JP2000502331A - Ctla―4のシグナル発生に伴うtリンパ球ダウンレギュレーションの遮断 - Google Patents
Ctla―4のシグナル発生に伴うtリンパ球ダウンレギュレーションの遮断Info
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- JP2000502331A JP2000502331A JP09521425A JP52142597A JP2000502331A JP 2000502331 A JP2000502331 A JP 2000502331A JP 09521425 A JP09521425 A JP 09521425A JP 52142597 A JP52142597 A JP 52142597A JP 2000502331 A JP2000502331 A JP 2000502331A
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
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- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.CTLA−4の細胞外ドメインに特異的に結合し、さらにCTLA−4シグ ナル発生を抑制するという特徴を有するCTLA−4遮断剤であって、当該遮 断剤が、CTLA−4の細胞外ドメインに対する抗体またはそのFabもしく はFab’フラグメント以外のものであり、さらに当該遮断剤が、哺乳類T細 胞の抗原刺激に対する反応を高めるか、または哺乳類ホストで腫瘍細胞の増殖 を低下させるために有効である前記CTLA−4遮断剤。 2.CTLA−4遮断剤および免疫反応刺激剤を含む組成物であって、当該 CTLA−4遮断剤がCTLA−4の細胞外ドメインに特異的に結合し、さら にCTLA−4シグナル発生を抑制するという特徴を有する前記組成物。 3.当該免疫反応刺激剤が、顆粒球−マクロファージコロニー刺激因子(GMー CSF)、マクロファージコロニー刺激因子(M−CSF)、顆粒球コロニー 刺激因子(G−CSF)、インターロイキン3(IL−3)、インターロイキ ン12(IL−12)、インターロイキン1(IL−1)、インターロイキン 2(IL−2)、B7、抗CD3および抗CD28から成る群から選ばれる請 求の範囲第2項の組成物。 4.当該免疫反応刺激剤が抗原である請求の範囲第2項の組成物。 5.当該抗原が腫瘍抗原である請求の範囲第4項の組成物。 6.当該抗原が病原体由来である請求の範囲第4項の組成物。 7.当該免疫反応刺激剤が化学療法剤である請求の範囲第2項の組成物。 8.抗原刺激に対する哺乳類T細胞の反応を高めるか、または哺乳類ホストで 腫瘍細胞の増殖を低下させるために免疫反応刺激剤の使用を併用するCTLA ー4遮断剤の使用であって、当該CTLA−4遮断剤がCTLA−4の細胞外 ドメインに特異的に結合し、さらにCTLA−4シグナル発生を抑制するとい う特徴を有する前記CTLA−4遮断剤の使用。 9.抗原刺激に対する哺乳類T細胞の反応を高めるか、または哺乳類ホストで腫 瘍細胞の増殖を低下させるために免疫反応刺激剤の使用を併用するCTLA− 4遮断剤の使用であって、当該遮断剤がCTLA−4の細胞外ドメインに特異 的に結合し、さらにCTLA−4シグナル発生を抑制するという特徴を有し、 さらに当該遮断剤がCTLA−4の細胞外ドメインに対する抗体またはそのF abもしくはFab’以外のものである前記CTLA−4遮断剤の使用。 10.当該免疫反応剌激剤が、化学療法剤、抗原、顆粒球−マクロファージコロニ ー刺激因子(GM−CSF)、マクロファージコロニー刺激因子(M−CSF )、顆粒球コロニー剌激因子(G−CSF)、インターロイキン3(IL−3 )、インターロイキン12(IL−12)、インターロイキン1(IL−1) 、インターロイキン2(IL−2)、B7、抗CD3および抗CD28から成 る群から選ばれる請求の範囲第7項または8項に記載の使用。 11.抗原刺激に対する哺乳類T細胞の反応を高めるか、または哺乳類ホストで腫 瘍細胞の増殖を低下させるためのCTLA−4遮断剤の使用であって、当該遮 断剤がCTLA−4の細胞外ドメインに特異的に結合し、さらにCTLA−4 シグナル発生を抑制するという特徴を有し、さらに当該遮断剤がCTLA−4 の細胞外ドメインに対する抗体またはそのFabもしくはFab’フラグメン ト以外のものである前記CTLA−4遮断剤の使用。 12.抗原刺激に対する哺乳類T細胞の反応を高めるか、または哺乳類ホストで腫 瘍細胞の増殖を低下させるために、免疫反応剌激因子を産生させる照射源の使 用を併用するCTLA−4遮断剤の使用であって、当該遮断剤がCTLA−4 の細胞外ドメインに特異的に結合し、さらにCTLA−4シグナル発生を抑制 するという特徴を有する前記CTLA−4遮断剤の使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/566,853 US5855887A (en) | 1995-07-25 | 1995-12-04 | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
US08/566,853 | 1996-05-08 | ||
US08/646,605 US5811097A (en) | 1995-07-25 | 1996-05-08 | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
US08/646,605 | 1996-05-08 | ||
PCT/US1996/019375 WO1997020574A1 (en) | 1995-12-04 | 1996-12-04 | Blockade of t lymphocyte down-regulation associated with ctla-4 signaling |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008291542A Division JP2009114191A (ja) | 1995-12-04 | 2008-11-13 | Ctla−4のシグナル発生に伴うtリンパ球ダウンレギュレーションの遮断 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000502331A true JP2000502331A (ja) | 2000-02-29 |
JP4477701B2 JP4477701B2 (ja) | 2010-06-09 |
Family
ID=27074292
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52142597A Expired - Lifetime JP4477701B2 (ja) | 1995-12-04 | 1996-12-04 | Ctla―4のシグナル発生に伴うtリンパ球ダウンレギュレーションの遮断 |
JP2008291542A Withdrawn JP2009114191A (ja) | 1995-12-04 | 2008-11-13 | Ctla−4のシグナル発生に伴うtリンパ球ダウンレギュレーションの遮断 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008291542A Withdrawn JP2009114191A (ja) | 1995-12-04 | 2008-11-13 | Ctla−4のシグナル発生に伴うtリンパ球ダウンレギュレーションの遮断 |
Country Status (12)
Country | Link |
---|---|
US (1) | US5811097A (ja) |
EP (3) | EP2106800B1 (ja) |
JP (2) | JP4477701B2 (ja) |
AT (1) | ATE415172T1 (ja) |
AU (1) | AU730500B2 (ja) |
CA (2) | CA2770851C (ja) |
DE (2) | DE69637762D1 (ja) |
DK (2) | DK0865293T3 (ja) |
