DK2070920T3 - Substituerede 2-(2,6-dioxopiperidin-3-yl)phthalimider og 1-oxoisoindoliner og fremgangsmåde til at reducere TNF-a-niveauer - Google Patents

Substituerede 2-(2,6-dioxopiperidin-3-yl)phthalimider og 1-oxoisoindoliner og fremgangsmåde til at reducere TNF-a-niveauer

Info

Publication number
DK2070920T3
DK2070920T3 DK09151443.0T DK09151443T DK2070920T3 DK 2070920 T3 DK2070920 T3 DK 2070920T3 DK 09151443 T DK09151443 T DK 09151443T DK 2070920 T3 DK2070920 T3 DK 2070920T3
Authority
DK
Denmark
Prior art keywords
oxoisoindolines
dioxopiperidin
phthalimides
substituted
levels
Prior art date
Application number
DK09151443.0T
Other languages
English (en)
Inventor
David Stirling
Roger Shen-Chu Chen
George W Muller
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08690258 external-priority patent/US5635517B1/en
Priority claimed from US08/701,494 external-priority patent/US5798368A/en
Application filed by Celgene Corp filed Critical Celgene Corp
Priority claimed from EP20020012942 external-priority patent/EP1285916B1/en
Application granted granted Critical
Publication of DK2070920T3 publication Critical patent/DK2070920T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DK09151443.0T 1996-07-24 1997-07-24 Substituerede 2-(2,6-dioxopiperidin-3-yl)phthalimider og 1-oxoisoindoliner og fremgangsmåde til at reducere TNF-a-niveauer DK2070920T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08690258 US5635517B1 (en) 1996-07-24 1996-07-24 Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US08/701,494 US5798368A (en) 1996-08-22 1996-08-22 Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
US4827897P 1997-05-30 1997-05-30
EP20020012942 EP1285916B1 (en) 1996-07-24 1997-07-24 Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and -1-oxoisoindolines and method of reducing TNF alpha levels

Publications (1)

Publication Number Publication Date
DK2070920T3 true DK2070920T3 (da) 2011-06-14

Family

ID=27104569

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10152833.9T DK2177517T3 (da) 1996-07-24 1997-07-24 Aminosubstitueret 2-(2,6-dioxopiperidin-3-yl)-phthalimid til at nedsætte TNF-alfa-niveauer
DK09151443.0T DK2070920T3 (da) 1996-07-24 1997-07-24 Substituerede 2-(2,6-dioxopiperidin-3-yl)phthalimider og 1-oxoisoindoliner og fremgangsmåde til at reducere TNF-a-niveauer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10152833.9T DK2177517T3 (da) 1996-07-24 1997-07-24 Aminosubstitueret 2-(2,6-dioxopiperidin-3-yl)-phthalimid til at nedsætte TNF-alfa-niveauer

Country Status (3)

Country Link
EP (2) EP2859895A1 (da)
JP (3) JP2008050368A (da)
DK (2) DK2177517T3 (da)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9109645D0 (en) 1991-05-03 1991-06-26 Celltech Ltd Recombinant antibodies
AU1531492A (en) * 1991-02-14 1992-09-15 Rockefeller University, The Method for controlling abnormal concentration tnf alpha in human tissues
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines

Also Published As

Publication number Publication date
DK2177517T3 (da) 2011-11-21
EP2177517B1 (en) 2011-10-26
JP2008050368A (ja) 2008-03-06
JP2013053169A (ja) 2013-03-21
EP2177517A1 (en) 2010-04-21
EP2859895A1 (en) 2015-04-15
JP2015131863A (ja) 2015-07-23

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DK2070920T3 (da) Substituerede 2-(2,6-dioxopiperidin-3-yl)phthalimider og 1-oxoisoindoliner og fremgangsmåde til at reducere TNF-a-niveauer