ATE414281T1 - Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k - Google Patents

Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k

Info

Publication number
ATE414281T1
ATE414281T1 AT06016205T AT06016205T ATE414281T1 AT E414281 T1 ATE414281 T1 AT E414281T1 AT 06016205 T AT06016205 T AT 06016205T AT 06016205 T AT06016205 T AT 06016205T AT E414281 T1 ATE414281 T1 AT E414281T1
Authority
AT
Austria
Prior art keywords
pi3k
phenylthiazole ligand
immobilized
phenylthiazole
ligand
Prior art date
Application number
AT06016205T
Other languages
English (en)
Inventor
Moore Giovanna Bergamini
Andrew Cansfield
Nigel Ramsden
Gitte Neubauer
Original Assignee
Cellzome Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ag filed Critical Cellzome Ag
Application granted granted Critical
Publication of ATE414281T1 publication Critical patent/ATE414281T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Vending Machines For Individual Products (AREA)
  • Networks Using Active Elements (AREA)
AT06016205T 2006-08-03 2006-08-03 Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k ATE414281T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06016205A EP1887359B1 (de) 2006-08-03 2006-08-03 Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K

Publications (1)

Publication Number Publication Date
ATE414281T1 true ATE414281T1 (de) 2008-11-15

Family

ID=37635850

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06016205T ATE414281T1 (de) 2006-08-03 2006-08-03 Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k

Country Status (11)

Country Link
US (1) US8153389B2 (de)
EP (1) EP1887359B1 (de)
JP (1) JP5234668B2 (de)
CN (1) CN101563612B (de)
AT (1) ATE414281T1 (de)
AU (1) AU2007280631B2 (de)
CA (1) CA2658904A1 (de)
DE (1) DE602006003651D1 (de)
DK (1) DK1887359T3 (de)
ES (1) ES2317382T3 (de)
WO (1) WO2008015013A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5336375B2 (ja) 2006-08-30 2013-11-06 セルゾーム リミテッド キナーゼ阻害剤としてのトリアゾール誘導体
MX2010005700A (es) 2007-11-27 2010-06-11 Cellzome Ltd Amino triazoles como inhibidores pi3k.
US20110111972A1 (en) * 2008-02-04 2011-05-12 Cellzome Ag Selectivity profiling of pi3k interacting molecules against multiple targets
JP2011521214A (ja) * 2008-05-16 2011-07-21 セルゾーム アーゲー Ｐａｒｐ相互作用分子の同定およびｐａｒｐタンパク質の精製のための方法
WO2010092015A1 (en) 2009-02-10 2010-08-19 Cellzome Limited Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors
WO2010103094A1 (en) 2009-03-13 2010-09-16 Cellzome Limited PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2414337B1 (de) 2009-04-03 2013-05-01 Cellzome GmbH Verfahren zur Identifizierung von mit Kinase interagierenden Molekülen und zur Reinigung von Kinase-Proteinen
EP2432782A1 (de) 2009-05-20 2012-03-28 Cellzome Ag Verfahren zur identifizierung von mit phosphatidylinositkinase wechselwirkenden molekülen und zur aufreinigung von phosphatidylinositkinaseproteinen
US9249129B2 (en) 2010-03-04 2016-02-02 Cellzome Limited Morpholino substituted urea derivatives as mTOR inhibitors
JP2014510122A (ja) 2011-04-04 2014-04-24 セルゾーム リミテッド ｍＴＯＲ阻害剤としてのジヒドロピロロピリミジン誘導体
ES2609606T3 (es) 2011-09-21 2017-04-21 Cellzome Limited Derivados de urea y carbamato de 2-morfolino-1,3,5-triazina como inhibidores de mTOR para el tratamiento de enfermedades inmunológicas o proliferativas
BR112014008241A2 (pt) 2011-10-07 2017-04-18 Cellzome Ltd composto, composição farmacêutica, métodos para tratar, controlar, retardar ou prevenir doenças e distúrbios, e para preparar um composto, e, uso de um composto
US20160022757A1 (en) * 2013-03-15 2016-01-28 Icahn School Of Medicine At Mount Sinai Therapeutic methods for treating solid tumors and related diagnostic methods
CN115754306A (zh) * 2022-12-02 2023-03-07 中国科学院生态环境研究中心 化合物下拉靶点蛋白的方法
CN116773823A (zh) * 2023-06-25 2023-09-19 济宁医学院附属医院 一种快速鉴定与蛋白相互作用的小分子代谢物配体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952512A (en) * 1984-06-22 1990-08-28 Loskutoff David J Gene encoding an inhibitor of tissue-type and urokinase-type plasminogen activators
US5994082A (en) * 1994-08-26 1999-11-30 Mach; Bernard Methods for the identification of inhibitors which suppress the activity of proteins displaying CIITA activity
AU735357B2 (en) * 1996-11-01 2001-07-05 Onyx Pharmaceuticals, Inc. Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof
TWI314928B (en) 2002-02-28 2009-09-21 Novartis A 5-phenylthiazole derivatives and use as pi3 kinase inhibitors
KR20060070572A (ko) * 2003-09-18 2006-06-23 콘포마 세러퓨틱스 코포레이션 Ｈｓｐ90-저해제로서의 신규 헤테로시클릭 화합물
SE0402735D0 (sv) * 2004-11-09 2004-11-09 Astrazeneca Ab Novel compounds
PL1891446T3 (pl) 2005-06-14 2013-08-30 Cellzome Gmbh Sposób identyfikacji nowych związków oddziałujących z enzymami
US20110111972A1 (en) 2008-02-04 2011-05-12 Cellzome Ag Selectivity profiling of pi3k interacting molecules against multiple targets

Also Published As

Publication number Publication date
EP1887359B1 (de) 2008-11-12
CN101563612A (zh) 2009-10-21
ES2317382T3 (es) 2009-04-16
US8153389B2 (en) 2012-04-10
CA2658904A1 (en) 2008-02-07
JP5234668B2 (ja) 2013-07-10
HK1111218A1 (en) 2008-08-01
DK1887359T3 (da) 2009-03-02
JP2010500870A (ja) 2010-01-14
WO2008015013A1 (en) 2008-02-07
AU2007280631B2 (en) 2013-02-21
US20100055711A1 (en) 2010-03-04
CN101563612B (zh) 2013-05-29
AU2007280631A1 (en) 2008-02-07
DE602006003651D1 (de) 2008-12-24
EP1887359A1 (de) 2008-02-13

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