HRP20180450T1 - Heterobiciklični spojevi kao inhibitori beta-laktamaze - Google Patents

Heterobiciklični spojevi kao inhibitori beta-laktamaze

Info

Publication number
HRP20180450T1
HRP20180450T1 HRP20180450TT HRP20180450T HRP20180450T1 HR P20180450 T1 HRP20180450 T1 HR P20180450T1 HR P20180450T T HRP20180450T T HR P20180450TT HR P20180450 T HRP20180450 T HR P20180450T HR P20180450 T1 HRP20180450 T1 HR P20180450T1
Authority
HR
Croatia
Prior art keywords
beta
lactamase inhibitors
heterobicyclic compounds
heterobicyclic
compounds
Prior art date
Application number
HRP20180450TT
Other languages
English (en)
Inventor
Helen Mcguire
Shanta Bist
Neil Bifulco
Liang Zhao
Ye Wu
Hoan Huynh
Hui Xiong
Janelle Comita-Prevoir
Daemian DUSSAULT
Bolin Geng
Brendan CHEN
Thomas Durand-Reville
Satenig GULER
Original Assignee
Entasis Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entasis Therapeutics Limited filed Critical Entasis Therapeutics Limited
Publication of HRP20180450T1 publication Critical patent/HRP20180450T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
HRP20180450TT 2012-04-02 2018-03-16 Heterobiciklični spojevi kao inhibitori beta-laktamaze HRP20180450T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261618993P 2012-04-02 2012-04-02
EP13715426.6A EP2834239B1 (en) 2012-04-02 2013-04-02 Heterobicyclic compounds as beta-lactamase inhibitors
PCT/GB2013/050869 WO2013150296A1 (en) 2012-04-02 2013-04-02 Heterobicyclic compounds as beta-lactamase inhibitors

Publications (1)

Publication Number Publication Date
HRP20180450T1 true HRP20180450T1 (hr) 2018-06-01

Family

ID=48083562

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180450TT HRP20180450T1 (hr) 2012-04-02 2018-03-16 Heterobiciklični spojevi kao inhibitori beta-laktamaze

Country Status (41)

Country Link
US (2) US9309245B2 (hr)
EP (1) EP2834239B1 (hr)
JP (1) JP6122484B2 (hr)
KR (1) KR102042867B1 (hr)
CN (1) CN104364254B (hr)
AP (1) AP2014007980A0 (hr)
AR (1) AR090539A1 (hr)
AU (1) AU2013245399B2 (hr)
BR (1) BR112014024279B1 (hr)
CA (1) CA2866467C (hr)
CL (1) CL2014002589A1 (hr)
CO (1) CO7071137A2 (hr)
CR (1) CR20140428A (hr)
CY (1) CY1120269T1 (hr)
DK (1) DK2834239T3 (hr)
DO (1) DOP2014000212A (hr)
ES (1) ES2663416T3 (hr)
HK (1) HK1207071A1 (hr)
HR (1) HRP20180450T1 (hr)
HU (1) HUE036722T2 (hr)
IL (1) IL234660A (hr)
IN (1) IN2014MN01882A (hr)
LT (1) LT2834239T (hr)
MA (1) MA37383A1 (hr)
ME (1) ME03031B (hr)
MX (1) MX354627B (hr)
MY (1) MY176969A (hr)
NO (1) NO2935238T3 (hr)
NZ (1) NZ630259A (hr)
PE (1) PE20142403A1 (hr)
PH (1) PH12014502224B1 (hr)
PL (1) PL2834239T3 (hr)
PT (1) PT2834239T (hr)
RS (1) RS56966B1 (hr)
RU (1) RU2645678C2 (hr)
SG (1) SG11201405965RA (hr)
SI (1) SI2834239T1 (hr)
TN (1) TN2014000417A1 (hr)
TW (1) TWI597281B (hr)
UY (1) UY34723A (hr)
WO (1) WO2013150296A1 (hr)

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AU2016257338B2 (en) * 2015-05-07 2020-03-05 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
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EP3608318A1 (en) * 2018-08-09 2020-02-12 Antabio SAS Diaazabicyclooctanone derivatives as antibacterials
RU2739761C2 (ru) * 2018-09-27 2020-12-28 Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук Способ получения n-алкил-n-{ [3-алкил-3,8-диазабицикло[3.2.1]окта-1(7),5-диен-8-ил]метил} аминов и их применение в качестве средств с антимикробной активностью
CN111196808B (zh) * 2018-11-16 2022-10-18 南京圣和药业股份有限公司 二氮杂双环类化合物及其应用
CN110615790A (zh) * 2019-10-24 2019-12-27 北京融英医药科技有限公司 一种利格列汀制备工艺的改进方法
CN113979981B (zh) * 2021-10-22 2023-04-07 天津医科大学 一种巯基响应型脱碱基位点捕获试剂及应用
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DOP2014000212A (es) 2014-10-31
BR112014024279B1 (pt) 2021-09-08
RS56966B1 (sr) 2018-05-31
IN2014MN01882A (hr) 2015-07-10
CN104364254A (zh) 2015-02-18
CA2866467A1 (en) 2013-10-10
CO7071137A2 (es) 2014-09-30
MY176969A (en) 2020-08-28
CL2014002589A1 (es) 2015-01-30
EP2834239A1 (en) 2015-02-11
PH12014502224A1 (en) 2015-01-12
AP2014007980A0 (en) 2014-10-31
NZ630259A (en) 2016-06-24
CA2866467C (en) 2020-03-24
AU2013245399A1 (en) 2014-10-02
KR102042867B1 (ko) 2019-11-08
UY34723A (es) 2015-07-31
CN104364254B (zh) 2017-02-22
LT2834239T (lt) 2018-03-26
US9623014B2 (en) 2017-04-18
TN2014000417A1 (en) 2016-03-30
AU2013245399B2 (en) 2016-04-21
SI2834239T1 (en) 2018-05-31
CR20140428A (es) 2015-01-12
JP6122484B2 (ja) 2017-04-26
HK1207071A1 (en) 2016-01-22
ES2663416T3 (es) 2018-04-12
AR090539A1 (es) 2014-11-19
NO2935238T3 (hr) 2018-05-26
WO2013150296A1 (en) 2013-10-10
US9309245B2 (en) 2016-04-12
ME03031B (me) 2018-10-20
PH12014502224B1 (en) 2015-01-12
MX2014011351A (es) 2014-12-05
KR20140140625A (ko) 2014-12-09
RU2645678C2 (ru) 2018-02-27
BR112014024279A8 (pt) 2018-04-03
PT2834239T (pt) 2018-03-23
CY1120269T1 (el) 2019-07-10
BR112014024279A2 (hr) 2017-06-20
MA37383A1 (fr) 2016-06-30
RU2014141579A (ru) 2016-05-27
JP2015512440A (ja) 2015-04-27
HUE036722T2 (hu) 2018-07-30
PE20142403A1 (es) 2015-01-23
TWI597281B (zh) 2017-09-01
US20150073011A1 (en) 2015-03-12
EP2834239B1 (en) 2017-12-27
PL2834239T3 (pl) 2018-06-29
TW201345907A (zh) 2013-11-16
SG11201405965RA (en) 2014-10-30
MX354627B (es) 2018-03-14
DK2834239T3 (en) 2018-03-26
US20160175290A1 (en) 2016-06-23
IL234660A (en) 2017-08-31

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