MX348799B - Enzimas aciltransferasa de lecitina-colesterol, modificadas. - Google Patents

Enzimas aciltransferasa de lecitina-colesterol, modificadas.

Info

Publication number
MX348799B
MX348799B MX2014001593A MX2014001593A MX348799B MX 348799 B MX348799 B MX 348799B MX 2014001593 A MX2014001593 A MX 2014001593A MX 2014001593 A MX2014001593 A MX 2014001593A MX 348799 B MX348799 B MX 348799B
Authority
MX
Mexico
Prior art keywords
cholesterol acyltransferase
modified lecithin
acyltransferase enzymes
active
amphiphilic
Prior art date
Application number
MX2014001593A
Other languages
English (en)
Inventor
Shan Bei
Zhou Mingyue
Boone Thomas
Park Meininger David
Schwarz Margrit
Shen Wenyan
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX348799B publication Critical patent/MX348799B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01043—Phosphatidylcholine-sterol O-acyltransferase (2.3.1.43), i.e. lecithin-cholesterol acyltransferase or LCAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)

Abstract

La presente invención se refiere a las composiciones farmacéuticas y los métodos para tratar la ateroesclerosis, la enfermedad cardiaca coronaria, la trombosis y para la disminución o prevención de la acumulación de colesterol en un sujeto, mediante la modificación del polipéptido LCAT.
MX2014001593A 2007-07-26 2008-07-25 Enzimas aciltransferasa de lecitina-colesterol, modificadas. MX348799B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95200707P 2007-07-26 2007-07-26
PCT/US2008/071119 WO2009015314A2 (en) 2007-07-26 2008-07-25 Modified lecithin-cholesterol acyltransferase enzymes

Publications (1)

Publication Number Publication Date
MX348799B true MX348799B (es) 2017-06-29

Family

ID=39864722

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001593A MX348799B (es) 2007-07-26 2008-07-25 Enzimas aciltransferasa de lecitina-colesterol, modificadas.

Country Status (26)

Country Link
US (3) US8168416B2 (es)
EP (4) EP2489730B1 (es)
JP (5) JP5643643B2 (es)
KR (1) KR20100040937A (es)
CN (1) CN101855344B (es)
AU (1) AU2008279065B2 (es)
BR (1) BRPI0814310A2 (es)
CA (1) CA2694590A1 (es)
CR (1) CR11272A (es)
CY (2) CY1114857T1 (es)
DK (2) DK2181190T3 (es)
EA (1) EA201070187A1 (es)
ES (3) ES2559353T3 (es)
HK (1) HK1138039A1 (es)
HR (1) HRP20140315T1 (es)
IL (1) IL203399A0 (es)
MX (1) MX348799B (es)
MY (1) MY159075A (es)
NZ (2) NZ597885A (es)
PL (2) PL2489731T3 (es)
PT (2) PT2181190E (es)
RS (1) RS53237B (es)
SG (1) SG186016A1 (es)
SI (2) SI2489731T1 (es)
UA (1) UA103304C2 (es)
WO (1) WO2009015314A2 (es)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
EA201070187A1 (ru) * 2007-07-26 2010-08-30 Эмджен Инк. Модифицированные ферменты лецитин-холестерин ацилтрансферазы
BRPI1012910A2 (pt) * 2009-06-12 2020-06-02 Alphacore Pharma Llc Uso de um agente que leva a atividade de lcat ou eleva o nível de plasma do lcat ou ambos e composição farmacêutica compreendendo tal agente
DK2566505T3 (da) 2010-05-06 2020-01-20 Alphacore Pharma Llc Fremføring af kolesterylester til steroidogene væv
WO2012114131A1 (en) * 2011-02-25 2012-08-30 University Of Patras Lecithin:cholesterol acyltransferase (lcat) and its role in nonalcoholic fatty liver disease (nafld)
BR112013028271B1 (pt) * 2011-05-05 2020-11-24 Wellstat Immuno Therapeutics, Llc Polipeptideo, acido nucleico, vetor viral, preparação farmaceutica, bem como uso dos mesmos no tratamento de doenqa mediada por complemento
CN104220460A (zh) 2011-12-08 2014-12-17 安姆根有限公司 激动人lcat抗原结合蛋白和它们在疗法中的用途
WO2016123569A2 (en) * 2015-01-29 2016-08-04 Plantvax, Inc. Highly expressed protective plant-derived broadly neutralizing hiv monoclonal antibodies for use in passive immunotherapy
WO2018022511A1 (en) 2016-07-25 2018-02-01 The Trustees Of The University Of Pennsylvania Compositions comprising a lecithin cholesterol acyltransferase variant and uses thereof
CA3082070A1 (en) * 2017-11-07 2019-05-16 Alphacore Pharma Llc Methods of treating and protecting against cardiac disease, cardiovascular disease and related conditions and symptoms
US20210115412A1 (en) * 2018-05-22 2021-04-22 Dsm Ip Assets B.V. Modified sterol acyltransferases
US11612619B2 (en) 2018-11-01 2023-03-28 National Institute Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Compostions and methods for enabling cholesterol catabolism in human cells
KR200493485Y1 (ko) * 2019-08-27 2021-04-07 주식회사 서원기술 배관용 고무링

