PT2928898T - Inibidores de beta-lactamase - Google Patents
Inibidores de beta-lactamaseInfo
- Publication number
- PT2928898T PT2928898T PT138611983T PT13861198T PT2928898T PT 2928898 T PT2928898 T PT 2928898T PT 138611983 T PT138611983 T PT 138611983T PT 13861198 T PT13861198 T PT 13861198T PT 2928898 T PT2928898 T PT 2928898T
- Authority
- PT
- Portugal
- Prior art keywords
- beta
- lactamase inhibitors
- lactamase
- inhibitors
- Prior art date
Links
- 239000003781 beta lactamase inhibitor Substances 0.000 title 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261734900P | 2012-12-07 | 2012-12-07 | |
US201361783238P | 2013-03-14 | 2013-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2928898T true PT2928898T (pt) | 2021-07-05 |
Family
ID=50884012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT138611983T PT2928898T (pt) | 2012-12-07 | 2013-12-05 | Inibidores de beta-lactamase |
Country Status (17)
Country | Link |
---|---|
US (5) | US9422314B2 (pt) |
EP (2) | EP3922635A1 (pt) |
JP (2) | JP6403219B2 (pt) |
KR (1) | KR102147420B1 (pt) |
CN (1) | CN105026407B (pt) |
AU (1) | AU2013355110B2 (pt) |
BR (1) | BR112015013123B1 (pt) |
CA (1) | CA2893943C (pt) |
ES (1) | ES2878118T3 (pt) |
HK (1) | HK1217334A1 (pt) |
HR (1) | HRP20210879T1 (pt) |
IL (1) | IL239212B (pt) |
PL (1) | PL2928898T3 (pt) |
PT (1) | PT2928898T (pt) |
RU (1) | RU2654692C2 (pt) |
WO (1) | WO2014089365A1 (pt) |
ZA (1) | ZA201504200B (pt) |
Families Citing this family (47)
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HUE048859T2 (hu) | 2010-08-10 | 2020-08-28 | Rempex Pharmaceuticals Inc | Gyûrûs bórsavészter származékok, eljárás elõállításukra, és terápiás alkalmazásuk |
WO2013033461A1 (en) | 2011-08-31 | 2013-03-07 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
KR102147420B1 (ko) | 2012-12-07 | 2020-08-25 | 베나토알엑스 파마슈티컬스, 인크. | 베타-락타마제 억제제 |
US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
EP2941247A4 (en) | 2013-01-04 | 2017-02-08 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
KR20150103269A (ko) * | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
US9403850B2 (en) | 2013-01-10 | 2016-08-02 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
WO2014151958A1 (en) | 2013-03-14 | 2014-09-25 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
EP3140310B1 (en) | 2014-05-05 | 2019-08-07 | Rempex Pharmaceuticals, Inc. | Synthesis of boronate salts and uses thereof |
EP3139930B1 (en) | 2014-05-05 | 2024-08-14 | Melinta Therapeutics, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
MX2016015093A (es) | 2014-05-19 | 2017-03-27 | Rempex Pharmaceuticals Inc | Derivados de acido boronico y sus usos terapeuticos. |
US20150361108A1 (en) * | 2014-06-11 | 2015-12-17 | VenatoRx Pharmaceuticals, Inc. | Orally bioavailable beta-lactamase inhibitors |
KR20220065084A (ko) * | 2014-06-11 | 2022-05-19 | 베나토알엑스 파마슈티컬스, 인크. | 베타-락타마제 억제제 |
US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
EP3164406A4 (en) * | 2014-07-01 | 2018-04-04 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
WO2016100043A1 (en) * | 2014-12-19 | 2016-06-23 | Rempex Pharmaceuticals, Inc. | Apparatus and continuous flow process for production of boronic acid derivatives |
US10336702B2 (en) * | 2014-12-23 | 2019-07-02 | Bergenbio Asa | Pharmaceutically active compounds |
US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US10399996B2 (en) | 2015-09-11 | 2019-09-03 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
CN105801610B (zh) * | 2016-04-19 | 2018-05-18 | 武汉维舜医药科技有限公司 | 新型广谱β-内酰胺酶抑制剂 |
PT3478693T (pt) * | 2016-06-30 | 2021-10-25 | Qpex Biopharma Inc | Derivados de ácido borónico e suas utilizações terapêuticas |
EP3494121B1 (en) | 2016-08-04 | 2021-10-06 | Venatorx Pharmaceuticals, Inc. | Boron-containing compounds |
GB201613946D0 (en) * | 2016-08-15 | 2016-09-28 | Univ Oslo | Compounds |
JP2020510661A (ja) * | 2017-03-06 | 2020-04-09 | ベナトルクス ファーマシューティカルズ,インク. | β−ラクタマーゼ阻害剤を含む固体形態及び組み合わせ組成物並びにその使用 |
WO2018199291A1 (ja) * | 2017-04-28 | 2018-11-01 | 大日本住友製薬株式会社 | ヘテロ環誘導体 |
GB201708002D0 (en) | 2017-05-18 | 2017-07-05 | Univ Oxford Innovation Ltd | ß-Lactamase inhibitors |
CN110959008A (zh) * | 2017-05-26 | 2020-04-03 | 维纳拓尔斯制药公司 | 青霉素结合蛋白抑制剂 |
EP3630783A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | PENICILLIN BINDING PROTEIN INHIBITORS |
BR112020007138B1 (pt) | 2017-10-11 | 2023-03-21 | Qpex Biopharma, Inc | Derivados de ácido borônico, métodos de síntese, composição farmacêutica e uso dos mesmos |
