CA2513797C - Constructions hybrides et leur utilisation pour produire des anticorps presentant une affinite de liaison accrue pour le recepteur fc et fonction d'effecteur - Google Patents

Constructions hybrides et leur utilisation pour produire des anticorps presentant une affinite de liaison accrue pour le recepteur fc et fonction d'effecteur Download PDF

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CA2513797C
CA2513797C CA2513797A CA2513797A CA2513797C CA 2513797 C CA2513797 C CA 2513797C CA 2513797 A CA2513797 A CA 2513797A CA 2513797 A CA2513797 A CA 2513797A CA 2513797 C CA2513797 C CA 2513797C
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Prior art keywords
localization domain
polypeptide
golgi localization
mammalian
host cell
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CA2513797A1 (fr
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Pablo Umana
Peter Bruenker
Claudia Ferrara
Tobias Suter
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Roche Glycart AG
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Roche Glycart AG
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Abstract

L'invention concerne le domaine de la formation de protéines par glycosylation. En particulier, l'invention concerne des molécules d'acide nucléique, comprenant des constructions hybrides, présentant une activité catalytique, et l'utilisation de celles-ci dans la formation de cellules hôtes par glycosylation, pour générer des polypeptides présentant des propriétés thérapeutiques améliorées, notamment des anticorps présentant une liaison améliorée avec le récepteur Fc, et une fonction d'effecteur améliorée.
CA2513797A 2003-01-22 2004-01-22 Constructions hybrides et leur utilisation pour produire des anticorps presentant une affinite de liaison accrue pour le recepteur fc et fonction d'effecteur Expired - Lifetime CA2513797C (fr)

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US44130703P 2003-01-22 2003-01-22
US60/441,307 2003-01-22
US49125403P 2003-07-31 2003-07-31
US60/491,254 2003-07-31
US49514203P 2003-08-15 2003-08-15
US60/495,142 2003-08-15
PCT/IB2004/000844 WO2004065540A2 (fr) 2003-01-22 2004-01-22 Constructions hybrides et leur utilisation pour produire des anticorps presentant une affinite de liaison accrue pour le recepteur fc et fonction d'effecteur

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