CR20220531A - Modulacion de enzimas y vías con compuestos de sulfhidrilo y sus derivados - Google Patents

Modulacion de enzimas y vías con compuestos de sulfhidrilo y sus derivados

Info

Publication number
CR20220531A
CR20220531A CR20220531A CR20220531A CR20220531A CR 20220531 A CR20220531 A CR 20220531A CR 20220531 A CR20220531 A CR 20220531A CR 20220531 A CR20220531 A CR 20220531A CR 20220531 A CR20220531 A CR 20220531A
Authority
CR
Costa Rica
Prior art keywords
relates
proteins
antibodies
enzyme
derivatives
Prior art date
Application number
CR20220531A
Other languages
English (en)
Inventor
Zhixin Shao
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20220531A publication Critical patent/CR20220531A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a proteínas, en particular, anticuerpos, tales como anticuerpos biespecíficos anti-CD20/anti-CD3 y anticuerpos anti-α-sinucleína, que tienen glucanos monogalactosilados (G1) y digalactosilados (G2). Más en particular, la presente invención se refiere a ingeniería de galactosilación para generar proteínas con propiedades terapéuticas mejoradas, que incluyen proteínas con título aumentado. Además, la invención se refiere a un medio de cultivo celular y una célula de mamífero, así como a métodos que usan dicho medio de cultivo celular y dicha célula de mamífero para producir dichas proteínas. Además, la presente invención se refiere al uso de dichos anticuerpos como un medicamento, tal como para el tratamiento de cáncer, en particular, cáncer asociado a linfocitos B, o enfermedad de Parkinson.
CR20220531A 2020-04-24 2021-04-23 Modulacion de enzimas y vías con compuestos de sulfhidrilo y sus derivados CR20220531A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20171356 2020-04-24
PCT/EP2021/060637 WO2021214277A1 (en) 2020-04-24 2021-04-23 Enzyme and pathway modulation with sulfhydryl compounds and their derivatives

Publications (1)

Publication Number Publication Date
CR20220531A true CR20220531A (es) 2022-11-28

Family

ID=70464886

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220531A CR20220531A (es) 2020-04-24 2021-04-23 Modulacion de enzimas y vías con compuestos de sulfhidrilo y sus derivados

Country Status (17)

Country Link
US (1) US20230265204A1 (es)
EP (1) EP4139349A1 (es)
JP (1) JP2023522417A (es)
KR (1) KR20230005172A (es)
CN (1) CN115427443A (es)
AR (1) AR121918A1 (es)
AU (1) AU2021258475A1 (es)
BR (1) BR112022021203A2 (es)
CA (1) CA3178472A1 (es)
CL (1) CL2022002885A1 (es)
CR (1) CR20220531A (es)
IL (1) IL296664A (es)
MX (1) MX2022013173A (es)
PE (1) PE20230078A1 (es)
TW (1) TW202206459A (es)
WO (1) WO2021214277A1 (es)
ZA (1) ZA202210643B (es)

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Also Published As

Publication number Publication date
PE20230078A1 (es) 2023-01-11
WO2021214277A1 (en) 2021-10-28
MX2022013173A (es) 2022-11-30
US20230265204A1 (en) 2023-08-24
EP4139349A1 (en) 2023-03-01
AU2021258475A1 (en) 2022-10-20
CA3178472A1 (en) 2021-10-28
AR121918A1 (es) 2022-07-20
KR20230005172A (ko) 2023-01-09
CL2022002885A1 (es) 2023-06-16
TW202206459A (zh) 2022-02-16
CN115427443A (zh) 2022-12-02
BR112022021203A2 (pt) 2022-12-06
ZA202210643B (en) 2023-06-28
JP2023522417A (ja) 2023-05-30
IL296664A (en) 2022-11-01

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