CN103694350B - 跨物种特异性CD3-ε结合结构域 - Google Patents

跨物种特异性CD3-ε结合结构域 Download PDF

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CN103694350B
CN103694350B CN201310520125.2A CN201310520125A CN103694350B CN 103694350 B CN103694350 B CN 103694350B CN 201310520125 A CN201310520125 A CN 201310520125A CN 103694350 B CN103694350 B CN 103694350B
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cdr
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antibody
mankind
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CN103694350A (zh
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马赛厄斯·克林格
托拜厄斯·劳姆
桃瑞丝·劳
苏珊娜·曼高德
罗曼·基谢尔
拉尔夫·鲁特布瑟
帕特里克·霍夫曼
彼得·库菲
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Amgen Research Munich GmbH
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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CN201310520125.2A 2007-04-03 2008-04-03 跨物种特异性CD3-ε结合结构域 Active CN103694350B (zh)

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EP07006990.1 2007-04-03
EP07006990 2007-04-03
EP07006988 2007-04-03
EP07006988.5 2007-04-03
US91366807P 2007-04-24 2007-04-24
US60/913,668 2007-04-24
EP08004741 2008-03-13
EP08004741.8 2008-03-13
CN200880018607.5A CN101687915B8 (zh) 2007-04-03 2008-04-03 跨物种特异性CD3-ε结合结构域

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EP (3) EP3461842A1 (de)
JP (1) JP2010524851A (de)
KR (2) KR101940944B1 (de)
CN (2) CN101687915B8 (de)
CY (1) CY1120822T1 (de)
DK (1) DK2520590T3 (de)
ES (2) ES2695047T3 (de)
FI (1) FI2155783T4 (de)
HR (1) HRP20181902T1 (de)
IL (1) IL201340A (de)
LT (1) LT2520590T (de)
MX (1) MX2009010610A (de)
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PL (2) PL2155783T5 (de)
PT (1) PT2155783E (de)
RS (2) RS53008B2 (de)
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SG (3) SG182234A1 (de)
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SG155883A1 (en) 2004-06-03 2009-10-29 Novimmune Sa Anti-cd3 antibodies and methods of use thereof
EP3770174A1 (de) 2005-10-11 2021-01-27 Amgen Research (Munich) GmbH Zusammensetzungen mit antikörpern mit artenübergreifender spezifität und verwendungen davon
WO2008119567A2 (en) † 2007-04-03 2008-10-09 Micromet Ag Cross-species-specific cd3-epsilon binding domain
PL2155788T3 (pl) * 2007-04-03 2013-02-28 Amgen Res Munich Gmbh Swoiste międzygatunkowe bispecyficzne czynniki wiążące
CA2683370C (en) * 2007-04-03 2022-12-13 Micromet Ag Cross-species-specific binding domain
SG194398A1 (en) 2008-10-01 2013-11-29 Amgen Res Munich Gmbh Cross-species-specific psmaxcd3 bispecific single chain antibody
CA2738566C (en) * 2008-10-01 2024-04-30 Micromet Ag Bispecific single chain antibodies with specificity for high molecular weight target antigens
AU2009299791B2 (en) * 2008-10-01 2016-02-25 Amgen Research (Munich) Gmbh Cross-species-specific PSCAxCD3, CD19xCD3, C-METxCD3, EndosialinxCD3, EpCAMxC D3, IGF-1RxCD3 or FAPalpha xCD3 bispecific single chain antibody
US10981998B2 (en) 2008-10-01 2021-04-20 Amgen Research (Munich) Gmbh Cross-species-specific single domain bispecific single chain antibody
DK2493503T4 (da) * 2009-10-27 2021-04-12 Amgen Res Munich Gmbh Doseringsplan for administrering af et cd19xcd3-bispecifikt antistof
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