MX2010008844A - Proceso para preparar derivados de piridona 226. - Google Patents

Proceso para preparar derivados de piridona 226.

Info

Publication number
MX2010008844A
MX2010008844A MX2010008844A MX2010008844A MX2010008844A MX 2010008844 A MX2010008844 A MX 2010008844A MX 2010008844 A MX2010008844 A MX 2010008844A MX 2010008844 A MX2010008844 A MX 2010008844A MX 2010008844 A MX2010008844 A MX 2010008844A
Authority
MX
Mexico
Prior art keywords
route
preparing
pyridone derivatives
formula
preparing pyridone
Prior art date
Application number
MX2010008844A
Other languages
English (en)
Inventor
John Leonard
Mark Richard Fielding
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2010008844A publication Critical patent/MX2010008844A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Una ruta para la preparación de un compuesto de fórmula (I), en donde X, R1, R2, R7, R8 y R9 son tal como se describen y definen en la especificación. Proceso de las etapas seguidas en la ruta e intermediarios nuevos preparados durante la ruta también son descritos y reivindicados. Los compuestos de fórmula (I) son utilizados en la elaboración de compuestos farmacéuticos, en particular, los inhibidores de MEK, útiles en el tratamiento de enfermedades hiperproliferativas como el cáncer y las enfermedades inflamatorias.
MX2010008844A 2008-02-11 2009-02-09 Proceso para preparar derivados de piridona 226. MX2010008844A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2758208P 2008-02-11 2008-02-11
PCT/GB2009/050124 WO2009101432A2 (en) 2008-02-11 2009-02-09 Process for preparing pyridone derivatives 226

Publications (1)

Publication Number Publication Date
MX2010008844A true MX2010008844A (es) 2010-09-07

Family

ID=40677907

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008844A MX2010008844A (es) 2008-02-11 2009-02-09 Proceso para preparar derivados de piridona 226.

Country Status (12)

Country Link
US (1) US20110015392A1 (es)
EP (1) EP2252588A2 (es)
JP (1) JP2011511784A (es)
KR (1) KR20100122921A (es)
CN (1) CN101939298A (es)
AU (1) AU2009213828A1 (es)
BR (1) BRPI0908782A2 (es)
CA (1) CA2713722A1 (es)
IL (1) IL207165A0 (es)
MX (1) MX2010008844A (es)
RU (1) RU2010137639A (es)
WO (1) WO2009101432A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101973936B (zh) * 2010-09-28 2012-02-08 太原理工大学 一种吡啶酮衍生物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT392789B (de) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten
US20020019527A1 (en) * 2000-04-27 2002-02-14 Wei-Bo Wang Substituted phenyl farnesyltransferase inhibitors
US7517994B2 (en) * 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) * 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof

Also Published As

Publication number Publication date
BRPI0908782A2 (pt) 2017-06-13
AU2009213828A1 (en) 2009-08-20
CN101939298A (zh) 2011-01-05
US20110015392A1 (en) 2011-01-20
KR20100122921A (ko) 2010-11-23
WO2009101432A3 (en) 2009-10-22
WO2009101432A2 (en) 2009-08-20
CA2713722A1 (en) 2009-08-20
JP2011511784A (ja) 2011-04-14
EP2252588A2 (en) 2010-11-24
IL207165A0 (en) 2010-12-30
RU2010137639A (ru) 2012-03-20

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal