ATE414281T1 - Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k - Google Patents
Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3kInfo
- Publication number
- ATE414281T1 ATE414281T1 AT06016205T AT06016205T ATE414281T1 AT E414281 T1 ATE414281 T1 AT E414281T1 AT 06016205 T AT06016205 T AT 06016205T AT 06016205 T AT06016205 T AT 06016205T AT E414281 T1 ATE414281 T1 AT E414281T1
- Authority
- AT
- Austria
- Prior art keywords
- pi3k
- phenylthiazole ligand
- immobilized
- phenylthiazole
- ligand
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06016205A EP1887359B1 (de) | 2006-08-03 | 2006-08-03 | Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE414281T1 true ATE414281T1 (de) | 2008-11-15 |
Family
ID=37635850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06016205T ATE414281T1 (de) | 2006-08-03 | 2006-08-03 | Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k |
Country Status (12)
Country | Link |
---|---|
US (1) | US8153389B2 (de) |
EP (1) | EP1887359B1 (de) |
JP (1) | JP5234668B2 (de) |
CN (1) | CN101563612B (de) |
AT (1) | ATE414281T1 (de) |
AU (1) | AU2007280631B2 (de) |
CA (1) | CA2658904A1 (de) |
DE (1) | DE602006003651D1 (de) |
DK (1) | DK1887359T3 (de) |
ES (1) | ES2317382T3 (de) |
HK (1) | HK1111218A1 (de) |
WO (1) | WO2008015013A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG174086A1 (en) | 2006-08-30 | 2011-09-29 | Cellzome Ltd | Triazole derivatives as kinase inhibitors |
SG186040A1 (en) | 2007-11-27 | 2012-12-28 | Cellzome Ltd | Amino triazoles as pi3k inhibitors |
AU2009211845A1 (en) * | 2008-02-04 | 2009-08-13 | Cellzome Gmbh | Selectivity profiling of PI3K interacting molecules against multiple targets |
ATE547707T1 (de) * | 2008-05-16 | 2012-03-15 | Cellzome Ag | Verfahren zur identifizierung von mit parp wechselwirkenden molekülen und zur aufreinigung von parp-proteinen |
WO2010092015A1 (en) | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
CA2755061A1 (en) | 2009-03-13 | 2010-09-16 | Cellzome Limited | Pyrimidine derivatives as mtor inhibitors |
ES2423804T3 (es) | 2009-04-03 | 2013-09-24 | Cellzome Gmbh | Métodos para la identificación de moléculas que interaccionan con cinasas y para la purificación de proteínas de cinasa |
US8367830B2 (en) | 2009-05-20 | 2013-02-05 | Cellzome Ag | Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins |
US9249129B2 (en) | 2010-03-04 | 2016-02-02 | Cellzome Limited | Morpholino substituted urea derivatives as mTOR inhibitors |
US20140163023A1 (en) | 2011-04-04 | 2014-06-12 | Cellzome Limited | Dihydropyrrolo pyrimidine derivatives as mtor inhibitors |
BR112014006743A8 (pt) | 2011-09-21 | 2018-01-09 | Cellzome Ltd | composto, uso de um composto, e, método para tratar, controlar, retardar ou impedir uma ou mais condições |
US9242993B2 (en) | 2011-10-07 | 2016-01-26 | Cellzome Limited | Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors |
US20160022757A1 (en) * | 2013-03-15 | 2016-01-28 | Icahn School Of Medicine At Mount Sinai | Therapeutic methods for treating solid tumors and related diagnostic methods |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4952512A (en) * | 1984-06-22 | 1990-08-28 | Loskutoff David J | Gene encoding an inhibitor of tissue-type and urokinase-type plasminogen activators |
US5994082A (en) * | 1994-08-26 | 1999-11-30 | Mach; Bernard | Methods for the identification of inhibitors which suppress the activity of proteins displaying CIITA activity |
CA2239463A1 (en) * | 1996-11-01 | 1998-05-14 | Onyx Pharmaceuticals, Inc. | Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof |
PE20030968A1 (es) * | 2002-02-28 | 2004-01-12 | Novartis Ag | Derivados de 5-feniltiazol como inhibidores de cinasas |
KR20060070572A (ko) * | 2003-09-18 | 2006-06-23 | 콘포마 세러퓨틱스 코포레이션 | Hsp90-저해제로서의 신규 헤테로시클릭 화합물 |
SE0402735D0 (sv) * | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
WO2006134056A1 (en) | 2005-06-14 | 2006-12-21 | Cellzome Ag | Process for the identification of novel enzyme interacting compounds |
AU2009211845A1 (en) | 2008-02-04 | 2009-08-13 | Cellzome Gmbh | Selectivity profiling of PI3K interacting molecules against multiple targets |
-
2006
- 2006-08-03 DK DK06016205T patent/DK1887359T3/da active
- 2006-08-03 ES ES06016205T patent/ES2317382T3/es active Active
- 2006-08-03 DE DE602006003651T patent/DE602006003651D1/de active Active
- 2006-08-03 EP EP06016205A patent/EP1887359B1/de not_active Not-in-force
- 2006-08-03 AT AT06016205T patent/ATE414281T1/de active
-
2007
- 2007-08-03 JP JP2009522180A patent/JP5234668B2/ja not_active Expired - Fee Related
- 2007-08-03 CN CN2007800344464A patent/CN101563612B/zh not_active Expired - Fee Related
- 2007-08-03 WO PCT/EP2007/006887 patent/WO2008015013A1/en active Application Filing
- 2007-08-03 AU AU2007280631A patent/AU2007280631B2/en not_active Ceased
- 2007-08-03 CA CA002658904A patent/CA2658904A1/en not_active Abandoned
- 2007-08-03 US US12/375,979 patent/US8153389B2/en not_active Expired - Fee Related
-
2008
- 2008-05-26 HK HK08105830.5A patent/HK1111218A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP5234668B2 (ja) | 2013-07-10 |
DK1887359T3 (da) | 2009-03-02 |
WO2008015013A1 (en) | 2008-02-07 |
DE602006003651D1 (de) | 2008-12-24 |
US8153389B2 (en) | 2012-04-10 |
HK1111218A1 (en) | 2008-08-01 |
CA2658904A1 (en) | 2008-02-07 |
CN101563612A (zh) | 2009-10-21 |
AU2007280631A1 (en) | 2008-02-07 |
CN101563612B (zh) | 2013-05-29 |
JP2010500870A (ja) | 2010-01-14 |
ES2317382T3 (es) | 2009-04-16 |
EP1887359B1 (de) | 2008-11-12 |
EP1887359A1 (de) | 2008-02-13 |
AU2007280631B2 (en) | 2013-02-21 |
US20100055711A1 (en) | 2010-03-04 |
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