DK1887359T3 - Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K - Google Patents

Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K

Info

Publication number
DK1887359T3
DK1887359T3 DK06016205T DK06016205T DK1887359T3 DK 1887359 T3 DK1887359 T3 DK 1887359T3 DK 06016205 T DK06016205 T DK 06016205T DK 06016205 T DK06016205 T DK 06016205T DK 1887359 T3 DK1887359 T3 DK 1887359T3
Authority
DK
Denmark
Prior art keywords
pi3k
phenylthiazole ligand
immobilized
phenylthiazole
ligand
Prior art date
Application number
DK06016205T
Other languages
English (en)
Inventor
Moore Giovanna Bergamini
Andrew Cansfield
Nigel Ramsden
Gitte Neubauer
Original Assignee
Cellzome Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ag filed Critical Cellzome Ag
Application granted granted Critical
Publication of DK1887359T3 publication Critical patent/DK1887359T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Water Treatments (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
DK06016205T 2006-08-03 2006-08-03 Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K DK1887359T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06016205A EP1887359B1 (en) 2006-08-03 2006-08-03 Methods for the identification of PI3K interacting molecules and for the purification of PI3K

Publications (1)

Publication Number Publication Date
DK1887359T3 true DK1887359T3 (da) 2009-03-02

Family

ID=37635850

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06016205T DK1887359T3 (da) 2006-08-03 2006-08-03 Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K

Country Status (12)

Country Link
US (1) US8153389B2 (da)
EP (1) EP1887359B1 (da)
JP (1) JP5234668B2 (da)
CN (1) CN101563612B (da)
AT (1) ATE414281T1 (da)
AU (1) AU2007280631B2 (da)
CA (1) CA2658904A1 (da)
DE (1) DE602006003651D1 (da)
DK (1) DK1887359T3 (da)
ES (1) ES2317382T3 (da)
HK (1) HK1111218A1 (da)
WO (1) WO2008015013A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007291190A1 (en) 2006-08-30 2008-03-06 Cellzome Limited Triazole derivatives as kinase inhibitors
BRPI0819606A2 (pt) 2007-11-27 2017-05-09 Cellzome Ltd amino triazóis como inobidores de pi3k
CN101965408B (zh) 2008-02-04 2013-08-28 塞尔卓姆有限责任公司 针对多重靶的pi3k相互作用分子的选择性概况分析
CN102027371A (zh) * 2008-05-16 2011-04-20 塞尔卓姆股份公司 Parp相互作用分子的鉴定方法和parp蛋白的纯化方法
WO2010092015A1 (en) 2009-02-10 2010-08-19 Cellzome Limited Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors
EP2406258B1 (en) 2009-03-13 2014-12-03 Cellzome Limited PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2414337B1 (en) 2009-04-03 2013-05-01 Cellzome GmbH Methods for the identification of kinase interacting molecules and for the purification of kinase proteins
WO2010133318A1 (en) 2009-05-20 2010-11-25 Cellzome Ag Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins
US9249129B2 (en) 2010-03-04 2016-02-02 Cellzome Limited Morpholino substituted urea derivatives as mTOR inhibitors
US20140163023A1 (en) 2011-04-04 2014-06-12 Cellzome Limited Dihydropyrrolo pyrimidine derivatives as mtor inhibitors
EP2758379B1 (en) 2011-09-21 2016-10-19 Cellzome Limited Urea and carbamate derivatives of 2-morpholino-1,3,5-triazine as mTOR inhibitors for the treatment of immunological or proliferative diseases
RU2609208C2 (ru) 2011-10-07 2017-01-31 Селлзоум Лимитед МОРФОЛИНО-ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ БИЦИКЛИЧЕСКИХ ПИРИМИДИНМОЧЕВИНЫ ИЛИ КАРБАМАТА В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR
US20160022757A1 (en) * 2013-03-15 2016-01-28 Icahn School Of Medicine At Mount Sinai Therapeutic methods for treating solid tumors and related diagnostic methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952512A (en) * 1984-06-22 1990-08-28 Loskutoff David J Gene encoding an inhibitor of tissue-type and urokinase-type plasminogen activators
US5994082A (en) * 1994-08-26 1999-11-30 Mach; Bernard Methods for the identification of inhibitors which suppress the activity of proteins displaying CIITA activity
CA2239463A1 (en) * 1996-11-01 1998-05-14 Onyx Pharmaceuticals, Inc. Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof
TWI314928B (en) 2002-02-28 2009-09-21 Novartis A 5-phenylthiazole derivatives and use as pi3 kinase inhibitors
EA010160B1 (ru) * 2003-09-18 2008-06-30 Конформа Терапьютикс Корпорейшн Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения
SE0402735D0 (sv) * 2004-11-09 2004-11-09 Astrazeneca Ab Novel compounds
EP1891446B1 (en) * 2005-06-14 2013-04-10 Cellzome GmbH Process for the identification of novel enzyme interacting compounds
CN101965408B (zh) 2008-02-04 2013-08-28 塞尔卓姆有限责任公司 针对多重靶的pi3k相互作用分子的选择性概况分析

Also Published As

Publication number Publication date
ATE414281T1 (de) 2008-11-15
CN101563612A (zh) 2009-10-21
HK1111218A1 (en) 2008-08-01
AU2007280631A1 (en) 2008-02-07
EP1887359B1 (en) 2008-11-12
US8153389B2 (en) 2012-04-10
AU2007280631B2 (en) 2013-02-21
JP2010500870A (ja) 2010-01-14
CN101563612B (zh) 2013-05-29
JP5234668B2 (ja) 2013-07-10
ES2317382T3 (es) 2009-04-16
CA2658904A1 (en) 2008-02-07
DE602006003651D1 (de) 2008-12-24
EP1887359A1 (en) 2008-02-13
WO2008015013A1 (en) 2008-02-07
US20100055711A1 (en) 2010-03-04

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