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Also Published As

Publication number Publication date
US9006408B2 (en) 2015-04-14
AU2008279065B2 (en) 2013-12-12
PL2489731T3 (pl) 2015-01-30
RS53237B (en) 2014-08-29
WO2009015314A3 (en) 2009-03-12
CR11272A (es) 2010-05-26
JP2016182136A (ja) 2016-10-20
JP2020058366A (ja) 2020-04-16
JP2014198047A (ja) 2014-10-23
EP2489730A1 (en) 2012-08-22
EP2522721A2 (en) 2012-11-14
PT2181190E (pt) 2014-02-24
CY1115573T1 (el) 2017-01-04
JP5643643B2 (ja) 2014-12-17
EA201070187A1 (ru) 2010-08-30
DK2181190T3 (da) 2014-03-31
BRPI0814310A2 (pt) 2015-01-06
HK1138039A1 (en) 2010-08-13
ES2559353T3 (es) 2016-02-11
EP2489731B1 (en) 2014-08-27
US8168416B2 (en) 2012-05-01
CA2694590A1 (en) 2009-01-29
CN101855344A (zh) 2010-10-06
JP2010534479A (ja) 2010-11-11
EP2181190B1 (en) 2014-01-08
AU2008279065A1 (en) 2009-01-29
CY1114857T1 (el) 2016-12-14
DK2489731T3 (en) 2014-11-17
EP2181190A2 (en) 2010-05-05
CN101855344B (zh) 2015-12-09
ES2449483T3 (es) 2014-03-19
JP2018161134A (ja) 2018-10-18
NZ597885A (en) 2013-08-30
NZ582794A (en) 2012-09-28
PL2181190T3 (pl) 2014-06-30
PT2489731E (pt) 2014-09-15
IL203399A0 (en) 2011-07-31
UA103304C2 (ru) 2013-10-10
ES2513716T3 (es) 2014-10-27
HRP20140315T1 (hr) 2014-05-09
KR20100040937A (ko) 2010-04-21
US20090081182A1 (en) 2009-03-26
WO2009015314A2 (en) 2009-01-29
EP2489730B1 (en) 2015-12-30
MY159075A (en) 2016-12-15
EP2522721A3 (en) 2013-01-23
EP2522721B1 (en) 2016-05-04
SG186016A1 (en) 2012-12-28
SI2489731T1 (sl) 2014-12-31
JP6033258B2 (ja) 2016-11-30
EP2489731A1 (en) 2012-08-22
US8703926B1 (en) 2014-04-22
SI2181190T1 (sl) 2014-04-30
US20140287479A1 (en) 2014-09-25

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