MX2022013890A - Sintesis y derivados de acido boronico, formas polimorficas y usos terapeuticos de los mismos. - Google Patents

Sintesis y derivados de acido boronico, formas polimorficas y usos terapeuticos de los mismos.

Info

Publication number
MX2022013890A
MX2022013890A MX2022013890A MX2022013890A MX2022013890A MX 2022013890 A MX2022013890 A MX 2022013890A MX 2022013890 A MX2022013890 A MX 2022013890A MX 2022013890 A MX2022013890 A MX 2022013890A MX 2022013890 A MX2022013890 A MX 2022013890A
Authority
MX
Mexico
Prior art keywords
acid derivatives
boronic acid
polymorphic forms
synthesis
therapeutic uses
Prior art date
Application number
MX2022013890A
Other languages
English (en)
Inventor
Yuanqing Fang
Laurent Lefort
Serge Henri Boyer
Scott J Hecker
Matthew M Bio
De Castro Angela Gonzales
Zuolin Zhu
Thomas Linder
Original Assignee
Qpex Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qpex Biopharma Inc filed Critical Qpex Biopharma Inc
Publication of MX2022013890A publication Critical patent/MX2022013890A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
    • B01J23/74—Iron group metals
    • B01J23/755—Nickel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

En la presente se describen compuestos antimicrobianos, formas polimórficas, composiciones, composiciones farmacéuticas, el método de uso y preparación de los mismos. Algunas modalidades se refieren a derivados de ácido borónico y su uso como agentes terapéuticos, por ejemplo, inhibidores de ß-lactamasa (BLI).
MX2022013890A 2020-05-05 2021-05-04 Sintesis y derivados de acido boronico, formas polimorficas y usos terapeuticos de los mismos. MX2022013890A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063020494P 2020-05-05 2020-05-05
PCT/US2021/030690 WO2021226114A1 (en) 2020-05-05 2021-05-04 Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
MX2022013890A true MX2022013890A (es) 2022-11-30

Family

ID=78468362

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022013890A MX2022013890A (es) 2020-05-05 2021-05-04 Sintesis y derivados de acido boronico, formas polimorficas y usos terapeuticos de los mismos.

Country Status (12)

Country Link
US (1) US12552815B2 (es)
EP (1) EP4149949A4 (es)
JP (1) JP2023524525A (es)
KR (1) KR20230020419A (es)
CN (1) CN115996933A (es)
AU (1) AU2021266715A1 (es)
BR (1) BR112022022367A2 (es)
CA (1) CA3180499A1 (es)
IL (1) IL297458A (es)
MX (1) MX2022013890A (es)
TW (1) TW202207945A (es)
WO (1) WO2021226114A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA124464C2 (uk) 2016-06-30 2021-09-22 Кьюпекс Біофарма, Інк. Похідні боронової кислоти та їх терапевтичні застосування
CN114539305B (zh) * 2022-02-24 2023-10-31 川北医学院 一种通过对苯并呋喃去芳构化制备双键有机化合物的方法
CN119118844B (zh) * 2023-06-13 2025-12-19 中国科学院兰州化学物理研究所 一种咪唑类化合物结构重整制备n-苯基苯二胺类化合物的方法
WO2025247268A1 (zh) * 2024-05-28 2025-12-04 江苏恒瑞医药股份有限公司 作为β-内酰胺酶抑制剂的硼酸衍生物的制备方法

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