ES (2) | ES2318853T3 (ja) |
LU (1) | LU91927I2 (ja) |
PT (2) | PT865293E (ja) |
WO (1) | WO1997020574A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2005529873A (ja) * | 2002-04-12 | 2005-10-06 | メダレックス インコーポレイテッド | Ctla−4抗体を使用した治療の方法 |
JP2016128399A (ja) * | 2014-12-11 | 2016-07-14 | リティックス バイオファーマ エイエス | 免疫チェックポイント阻害剤の組み合わせ |
JP2017052784A (ja) * | 2005-05-09 | 2017-03-16 | 小野薬品工業株式会社 | Programmed Death 1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
CN111050789A (zh) * | 2017-06-15 | 2020-04-21 | 癌症进展有限公司 | 用于诱导针对肿瘤和癌症的体液免疫和细胞免疫的组合物和方法 |
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US6051227A (en) * | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
US7964190B2 (en) * | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
US20060034844A1 (en) * | 1996-12-04 | 2006-02-16 | The Regents Of The University Of California | Stimulation of T cells against self antigens using CTLA-4 blocking agents |
JP2001523958A (ja) * | 1997-03-21 | 2001-11-27 | ブライハム アンド ウィミンズ ホスピタル,インコーポレイテッド | 免疫療法のctla−4結合ペプチド |
CA2285571C (en) * | 1997-04-16 | 2008-12-02 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Immunomodulatory molecules and process for producing the same |
EP1093457B8 (en) | 1998-03-19 | 2011-02-02 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
CA2352783C (en) * | 1998-12-03 | 2012-04-10 | The Regents Of The University Of California | Stimulation of t cells against self antigens using ctla-4 blocking agents |
US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
KR100856446B1 (ko) | 1998-12-23 | 2008-09-04 | 화이자 인크. | Ctla-4에 대한 인간 단일클론 항체 |
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ES2282133T3 (es) | 1999-08-24 | 2007-10-16 | Medarex, Inc. | Anticuerpos frente a la ctla-4 humano y sus usos. |
US7605238B2 (en) * | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7700359B2 (en) * | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
AU2001282856A1 (en) | 2000-06-15 | 2001-12-24 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
EP1683865A3 (en) | 2001-02-02 | 2006-10-25 | Eli Lilly & Company | Mammalian proteins and in particular CD200 |
CN1564826A (zh) | 2001-02-09 | 2005-01-12 | 人类基因组科学公司 | 人类g蛋白趋化因子受体(ccr5)hdgnr10 |
EP2228389B1 (en) | 2001-04-13 | 2015-07-08 | Human Genome Sciences, Inc. | Antibodies against vascular endothelial growth factor 2 |
IL149701A0 (en) * | 2001-05-23 | 2002-11-10 | Pfizer Prod Inc | Use of anti-ctla-4 antibodies |
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HUE027902T2 (en) | 2004-02-09 | 2016-11-28 | Human Genome Sciences Inc Corp Service Company | Albumin fusion proteins |
KR100845354B1 (ko) * | 2004-03-26 | 2008-07-09 | 화이자 프로덕츠 인코포레이티드 | 항-ctla-4 항체의 용도 |
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WO1997020574A1 (en) | 1997-06-12 |
DE122012000002I1 (de) | 2012-06-14 |
DE69637762D1 (de) | 2009-01-08 |
US5811097A (en) | 1998-09-22 |
ATE415172T1 (de) | 2008-12-15 |
EP0865293A4 (en) | 2002-02-06 |
AU1147397A (en) | 1997-06-27 |
CA2770851C (en) | 2013-09-24 |
CA2239448C (en) | 2013-10-01 |
ES2318853T3 (es) | 2009-05-01 |
EP2106800A1 (en) | 2009-10-07 |
PT865293E (pt) | 2009-03-06 |
DK0865293T3 (da) | 2009-03-23 |
JP2009114191A (ja) | 2009-05-28 |
LU91927I2 (fr) | 2012-03-09 |
JP4477701B2 (ja) | 2010-06-09 |
EP2106800B1 (en) | 2016-12-07 |
DK2332561T3 (en) | 2016-06-06 |
AU730500B2 (en) | 2001-03-08 |
ES2579277T3 (es) | 2016-08-09 |
CA2239448A1 (en) | 1997-06-12 |
EP0865293A1 (en) | 1998-09-23 |
EP0865293B1 (en) | 2008-11-26 |
EP2332561A1 (en) | 2011-06-15 |
PT2332561E (pt) | 2016-06-14 |
EP2332561B1 (en) | 2016-03-30 |
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