WO2019089542A1 (en) * | 2017-11-01 | 2019-05-09 | Rempex Pharmaceuticals, Inc. | Synthesis of boronate ester derivatives and uses thereof |
US12016868B2 (en) | 2018-04-20 | 2024-06-25 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
JP7360132B2 (ja) | 2018-04-27 | 2023-10-12 | 住友ファーマ株式会社 | オキソ置換化合物 |
WO2019226931A1 (en) | 2018-05-25 | 2019-11-28 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
WO2020056048A1 (en) | 2018-09-12 | 2020-03-19 | VenatoRx Pharmaceuticals, Inc. | Combination compositions comprising a beta-lactamase inhibitor |
WO2020205932A1 (en) * | 2019-04-02 | 2020-10-08 | VenatoRx Pharmaceuticals, Inc. | Solid forms of an orally-delivered beta-lactamase inhibitor and uses thereof |
JP7550421B2 (ja) | 2019-10-25 | 2024-09-13 | 住友ファーマ株式会社 | オキソ置換化合物からなる医薬 |
KR20220088736A (ko) | 2019-10-25 | 2022-06-28 | 스미토모 파마 가부시키가이샤 | 신규 치환 축환형 화합물 |
US11058695B2 (en) * | 2019-11-08 | 2021-07-13 | Myongji University Industry And Academia Cooperation Foundation | Inhibitor of carbapenem-hydrolyzing class D beta-lactamases |
EP4201942A4 (en) | 2020-08-20 | 2024-08-21 | Phaeno Therapeutics Co Ltd | BORACIC ACID COMPOUND |
TW202228720A (zh) * | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
WO2022187362A1 (en) * | 2021-03-02 | 2022-09-09 | Case Western Reserve University | Β-lactamase inhibitors and uses thereof |
JP2024514055A (ja) | 2021-04-13 | 2024-03-28 | 上海拓界生物医薬科技有限公司 | β-ラクタマーゼ阻害剤としてのホウ酸誘導体 |
WO2023155869A1 (zh) * | 2022-02-18 | 2023-08-24 | 辉诺生物医药科技(杭州)有限公司 | 新的硼酸类化合物的晶型及其制备方法 |
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KR20150103269A (ko) | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
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US10399996B2 (en) | 2015-09-11 | 2019-09-03 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
CN105801610B (zh) | 2016-04-19 | 2018-05-18 | 武汉维舜医药科技有限公司 | 新型广谱β-内酰胺酶抑制剂 |
EP3494121B1 (en) | 2016-08-04 | 2021-10-06 | Venatorx Pharmaceuticals, Inc. | Boron-containing compounds |
JP2020510661A (ja) | 2017-03-06 | 2020-04-09 | ベナトルクス ファーマシューティカルズ,インク. | β−ラクタマーゼ阻害剤を含む固体形態及び組み合わせ組成物並びにその使用 |
EP3630783A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | PENICILLIN BINDING PROTEIN INHIBITORS |
CN110959008A (zh) | 2017-05-26 | 2020-04-03 | 维纳拓尔斯制药公司 | 青霉素结合蛋白抑制剂 |
US11247965B2 (en) | 2017-12-11 | 2022-02-15 | VenatoRx Pharmaceuticals, Inc. | Hepatitis B capsid assembly modulators |
WO2019226931A1 (en) | 2018-05-25 | 2019-11-28 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
-
2013
- 2013-12-05 KR KR1020157017875A patent/KR102147420B1/ko active IP Right Grant
- 2013-12-05 PT PT138611983T patent/PT2928898T/pt unknown
- 2013-12-05 CA CA2893943A patent/CA2893943C/en active Active
- 2013-12-05 PL PL13861198T patent/PL2928898T3/pl unknown
- 2013-12-05 JP JP2015545855A patent/JP6403219B2/ja active Active
- 2013-12-05 CN CN201380072524.5A patent/CN105026407B/zh active Active
- 2013-12-05 EP EP21164891.0A patent/EP3922635A1/en active Pending
- 2013-12-05 RU RU2015126912A patent/RU2654692C2/ru active
- 2013-12-05 BR BR112015013123-9A patent/BR112015013123B1/pt active IP Right Grant
- 2013-12-05 WO PCT/US2013/073428 patent/WO2014089365A1/en active Application Filing
- 2013-12-05 EP EP13861198.3A patent/EP2928898B1/en active Active
- 2013-12-05 AU AU2013355110A patent/AU2013355110B2/en active Active
- 2013-12-05 US US14/649,527 patent/US9422314B2/en active Active
- 2013-12-05 ES ES13861198T patent/ES2878118T3/es active Active
- 2013-12-06 US US14/099,633 patent/US8912169B2/en active Active
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2015
- 2015-06-04 IL IL23921215A patent/IL239212B/en active IP Right Grant
- 2015-06-10 ZA ZA2015/04200A patent/ZA201504200B/en unknown
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2016
- 2016-04-29 HK HK16104964.6A patent/HK1217334A1/zh unknown
- 2016-07-18 US US15/212,959 patent/US9828391B2/en active Active
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2017
- 2017-10-18 US US15/787,224 patent/US10214547B2/en active Active
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2018
- 2018-06-15 JP JP2018114967A patent/JP2018184409A/ja active Pending
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2019
- 2019-01-02 US US16/238,363 patent/US10669290B2/en active Active
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2021
- 2021-06-02 HR HRP20210879TT patent/HRP20210879T1/hr unknown
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