EP1962863A4 - Orally active purine-based inhibitors of heat shock protein 90 - Google Patents

Orally active purine-based inhibitors of heat shock protein 90

Info

Publication number
EP1962863A4
EP1962863A4 EP06845721A EP06845721A EP1962863A4 EP 1962863 A4 EP1962863 A4 EP 1962863A4 EP 06845721 A EP06845721 A EP 06845721A EP 06845721 A EP06845721 A EP 06845721A EP 1962863 A4 EP1962863 A4 EP 1962863A4
Authority
EP
European Patent Office
Prior art keywords
heat shock
shock protein
orally active
based inhibitors
active purine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06845721A
Other languages
German (de)
French (fr)
Other versions
EP1962863A2 (en
Inventor
Srinivas R Kasibhatla
Lin Zhang
Marcus F Boehm
Junhua Fan
Kevin D Hong
Marco Biamonte
Jiandong Shi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Conforma Therapeutics Corp
Original Assignee
Conforma Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conforma Therapeutics Corp filed Critical Conforma Therapeutics Corp
Publication of EP1962863A2 publication Critical patent/EP1962863A2/en
Publication of EP1962863A4 publication Critical patent/EP1962863A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
EP06845721A 2005-12-22 2006-12-18 Orally active purine-based inhibitors of heat shock protein 90 Withdrawn EP1962863A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75344805P 2005-12-22 2005-12-22
US75369805P 2005-12-22 2005-12-22
US75363605P 2005-12-22 2005-12-22
PCT/US2006/048250 WO2007075572A2 (en) 2005-12-22 2006-12-18 Orally active purine-based inhibitors of heat shock protein 90

Publications (2)

Publication Number Publication Date
EP1962863A2 EP1962863A2 (en) 2008-09-03
EP1962863A4 true EP1962863A4 (en) 2010-11-24

Family

ID=38218505

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06845721A Withdrawn EP1962863A4 (en) 2005-12-22 2006-12-18 Orally active purine-based inhibitors of heat shock protein 90

Country Status (5)

Country Link
EP (1) EP1962863A4 (en)
JP (1) JP2009521446A (en)
AU (1) AU2006331917A1 (en)
CA (1) CA2634723A1 (en)
WO (1) WO2007075572A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2038041A4 (en) * 2006-05-12 2010-02-17 Myriad Genetics Inc Therapeutic compounds and their use in cancer
KR101313804B1 (en) * 2007-03-20 2013-10-01 쿠리스 인코퍼레이션 Fused amino pyridine as hsp90 inhibitors
JP2011503206A (en) * 2007-11-14 2011-01-27 ミレクシス， インコーポレイテッド Therapeutic compounds and methods of use thereof in the treatment of diseases and disorders
WO2010083403A1 (en) 2009-01-16 2010-07-22 Curis, Inc. Fused amino pyridines for the treatment of brain tumors
KR102010222B1 (en) 2011-04-05 2019-08-13 슬로안-케테링인스티튜트퍼캔서리서치 Hsp90 inhibitors
CA2832099C (en) 2011-04-05 2019-07-09 Sloan-Kettering Institute For Cancer Research Hsp90 inhibitors
EP2912036A1 (en) 2012-10-04 2015-09-02 Pfizer Limited Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
AU2014306417C1 (en) 2013-08-16 2019-07-25 Memorial Sloan-Kettering Cancer Center Selective Grp94 inhibitors and uses thereof
CN109721499A (en) * 2018-12-19 2019-05-07 南京杰科丰环保技术装备研究院有限公司 A kind of nitrotoleune adds hydrogen to prepare the preparation method of methylaniline

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037860A2 (en) * 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
US20040102458A1 (en) * 2000-11-02 2004-05-27 Gabriela Chiosis Small molecule compositions for binding to hsp90
WO2006084030A2 (en) * 2005-02-01 2006-08-10 Sloan-Kettering Institute For Cancer Research Small-molecule hsp90 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971972A (en) * 1989-03-23 1990-11-20 Schering Corporation Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
US7129239B2 (en) * 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
US7138401B2 (en) * 2003-09-18 2006-11-21 Conforma Therapeutics Corporation 2-aminopurine analogs having HSP90-inhibiting activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040102458A1 (en) * 2000-11-02 2004-05-27 Gabriela Chiosis Small molecule compositions for binding to hsp90
WO2003037860A2 (en) * 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
US20050049263A1 (en) * 2001-10-30 2005-03-03 Kasibhatla Srinivas Rao Purine analogs having hsp90-inhibiting activity
WO2006084030A2 (en) * 2005-02-01 2006-08-10 Sloan-Kettering Institute For Cancer Research Small-molecule hsp90 inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
L. LLAUGER ET AL.: "Evaluation of 8-Arylsulfany, 8-Arylsulfoxyl, and 8-Arylsulfonyl Adenine Derivatives as Inhibitors of the Heat Shock Protein 90", J. MED. CHEM., vol. 48, no. 8, 25 March 2005 (2005-03-25), pages 2892 - 2905, XP002602270 *
M. A. BIAMONTE ET AL.: "Preparation of 8-(Arylsulfanyl)adenines with Diazonium Salts under Mild, Aerobic Conditions", J. ORG. CHEM., vol. 70, no. 2, 21 December 2004 (2004-12-21), pages 717 - 720, XP002602397 *

Also Published As

Publication number Publication date
JP2009521446A (en) 2009-06-04
AU2006331917A1 (en) 2007-07-05
EP1962863A2 (en) 2008-09-03
CA2634723A1 (en) 2007-07-05
WO2007075572A3 (en) 2009-05-07
WO2007075572A2 (en) 2007-07-05

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20080328

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SHI, JIANDONG

Inventor name: BIAMONTE, MARCO

Inventor name: HONG, KEVIN D.

Inventor name: FAN, JUNHUA

Inventor name: BOEHM, MARCUS F.

Inventor name: ZHANG, LIN

Inventor name: KASIBHATLA, SRINIVAS R.

R17D Deferred search report published (corrected)

Effective date: 20090507

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 473/00 20060101ALI20090623BHEP

Ipc: A61K 31/675 20060101AFI20090623BHEP

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/675 20060101ALI20100929BHEP

Ipc: C07D 473/36 20060101AFI20100929BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20101027

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20110526