MX2009003738A - Diagnóstico y tratamiento de cáncer usando anticuerpo anti-ereg. - Google Patents
Diagnóstico y tratamiento de cáncer usando anticuerpo anti-ereg.Info
- Publication number
- MX2009003738A MX2009003738A MX2009003738A MX2009003738A MX2009003738A MX 2009003738 A MX2009003738 A MX 2009003738A MX 2009003738 A MX2009003738 A MX 2009003738A MX 2009003738 A MX2009003738 A MX 2009003738A MX 2009003738 A MX2009003738 A MX 2009003738A
- Authority
- MX
- Mexico
- Prior art keywords
- ereg
- cancer
- diagnosis
- protein
- treatment
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
Abstract
Se describe un método para el diagnóstico de cáncer, el cual se caracteriza por detectar una proteína epiregulina (EREG). Se ha encontrado que la expresión de una EREG se mejora a una frecuencia muy alta en un nivel de gen o un nivel de proteína en cáncer gastrointestinal, adenocarcinoma pulmonar, cáncer pancreático, cáncer gástrico o cáncer renal. En el diagnóstico o tratamiento de cáncer, se utiliza un anticuerpo que reconoce la proteína EREG. También se describen una composición farmacéutica, un inhibidor de proliferación de célula y un agente anti-cáncer, cada uno comprendiendo un anticuerpo capaz de unirse a una EREG como un ingrediente activo. Además se describe un método para inducir citopatía en una célula que expresa EREG o inhibir la proliferación de una célula que expresa EREG, poniendo en contacto la célula que expresa EREG con un anticuerpo capaz de unirse a una EREG.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006278819 | 2006-10-12 | ||
PCT/JP2007/069988 WO2008047723A1 (en) | 2006-10-12 | 2007-10-12 | Diagnosis and treatment of cancer using anti-ereg antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003738A true MX2009003738A (es) | 2009-07-17 |
Family
ID=39313954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003738A MX2009003738A (es) | 2006-10-12 | 2007-10-12 | Diagnóstico y tratamiento de cáncer usando anticuerpo anti-ereg. |
Country Status (16)
Country | Link |
---|---|
US (1) | US9017684B2 (es) |
EP (1) | EP2070548B1 (es) |
JP (2) | JP5687822B2 (es) |
KR (1) | KR101493779B1 (es) |
CN (2) | CN101594883B (es) |
AU (1) | AU2007312367B2 (es) |
BR (1) | BRPI0719202A2 (es) |
CA (1) | CA2665528C (es) |
IL (2) | IL197914A (es) |
MX (1) | MX2009003738A (es) |
MY (1) | MY162056A (es) |
NO (1) | NO20091842L (es) |
NZ (2) | NZ601022A (es) |
RU (2) | RU2537245C2 (es) |
UA (1) | UA106194C2 (es) |
WO (1) | WO2008047723A1 (es) |
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IT1397083B1 (it) * | 2009-12-04 | 2012-12-28 | Biouniversa Srl | Marcatore biochimico serico |
EP4190149A1 (en) | 2009-12-25 | 2023-06-07 | Chugai Seiyaku Kabushiki Kaisha | Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein |
RU2740479C2 (ru) * | 2010-02-24 | 2021-01-14 | Иммьюноджен, Инк. | Антитела против рецептора фолиевой кислоты 1, их иммуноконъюгаты и использование |
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GB0909906D0 (en) | 2009-06-09 | 2009-07-22 | Affitech As | Antibodies |
GB0909904D0 (en) | 2009-06-09 | 2009-07-22 | Affitech As | Product |
TWI593705B (zh) | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
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2007
- 2007-10-12 JP JP2008539791A patent/JP5687822B2/ja active Active
- 2007-10-12 WO PCT/JP2007/069988 patent/WO2008047723A1/ja active Application Filing
- 2007-10-12 US US12/444,916 patent/US9017684B2/en active Active
- 2007-10-12 EP EP07829724.9A patent/EP2070548B1/en active Active
- 2007-10-12 RU RU2009117669/15A patent/RU2537245C2/ru not_active IP Right Cessation
- 2007-10-12 CN CN200780045915.2A patent/CN101594883B/zh not_active Expired - Fee Related
- 2007-10-12 AU AU2007312367A patent/AU2007312367B2/en not_active Ceased
- 2007-10-12 KR KR1020097008620A patent/KR101493779B1/ko not_active IP Right Cessation
- 2007-10-12 NZ NZ601022A patent/NZ601022A/en not_active IP Right Cessation
- 2007-10-12 UA UAA200904419A patent/UA106194C2/ru unknown
- 2007-10-12 MY MYPI20091462A patent/MY162056A/en unknown
- 2007-10-12 CA CA2665528A patent/CA2665528C/en not_active Expired - Fee Related
- 2007-10-12 BR BRPI0719202-9A patent/BRPI0719202A2/pt not_active IP Right Cessation
- 2007-10-12 CN CN2013103003558A patent/CN103396486A/zh active Pending
- 2007-10-12 MX MX2009003738A patent/MX2009003738A/es active IP Right Grant
- 2007-10-12 NZ NZ576855A patent/NZ576855A/xx not_active IP Right Cessation
-
2009
- 2009-04-05 IL IL197914A patent/IL197914A/en active IP Right Grant
- 2009-05-11 NO NO20091842A patent/NO20091842L/no not_active Application Discontinuation
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2013
- 2013-03-21 IL IL225386A patent/IL225386A/en active IP Right Grant
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2014
- 2014-10-03 JP JP2014204708A patent/JP5992480B2/ja active Active
- 2014-10-13 RU RU2014141151A patent/RU2014141151A/ru not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ576855A (en) | 2012-08-31 |
AU2007312367B2 (en) | 2012-09-06 |
RU2537245C2 (ru) | 2014-12-27 |
US20090324491A1 (en) | 2009-12-31 |
BRPI0719202A2 (pt) | 2015-06-16 |
CA2665528C (en) | 2018-01-23 |
KR20090079214A (ko) | 2009-07-21 |
CN103396486A (zh) | 2013-11-20 |
EP2070548B1 (en) | 2017-01-18 |
CN101594883B (zh) | 2018-04-10 |
RU2014141151A3 (es) | 2018-07-18 |
IL197914A0 (en) | 2011-08-01 |
CN101594883A (zh) | 2009-12-02 |
CA2665528A1 (en) | 2008-04-24 |
IL197914A (en) | 2014-07-31 |
JP5687822B2 (ja) | 2015-03-25 |
WO2008047723A1 (en) | 2008-04-24 |
JP5992480B2 (ja) | 2016-09-14 |
IL225386A0 (en) | 2013-06-27 |
MY162056A (en) | 2017-05-31 |
RU2009117669A (ru) | 2010-11-20 |
EP2070548A4 (en) | 2010-09-01 |
UA106194C2 (ru) | 2014-08-11 |
EP2070548A1 (en) | 2009-06-17 |
KR101493779B1 (ko) | 2015-02-16 |
JP2015091796A (ja) | 2015-05-14 |
US9017684B2 (en) | 2015-04-28 |
AU2007312367A1 (en) | 2008-04-24 |
NO20091842L (no) | 2009-07-13 |
IL225386A (en) | 2014-07-31 |
JPWO2008047723A1 (ja) | 2010-02-25 |
RU2014141151A (ru) | 2016-05-10 |
NZ601022A (en) | 2014-09-26 |
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