903A (es) Compuestos antihipercolesterolemicos
BR112013001753A2 (pt) método para preparar uma composição d einter-alfa-inibidor (iaip) eriquecida de plasma, solução aquosa de iaip, e, método para tratar uma doença ou distúrbio associado com disfunção de iaip e associado com atividadede protease de serina no plasma aumentada.
ECSP077340A (es) Nuevos derivados de pirimidina y su uso como moduladores del ppar-alfa
RS54733B1 (sr) Tritokvalin za upotrebu u tretiranju cistične fibroze
ITRM20050179A1 (it) Composizione impiegabile per il trattamento delle patologie paradontali.
DOP2006000024A (es) Tiazolidinonas, su preparación y su uso como medicamento
ECSP11011472A (es) Antagonistas ccr3 arilsulfonamida 2, 5- disustituídos
ECSP003707A (es) Diazepanes
DE602006010852D1 (de) Proliferationshemmendes arzneimittel
EA200970293A1 (ru) Новые производные 5-тиоксилопиранозы
EA200970292A1 (ru) Производные 5-тиоксилопиранозы и их применение в терапии
CY1115512T1 (el) Ενωσεις και συνθεσεις ως αναστολεις πρωτεϊνικης κινασης
DOP2005000177A (es) Nuevos derivados de pirimidina y su uso