CA2539548A1 - Novel heterocyclic compounds as hsp90-inhibitors - Google Patents
Novel heterocyclic compounds as hsp90-inhibitors Download PDFInfo
- Publication number
- CA2539548A1 CA2539548A1 CA002539548A CA2539548A CA2539548A1 CA 2539548 A1 CA2539548 A1 CA 2539548A1 CA 002539548 A CA002539548 A CA 002539548A CA 2539548 A CA2539548 A CA 2539548A CA 2539548 A1 CA2539548 A1 CA 2539548A1
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- CA
- Canada
- Prior art keywords
- compound
- aryl
- heteroaryl
- group
- tautomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 230000002401 inhibitory effect Effects 0.000 claims abstract description 8
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- 125000000217 alkyl group Chemical group 0.000 claims description 452
- 125000001072 heteroaryl group Chemical group 0.000 claims description 405
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- 239000000651 prodrug Substances 0.000 claims description 300
- 125000001424 substituent group Chemical group 0.000 claims description 268
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- 125000006413 ring segment Chemical group 0.000 claims description 196
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- 125000000304 alkynyl group Chemical group 0.000 claims description 184
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 177
- -1 araalkyl Chemical group 0.000 claims description 161
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Classifications
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- C07D471/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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Landscapes
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- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US50413503P | 2003-09-18 | 2003-09-18 | |
| US60/504,135 | 2003-09-18 | ||
| US59146704P | 2004-07-26 | 2004-07-26 | |
| US60/591,467 | 2004-07-26 | ||
| PCT/US2004/031248 WO2005028434A2 (en) | 2003-09-18 | 2004-09-20 | Novel heterocyclic compounds as hsp90-inhibitors |
Publications (1)
| Publication Number | Publication Date |
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| CA2539548A1 true CA2539548A1 (en) | 2005-03-31 |
Family
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Family Applications (1)
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| CA002539548A Abandoned CA2539548A1 (en) | 2003-09-18 | 2004-09-20 | Novel heterocyclic compounds as hsp90-inhibitors |
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| JP (1) | JP2007505933A (enExample) |
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| AU (2) | AU2004274507B2 (enExample) |
| BR (1) | BRPI0414533A (enExample) |
| CA (1) | CA2539548A1 (enExample) |
| EA (1) | EA010160B1 (enExample) |
| IL (1) | IL174375A0 (enExample) |
| MX (1) | MXPA06002997A (enExample) |
| NO (1) | NO20061396L (enExample) |
| NZ (1) | NZ546611A (enExample) |
| WO (1) | WO2005028434A2 (enExample) |
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| US11524968B2 (en) | 2017-10-18 | 2022-12-13 | Hk Inno.N Corporation | Heterocyclic compound as a protein kinase inhibitor |
| US12180185B2 (en) | 2018-11-15 | 2024-12-31 | Hk Inno.N Corporation | Compound as protein kinase inhibitor, and pharmaceutical composition comprising thereof |
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- 2004-09-20 EP EP09157018A patent/EP2145888A1/en not_active Withdrawn
- 2004-09-20 KR KR1020067007478A patent/KR20060070572A/ko not_active Ceased
- 2004-09-20 EA EA200600594A patent/EA010160B1/ru not_active IP Right Cessation
- 2004-09-20 US US10/946,645 patent/US7138401B2/en not_active Expired - Lifetime
- 2004-09-20 US US10/946,628 patent/US7129244B2/en not_active Expired - Lifetime
- 2004-09-20 CN CN2010101575972A patent/CN101906106A/zh active Pending
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- 2004-09-20 EP EP04788954A patent/EP1670802A4/en not_active Withdrawn
- 2004-09-20 AU AU2004274507A patent/AU2004274507B2/en not_active Ceased
- 2004-09-20 US US10/946,637 patent/US7148228B2/en not_active Expired - Lifetime
- 2004-09-20 US US10/945,851 patent/US7138402B2/en not_active Expired - Lifetime
- 2004-09-20 WO PCT/US2004/031248 patent/WO2005028434A2/en not_active Ceased
- 2004-09-20 JP JP2006527162A patent/JP2007505933A/ja not_active Ceased
- 2004-09-20 NZ NZ546611A patent/NZ546611A/en not_active IP Right Cessation
- 2004-09-20 BR BRPI0414533-0A patent/BRPI0414533A/pt not_active IP Right Cessation
- 2004-09-20 MX MXPA06002997A patent/MXPA06002997A/es active IP Right Grant
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2006
- 2006-03-16 IL IL174375A patent/IL174375A0/en unknown
- 2006-03-27 NO NO20061396A patent/NO20061396L/no not_active Application Discontinuation
- 2006-09-12 US US11/531,218 patent/US20070173483A1/en not_active Abandoned
- 2006-09-12 US US11/531,221 patent/US20070185064A1/en not_active Abandoned
- 2006-09-29 US US11/537,002 patent/US20070111996A1/en not_active Abandoned
- 2006-09-29 US US11/537,017 patent/US20070111997A1/en not_active Abandoned
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11524968B2 (en) | 2017-10-18 | 2022-12-13 | Hk Inno.N Corporation | Heterocyclic compound as a protein kinase inhibitor |
| US12180185B2 (en) | 2018-11-15 | 2024-12-31 | Hk Inno.N Corporation | Compound as protein kinase inhibitor, and pharmaceutical composition comprising thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010202750A1 (en) | 2010-07-22 |
| US20070185064A1 (en) | 2007-08-09 |
| IL174375A0 (en) | 2006-08-01 |
| EA200600594A1 (ru) | 2006-10-27 |
| EP1670802A4 (en) | 2010-07-07 |
| NO20061396L (no) | 2006-06-16 |
| MXPA06002997A (es) | 2007-02-08 |
| JP2007505933A (ja) | 2007-03-15 |
| EA010160B1 (ru) | 2008-06-30 |
| AU2010202750B2 (en) | 2011-09-01 |
| CN101906106A (zh) | 2010-12-08 |
| US20050113340A1 (en) | 2005-05-26 |
| US20050107343A1 (en) | 2005-05-19 |
| US7129244B2 (en) | 2006-10-31 |
| KR20060070572A (ko) | 2006-06-23 |
| US20050113339A1 (en) | 2005-05-26 |
| US7148228B2 (en) | 2006-12-12 |
| US20070111997A1 (en) | 2007-05-17 |
| NZ546611A (en) | 2010-02-26 |
| BRPI0414533A (pt) | 2006-11-07 |
| US7138402B2 (en) | 2006-11-21 |
| AU2004274507B2 (en) | 2010-08-19 |
| US20070111996A1 (en) | 2007-05-17 |
| WO2005028434A2 (en) | 2005-03-31 |
| EP1670802A2 (en) | 2006-06-21 |
| US7138401B2 (en) | 2006-11-21 |
| EP2145888A1 (en) | 2010-01-20 |
| US20050119282A1 (en) | 2005-06-02 |
| US20070173483A1 (en) | 2007-07-26 |
| WO2005028434A3 (en) | 2006-03-23 |
| AU2004274507A1 (en) | 2005-03-31 |
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