MX2011008677A - Derivados de pirazolopirimidina triciclicos. - Google Patents

Derivados de pirazolopirimidina triciclicos.

Info

Publication number
MX2011008677A
MX2011008677A MX2011008677A MX2011008677A MX2011008677A MX 2011008677 A MX2011008677 A MX 2011008677A MX 2011008677 A MX2011008677 A MX 2011008677A MX 2011008677 A MX2011008677 A MX 2011008677A MX 2011008677 A MX2011008677 A MX 2011008677A
Authority
MX
Mexico
Prior art keywords
formula
compound represented
hsp90
inhibits
activity
Prior art date
Application number
MX2011008677A
Other languages
English (en)
Inventor
Nobuyuki Suzuki
Masahiro Ikeda
Yoshihiro Shibata
Hitoshi Ohki
Masahiro Ota
Toshiyuki Nakanishi
Yasusi Ueda
Tooru Okayama
Shinji Matuura
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of MX2011008677A publication Critical patent/MX2011008677A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/16—Peri-condensed systems

Abstract

Se describe un compuesto novedoso que inhibe una actividad de HSP90, en particular un compuesto novedoso que inhibe una función de HSP90 como una proteína chaperona y que tiene una actividad antitumoral. Se describen específicamente: un compuesto de pirazolopirimidina representado por la fórmula (1) (ver fórmula (I)) que tiene varios sustituyentes, el cual inhibe una actividad ATPasa de HSP90 y tiene una actividad antitumoral; un inhibidor de HSP90 que contiene un compuesto representado por la fórmula (1); una formulación farmacéutica que contiene un compuesto representado por la fórmula (1); un agente antitumoral que contiene un compuesto representado por la fórmula (1); una composición farmacéutica que contiene un compuesto representado por la fórmula (1); y un método para tratar un cáncer, en el que se usa el compuesto representado por la fórmula (1).
MX2011008677A 2009-02-25 2010-02-24 Derivados de pirazolopirimidina triciclicos. MX2011008677A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009042963 2009-02-25
PCT/JP2010/052855 WO2010098344A1 (ja) 2009-02-25 2010-02-24 三環性ピラゾロピリミジン誘導体

Publications (1)

Publication Number Publication Date
MX2011008677A true MX2011008677A (es) 2011-09-08

Family

ID=42665550

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011008677A MX2011008677A (es) 2009-02-25 2010-02-24 Derivados de pirazolopirimidina triciclicos.

Country Status (17)

Country Link
US (2) US8236813B2 (es)
EP (1) EP2402349B1 (es)
JP (1) JP5565913B2 (es)
KR (1) KR20110131190A (es)
CN (1) CN102333781B (es)
AU (1) AU2010218853A1 (es)
BR (1) BRPI1008000A2 (es)
CA (1) CA2753304C (es)
CO (1) CO6430466A2 (es)
ES (1) ES2576056T3 (es)
IL (1) IL214541A (es)
MX (1) MX2011008677A (es)
NZ (1) NZ595233A (es)
RU (1) RU2520966C2 (es)
SG (1) SG173829A1 (es)
TW (1) TWI441829B (es)
WO (1) WO2010098344A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011008677A (es) * 2009-02-25 2011-09-08 Daiichi Sankyo Co Ltd Derivados de pirazolopirimidina triciclicos.
EP2610260A4 (en) * 2010-08-23 2014-01-15 Daiichi Sankyo Co Ltd TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE IN CRYSTALLINE FORM
KR20130099006A (ko) * 2010-08-23 2013-09-05 다이이찌 산쿄 가부시키가이샤 3 고리성 피라졸로피리미딘 유도체의 프리체 결정
CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
US20170327504A1 (en) * 2014-10-30 2017-11-16 Sandoz Ag Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
WO2018079988A1 (ko) * 2016-10-26 2018-05-03 울산과학기술원 Trap1 저해제로서 유용한 화합물 및 이를 포함하는 항암용 조성물

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250527A (en) 1985-10-24 1993-10-05 Smithkline & French Laboratories Limited Pyridyl containing benzimidazoles, compositions and use
RU2167877C2 (ru) * 1995-05-31 2001-05-27 Эйсай Ко., Лтд. Производные конденсированных полициклических гетероциклических соединений и способ их получения
WO1998043991A1 (en) 1997-04-02 1998-10-08 Amersham Pharmacia Biotech Uk Limited Tricyclic base analogues
GB0024795D0 (en) 2000-10-10 2000-11-22 Hoffmann La Roche Pyrazole derivatives for the treatment of viral diseases
JP3988830B2 (ja) 2002-11-22 2007-10-10 日本たばこ産業株式会社 縮合二環式窒素含有複素環
BRPI0414019A (pt) 2003-08-27 2006-10-24 Biota Inc nucleosìdios ou nucleotìdio tricìclicos como agentes terapêuticos
WO2005028434A2 (en) 2003-09-18 2005-03-31 Conforma Therapeutics Corporation Novel heterocyclic compounds as hsp90-inhibitors
WO2006015263A2 (en) 2004-07-29 2006-02-09 Threshold Pharmaceuticals, Inc. Lonidamine analogs
PT2065388E (pt) * 2006-09-19 2011-11-10 Daiichi Sankyo Co Ltd Derivado de pirazolopirimidina
CL2007002994A1 (es) 2006-10-19 2008-02-08 Wyeth Corp Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros.
CA2675677A1 (en) 2007-02-01 2008-08-07 Astrazeneca Ab 5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors
US8324179B2 (en) 2007-02-09 2012-12-04 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
JP2009256323A (ja) * 2008-03-17 2009-11-05 Daiichi Sankyo Co Ltd ピラゾロピリミジン誘導体
MX2011008677A (es) * 2009-02-25 2011-09-08 Daiichi Sankyo Co Ltd Derivados de pirazolopirimidina triciclicos.

Also Published As

Publication number Publication date
CO6430466A2 (es) 2012-04-30
EP2402349B1 (en) 2016-04-06
RU2011139157A (ru) 2013-04-20
JP5565913B2 (ja) 2014-08-06
CN102333781B (zh) 2014-06-11
SG173829A1 (en) 2011-09-29
US20120202833A1 (en) 2012-08-09
TW201036982A (en) 2010-10-16
CA2753304A1 (en) 2010-09-02
CA2753304C (en) 2014-07-15
IL214541A0 (en) 2011-09-27
AU2010218853A1 (en) 2011-10-06
ES2576056T3 (es) 2016-07-05
TWI441829B (zh) 2014-06-21
US8445504B2 (en) 2013-05-21
CN102333781A (zh) 2012-01-25
JPWO2010098344A1 (ja) 2012-09-06
EP2402349A1 (en) 2012-01-04
RU2520966C2 (ru) 2014-06-27
US20110071170A1 (en) 2011-03-24
BRPI1008000A2 (pt) 2016-02-23
KR20110131190A (ko) 2011-12-06
EP2402349A4 (en) 2012-05-30
US8236813B2 (en) 2012-08-07
IL214541A (en) 2014-06-30
NZ595233A (en) 2013-01-25
WO2010098344A1 (ja) 2010-09-02

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