CA2967367C - Compositions and methods of treating amyotrophic lateral sclerosis (als) - Google Patents
Compositions and methods of treating amyotrophic lateral sclerosis (als) Download PDFInfo
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| LT3126499T (lt) | 2014-04-01 | 2020-07-27 | Biogen Ma Inc. | Kompozicijos, skirtos sod-1 ekspresijos moduliavimui |
| WO2016077687A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| CN112375760A (zh) | 2014-11-14 | 2021-02-19 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| IL302748B1 (en) | 2016-05-18 | 2025-09-01 | Voyager Therapeutics Inc | Modulatory polynucleotides |
| SG11201809643UA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
| GB201609597D0 (en) | 2016-06-01 | 2016-07-13 | Univ Sheffield | Therapy |
| US11752181B2 (en) * | 2017-05-05 | 2023-09-12 | Voyager Therapeutics, Inc. | Compositions and methods of treating Huntington's disease |
| CA3061365A1 (en) * | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| EP3618839A4 (en) * | 2017-05-05 | 2021-06-09 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| CN111479924B (zh) * | 2017-10-16 | 2024-06-14 | 沃雅戈治疗公司 | 肌萎缩性侧索硬化症(als)的治疗 |
| WO2019079242A1 (en) * | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| US20210261981A1 (en) * | 2017-10-23 | 2021-08-26 | Prevail Therapeutics, Inc. | Gene therapies for neurodegenerative diseases |
| KR102112476B1 (ko) | 2017-12-29 | 2020-05-19 | 주식회사 헬릭스미스 | 하이브리드 HGF 유전자가 도입된 AAV(Adeno-Associated Virus) 벡터 |
| MX2020012532A (es) * | 2018-05-31 | 2021-04-28 | Immunity Pharma Ltd | Composiciones y procedimientos de su uso para el tratamiento de esclerosis lateral amiotrofica (ela). |
| US12060567B2 (en) | 2018-06-13 | 2024-08-13 | Voyager Therapeutics, Inc. | Engineered untranslated regions (UTR) for AAV production |
| JP7565218B2 (ja) * | 2018-07-02 | 2024-10-10 | ボイジャー セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症および脊髄に関連する障害の治療 |
| US20210361318A1 (en) | 2018-07-02 | 2021-11-25 | Voyager Therapeutics, Inc. | Cannula system and use thereof |
| CN112770812A (zh) | 2018-07-24 | 2021-05-07 | 沃雅戈治疗公司 | 产生基因治疗制剂的系统和方法 |
| TW202035689A (zh) | 2018-10-04 | 2020-10-01 | 美商航海家醫療公司 | 測量病毒載體粒子的效價及強度之方法 |
| AU2019354793A1 (en) | 2018-10-05 | 2021-05-13 | Voyager Therapeutics, Inc. | Engineered nucleic acid constructs encoding AAV production proteins |
| JP2022505106A (ja) | 2018-10-15 | 2022-01-14 | ボイジャー セラピューティクス インコーポレイテッド | バキュロウイルス／Ｓｆ９システムにおけるｒＡＡＶの大規模産生のための発現ベクター |
| KR20210102294A (ko) * | 2018-12-06 | 2021-08-19 | 바이오젠 엠에이 인코포레이티드 | 근위축성 측삭 경화증에서 치료요법적 중재를 안내하기 위한 신경필라멘트 단백질 |
| UY38506A (es) * | 2018-12-14 | 2020-06-30 | Biogen Ma Inc | Composiciones y metodos para tratar y prevenir la esclerosis lateral amiotrofica |
| WO2020150556A1 (en) | 2019-01-18 | 2020-07-23 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| AU2020216480A1 (en) | 2019-01-31 | 2021-09-09 | Oregon Health & Science University | Methods for using transcription-dependent directed evolution of AAV capsids |
| US20220168450A1 (en) * | 2019-04-29 | 2022-06-02 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis and disorders associated with the spinal cord |
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| EP4010465A1 (en) | 2019-08-09 | 2022-06-15 | Voyager Therapeutics, Inc. | Cell culture medium for use in producing gene therapy products in bioreactors |
| EP4022070A1 (en) | 2019-08-26 | 2022-07-06 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
| WO2021092166A1 (en) * | 2019-11-05 | 2021-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating neurodegenerative diseases caused by g4c2 expansion in c90rf72 |
| EP3892283A1 (en) * | 2020-04-09 | 2021-10-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nucleic acids encoding human fus protein and use in the treatment of amyotrophic lateral sclerosis (als) |
| BR112023001648A2 (pt) | 2020-07-27 | 2023-04-04 | Anjarium Biosciences Ag | Moléculas de dna de fita dupla, veículo de entrega e método para preparar uma molécula de dna com extremidade em grampo |
| US20230295656A1 (en) | 2020-08-06 | 2023-09-21 | Voyager Therapeutics, Inc. | Cell culture medium for use in producing gene therapy products in bioreactors |
| PH12023550145A1 (en) * | 2020-08-12 | 2024-03-18 | UCB Biopharma SRL | Gene therapy using nucleic acid constructs comprising methyl cpg binding protein 2 (mecp2) promoter sequences |
| US20230416317A1 (en) * | 2020-11-20 | 2023-12-28 | Texas Tech University System | Methods of treating or preventing neurological disorders using zpr1 |
| AU2022220704A1 (en) * | 2021-02-12 | 2022-08-18 | Alnylam Pharmaceuticals, Inc. | Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases |
| WO2022187548A1 (en) | 2021-03-03 | 2022-09-09 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
| US20240141377A1 (en) | 2021-03-03 | 2024-05-02 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
| CN117915952A (zh) | 2021-09-16 | 2024-04-19 | H.隆德贝克有限公司 | 用于治疗突触核蛋白病的组合物和方法 |
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| CN116270704A (zh) * | 2023-02-24 | 2023-06-23 | 西交利物浦大学 | 一种抑制sod1基因表达的药物组合物及其应用 |
| WO2024226761A2 (en) | 2023-04-26 | 2024-10-31 | Voyager Therapeutics, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
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| US5171680A (en) | 1988-06-14 | 1992-12-15 | Chiron Corporation | Superoxide dismutase analogs having novel binding properties |
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| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
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