CA2239448C - Blockade of t lymphocyte down-regulation associated with ctla-4 signaling - Google Patents

Blockade of t lymphocyte down-regulation associated with ctla-4 signaling Download PDF

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Publication number
CA2239448C
CA2239448C CA2239448A CA2239448A CA2239448C CA 2239448 C CA2239448 C CA 2239448C CA 2239448 A CA2239448 A CA 2239448A CA 2239448 A CA2239448 A CA 2239448A CA 2239448 C CA2239448 C CA 2239448C
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Prior art keywords
ctla
cells
antibody
use according
antigen
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Expired - Lifetime
Application number
CA2239448A
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English (en)
French (fr)
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CA2239448A1 (en
Inventor
James Patrick Allison
Dana R. Leach
Matthew F. Krummel
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University of California San Diego UCSD
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University of California San Diego UCSD
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27074292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2239448(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/566,853 external-priority patent/US5855887A/en
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Priority to CA2770851A priority Critical patent/CA2770851C/en
Publication of CA2239448A1 publication Critical patent/CA2239448A1/en
Application granted granted Critical
Publication of CA2239448C publication Critical patent/CA2239448C/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
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    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/81Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy

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  • Epidemiology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
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  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Radiation-Therapy Devices (AREA)
  • External Artificial Organs (AREA)
CA2239448A 1995-12-04 1996-12-04 Blockade of t lymphocyte down-regulation associated with ctla-4 signaling Expired - Lifetime CA2239448C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2770851A CA2770851C (en) 1995-12-04 1996-12-04 Blockade of t lymphocyte down-regulation associated with ctla-4 signaling

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/566,853 US5855887A (en) 1995-07-25 1995-12-04 Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
US08/566,853 1995-12-04
US08/646,605 1996-05-08
US08/646,605 US5811097A (en) 1995-07-25 1996-05-08 Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
PCT/US1996/019375 WO1997020574A1 (en) 1995-12-04 1996-12-04 Blockade of t lymphocyte down-regulation associated with ctla-4 signaling

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2770851A Division CA2770851C (en) 1995-12-04 1996-12-04 Blockade of t lymphocyte down-regulation associated with ctla-4 signaling

Publications (2)

Publication Number Publication Date
CA2239448A1 CA2239448A1 (en) 1997-06-12
CA2239448C true CA2239448C (en) 2013-10-01

Family

ID=27074292

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Application Number Title Priority Date Filing Date
CA2239448A Expired - Lifetime CA2239448C (en) 1995-12-04 1996-12-04 Blockade of t lymphocyte down-regulation associated with ctla-4 signaling
CA2770851A Expired - Lifetime CA2770851C (en) 1995-12-04 1996-12-04 Blockade of t lymphocyte down-regulation associated with ctla-4 signaling

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2770851A Expired - Lifetime CA2770851C (en) 1995-12-04 1996-12-04 Blockade of t lymphocyte down-regulation associated with ctla-4 signaling

Country Status (12)

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US (1) US5811097A (enExample)
EP (3) EP0865293B1 (enExample)
JP (2) JP4477701B2 (enExample)
AT (1) ATE415172T1 (enExample)
AU (1) AU730500B2 (enExample)
CA (2) CA2239448C (enExample)
DE (2) DE69637762D1 (enExample)
DK (2) DK0865293T3 (enExample)
ES (2) ES2318853T3 (enExample)
LU (1) LU91927I2 (enExample)
PT (2) PT865293E (enExample)
WO (1) WO1997020574A1 (enExample)

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