MXPA05007781A - Constructos de fusion y uso de los mismos para producir anticuerpos con afinidad incrementada de enlace al receptor fc y funcion efectora. - Google Patents

Constructos de fusion y uso de los mismos para producir anticuerpos con afinidad incrementada de enlace al receptor fc y funcion efectora.

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Publication number
MXPA05007781A
MXPA05007781A MXPA05007781A MXPA05007781A MXPA05007781A MX PA05007781 A MXPA05007781 A MX PA05007781A MX PA05007781 A MXPA05007781 A MX PA05007781A MX PA05007781 A MXPA05007781 A MX PA05007781A MX PA05007781 A MXPA05007781 A MX PA05007781A
Authority
MX
Mexico
Prior art keywords
increased
receptor binding
same
effector function
fusion constructs
Prior art date
Application number
MXPA05007781A
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English (en)
Inventor
Suter Tobias
Original Assignee
Glycart Biotechnology Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycart Biotechnology Ag filed Critical Glycart Biotechnology Ag
Publication of MXPA05007781A publication Critical patent/MXPA05007781A/es

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Abstract

La presente invencion se refiere al campo de la ingenieria de glicosilacion de proteinas. Mas particularmente, la presente invencion se refiere a moleculas de acido nucleico que incluyen constructos de fusion, que tienen actividad catalitica y al uso de los mismos en ingenieria de glicosilacion de celulas hospederas, para generar polipeptidos con propiedades terapeuticas mejoradas, que incluyen anticuerpos con enlace incrementado al receptor Fc y funcion efectora incrementada.
MXPA05007781A 2003-01-22 2004-01-22 Constructos de fusion y uso de los mismos para producir anticuerpos con afinidad incrementada de enlace al receptor fc y funcion efectora. MXPA05007781A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44130703P 2003-01-22 2003-01-22
US49125403P 2003-07-31 2003-07-31
US49514203P 2003-08-15 2003-08-15
PCT/IB2004/000844 WO2004065540A2 (en) 2003-01-22 2004-01-22 Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function

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