PL415463A1 - Wyizolowany kwas nukleinowy, ssaczy wektor ekspresyjny, fuzje polipeptydowe, komórki gospodarza, sposób wytwarzania fuzji polipeptydowych, sposoby in vitro i ex vivo modyfikowania profilu glikozylacji, wyizolowana cząsteczka kwasu nukleinowego - Google Patents

Wyizolowany kwas nukleinowy, ssaczy wektor ekspresyjny, fuzje polipeptydowe, komórki gospodarza, sposób wytwarzania fuzji polipeptydowych, sposoby in vitro i ex vivo modyfikowania profilu glikozylacji, wyizolowana cząsteczka kwasu nukleinowego

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Publication number
PL415463A1
PL415463A1 PL415463A PL41546304A PL415463A1 PL 415463 A1 PL415463 A1 PL 415463A1 PL 415463 A PL415463 A PL 415463A PL 41546304 A PL41546304 A PL 41546304A PL 415463 A1 PL415463 A1 PL 415463A1
Authority
PL
Poland
Prior art keywords
nucleic acid
polypeptide fusions
isolated
host cells
vitro
Prior art date
Application number
PL415463A
Other languages
English (en)
Other versions
PL224787B1 (pl
Inventor
Pablo Umana
Peter Bruenker
Claudia Ferrara
Tobias Suter
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of PL415463A1 publication Critical patent/PL415463A1/pl
Publication of PL224787B1 publication Critical patent/PL224787B1/pl

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Abstract

Niniejszy wynalazek dotyczy wyizolowanego kwasu nukleinowego obejmującego sekwencję kodującą fuzję polipeptydową mającą aktywność ß(1,4)-galaktozylotransferazy (GalT), przy czym fuzja polipeptydowa obejmuje domenę katalityczną GalT i domenę lokalizacji w aparacie Golgiego ß(1, 2)-N-acetyloglukoza-minylotransferazy I (GnTI) lub mannozydazy II (Man II), przy czym domena katalityczna GalT obejmuje sekwencję aminokwasową co najmniej w 90% identyczną z sekwencją aminokwasową o SEK.ID.NR: 22, z konserwatywnymi podstawieniami aminokwasowymi, a domena lokalizacji Man II w aparacie Golgiego obejmuje sekwencję aminokwasową co najmniej w 90% identyczną z sekwencją aminokwasową o SEK. ID. NR: 23, z konserwatywnymi podstawieniami aminokwasowymi, a domena GnTI lokalizacji w aparacie Golgiego obejmuje sekwencję aminokwasową co najmniej w 90% identyczną z sekwencją aminokwasową o SEK.ID. NR:24, z konserwatywnymi podstawieniami aminokwasowymi. Ponadto w zakres wynalazku wchodzą ssaczy wektor ekspresyjny, fuzje polipeptydowe, komórki gospodarza, sposób wytwarzania fuzji polipeptydowych, sposoby in vitro i ex vivo modyfikowania profilu glikozylacji oraz wyizolowana cząsteczka kwasu nukleinowego.
PL415463A 2003-01-22 2004-01-22 Wyizolowany kwas nukleinowy, ssaczy wektor ekspresyjny, fuzje polipeptydowe, komórki gospodarza, sposób wytwarzania fuzji polipeptydowych, sposoby in vitro i ex vivo modyfikowania profilu glikozylacji, wyizolowana cząsteczka kwasu nukleinowego PL224787B1 (pl)

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