EA200901249A1 - Ингибиторы связывания протеинкиназ - Google Patents

Ингибиторы связывания протеинкиназ

Info

Publication number
EA200901249A1
EA200901249A1 EA200901249A EA200901249A EA200901249A1 EA 200901249 A1 EA200901249 A1 EA 200901249A1 EA 200901249 A EA200901249 A EA 200901249A EA 200901249 A EA200901249 A EA 200901249A EA 200901249 A1 EA200901249 A1 EA 200901249A1
Authority
EA
Eurasian Patent Office
Prior art keywords
proteinkinaz
binding inhibitors
methods
relates
inhibitors
Prior art date
Application number
EA200901249A
Other languages
English (en)
Inventor
Уильям Г. Кэнс
Елена Куренова
Вита Голубовская
Давид А. Остров
Original Assignee
Юниверсити Оф Флорида Ресерч Фаундэйшн, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юниверсити Оф Флорида Ресерч Фаундэйшн, Инк. filed Critical Юниверсити Оф Флорида Ресерч Фаундэйшн, Инк.
Publication of EA200901249A1 publication Critical patent/EA200901249A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к соединениям ингибиторов связывания белков и способам их идентификации и применения. Изобретение также относится к фармацевтическим композициям и способам лечения клеточных пролиферативных расстройств, в особенности рака.
EA200901249A 2007-03-16 2008-03-14 Ингибиторы связывания протеинкиназ EA200901249A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91861507P 2007-03-16 2007-03-16
US6924808P 2008-03-12 2008-03-12
PCT/US2008/003451 WO2008115443A1 (en) 2007-03-16 2008-03-14 Kinase protein binding inhibitors

Publications (1)

Publication Number Publication Date
EA200901249A1 true EA200901249A1 (ru) 2010-04-30

Family

ID=39766243

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901249A EA200901249A1 (ru) 2007-03-16 2008-03-14 Ингибиторы связывания протеинкиназ

Country Status (8)

Country Link
US (1) US8404669B2 (ru)
EP (1) EP2136829A4 (ru)
JP (1) JP2010522697A (ru)
CN (1) CN101801401A (ru)
AU (1) AU2008229483A1 (ru)
CA (1) CA2681038A1 (ru)
EA (1) EA200901249A1 (ru)
WO (1) WO2008115443A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010221294A1 (en) * 2009-03-06 2011-10-06 University Of Florida Research Foundation, Inc. Kinase protein binding inhibitors
US8051947B2 (en) * 2009-03-12 2011-11-08 E.I. Du Pont De Nemours And Company Energy absorbing thermoplastic elastomer
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
CN103534240B (zh) 2011-02-17 2015-12-09 癌症疗法Crc私人有限公司 选择性fak抑制剂
EP2675793B1 (en) 2011-02-17 2018-08-08 Cancer Therapeutics Crc Pty Limited Fak inhibitors
EA017179B1 (ru) * 2011-04-06 2012-10-30 Ооо "Метамакс" Фармацевтическая композиция для лечения гиперпролиферативных заболеваний и её применение
WO2012139001A2 (en) * 2011-04-08 2012-10-11 Roswell Park Cancer Institute Kinase protein binding inhibitors
CN103739680B (zh) * 2013-12-31 2016-03-30 浙江元太生物科技有限公司 一种抑制粘附斑激酶多肽及其应用
US10905750B2 (en) * 2017-11-10 2021-02-02 Donald J. Davidson GRP78 antagonist that block binding of receptor tyrosine kinase orphan receptors as immunotherapy anticancer agents
CN110275010B (zh) * 2019-06-21 2022-07-01 中山大学孙逸仙纪念医院 一种用于治疗前列腺癌药物的P38a MAPK信号通路抑制剂的筛选方法
CA3148882A1 (en) * 2019-08-31 2021-03-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Peptide inhibitors of focal adhesion kinase activity and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0004886D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
PL379330A1 (pl) * 2002-12-20 2006-08-21 Pfizer Products Inc. Pochodne pirymidyny dla leczenia nienormalnego wzrostu komórek
CA2528774A1 (en) 2003-06-20 2005-01-27 Coley Pharmaceutical Gmbh Small molecule toll-like receptor (tlr) antagonists
US20050037963A1 (en) * 2003-07-10 2005-02-17 Jun-Lin Guan Methods of regulating focal adhesion kinase and its associated cellular functions by fak family-interacting protein
WO2005049852A2 (en) * 2003-11-17 2005-06-02 University Of Florida Methods and compositions for inducing apoptosis
CA2694973A1 (en) * 2007-08-15 2009-02-19 Idera Pharmaceuticals, Inc. Toll like receptor modulators

Also Published As

Publication number Publication date
US20090239850A1 (en) 2009-09-24
AU2008229483A1 (en) 2008-09-25
CA2681038A1 (en) 2008-09-25
JP2010522697A (ja) 2010-07-08
CN101801401A (zh) 2010-08-11
EP2136829A1 (en) 2009-12-30
WO2008115443A1 (en) 2008-09-25
US8404669B2 (en) 2013-03-26
EP2136829A4 (en) 2012-07-18

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